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CN-122005335-A - Stable sustained-release carbamide peroxide tooth whitening agent composition and preparation method thereof

CN122005335ACN 122005335 ACN122005335 ACN 122005335ACN-122005335-A

Abstract

The invention discloses a stable sustained-release carbamide peroxide tooth whitening agent composition and a preparation method thereof, wherein the composition comprises whitening gel and a catalyst; the whitening gel comprises carbamide peroxide micropowder, a thickener, essence and propylene glycol, and the catalyst comprises inorganic salt, a thickener, an alkaline catalyst, essence and water. The anhydrous whitening gel component of the invention takes propylene glycol as a matrix carrier and takes the catalyst as aqueous gel, when in use, the propylene glycol and the aqueous gel are mixed in a ratio of 4:1, and the mixed product is slowly dissolved by saliva moisture of oral cavity, and the carbamide peroxide active ingredient is continuously released, so that the whitening effect of the product is obviously improved.

Inventors

  • SHI YUE
  • ZHENG CHAO

Assignees

  • 皓白(浙江)医疗器械有限公司

Dates

Publication Date
20260512
Application Date
20260414

Claims (9)

  1. 1. A stable sustained-release carbamide peroxide tooth whitening agent composition, which is characterized by comprising whitening gel and a catalyst; The whitening gel comprises carbamide peroxide micropowder, a thickener, essence and propylene glycol; The catalyst comprises inorganic salt, a thickening agent, an alkaline catalyst, essence and water.
  2. 2. The stable sustained-release carbamide peroxide tooth whitening agent composition according to claim 1, wherein the whitening gel comprises the following components, by mass, 10-50% of carbamide peroxide micropowder, 2-6% of a thickener, 0.05-0.5% of essence, and the balance of propylene glycol.
  3. 3. The stable sustained-release carbamide peroxide tooth whitening composition according to claim 1, wherein the catalyst comprises the following components, by mass, 2-27% of inorganic salt, 6-8% of thickener, 0.2-6.0% of alkaline catalyst, 0.05-0.5% of essence, and the balance of water.
  4. 4. A stable sustained release carbamide peroxide tooth whitening composition according to any of claims 1-3, wherein said thickener is hydroxyethyl acrylate/sodium acryloyldimethyl taurate copolymer.
  5. 5. A stable sustained release carbamide peroxide tooth whitening composition according to claim 1 or 3, wherein said inorganic salt comprises one or more of potassium nitrate and sodium fluoride.
  6. 6. The stable sustained-release carbamide peroxide tooth whitening composition according to claim 1 or 3, wherein the basic catalyst comprises one of sodium hydroxide, potassium hydroxide or a strong organic base, and the pH of the whitening gel and the catalyst after mixing is 7 to 10.
  7. 7. The stable slow release carbamide peroxide tooth whitening composition according to claim 1, wherein the whitening gel and the catalyst are mixed in a volume ratio of 4:1.
  8. 8. A method for preparing a stable sustained-release carbamide peroxide tooth whitening composition, which is characterized in that the method comprises the following steps: S1, preparing whitening gel, namely adding hydroxyethyl acrylate/sodium acryloyldimethyl taurate copolymer and essence into propylene glycol, stirring for 2-10 minutes at a stirring speed of 1000-2000rpm, standing for 2-4 hours, then adding carbamide peroxide micro powder, stirring for 2-20 minutes at a stirring speed of 1000-2000rpm, uniformly dispersing, and finally carrying out vacuum degassing to obtain the whitening gel; S2, preparing a catalyst, namely adding potassium nitrate and sodium fluoride into water, stirring and dissolving, adding hydroxyethyl acrylate/sodium acryloyldimethyl taurate copolymer, stirring for 2-10 minutes at a stirring speed of 1000-2000rpm, standing for 2-4 hours, adding essence and sodium hydroxide, stirring for 2-20 minutes at a stirring speed of 1000-2000rpm, and finally carrying out vacuum degassing to obtain the catalyst.
  9. 9. The method for preparing a stable sustained-release carbamide peroxide tooth whitening composition according to claim 8, wherein the preparation method of carbamide peroxide micropowder is as follows: Adding 35% hydrogen peroxide solution and urea into a jacketed double-layer stirring kettle, wherein the weight ratio of the hydrogen peroxide solution to the urea is 2:1; 2) Controlling the temperature in the double-layer stirring kettle to be 20-30 ℃, starting a frame type stirring motor, and stirring the stirring paddle at the rotating speed of 50-90rpm for reaction for 30-60min; 3) Then controlling the temperature in the double-layer stirring kettle to be 0-5 ℃, starting a frame type stirring motor and a high-speed shearing dispersing motor, continuously stirring the mixed material body by a stirring paddle at the rotating speed of 50-90rpm and a dispersing disc at the rotating speed of 1000-1500rpm, and gradually adding a proper amount of cyclohexane in the process to precipitate carbamide peroxide; 4) Filtering the precipitated carbamide peroxide; 5) Drying or decompressing and drying the carbamide peroxide powder at normal temperature; 6) And (3) sieving the carbamide peroxide powder with a 200-mesh nylon screen to obtain carbamide peroxide micropowder.

Description

Stable sustained-release carbamide peroxide tooth whitening agent composition and preparation method thereof Technical Field The invention relates to the field of tooth whitening compositions, in particular to a stable sustained-release carbamide peroxide tooth whitening agent composition and a preparation method thereof. Background The method for whitening teeth mainly comprises chemical bleaching, masking and whitening and the like through medicines, and also comprises the steps of tooth washing and tooth cleaning and sand blasting to restore the natural color of the teeth. With the increasing development of beauty and dentistry, a chemical bleaching method containing peroxide is becoming more and more popular, and the method is to decompose organic dyeing macromolecules on the surface of teeth into small molecules through oxidation-reduction chemical reaction of the peroxide, so that the color of the organic dyeing macromolecules is changed from deep to light, and the pigments deposited on the surface and deep layer of the teeth are reduced, so that the teeth are whitened. The most commonly used active chemical ingredients for tooth whitening are hydrogen peroxide or carbamide peroxide, which is an adduct of hydrogen peroxide and urea formed by hydrogen bonds, dissociated into free carbamide peroxide and urea in aqueous solution. The carbamide peroxide-containing tooth whitening agent is commonly used for whitening home teeth, namely, the agent is taken home by a patient under the supervision and guidance of a dentist and is usually used for 2-8 hours per day, the agent is continuously used for about two weeks, and the patient extrudes the product into a customized dental tray to wear the dental whitening agent when the agent is used each time. Commercial household tooth whitening products containing carbamide peroxide generally comprise a single component and a double component, wherein the double component products are added with a catalyst component on the basis of the single component, namely, a whitening gel component containing carbamide peroxide is arranged at one end, and a catalyst component containing an activating component is arranged at one end. According to patent number 202311236889.9, the name is a tooth whitening composition based on bi-component solid particles, a preparation method and application thereof, the tooth whitening composition comprises inert polymer solid particles containing whitening active ingredients and inert polymer solid particles containing a catalyst, the two solid particles are mixed to obtain the tooth whitening composition based on the bi-component solid particles, and the two substances are mixed together, so that the requirements on storage conditions are high, and the stability is not high. For example, patent number 2024116194111.9 discloses a toothpaste for whitening teeth, a preparation method thereof and a method for whitening teeth, wherein the first paste comprises peroxide and a first carrier, the second paste comprises low-valence metal salt and a second carrier, and Fenton-like reaction occurs after the first paste and the second paste are contacted to generate free hydroxyl groups which act on the teeth, so that the whitening effect is realized. On the other hand, when the whitening product is used, in order to activate carbamide peroxide as a whitening component, the pH of the mixture of the two components is usually adjusted to 7-10, the pH of the whitening gel component is generally slightly acidic due to the characteristics of peroxide, the pH is approximately 3-5, the common proportion of the whitening gel component and the catalyst component is generally 4:1, thus, the alkalinity of the catalyst component must be high enough (such as the pH value of the catalyst component is as high as about 10 even if the catalyst component is diluted by ten thousand times), the conventional thickening agent such as carbomer cannot resist under the environment with high alkalinity and salt content, gel can only be formed marginally, and when the product is used when the whitening gel and the catalyst component are mixed, the aqueous gel of the catalyst with high alkalinity and the catalyst component encounters anhydrous or trace amount of aqueous carbamide peroxide, and the carbomer gel can not be used after two phases contact. Other common thickeners are not ideal, such as poor colloid form, easy thickening and glue separation during storage, easy leakage of separated water to affect use, weak acidity of the silica, acid-base neutralization reaction with alkaline catalytic components such as sodium hydroxide to cause poor collocation of the composition and influence the product effect, and nonionic surfactants such as poloxamer thickeners, so that the prepared gel has poor thixotropic property and poor leveling property and is not easy to smear to affect use. Disclosure of Invention Based on the above, the invention aims to provide a stable sustained-release