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CN-122005358-A - Ethylhexyl triazinone sun-screening agent suitable for sensitive muscles and process

CN122005358ACN 122005358 ACN122005358 ACN 122005358ACN-122005358-A

Abstract

The invention discloses an ethylhexyl triazinone sun-screening agent suitable for sensitive muscles and a preparation process thereof, wherein ethylhexyl triazinone is dissolved in caprylic acid/capric acid triglyceride and is emulsified into a nanoscale oil phase sun-screening core through a low-content nano emulsifier; the pH responsive nano-carrier is formed by the sodium alginate, chitosan and calcium chloride through a crosslinking system, the nano-carrier is embedded with a nano-level oil phase sun-proof core through a nano-particle structure, and glycerin and disodium ethylenediamine tetraacetate are mixed to form a water phase matrix based on deionized water for dispersing the pH responsive nano-carrier. The invention obviously reduces the oil phase content of the system and the addition amount of the emulsifier, improves the skin feel and reduces the irritation, isolates the ethylhexyl triazone from being in direct contact with the skin through the embedding load effect of the carrier, reduces the percutaneous penetration of the ethylhexyl triazone and reduces the irritation risk to sensitive skin, and in addition, the whole sunscreen agent has a mild and comfortable formula, is fresh and not sticky, and has more uniform film formation.

Inventors

  • SHI XIAONAN
  • CAI JIAN
  • ZHANG GONGGUO
  • ZHANG CHUNXIAN

Assignees

  • 济宁学院

Dates

Publication Date
20260512
Application Date
20260323

Claims (9)

  1. 1. The ethylhexyl triazinone sun-screening agent suitable for the sensitive muscles is characterized by comprising the following components in parts by weight: 2.0 to 5.0 parts of ethylhexyl triazone, 1.0 to 2.0 parts of sodium alginate, 0.3 to 1.5 parts of chitosan, 0.05 to 0.2 parts of calcium chloride, 3.0 to 5.0 parts of caprylic/capric triglyceride, 1.5 to 3.0 parts of low-content nanoemulsion, 2.0 to 4.0 parts of 1, 2-pentanediol, 3.0 to 5.0 parts of glycerol, 0.05 to 0.1 part of disodium edetate, 0.5 to 0.8 part of preservative and 70 to 75 parts of deionized water; The ethylhexyl triazone is dissolved in caprylic/capric triglyceride and is emulsified into a nanoscale oil phase sun-proof core through a low-content nanoemulsion; The pH response type nano-carrier is constructed by the sodium alginate, the chitosan and the calcium chloride through a crosslinking system, and the nano-level oil phase sun-proof core is embedded and loaded in the pH response type nano-carrier through a nano-particle structure; Based on the deionized water, mixing glycerol and disodium ethylenediamine tetraacetate to form a water phase matrix, and dispersing the pH responsive nano-carrier of the embedded oil phase sun-screening core in the water phase matrix.
  2. 2. The ethylhexyl triazone sun-screening agent for sensitive muscles according to claim 1, wherein 0.05-0.15 parts of xanthan gum is added into the ethylhexyl triazone sun-screening agent.
  3. 3. The ethylhexyl triazone sun-screening agent for sensitive muscles according to claim 2, wherein the nanoemulsifier is nano-scale polyglycerol-6 distearate or Tween 80.
  4. 4. The ethylhexyl triazone sun-screening agent for sensitive muscles according to claim 3, wherein said preservative is phenoxyethanol.
  5. 5. The ethylhexyl triazone sun-screening agent for sensitive muscles according to claim 4, wherein the pH responsive nanocarrier is tightly combined with sodium alginate under normal muscle conditions with pH value of 4.5-6.0 to lock the nanoscale oil phase sun-screening core; under the condition of sensitive muscles with the pH value of 6.0-7.0, the charge effect of chitosan is weakened, the chitosan and the carrier crosslinked by sodium alginate can be controllably swelled, and the nanoscale oil phase sun-screening core is slowly released.
  6. 6. A process for the preparation of ethylhexyl triazone sunscreens suitable for sensitive muscles as claimed in claim 5, comprising the following process steps: Step one, preparing a nanoscale oil phase sun-proof inner core: Adopting a secondary emulsification mode to prepare ethylhexyl triazone, caprylic/capric triglyceride and nanoemulsion into a nanoscale oil phase sun-proof core with the particle size smaller than 100 nm; Step two, preparing a sodium alginate phase: Adding disodium ethylenediamine tetraacetate and glycerol into the rest deionized water, and stirring until the disodium ethylenediamine tetraacetate and the glycerol are completely dissolved; Adding sodium alginate, stirring at high speed, dispersing until completely dissolving to obtain uniform sodium alginate phase, and keeping the temperature for later use; step three, chitosan phase preparation: Dissolving chitosan in acidic aqueous solution, stirring until chitosan is completely dissolved to obtain chitosan phase for standby; Step four, preparing a primary emulsion: Slowly adding the well-insulated nanoscale oil phase sun-proof inner core into a sodium alginate phase, and emulsifying under high-speed shearing condition for 5-10 min to prepare O/W type primary emulsion; Step five, electrostatic self-assembly and ionic crosslinking: slowly dripping the chitosan phase solution into the O/W type primary emulsion under the stirring condition, and continuously stirring for 20-40min so that the sodium alginate and the chitosan form a core-shell structure precursor through electrostatic interaction; slowly dropwise adding a calcium chloride aqueous solution, stirring for 30-60min, completing ionic crosslinking of Ca 2+ on sodium alginate, and curing the pH response type nano-carrier structure; step six, thickening and viscosity regulating: Continuously adding a xanthan gum solution into the solution product obtained in the step five, stirring until the mixture is uniform, and regulating the viscosity of the system; Step seven, preservative and post treatment: And D, cooling the sun-screening agent subjected to viscosity regulation in the step six to below 35 ℃, adding a preservative, uniformly stirring, and then defoaming, filtering and discharging to obtain the pH response type nano-carrier ethylhexyl triazone sun-screening agent.
  7. 7. The preparation process of the ethylhexyl triazone sun-screening agent for sensitive muscles according to claim 6, wherein in the first step, the secondary emulsification process is that the ethylhexyl triazone and the caprylic/capric triglyceride nanoemulsifier are added into an oil phase container according to the weight requirement; heating to 45-55 ℃, and stirring until the ethylhexyl triazone is completely dissolved to obtain a uniform and transparent primary emulsified oil phase; And 3-5 parts by weight of deionized water is taken and continuously added into the primary emulsified oil phase in a dropwise manner for dilution, and the nanoscale oil phase sun-screening inner core with the particle size smaller than 100 nm is obtained through spontaneous microemulsification.
  8. 8. The process for preparing the ethylhexyl triazone sun-screening agent for sensitive muscles as claimed in claim 7, wherein in the third step, the chitosan phase is prepared by adopting any one of dilute aqueous citric acid solution and dilute aqueous lactic acid solution and adjusting the pH to 4.0-5.5.
  9. 9. The preparation process of the ethylhexyl triazone sun-screening agent for sensitive muscles according to claim 8, wherein in the step six, the proper range of the system viscosity is 3000-6000 mPa.s under the condition of 25 ℃.

Description

Ethylhexyl triazinone sun-screening agent suitable for sensitive muscles and process Technical Field The invention relates to a sun-screening agent and a process, in particular to an ethylhexyl triazinone sun-screening agent and a process suitable for sensitive muscles. Background Ethylhexyl triazone (Ethylhexyl Triazone) is a high quality UVB/UVA-II sunscreen ingredient with high efficacy, light stability, low transdermal absorption, low irritation, and is commonly used in current sunscreen products. The traditional ethylhexyl triazinone sun-screening agent is mainly an open system without nano carriers and embedding systems, however, the ethylhexyl triazinone is solid or high-viscosity oily and can be added into a formula only by being dissolved in a large amount of grease, so that the traditional ethylhexyl triazinone sun-screening agent has the defects of thick grease and poor skin feel of the formula, and further the thick grease can block pores to aggravate inflammation, so that the traditional ethylhexyl triazinone sun-screening agent is unfriendly to sensitive muscles, in addition, in order to stably disperse the oil-soluble ethylhexyl triazinone in a water-based system, emulsification treatment is required, the ethylhexyl triazinone is easy to crystallize and has high requirements on the stability of an emulsifying system, the system is required to be kept stable by using a high-dose and strong-irritation emulsifier, the skin barrier is easy to break, and the sensitization and irritation risks are further increased, so that the traditional formula of the ethylhexyl triazinone sun-screening agent is difficult to meet the requirements of sensitive muscles and mild sun-screening. Disclosure of Invention In order to solve the defects of the technology, the invention provides an ethylhexyl triazone sun-screening agent and a process suitable for sensitive muscles. In order to solve the technical problems, the invention adopts the technical scheme that the ethylhexyl triazone sun-screening agent suitable for sensitive muscles comprises the following components in parts by weight: 2.0 to 5.0 parts of ethylhexyl triazone, 1.0 to 2.0 parts of sodium alginate, 0.3 to 1.5 parts of chitosan, 0.05 to 0.2 parts of calcium chloride, 3.0 to 5.0 parts of caprylic/capric triglyceride, 1.5 to 3.0 parts of low-content nanoemulsion, 2.0 to 4.0 parts of 1, 2-pentanediol, 3.0 to 5.0 parts of glycerol, 0.05 to 0.1 part of disodium edetate, 0.5 to 0.8 part of preservative and 70 to 75 parts of deionized water; Ethylhexyl triazone is dissolved in caprylic/capric triglyceride and is emulsified into a nanoscale oil phase sun-protection core through a low-content nanoemulsion; constructing a pH response type nano-carrier by using sodium alginate, chitosan and calcium chloride through a crosslinking system, and embedding a nano-level oil phase loaded sun-proof core by using the pH response type nano-carrier through a nano-particle structure; Based on deionized water, glycerin and disodium ethylenediamine tetraacetate are mixed to form a water phase matrix, and the pH responsive nano-carrier of the embedded oil phase sun-screening core is dispersed in the water phase matrix. Preferably, 0.05-0.15 parts of xanthan gum is also added into the ethylhexyl triazone sun-screening agent. Preferably, the nanoemulsion is nano-scale polyglycerol-6 distearate or tween 80. Preferably, the preservative is phenoxyethanol. Preferably, under the normal muscle condition that the pH value of the pH responsive nano-carrier is 4.5-6.0, chitosan and sodium alginate are tightly combined to lock the nano-scale oil phase sun-proof inner core; Under the condition of sensitive muscles with pH value of 6.0-7.0, the pH response type nano-carrier weakens the charge effect of chitosan, the carrier crosslinked by chitosan and sodium alginate can be controllably swelled, and the nano-scale oil phase sun-proof core is slowly released. A process for preparing ethylhexyl triazone sun-screening agent suitable for sensitive muscles, comprising the following process steps: Step one, preparing a nanoscale oil phase sun-proof inner core: Adopting a secondary emulsification mode to prepare ethylhexyl triazone, caprylic/capric triglyceride and nanoemulsion into a nanoscale oil phase sun-proof core with the particle size smaller than 100 nm; Step two, preparing a sodium alginate phase: Adding disodium ethylenediamine tetraacetate and glycerol into the rest deionized water, and stirring until the disodium ethylenediamine tetraacetate and the glycerol are completely dissolved; Adding sodium alginate, stirring at high speed, dispersing until completely dissolving to obtain uniform sodium alginate phase, and keeping the temperature for later use; step three, chitosan phase preparation: Dissolving chitosan in acidic aqueous solution, stirring until chitosan is completely dissolved to obtain chitosan phase for standby; Step four, preparing a primary emulsion: Slowly adding the w