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CN-122005334-A - Polyglycerol-10 oleate nanometer inclusion with particle size smaller than 20nm and natural sources, and preparation method, application and composition thereof

CN122005334ACN 122005334 ACN122005334 ACN 122005334ACN-122005334-A

Abstract

The invention discloses a polyglycerol-10 oleate nanometer inclusion with a particle size smaller than 20nm and a natural source, a preparation method, application and a composition thereof, wherein the nanometer inclusion comprises, by mass, 20-30% of polyglycerol-10 oleate, 30-60% of glycerol, 1-10% of straight-chain natural source grease and 12-30% of dihydric alcohol. The straight-chain natural source oil is selected from at least one of coco caprylate caprate and tocopheryl acetate, and the dihydric alcohol is selected from 1, 2-pentanediol and 1, 3-butanediol. Also discloses a preparation method, application and a composition of the polyglycerol-10 oleate nanometer inclusion. The invention adopts a low-energy emulsifying system to prepare the polyglycerol-10 oleate nanometer inclusion, the prepared nanometer inclusion can load oil-soluble active substances in a universal way, the particle size of the inclusion is smaller than 20nm, and the stability and the safety are good.

Inventors

  • LIN BOCHUAN
  • GAO HONGQI
  • GAO CHENGLONG
  • LENG ZHE
  • WANG YUMEI
  • YU QIBO
  • WANG LILI
  • SANG JIANMEI

Assignees

  • 上海林清轩化妆品集团股份有限公司

Dates

Publication Date
20260512
Application Date
20260416

Claims (10)

  1. 1. The polyglycerol-10 oleate nano inclusion with the particle size smaller than 20nm and natural sources is characterized by comprising the following components in percentage by mass: 20-30% of polyglycerol-10 oleate; 30% -60% of glycerol; 1-10% of straight-chain natural source grease; 12-30% of dihydric alcohol.
  2. 2. The polyglycerol-10 oleate nanosincluding of claim 1, wherein the glycol is at least one selected from the group consisting of 1, 2-pentanediol and 1, 3-butanediol.
  3. 3. The polyglycerol-10 oleate nano-inclusion according to claim 2, wherein the glycol comprises 1, 2-pentanediol and 1, 3-butanediol in a mass ratio of 2-3:2-3.
  4. 4. The polyglycerol-10 oleate nanoshell of claim 1, wherein the straight-chain natural source oil or fat is selected from at least one of coco caprylate caprate and tocopheryl acetate.
  5. 5. A method for preparing the polyglycerol-10 oleate nano-inclusion according to any one of claims 1 to 4, comprising the steps of: S1, mixing polyglycerol-10 oleate and glycerol, and heating and uniformly stirring; S2, adding straight-chain natural source grease, heating and stirring uniformly; s3, adding dihydric alcohol, heating, stirring uniformly, and cooling to obtain the final product.
  6. 6. The method according to claim 5, wherein in step S1, the temperature of the heating and stirring is 55-75 ℃ and the time is 10-30 min.
  7. 7. The method according to claim 5, wherein in step S2, the temperature of the heating and stirring is 55-75 ℃ and the time is 10-30 min.
  8. 8. The method according to claim 5, wherein in step S3, the temperature of the heating and stirring is 55-75 ℃ for 10-30 min; and/or the temperature of the cooling is 0-40 ℃.
  9. 9. Use of the polyglycerol-10 oleate nano-inclusion according to any one of claims 1 to 4 for the preparation of a cosmetic or skin care product.
  10. 10. A composition comprising the polyglycerol-10 oleate nanocapsules of any one of claims 1-4, wherein the polyglycerol-10 oleate nanocapsules are surrounded by an oil-soluble active material comprising at least one of tocopheryl nicotinate, tetraisopalmitate, dipalmitate, ascorbyl palmitate, ascorbyl stearate, ascorbyl tetrahexyldecanol ascorbate, hydroxy pinacolone retinoate, tocopheryl retinoate, retinol propionate, retinol Huang Chunya oleate, retinol acetate, retinol palmitate, retinol, tocopheryl linoleate, tocopheryl palmitate.

Description

Polyglycerol-10 oleate nanometer inclusion with particle size smaller than 20nm and natural sources, and preparation method, application and composition thereof Technical Field The invention relates to the technical field of cosmetics, in particular to a polyglycerol-10 oleate nano inclusion with a particle size smaller than 20nm and a natural source, and a preparation method, application and a composition thereof. Background In the cosmetic field, the small-particle-size coating system can penetrate through the stratum corneum more efficiently, the transdermal efficiency of the active substance is improved, and meanwhile, the system stability is higher due to the extremely small particle size, and precipitation or layering is not easy to occur. However, the preparation of such small-particle-size inclusion bodies in the prior art still faces significant challenges, namely that firstly the preparation difficulty of the small-particle-size inclusion bodies is high, the requirement on the component proportioning is severe, a large amount of surfactant is often required, and the small-particle-size inclusion bodies can have potential irritation to skin, or the large-particle-size inclusion bodies are not beneficial to scale production due to the dependence on high-energy emulsifying equipment (such as a high-pressure homogenizer, an ultrasonic instrument and the like), and secondly, the particle size of the nanometer inclusion bodies in the prior art is still large, most of the particle size of the nanometer inclusion bodies is between 20 and 500 nm, and the development of the advantages and the potential of the ultra-small particle size is still insufficient. The Chinese patent application CN120531635A discloses a self-assembled inclusion of glabridin with ultra-small particle size, a preparation method and application thereof, and mainly relates to a nano inclusion of glabridin which is constructed by liquorice carrier components, specific sucrose ester emulsifier combination and polyalcohol, and the nano inclusion of glabridin is prepared by simple heating and stirring, and the particle size of the prepared glabridin self-assembled inclusion is 10-15 nm. However, the active substance in this patent is only glabridin, and is not applicable to other active substances, and therefore, the versatility is not sufficient, and the oil-soluble active substance cannot be loaded. In addition, the liquorice carrier component used by the method is at least one of glycyrrhizic acid, ammonium glycyrrhetate and glycyrrhetinic acid, the pH can obviously influence the self-assembly behavior of the glycyrrhizic acid carrier, even the glycyrrhetinic acid can be separated out under the acidic condition, so that the higher requirement on the pH of the formula is provided, and the application range of the glycyrrhetinic acid is limited. Furthermore, the emulsifier in this patent must be used by compounding two kinds of emulsifiers, resulting in an increase in production cost. The Chinese patent application CN117919180A discloses idebenone nano liposome and a preparation method thereof, and the patent mainly relates to a idebenone-coated liposome inclusion constructed by emulsifying agents such as PEG-40 hydrogenated castor oil, polyalcohol, phospholipid, cholesterol, water and the like, and the particle size is below 15 nm. However, the preparation method of the patent requires the use of high-energy emulsification processes such as ultrasonic dispersion and high-pressure homogenization, which leads to increased production cost and process complexity, and requires the compounding of phospholipid and an emulsifier to achieve the effect. The Chinese patent application CN104606063A discloses a liposome containing cosmetic active ingredients, a preparation method and application thereof, mainly relates to liposome inclusion constructed by cyclodextrin, surfactant, phospholipid and the like, and adopts a host-guest grafting method to interact host molecules such as cyclodextrin and the like with the surfactant guest molecules to prepare the liposome with the particle size of 20-50 nm. However, the technology needs to use organic solvents such as chloroform and the like, has strict requirements on components, and is not beneficial to large-scale production. In summary, for the ultra-small particle size coating system, the prior art has the defects of strict component requirements, complex process and the like. Based on the method, the polyglycerol-10 oleate is taken as a single emulsifier, so that the ultra-small particle size inclusion with the particle size smaller than 20 nm is prepared, and meanwhile, the method has the advantages of 1 of full-component natural index sources, strong stability and simplicity in preparation, and has extremely high application value in the field of cosmetics. Disclosure of Invention In order to solve the technical problems, the invention aims to provide a polyglycerol-10 oleate nanometer inclusion bod