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CN-122005330-A - Relief composition containing trans-4-tert-butylcyclohexanol

CN122005330ACN 122005330 ACN122005330 ACN 122005330ACN-122005330-A

Abstract

The invention relates to a relief composition containing trans-4-tert-butylcyclohexanol, belonging to the technical field of cosmetics; the soothing composition comprises a main agent, wherein the main agent comprises trans-4-tert-butylcyclohexanol, nordihydroguaiaretic acid and troxerutin, the soothing composition further comprises an auxiliary agent, the auxiliary agent is prepared by the following steps of S1, preprocessing white water lily roots to obtain white water lily root powder, S2, preprocessing the white water lily roots to obtain the white water lily root powder, S3, extracting active substances of the white water lily root powder and the white water lily root powder from deionized water environment under the action of cellulase, and the soothing composition is high in safety adaptability, easy to accept by skin, reduces sensitive irritation, has a prominent synergistic effect among components, and promotes further application of the trans-4-tert-butylcyclohexanol in the cosmetic field.

Inventors

  • ZHANG WEI
  • HU CHUNQIU

Assignees

  • 广州端木生物科技有限公司

Dates

Publication Date
20260512
Application Date
20260226

Claims (10)

  1. 1. A soothing composition containing trans-4-tert-butylcyclohexanol is characterized by comprising a main agent, wherein the main agent comprises trans-4-tert-butylcyclohexanol, nordihydroguaiaretic acid and troxerutin.
  2. 2. A soothing composition comprising trans-4-tert-butylcyclohexanol according to claim 1, wherein the main agent comprises 40-55 parts by weight of trans-4-tert-butylcyclohexanol, 18-26 parts by weight of nordihydroguaiaretic acid and 12-15 parts by weight of troxerutin.
  3. 3. A soothing composition containing trans-4-tert-butylcyclohexanol according to claim 1, wherein the soothing composition further comprises a side agent, the weight ratio of the main agent to the side agent being 12-18:5-5.8.
  4. 4. A soothing composition comprising trans-4-tert-butylcyclohexanol according to claim 3, wherein said secondary agent is prepared by: S1, taking white water lily roots, cleaning, and sequentially drying and powdering to obtain white water lily root powder; S2, taking withania root, cleaning, and sequentially drying and powdering to obtain withania root powder; S3, adding white water lily root powder and withania root powder into deionized water, performing ultrasonic dispersion, adding cellulase, performing enzymolysis at a controlled temperature, inactivating enzyme, cooling, and sequentially performing centrifugation, filtration and spray drying.
  5. 5. The soothing composition containing trans-4-t-butylcyclohexanol according to claim 4, wherein in step S3, the weight ratio of white water lily root powder to withania root powder is 26-54:35-48, the weight of deionized water is 14-22 times of the total weight of white water lily root powder and withania root powder, and the weight of cellulase is 1-2.7% of the total weight of white water lily root powder and withania root powder.
  6. 6. A soothing composition comprising trans-4-tert-butylcyclohexanol according to claim 4, wherein in step S3, the cellulase has an enzyme activity of 8000-10000U/g.
  7. 7. A soothing composition containing trans-4-tert-butylcyclohexanol according to claim 4, wherein in step S3, the temperature-controlled enzymolysis is performed by heating to 48-58 ℃ in condensing reflux at a speed of 150-200r/min and then performing constant temperature treatment for 90-120min.
  8. 8. A soothing composition containing trans-4-tert-butylcyclohexanol according to claim 4, wherein in step S3, said cooling means treating in condensing reflux in 15-25 ℃ water bath for 5-10min.
  9. 9. A soothing composition comprising trans-4-tert-butylcyclohexanol according to claim 4, wherein in step S3, the centrifugation is carried out for a period of 5-10min at a speed of 6000-10000r/min at a temperature of 25-30 ℃.
  10. 10. A soothing composition comprising trans-4-tert-butylcyclohexanol according to claim 4, wherein in step S3, the filtration accuracy is 0.45-1. Mu.m.

Description

Relief composition containing trans-4-tert-butylcyclohexanol Technical Field The invention belongs to the technical field of cosmetics, and particularly relates to a soothing composition containing trans-4-tert-butylcyclohexanol. Background The trans-4-tert-butylcyclohexanol is a cyclohexanol compound with a specific stereochemical configuration, wherein a tert-butyl substituent is positioned at the 4-position of a cyclohexane skeleton and exists in a trans-form, so that the whole molecule presents a relatively stable space structure. The space structure ensures that the external preparation system has certain physical and chemical stability, and can participate in the perception process of regulating the skin to the external stimulus. Studies have shown that trans-4-tert-butylcyclohexanol reduces skin-induced discomfort caused by irritants, such as stinging, erythema, burning, etc. Based on the above characteristics, trans-4-tert-butylcyclohexanol has been introduced into the cosmetic field for application as a functional raw material having a soothing effect. From the existing application situation, the trans-4-tert-butylcyclohexanol still has obvious defects. Firstly, the synergistic effect of the trans-4-tert-butylcyclohexanol and other active raw materials in a multi-component system is not outstanding, the relieving performance of the trans-4-tert-butylcyclohexanol is difficult to be obviously enhanced under the compounding condition, and the application value is limited. More importantly, the safety adaptability of the trans-4-tert-butylcyclohexanol is still lack of demonstration when the trans-4-tert-butylcyclohexanol is used cooperatively with other active raw materials. Due to the possible molecular interactions between the different components, it is possible to alter the skin microenvironment or influence the mode of action of the active substances after cooperation, leading to an increased risk of irritation. In this case, the desired soothing effect is difficult to exert effectively, and may cause additional irritation to the skin and even induce or exacerbate the existing discomfort. In view of the foregoing, in order to facilitate further applications of trans-4-tert-butylcyclohexanol in the cosmetic field, there is a need for further technical improvements in synergy and safety adaptations. Disclosure of Invention The present invention aims to solve one or more of the technical problems of the prior art described above, and at least provides an advantageous option. In particular, the invention provides a soothing composition containing trans-4-tert-butylcyclohexanol, which has outstanding synergistic effect among components in terms of soothing effect, reduces sensitive irritation, has high safety adaptability, and promotes the application of trans-4-tert-butylcyclohexanol in the field of cosmetics. In order to achieve the aim of the invention, the invention adopts the following technical scheme: A soothing composition containing trans-4-tert-butylcyclohexanol comprises a main agent, wherein the main agent comprises trans-4-tert-butylcyclohexanol, nordihydroguaiaretic acid and troxerutin. In a preferred embodiment of the present invention, the main agent comprises 40-55 parts by weight of trans-4-t-butylcyclohexanol, 18-26 parts by weight of nordihydroguaiaretic acid and 12-15 parts by weight of troxerutin. In a preferred embodiment of the application of the present invention, the soothing composition further comprises a secondary agent, wherein the weight ratio of the primary agent to the secondary agent is 12-18:5-5.8. Preferably, the side agent is prepared by the steps of: S1, taking white water lily roots, cleaning, and sequentially drying and powdering to obtain white water lily root powder; S2, taking withania root, cleaning, and sequentially drying and powdering to obtain withania root powder; S3, adding white water lily root powder and withania root powder into deionized water, performing ultrasonic dispersion, adding cellulase, performing enzymolysis at a controlled temperature, inactivating enzyme, cooling, and sequentially performing centrifugation, filtration and spray drying. Most preferably, in step S1, the temperature of the drying is 40-45 ℃ and the time is 18-24 hours. Most preferably, in the step S1, the powder is sieved by a sieve of 80-100 meshes after finishing the powder grinding. Most preferably, in step S2, the temperature of the drying is 40-45 ℃ and the time is 18-24 hours. Most preferably, in the step S2, the powder is further sieved by a 80-100 mesh sieve after finishing the powder grinding. Most preferably, in the step S3, the weight ratio of the white water lily root powder to the withania root powder is 26-54:35-48, the weight of the deionized water is 14-22 times of the total weight of the white water lily root powder and the withania root powder, and the weight of the cellulase is 1-2.7% of the total weight of the white water lily root powder and the withani