CN-122005321-A - Composition for whitening, removing spots and resisting wrinkles, preparation method, essence containing composition and application of essence

Abstract

The application discloses a composition for whitening, removing spots and resisting wrinkles and a preparation method thereof. The raw materials comprise, by mass, 30-50 parts of a temperature-sensitive nano-carrier, 10-20 parts of a self-assembly auxiliary agent, 8-18 parts of a whitening composition, 9-14 parts of an anti-wrinkle composition, 1-6 parts of a spot-fading composition, 2-5 parts of a coating agent and 1-2 parts of a softening agent. In the scheme, the composition can effectively improve the chemical stability of the active ingredients and enhance the synergistic effect of multicomponent delivery, thereby practically overcoming the technical problems of skin whitening, freckle fading and wrinkle resistance non-uniformity caused by easy degradation and low delivery efficiency of the active ingredients in the prior art and obviously improving the long-term stability.

Inventors

• HONG ZIANG
• LIU CHUNLIANG
• BAO CAIJU

Assignees

• 广州市花木草生物科技有限公司

Dates

Publication Date

20260512

Application Date

20260317

Claims (10)

1. 1. The whitening, freckle-removing and wrinkle-resisting composition is characterized by comprising the following components in parts by mass except purified water: A. 30-50 parts of temperature-sensitive nano-carrier; B. 10-20 parts of self-assembly auxiliary agent; C. 8-18 parts of a whitening composition; D. 9-14 parts of an anti-wrinkle composition; E. 1-6 parts of a spot-eliminating composition; F. 2-5 parts of coating agent; G. 1-2 parts of softening agent.
2. 2. The composition for whitening, reducing speckle and resisting wrinkle according to claim 1, wherein the temperature-sensitive nano-carrier comprises any one of Wen Minzhi plastids and temperature-sensitive polymer vesicles.
3. 3. The whitening, speckle-reducing and wrinkle-reducing composition according to claim 1, wherein the self-assembly aid comprises a mixture of hyaluronic acid or chitosan and gelatin, wherein the mass ratio of hyaluronic acid or chitosan to gelatin is 1:1-3:1.
4. 4. The whitening, speckle-reducing and wrinkle-resisting composition according to claim 1, wherein the whitening composition comprises nicotinamide and sclareolide, and the mass ratio of the nicotinamide to the sclareolide is 1:1-1:2.
5. 5. The whitening, speckle-reducing and wrinkle-reducing composition according to claim 1, wherein the wrinkle-reducing composition comprises a mixture of hydroxyethylpiperazine ethane sulfonic acid or arbutin and glucosylrutin, wherein the mass ratio of the hydroxyethylpiperazine ethane sulfonic acid to the glucosylrutin is 1:0.5-1:3.
6. 6. The whitening, speckle-reducing and wrinkle-reducing composition according to claim 1, wherein the speckle-reducing composition comprises phenethyl resorcinol and tranexamic acid, and the mass ratio between the phenethyl resorcinol and the tranexamic acid is 1:0.5-1:10.
7. 7. A method for preparing the whitening, speckle-reducing and wrinkle-reducing composition according to any one of claims 1-6, comprising the steps of: S1, taking a temperature-sensitive nano carrier and a self-assembly auxiliary agent, and mixing at 55-80 ℃ to form a uniform dispersion liquid for later use; S2, slowly adding the whitening composition, the anti-wrinkle composition, the spot-fading composition and the coating agent into the dispersion liquid prepared in the step S1 at the temperature of 20-40 ℃ and stirring and mixing to obtain a mixture for later use; S3, adopting an ultrasonic emulsification or high-pressure emulsification process, and completing emulsification treatment on the mixture prepared in the step S2 within 10-25 minutes, so that active ingredients of whitening, wrinkle resistance and speckle reduction are coated in the temperature-sensitive nano carrier to obtain an emulsion for later use; S4, stirring the emulsion prepared in the step S3 for 1.5-2.5 hours at 15-25 ℃ to form stable multicomponent nano vesicle dispersion for later use; S5, taking a penetration enhancer, adding purified water into the multicomponent nano vesicle dispersion prepared in the step S4, and uniformly mixing and stirring to obtain the whitening, freckle-fading and wrinkle-resisting composition.
8. 8. The essence is characterized by comprising, in addition to purified water, 50-70 parts by weight of the whitening, freckle-fading and wrinkle-resisting composition according to any one of claims 1-6; H. 8-15 parts of humectant I. 4-5 parts of preservative; J. 2-3 parts of chelating agent; K. 3-5 parts of a thickening agent; l, emollient 2-4 parts; M. 1-2 parts of skin protectant.
9. 9. The essence according to claim 8, wherein the humectant comprises one or more of methyl propylene glycol, 1, 3-butylene glycol, glycerin polyether-26, panthenol.
10. 10. Use of the whitening, speckle-reducing and wrinkle-reducing composition according to any one of claims 1-6 in the preparation of cosmetics.

Description

Composition for whitening, removing spots and resisting wrinkles, preparation method, essence containing composition and application of essence Technical Field The application relates to the technical field of cosmetics, in particular to a whitening, freckle-removing and wrinkle-resisting composition, a preparation method, essence containing the composition and application. Background For thousands of years, women's pursuit of whitening has never stopped as has humans pursued brightness. It is well known that human skin color is mainly determined by the amount and distribution of melanin. The production and consumption process of melanin mainly comprises the following steps of stimulating skin by external factors such as ultraviolet rays, generating inflammatory factors, oxygen free radicals and the like, activating tyrosinase and stimulating melanocytes to synthesize melanin by using tyrosine under the participation of tyrosinase, transferring the melanin to keratinocytes through dendrites, and finally falling off along with the keratinocytes. With the continuous increase of the demands of functional cosmetics for whitening skin, lightening spots and anti-wrinkle, the cosmetic field is continuously advancing for the development of multifunctional compositions. The prior art focuses mainly on the optimization of the synergistic effect of antioxidant ingredients to promote the stability and effectiveness of the active ingredients in the skin. According to the disclosure of the prior patent document KR102749722B1, the patent builds a multi-layer antioxidant network by introducing antioxidant components such as alpha-lipoic acid, glutathione, vitamin C, vitamin E, coenzyme Q10 and the like, and aims to improve the problems of skin aging, pigmentation, wrinkles and the like. Although the technology realizes cell regeneration and metabolism regulation through the chain reaction of multiple antioxidants, has a certain effect in the anti-aging and whitening fields, the technical problem of insufficient chemical stability in the storage and use processes is caused by the lack of a molecular anchoring and structure regulating mechanism for active ingredients. Therefore, the problems of stability of the active ingredients and mutual synergy among various active ingredients in the prior art are not solved effectively, so that the active ingredients are unstable and are out of control in delivery, and the market demands of high-efficiency whitening, wrinkle resistance and speckle reduction cannot be met. Disclosure of Invention [ Problem ] to be solved The present application aims to solve at least one of the technical problems existing in the prior art. Therefore, an object of the present application is to provide a composition for whitening, lightening and anti-wrinkle and a preparation method thereof, which can effectively improve chemical stability of active ingredients and enhance synergistic effect of multicomponent delivery, thereby practically overcoming technical problems of uneven effects of whitening, lightening and anti-wrinkle caused by easy degradation and low delivery efficiency of active ingredients in the prior art, and remarkably improving long-term stability. [ Means for solving the problems ] The prior art generally adopts an antioxidant ingredient synergistic system or a ligand inclusion mode to improve the stability of active molecules, but still has the following prominent defects: firstly, most of the traditional physical inclusion or chemical complexation is only remained in the protection of the space blocking layer, and is difficult to effectively inhibit the degradation of active ingredients in external environments such as high temperature, illumination or pH fluctuation due to lack of accurate control on the internal structure and the stimulation response of molecules. Secondly, the traditional multicomponent delivery system is generally realized by simple mixing, and the absorption efficiency and the distribution uniformity of the multifunctional components in actual use are insufficient due to the fact that a controllable release or targeted enrichment mechanism is not utilized, so that multiple effects such as whitening, wrinkle resistance and the like are difficult to be achieved. In the related art, the oil phase/water phase interface coordination is optimized, and the exogenous slow release auxiliary agent is used for coating or changing the dosage form proportion. However, these conventional improvements are still generally limited by single structure, limited stimulus response capability, insufficient bamboo-like multi-target synergy, and the like. In comparison, the application creatively combines the temperature-sensitive nano-carrier and the self-assembly auxiliary agent, not only can strengthen the active inner sealing steady state in the storage period, but also can realize multi-component precise cooperative release and directional enrichment through depolymerization of the t