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CN-122005325-A - Composite sun-screening agent based on encapsulation technology and preparation method and application thereof

CN122005325ACN 122005325 ACN122005325 ACN 122005325ACN-122005325-A

Abstract

The invention provides a composite sun-screening agent based on an encapsulation technology, and a preparation method and application thereof. The preparation method of the composite sun-screening agent comprises the steps of fully dispersing hydroxyapatite nano particles in an alkaline solvent, adding dopamine monomers, performing oxidative polymerization reaction, centrifugally washing and drying to obtain HAP-PDA composite nano particles, fully dispersing the HAP-PDA composite nano particles in the solvent, adding a mixed solution of a chemical sun-screening agent and an antioxidant and a surfactant, performing encapsulation reaction, and centrifuging to obtain the composite sun-screening agent. The invention innovatively adopts the poly-dopamine and hydroxyapatite composite encapsulation technology, which not only remarkably improves the stability and biocompatibility of the sun-screening agent and the antioxidant and enhances the sun-screening effect, but also endows the product with lasting sun-screening effect and excellent oxidation resistance. The invention breaks through the limitation of the traditional sun-proof products and can provide safer, more efficient and comfortable sun-proof experience for consumers.

Inventors

  • LUO XINGWEI
  • CUI YING
  • WANG CHUNJIE

Assignees

  • 齐鲁师范学院
  • 山东科妍生物医药有限公司

Dates

Publication Date
20260512
Application Date
20250409

Claims (10)

  1. 1. A method for preparing a composite sun-screening agent based on encapsulation technology, comprising the steps of: (1) Fully dispersing hydroxyapatite nano particles (HAP) in an alkaline solvent, adding dopamine monomer (PDA), performing oxidative polymerization reaction, centrifugally washing and drying to obtain HAP-PDA composite nano particles; (2) Fully dispersing HAP-PDA composite nano particles in a solvent, adding a mixed solution of a chemical sun-screening agent and an antioxidant and a surfactant, carrying out encapsulation reaction, and centrifuging to obtain the composite sun-screening agent based on an encapsulation technology.
  2. 2. The method of preparing a composite sunscreen according to claim 1, wherein in step (1) one or more of the following conditions are included: i. The particle size of the hydroxyapatite nano particles is 20-100nm; ii. The alkaline solvent is Tris (hydroxymethyl) aminomethane-hydrochloric acid (Tris-HCl) buffer solution, wherein the concentration of Tris (hydroxymethyl) aminomethane in the buffer solution is 0.05-0.1mol/L, and the pH value of the buffer solution is 7-14; iii, the volume ratio of the mass of the hydroxyapatite nanoparticle (HAP) to the alkaline solvent is 1-5:100g/mL.
  3. 3. The method for preparing the composite sun-screening agent based on the encapsulation technology according to claim 1, wherein in the step (1), the mass ratio of the hydroxyapatite nanoparticles to the dopamine is 1-2:1.
  4. 4. The method for preparing the composite sun-screening agent based on the encapsulation technology according to claim 1, wherein in the step (1), the temperature of the oxidation polymerization reaction is room temperature, the reaction time is 12-24 hours, and the reaction is carried out under the condition of light-shielding vibration.
  5. 5. The method for preparing the composite sun-screening agent based on the encapsulation technology according to claim 1, wherein in the step (2), the solvent is deionized water, and the mass-to-solvent volume ratio of the HAP-PDA composite nano particles is 0.01-0.5g/mL.
  6. 6. The method of preparing a composite sunscreen according to claim 1, wherein in step (2) one or more of the following conditions are included: i. The chemical sun-screening agent is a combination of UVA and UVB sun-screening agents, preferably, the chemical sun-screening agent is a combination of two or more of avobenzone, bis-ethylhexyl oxyphenoxyphenyl triazine, ethylhexyl methoxycinnamate, ethylhexyl triazone, ethylhexyl salicylate, diethylcarbamoylbenzoate, homosalate, octocrylene or oxybenzone; ii. The antioxidant is one or more of ascorbic acid and its derivatives, vitamin E and its derivatives or green tea extract; iii, the surfactant is one or the combination of more than two of tween, alkyl polyglycoside or sucrose ester.
  7. 7. The method for preparing the composite sun-screening agent based on the encapsulation technology according to claim 1, wherein in the step (2), the mass ratio of the HAP-PDA composite nano particles to the chemical sun-screening agent is 1:3.75-7.5, the mass ratio of the chemical sun-screening agent to the antioxidant is 1-3:1, and the addition amount of the surfactant accounts for 1-8wt% of the total mass of the HAP-PDA composite nano particles, the chemical sun-screening agent and the antioxidant.
  8. 8. The method of preparing a composite sunscreen according to claim 1, wherein in step (2) one or more of the following conditions are included: i. In the mixed solution of the chemical sun-screening agent and the antioxidant, the mass concentration of the chemical sun-screening agent is 40% -60%, and the solvent is ethanol, propanol, mineral oil or olive oil; ii. The encapsulation reaction is carried out under the conditions of stirring and ultrasound, the stirring speed is 100-300r/min, the ultrasound power is 200-1300W, and the encapsulation reaction time is 1-20min.
  9. 9. A composite sunscreen based on encapsulation technology, characterized in that it is prepared by the process according to any one of claims 1 to 8.
  10. 10. Use of a composite sunscreens based on encapsulation technology as claimed in any of claims 1 to 8 in sunscreening cosmetics.

Description

Composite sun-screening agent based on encapsulation technology and preparation method and application thereof Technical Field The invention belongs to the technical field of cosmetics, and particularly relates to a composite sun-screening agent based on an encapsulation technology, and a preparation method and application thereof. Background With the improvement of living standard, people pay more attention to the health and beauty of the skin, and sun protection is one of the skin care hot spots of modern people. The market demand for sunblocks continues to rise as one of the most effective tools for protecting skin from ultraviolet light. Sunscreens are key components to the protection of the skin from Ultraviolet (UV) radiation, their performance and stability are directly related to the effectiveness and safety of the product. With the penetration of scientific research and the increasing consumer demand, the sun protection technology has undergone a transition from traditional physical sun protection to chemical sun protection, to today's pursuing an efficient, stable, low-irritation integrated sun protection solution. Traditional physical sunscreens, such as zinc oxide and titanium dioxide, achieve a sun protection effect by reflecting or scattering ultraviolet rays, and are high in safety, but often have the defects of thick skin feel, easy whitening and the like. The chemical sun-screening agent has the advantages of light texture and good transparency by absorbing ultraviolet rays and converting the ultraviolet rays into heat energy for release, but has limited wide application due to the problems of poor stability, easiness in photodegradation, possibility of skin irritation and the like. To overcome these drawbacks of sunscreens, researchers have begun to explore various encapsulation techniques aimed at improving the stability and bioavailability of sunscreens. The encapsulation technology forms tiny particles or capsules by wrapping the sun-screening agent in a specific carrier material, thereby protecting the sun-screening agent from the external environment, and simultaneously controlling the release rate of the sun-screening agent to realize the long-acting sun-screening effect. Polydopamine (PDA) is a similar composition of human melanin that can form a nuclear upper cap in human epidermal keratinocytes, mimicking the cellular DNA damage caused by blocking ultraviolet radiation by melanosomes, and has many properties such as light absorption, adhesion, biocompatibility and antioxidant. Inspired by mussel adhesion, PDAs based on dopamine in situ oxidation and self-polymerization can bind to almost all types of surfaces, including hydrophobic and hydrophilic surfaces, as well as inorganic and organic substrates. In addition, the good biocompatibility, ultraviolet resistance and bioadhesion make the polydopamine become an appropriate additive material for ultraviolet resistance, human body sun protection and skin care. For example, zhang et al hybridized PDA with zinc oxide by a one-pot sol-gel method, and added a sun-screening sample of ZnO-PDA sunscreen agent in an amount of only 10wt% to achieve good SPF (77.2) and PA (PA++) values, so that the sun-screening effect of the sunscreen agent can meet the daily use requirement by (Mussel-inspired anti-permeation hybrid sunscreen with reinforcedUV-blocking and safety performance)., but the use of zinc oxide still has the defect of generating active oxygen free radicals. in addition, zhang et al have been simple based on the excellent UV absorption and radical scavenging properties of the biofilm PDA components, The SiO 2 -PDA nano particles are prepared by a high-efficiency one-pot method, the SiO 2 -PDA nano particles are used as a physical blocker to protect skin from harmful ultraviolet rays, and the surfactant-free sun-screening emulsion (Tint-Adjustable Pickering Emulsion Sunscreen Based on Polydopamine-Coated Silica Nanoparticles) is constructed, and has higher safety, but poorer sun-screening performance and SPF value far lower than commercial sun-screening cream. chinese patent document CN 111228141A discloses a bioadhesive lignin-polydopamine/chemical sunscreen microcapsule, a preparation method and application thereof. The method comprises the steps of dissolving 1-10 parts by weight of lignin and 0.2-2 parts by weight of dopamine hydrochloride in Tris-HCl buffer solution, adding 0.01-0.5 part by weight of ammonium persulfate and 0.02-2 parts by weight of hydrogen peroxide, stirring at an open room temperature for 8-36 hours, centrifuging to obtain upper liquid, dialyzing to obtain lignin-polydopamine, dissolving 1-10 parts by weight of lignin-polydopamine in alkaline solution, adding a sun-screening agent and a surfactant, and carrying out ultrasonic cavitation to obtain lignin-polydopamine/chemical sun-screening agent microcapsule emulsion. The lignin/chemical sunscreen microcapsules have excellent ultraviolet absorption perf