CN-122005355-A - Composition with heat protection effect and preparation method and application thereof

CN122005355ACN 122005355 ACN122005355 ACN 122005355ACN-122005355-A

Abstract

The invention relates to the technical field of raw materials with efficacy of cosmetics, in particular to a composition with efficacy of heat protection, a preparation method and application thereof. The invention provides a composition with heat protection effect, which adopts the combination of cactus polysaccharide, glucan, ectoin and carnosine in a specific proportion, can effectively improve the skin temperature rise and skin sensitive redness caused by heat injury, and has good heat protection effect. The preparation method of the composition has simple process, is suitable for industrial production, and can be widely applied to cosmetics and/or medicines with heat aging resistance requirements.

Inventors

Di Taiju
DU YIJIE
WEI ZHENG
REN HANKUN
QIU XIANRONG
CHEN XIAOPENG
LI YUTING
YAN ERPING
PAN MEIHONG

Assignees

北京东方淼森生物科技有限公司
广东袋鼠妈妈集团有限公司

Dates

Publication Date: 20260512
Application Date: 20260210

Claims (9)

1. The composition with the heat protection effect is characterized by comprising the following components in parts by weight: 50-70 parts of cactus polysaccharide, 25-45 parts of glucan, 1-4 parts of ectoin and 1 part of carnosine.
2. A composition with thermal protection effect according to claim 1, wherein said cactus polysaccharide comprises cactus polysaccharide a, cactus polysaccharide B and cactus polysaccharide C; wherein the number average molecular weight of the cactus polysaccharide A is more than 100000 Da, the number average molecular weight of the cactus polysaccharide B is 10000-100000 Da, and the number average molecular weight of the cactus polysaccharide C is less than 10000 Da; The mass ratio of the cactus polysaccharide A to the cactus polysaccharide B to the cactus polysaccharide C in the cactus polysaccharide is (5-15) = (50-70)/(10-30) of the cactus polysaccharide A to the cactus polysaccharide B to the cactus polysaccharide C.
3. The composition with heat protection effect according to claim 2, wherein the cactus polysaccharide a, the cactus polysaccharide B and the cactus polysaccharide C are prepared by respectively subjecting aqueous cactus extracts to enzymolysis with amylase; Preferably, the preparation method of the cactus polysaccharide comprises the steps of respectively screening cactus polysaccharide A with the number average molecular weight of 100000-Da and cactus polysaccharide B with the number average molecular weight of 10000-100000 Da and cactus polysaccharide C with the number average molecular weight of 10000 Da or less after enzymolysis of the cactus aqueous extract by amylase, and uniformly mixing the cactus polysaccharide A, the cactus polysaccharide B and the cactus polysaccharide C according to the mass ratio of the cactus polysaccharide A to the cactus polysaccharide B to the cactus polysaccharide C= (5-15) to the cactus polysaccharide C= (50-70) to the ratio (10-30).
4. An oily skin care composition according to claim 3, wherein the aqueous extract of cactus is prepared by extracting the stems of cactus with water at 40-70 ℃ for 1-3 hours; Preferably, the mass ratio of the cactus stems to water is cactus: water=1, (10-40); preferably, the mixture is left to stand for 12 to 18 hours after extraction; preferably, the cactus water extract is subjected to enzymolysis after decoloration and filtration; Preferably, the cactus water extract is decolorized by active carbon, and the dosage is 0.5-2.0% of the mass of the material; preferably, the amylase comprises an alpha-amylase; Preferably, the enzymolysis adopts amylase with the dosage of 0.005-0.02% of the mass of the material; Preferably, the enzymolysis temperature is 50-55 ℃; Preferably, the obtained material is desalted after enzymolysis, and then cactus polysaccharide A with the number average molecular weight of more than 100000 Da, cactus polysaccharide B with the number average molecular weight of 10000-100000 Da and cactus polysaccharide C with the number average molecular weight of less than 10000 Da are respectively screened out; Preferably, the desalting is performed with a cationic resin and an anionic resin; Preferably, the screening is carried out in a membrane separation mode, materials with the number average molecular weight of more than 100000 Da are respectively intercepted to be used as cactus polysaccharide A, materials with the number average molecular weight of 10000-100000 Da are intercepted to be used as cactus polysaccharide B, and materials with the number average molecular weight of less than 10000 Da are intercepted to be used as cactus polysaccharide C; Preferably, the mixture is compounded after being uniformly mixed; Preferably, the glycerin is selected for compounding, and the mass ratio of the material mass to the glycerin dosage is that the material is glycerin=1 (0.5-1.5); Preferably, adding a preservative after compounding, wherein the dosage of the preservative is 1% -3% of the total mass of the materials; preferably, the preservative comprises pentanediol/hexanediol Preferably, the final material is sterilized to obtain cactus polysaccharide; preferably, the sterilization comprises sterilization at 95-100 ℃ for more than 40 min.
5. The composition with heat protection effect according to claim 1, wherein the preparation method of the glucan comprises the following steps: And carrying out enzymolysis on the material containing the glucan by using an endonuclease for specifically treating 1,4 glycosidic bonds to obtain a glucan product, wherein the number ratio of 1,4 glycosidic bonds/1, 3 glycosidic bonds in the glucan product is below 1.8.
6. A composition having a thermal protective effect according to claim 5 wherein said glucan comprises beta-glucan; Preferably, the glucan comprises cereal beta-glucan; preferably, the glucan comprises one or more of oat beta-glucan, highland barley beta-glucan and barley beta-glucan; Preferably, the endoenzymes specifically treating 1,4 glycosidic bonds comprise one or more of cellulose endoenzymes, mannanases and glucanases; preferably, the enzymolysis time is 30-60min; Preferably, the enzymolysis temperature is 50-60 ℃; the material containing the glucan is obtained by carrying out enzymolysis extraction on plant raw materials containing the glucan or is prepared by dissolving raw materials containing the glucan; Preferably, the enzymatic extraction is performed with alkaline protease; preferably, during the enzymolysis extraction, the mass ratio of the plant raw material containing glucan to water is 1 (10-20), preferably 1:15; Preferably, when the glucan-containing raw material is dissolved, the mass ratio of the glucan-containing raw material to water is 1 (12-70), preferably 1:14; Preferably, the temperature of the enzymolysis extraction is 70-90 ℃, preferably 80-85 ℃; Preferably, the temperature at which the glucan-containing feedstock is dissolved is from 70 to 90 ℃, preferably from 80 to 85 ℃; The glucan-containing plant material comprises cereal, preferably one or more of oat, highland barley and barley; Preferably, the glucan-containing plant material comprises plant bran; the preparation method further comprises at least one of decolorization, desalination and deproteinization; The number of times of decoloring is 1 to 3 times, preferably 2 times; Preferably, the total addition amount of the decoloring agent is 2-5% of the total mass of the material to be decolored, and more preferably 2-3%; preferably, the decolorizing agent comprises activated carbon; preferably, the time of each decolorization is 30-60min; preferably, the temperature of each decolorization is 75-85 ℃; further preferably, the number of times of decolorization is 2, wherein 3% of the total mass of the material to be decolorized is added in the first time, decolorized for 30min at 80-85 ℃, 2% of the total mass of the material to be decolorized is added in the second time, and decolorized for 30min at 80-85 ℃; preferably, desalting is performed by using anion-cation exchange resin; preferably, the material flow rate in the desalting process is 1-3 t/h, and further preferably, the material flow rate in the desalting process is 2-3 t/h; filtering the obtained product and compounding to obtain a glucan product; preferably, one or more of hexanediol, pentanediol, glycerin and PEHG are adopted as a compound solvent for compounding; Preferably, sterilization is performed after compounding.
7. The method of preparing a composition having a heat protective effect according to any one of claims 1 to 6, wherein cactus polysaccharide, dextran, ectoin and carnosine are uniformly mixed.
8. The method for preparing the composition with the heat protection effect according to claim 1, which is characterized by comprising the steps of mixing cactus polysaccharide and glucan, heating to 40-60 ℃, stirring for 0.5-1h, adding the ectoin and carnosine into the mixed solution of the cactus polysaccharide and the glucan, and continuing stirring for 0.5-1h until the mixture is uniform; Preferably, filtering after uniformly mixing, collecting filtrate and sterilizing; preferably, the sterilization temperature is 80-90 ℃, and the sterilization time is 30-50 min.
9. Use of a composition with thermal protection according to any one of claims 1 to 6 or a composition with thermal protection according to claim 7 or 8 for the preparation of cosmetics and/or pharmaceuticals.

Description

Composition with heat protection effect and preparation method and application thereof Technical Field The invention relates to the technical field of raw materials with efficacy of cosmetics, in particular to a composition with efficacy of heat protection, a preparation method and application thereof. Background With the increase of high-temperature environment exposure scenes, the demand of the cosmetic field for heat protection raw materials is increasing. The TRPV1 channels on the heat activatable cell membrane trigger ca2+ influx, activate the Protein Kinase C (PKC) pathway, and at the same time induce ROS production, both of which together activate the MAPK family and further up-regulate MMPs expression, degrading collagen and elastin in the skin, ultimately leading to premature skin aging. In addition, the thermal injury can also increase the expression of the angiogenesis factor VEGF, reduce the expression of the anti-angiogenesis factor and cause the skin redness inflammation. In the prior art, researches on skin thermal protection are concentrated on single active ingredients or simple compound systems, such as polysaccharide, amino acids, micromolecular protective agents and other raw materials, and local thermal injury symptoms can be relieved to a certain extent, but the whole efficacy performance has obvious limitations, wherein the improvement effect on thermal injury is weak in the practical application due to the mutual influence of the ingredients of part of the compound systems, and related ingredients possibly need to be additionally modified, so that the practical requirement of cosmetics on the thermal protection efficacy is difficult to be met. Meanwhile, the conventional polysaccharide raw materials sold in the market often have the problems of poor stability, poor compatibility with a cosmetic system, insufficient efficacy exertion and the like, and further limit the industrialized application of the heat protection efficacy raw materials. Therefore, the research and development of the multi-component synergistic heat protection effect composition capable of improving skin problems caused by heat injury in multiple aspects meets the practical application requirements of cosmetics on resisting heat aging and relieving heat stimulation, and becomes the research focus and development direction in the field. In view of this, the present invention has been made. Disclosure of Invention An object of the present invention is to provide a composition with heat protection effect, a preparation method and application thereof, and the composition has excellent heat protection effect. Another object of the present invention is to provide a method for preparing the composition with heat protection effect, which is simple in process and suitable for industrial production. A third object of the present invention is to provide an application of the composition with thermal protection effect in preparing cosmetics and/or pharmaceuticals, which has a wide application prospect in cosmetics and/or pharmaceuticals with thermal aging resistance requirements due to its excellent thermal protection effect. In order to achieve the above purpose, the invention provides a composition with heat protection effect, which comprises the following components in parts by weight: 50-70 parts of cactus polysaccharide, 25-45 parts of glucan, 1-4 parts of ectoin and 1 part of carnosine. The composition with the heat protection effect comprises cactus polysaccharide, glucan, ectoin and carnosine in a specific proportion, can effectively improve skin temperature rise and skin sensitive redness caused by heat injury, and has a good heat protection effect. The invention also provides a preparation method of the composition with the heat protection effect, which comprises the step of uniformly mixing the cactus polysaccharide, the glucan, the ectoin and the carnosine. In another aspect, the invention provides the use of a composition with the heat protection effect in the preparation of cosmetics and/or medicines. The oily skin care composition has excellent heat protection effect and can be widely applied to cosmetics and/or medicines with heat aging resistance requirements. Compared with the prior art, the invention has the beneficial effects that: the invention adopts the combination of the cactus polysaccharide, the glucan, the ectoin and the carnosine in a specific proportion, can effectively improve the skin temperature rise and the skin sensitive redness caused by thermal injury, and has good thermal protection effect. The preparation method of the composition has simple process, is suitable for industrial production, and can be widely applied to cosmetics and/or medicines with heat aging resistance requirements. Drawings In order to more clearly illustrate the embodiments of the present invention or the technical solutions in the prior art, the drawings that are needed in the description of the embodiments or the pri