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CN-122005343-A - Repair gel containing PDRN and preparation method thereof

CN122005343ACN 122005343 ACN122005343 ACN 122005343ACN-122005343-A

Abstract

The invention relates to a repair gel containing PDRN and a preparation method thereof, and relates to the technical field of medical instrument preparation, wherein the repair gel comprises, by weight, 0.05-1.0 part of PDRN, 0.01-0.3 part of recombinant humanized collagen, 5.0-8.0 parts of trehalose, 1.0-8.0 parts of glycerol, 0.05-0.8 part of carbomer, 0.1-0.2 part of hexanediol, 0.02-0.12 part of octanoyl hydroxamic acid, 0.05-0.8 part of triethanolamine and 80.78-93.72 parts of water. The composition is simple, the cost is low, the skin is not rejected, the application range is increased, the processing technology is simple, the complexity is low, and the popularization is easy.

Inventors

  • ZHANG CHAO

Assignees

  • 碧研生物科技(江苏)有限公司

Dates

Publication Date
20260512
Application Date
20241112

Claims (7)

  1. 1. A repair gel containing PDRN and a preparation method thereof are characterized by comprising, by weight, 0.05-1.0 part of PDRN, 0.01-0.3 part of recombinant humanized collagen, 5.0-8.0 parts of trehalose, 1.0-8.0 parts of glycerol, 0.05-0.8 parts of carbomer, 0.1-0.2 part of hexanediol, 0.02-0.12 part of octanoyl hydroxamic acid, 0.05-0.8 part of triethanolamine and 80.78-93.72 parts of water.
  2. 2. The repair gel containing the PDRN and the preparation method thereof according to claim 1, wherein the repair gel comprises, by weight, 0.05-1.0 part of the PDRN, 0.01-0.3 part of recombinant humanized collagen, 5.0-8.0 parts of trehalose, 1.0-8.0 parts of glycerol, 0.05-0.8 part of carbomer, 0.1-0.2 part of hexanediol, 0.02-0.12 part of octanoyl hydroxamic acid, 0.05-0.8 part of triethanolamine and 80.78-93.72 parts of water.
  3. 3. The repair gel containing PDRN according to claim 1, wherein the PDRN is a salmon testis extract with a molecular weight of 50 KD-350 KD.
  4. 4. A method for preparing a repair gel containing PDRN, which is characterized in that: Adding 0.05-1.0 part of PDRN, 0.01-0.3 part of recombinant humanized collagen, 5.0-8.0 parts of trehalose, 1.0-8.0 parts of glycerol, 0.1-0.2 part of hexanediol and 0.02-0.12 part of octanoyl hydroxamic acid into a stirring kettle, and adding 80.78-93.72 parts of water for stirring and dissolving; And (II) adding 0.05-0.8 part of carbomer into the mixed solution formed in the step (I), and stirring for dissolving to obtain a carbomer mother solution after swelling.
  5. 5. And step three, finely filtering the mixed solution obtained in the step two in fine filtering equipment.
  6. 6. Step four, adding 0.05-0.8 part of triethanolamine in the step three, and adjusting the pH value to obtain the repair gel of the PDRN; And fifthly, filling the repair gel of the PDRN meeting the detection standard by using filling equipment, packaging the package boxes by using packaging equipment, and coding and warehousing.
  7. 7. The method of claim 5, wherein the fine filtration device in step (III) is sterilized by an ultraviolet sterilizing lamp before use.

Description

Repair gel containing PDRN and preparation method thereof Technical Field The invention relates to the technical field of medical instrument preparation, in particular to a repair gel containing PDRN and a preparation method thereof. Background Regeneration medicine (REGENERATIVE MEDICINE) is a science that searches for effective biological treatment and engineering methods by researching normal tissue characteristics and functions, wound repair and regeneration mechanisms and cell differentiation mechanisms of an organism, promoting self-repair and regeneration of the organism, or constructing new tissues and organs to improve or restore functions of damaged tissues and organs. The method for improving the medical level and medical quality of medical cosmetology by using the advanced knowledge and achievements of regenerative medicine, exploring and finding new biomedical technology and new method of cosmetology and establishing a transformation mode, a tissue mode and a market mechanism of the biomedical technology of the cosmetology will be one of important mission, object and task of the cosmetology industry. Polydeoxyribonucleotides (PDRNs for short) are currently known as the most similar nucleic acids to human DNA as the important genetic material for organisms. PDRN activates the DNA activity of aging cells, improves skin microcirculation, shortens the period of skin cell metabolism, promotes deep collagen secretion, and builds up young healthy muscle. However, how to obtain the skin care product with good transdermal absorbability, improved curative effect and reduced side effects, and safe and reliable repair and regeneration is an urgent problem to be solved. The components of the repairing gel are too complex and various, so that the repairing gel is high in cost and high in price, and meanwhile, the components are complex, so that people with sensitive skin cannot use the repairing gel, and the repairing gel cannot be popularized. Disclosure of Invention Aiming at the defects and shortcomings of the prior art, the invention provides the repair gel containing the PDRN and the preparation method thereof, which have the advantages of simple components, low cost, no rejection to sensitive skin, wide application range, simple processing technology, no complexity and easy popularization. In order to achieve the aim, the repair gel for the PDRN comprises, by weight, 0.05-1.0 part of PDRN, 0.01-0.3 part of recombinant humanized collagen, 5.0-8.0 parts of trehalose, 1.0-8.0 parts of glycerol, 0.05-0.8 parts of carbomer, 0.1-0.2 part of hexanediol, 0.02-0.12 part of octanoyl hydroxamic acid, 0.05-0.8 part of triethanolamine and 80.78-93.72 parts of water. Further, the repair gel comprises, by weight, 0.05-1.0 parts of PDRN, 0.01-0.3 parts of recombinant humanized collagen, 5.0-8.0 parts of trehalose, 1.0-8.0 parts of glycerol, 0.05-0.8 parts of carbomer, 0.1-0.2 parts of hexanediol, 0.02-0.12 parts of octanoyl hydroxamic acid, 0.05-0.8 parts of triethanolamine and 80.78-93.72 parts of water. Further, the repair gel is characterized in that the PDRN is a salmon testis extract, and the molecular weight of the PDRN is 50 KD-350 KD. The preparation method of the repair gel provided by the invention comprises the following steps: Adding 0.05-1.0 part of PDRN, 0.01-0.3 part of recombinant humanized collagen, 5.0-8.0 parts of trehalose, 1.0-8.0 parts of glycerol, 0.1-0.2 part of hexanediol and 0.02-0.12 part of octanoyl hydroxamic acid into a stirring kettle, and adding 80.78-93.72 parts of water for stirring and dissolving; And (II) adding 0.05-0.8 part of carbomer into the mixed solution formed in the step (I), and stirring for dissolving to obtain a carbomer mother solution after swelling. And step three, finely filtering the mixed solution obtained in the step two in fine filtering equipment. Step four, adding 0.05-0.8 part of triethanolamine in the step three, and adjusting the pH value to obtain the repair gel of the PDRN; And fifthly, filling the repair gel of the PDRN meeting the detection standard by using filling equipment, packaging the package boxes by using packaging equipment, and coding and warehousing. Further, before the fine filtering device in the third step is used, the interior of the fine filtering device is sterilized by an ultraviolet sterilizing lamp. After the structure is adopted, the invention provides the repair gel containing the PDRN and the preparation method thereof, which have the advantages of simple components, low cost, no rejection to sensitive skin, wide application range, simple processing technology, no complexity and easy popularization. Detailed Description The repair gel in the specific embodiment (example I) comprises 1.0 part of PDRN, 0.3 part of recombinant humanized collagen, 8.0 parts of trehalose, 8.0 parts of glycerol, 0.8 part of carbomer, 0.2 part of hexanediol, 0.12 part of octanoyl hydroxamic acid, 0.8 part of triethanolamine and 80.78 parts of water. The p