CN-122005344-A - High-solubility and high-stability glabridin whitening oil and preparation method thereof

Abstract

The invention provides a high-solubility and high-stability glabridin whitening oil agent and a preparation method and application thereof, and belongs to the technical field of cosmetics. According to the invention, by introducing specific natural glycolipid, the solubility and long-term stability of glabridin in various common oils can be remarkably improved, and a uniform oil phase system with clear and transparent appearance and light texture is formed. The composition avoids the turbid feeling, sticky skin feeling and safety concern brought by the traditional chemical solubilizer or emulsifier, conforms to the development trend of natural, safe and efficient cosmetics, provides a core solution for developing the 'skin care with oil' type whitening effect product with high quality and transparent appearance, and meets the market demand of high-end skin care oil with excellent effect and pleasant sensory experience.

Inventors

• CAI BINDI
• YUE HUI
• FENG QIUHONG
• LIU SITONG

Assignees

• 广东梵蜜琳生物科技有限公司

Dates

Publication Date

20260512

Application Date

20260119

Claims (10)

1. 1. The use of mannitol erythritol lipid to increase the solubility of glabridin in oil and fat.
2. 2. A glabridin solubilizer, which is characterized in that the glabridin solubilizer contains mannitol erythritol lipid.
3. 3. An oil composition of glabridin, which is characterized by comprising, by weight, 80-120 parts of grease, 0.01-20 parts of glabridin and 0.5-20 parts of solubilizer according to claim 2.
4. 4. A glabridin oil composition according to claim 3, wherein said oil and fat is selected from one or more of caprylic capric triglyceride, squalane, jojoba oil and almond oil.
5. 5. The glabridin oil composition according to claim 4, wherein said oil and fat is caprylic/capric triglyceride.
6. 6. The glabridin oil composition of claim 3, further comprising other whitening active ingredients other than glabridin.
7. 7. The glabridin oil composition according to claim 6, wherein the other whitening active ingredients include at least one of pterostilbene, undecylenoyl phenylalanine, arbutin, phenethyl resorcinol or a plant extract having whitening activity.
8. 8. The method for preparing the glabridin oil composition according to any one of claims 3 to 7, comprising the steps of premixing glabridin with a solubilizer and a part of oil to form a mixed carrier, heating and stirring the mixed carrier, and then adding and mixing the rest of oil to obtain the glabridin oil composition; Or premixing glabridin, solubilizer, other whitening active ingredients other than glabridin and part of grease to form a mixture, heating and stirring the mixture, and then adding the rest of grease and mixing to obtain the glabridin oil composition.
9. 9. The method according to claim 8, wherein the temperature of the heat-stirring treatment is 70 ℃ to 90 ℃; and/or the heating and stirring treatment is carried out for 20 minutes to 40 minutes; And/or the weight of the part of grease is 5-30% of the total weight of the grease.
10. 10. An oil-based cosmetic comprising the glabridin oil composition according to any one of claims 3 to 7 or the glabridin oil composition produced by the production method according to claim 8 or 9.

Description

High-solubility and high-stability glabridin whitening oil and preparation method thereof Technical Field The invention relates to the technical field of cosmetics, in particular to a glabridin whitening oil with high solubility and high stability and a preparation method thereof. Background Glabridin is a natural flavonoid extracted from glabra licorice, and is widely considered as a high-efficiency whitening active ingredient because of the strong inhibition effect on tyrosinase, a key enzyme for skin melanin generation, and is paid attention to in the field of cosmetics. With the popularity of the concept of "skin care with oil", oil-based skin care products are increasingly favored for their good skin-friendly, repairability and delivery potential for fat-soluble active ingredients. However, many highly effective whitening actives, including glabridin, have very low solubility in conventional oil solvents due to their inherent molecular structure characteristics, which severely limits their use in oil-based products in transparent, anhydrous formulations. Currently, the conventional means in the cosmetic industry for improving the dispersion of poorly soluble ingredients in the oil phase mainly involve the use of chemically synthesized solubilizers or by emulsification to form emulsion systems. Although the use of synthetic solubilisers can improve solubility to some extent, it is possible to introduce ingredients that are not skin friendly, and excessive use can affect the natural claims and skin feel of the formulation, while the emulsifying system can make the product appear opaque milky-white, losing the due clear texture of the oil product itself, while the system is relatively complex and stability challenges are greater. Therefore, there is a strong need in the market for a new technology that allows efficient and poorly soluble whitening ingredients such as glabridin to be effectively and stably incorporated into an oil phase carrier without sacrificing transparency, safety and skin feel. Disclosure of Invention The invention aims to provide a high-solubility and high-stability glabridin whitening oil and a preparation method thereof, which solve the technical problems that the high-activity whitening component glabridin has poor solubility in an oil phase system, is easy to separate out, causes unstable formula and is difficult to apply to transparent oil-based cosmetics. In order to achieve the above object, the present invention provides the following technical solutions: the invention provides an application of mannitol erythritol lipid in improving solubility of glabridin in grease. The invention also provides a glabridin solubilizer, which contains mannitol erythritol lipid. The invention also provides a glabridin oil composition, which comprises, by weight, 80-120 parts of grease, 0.01-20 parts of glabridin and 0.5-20 parts of glabridin solubilizer. Preferably, the grease is selected from one or more of caprylic capric triglyceride, squalane, jojoba oil and almond oil. Preferably, the fat is caprylic capric triglyceride. Preferably, the composition further comprises other whitening active ingredients than glabridin. Preferably, the other whitening active ingredients include at least one of pterostilbene, undecylenoyl phenylalanine, arbutin, phenethyl resorcinol or a plant extract having whitening activity. The invention also provides a preparation method of the glabridin oil composition, which is characterized by comprising the following steps of premixing glabridin, a solubilizer and part of grease to form a mixed carrier, heating and stirring the mixed carrier, and then adding the rest of grease and mixing to obtain the glabridin oil composition; Or premixing glabridin, solubilizer, other whitening active ingredients other than glabridin and part of grease to form a mixture, heating and stirring the mixture, and then adding the rest of grease and mixing to obtain the glabridin oil composition. Preferably, the temperature of the heating and stirring treatment is 70 ℃ to 90 ℃; and/or the heating and stirring treatment is carried out for 20 minutes to 40 minutes; And/or the weight of the part of grease is 5-30% of the total weight of the grease. The present invention also provides an oil-based cosmetic characterized by comprising the glabridin oil composition according to any one of claims 3 to 7 or the glabridin oil composition prepared by the preparation method of claim 8 or 9. The invention has the beneficial effects that: According to the invention, by introducing specific natural glycolipid, the solubility and long-term stability of glabridin in various common oils can be remarkably improved, and a uniform oil phase system with clear and transparent appearance and light texture is formed. The composition avoids the turbid feeling, sticky skin feeling and safety concern brought by the traditional chemical solubilizer or emulsifier, conforms to the development trend of natural, safe and