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CN-122005361-A - Targeted antiperspirant

CN122005361ACN 122005361 ACN122005361 ACN 122005361ACN-122005361-A

Abstract

The invention provides a targeted antiperspirant, and relates to the technical field of targeted antiperspirants. The preparation method of the targeted antiperspirant specifically comprises the following steps of (1) preparing a chelating protective agent, (2) preparing aluminum chlorohydrate activating solution, (3) preparing blank micelle, (4) carrying out micelle loading, (5) cooling and solidifying, and (6) emulsifying. According to the technology, the poloxamer 407 self-assembled characteristic is utilized, a micelle with the particle size of about 20nm is formed through self-assembly, the core-thinning efficient encapsulation of the aluminum chlorohydrate hydrolysis intermediate is realized, the intelligent release micelle is disintegrated at the skin temperature, the aluminum chlorohydrate nanogel cluster is released, and is crosslinked into a porous physical membrane after sweat is encountered, so that sweat ducts are reversibly blocked, sweat is prevented from being smoothly discharged to the skin surface, the efficient antiperspirant effect is realized, inulin and antibacterial components are added to maintain the balance of armpit flora, so that the antiperspirant and deodorization are realized, the bisabolol is effectively fused, the skin can be relaxed during nursing, and the skin barrier is strengthened.

Inventors

  • CAO JUNYI
  • CUI CHUNLI
  • JIA YONGGANG
  • ZHANG YIBIN
  • CHENG XIAOFENG

Assignees

  • 粒子树(西安)生物科技有限公司

Dates

Publication Date
20260512
Application Date
20260202

Claims (6)

  1. 1. A method for preparing a targeted antiperspirant, comprising the steps of: (1) Preparing a chelating protective agent, namely dissolving 0.1 part of EDTA disodium, 0.8 part of triethyl citrate and 5 parts of dipropylene glycol into 10 parts of water by mass, and stirring at 60 ℃ to form a transparent solution; (2) Preparing activated solution of aluminum hydroxide chloride, namely adding 8 parts of aluminum hydroxide chloride into the solution obtained in the step (1), and adding saturated solution of sodium bicarbonate under high-speed stirring to adjust the pH to 6.0; (3) Preparing blank micelle, namely dissolving 3 parts of poloxamer 407 into 57 parts of deionized water, refrigerating and stirring at 4 ℃ until a transparent blank micelle solution is formed; (4) Micelle loading, namely heating the blank micelle solution obtained in the step (3) to 15 ℃, adding the activation solution obtained in the step (2), heating to 37 ℃ at a speed of 1 ℃ per min under stirring at 300rpm, and carrying out heat preservation and stirring for 30 minutes to enable Al3+ to be coated in micelle hydrophobic cores; (5) Cooling and solidifying, namely cooling the system obtained in the step (4) to 25 ℃, adding 1.5 parts of trehalose and 10 parts of dipropylene glycol, and stirring and dissolving to obtain micelle dispersion liquid; (6) The preparation method comprises the steps of dissolving 2 parts of inulin in 88.595 parts of deionized water, uniformly mixing, mixing 0.2 part of bisabolol, 0.3 part of peppermint oil, 0.005 part of rose essence, 1.2 parts of phenoxyethanol, 0.7 part of hexyl glycerol and 2 parts of emulsifying agent WR-H07 in a hot melt manner, adding the mixture into an inulin aqueous solution, homogenizing at a high speed, cooling to normal temperature, adding 8 parts of micelle dispersion liquid obtained in the step (5), and uniformly mixing to obtain the targeted antiperspirant.
  2. 2. A method of preparing a targeted antiperspirant according to claim 1, wherein: the pH value of the targeted antiperspirant prepared by the method is 6.0-6.5.
  3. 3. The method of claim 1, wherein the average particle size of the nano-micelle of the active ingredient in the targeted antiperspirant is 20nm to 150nm.
  4. 4. The method of claim 1 wherein the nanomicelle dissociates and releases aluminum chlorohydrate nanogel clusters at skin temperature, and wherein the nanogel clusters cross-link to form a porous physical membrane at sweat pH >6.5 to reversibly occlude sweat gland ducts.
  5. 5. A method of preparing a targeted antiperspirant according to claim 1, wherein the inulin is used to regulate the balance of skin flora and the bisabolol is used to soothe the skin and repair skin barriers.
  6. 6. The antiperspirant efficacy assessment method of a targeted antiperspirant according to any of claims 1-5, comprising the steps of: (a) Uniformly coating the antiperspirant on filter paper, and drying to form a film; (b) Dripping the artificial simulated sweat into a film forming area, and recording the time of penetrating the filter paper and the transverse diffusion diameter of the sweat; (c) Antiperspirant efficacy was assessed by penetration time and diffusion diameter.

Description

Targeted antiperspirant Technical Field The invention relates to the technical field of targeted antiperspirants, in particular to a targeted antiperspirants. Background Antiperspirant is a personal care product used to reduce perspiration in humans and its principal active ingredient is typically an aluminum salt compound (such as aluminum chlorohydrate). Its core effect is not to completely prevent perspiration, which is critical to body heat dissipation and health, but rather to significantly reduce the amount of perspiration secreted by specific sites (e.g. the underarm) by the aluminum salt component therein mixing with the perspiration at the skin surface, forming a gel-like mass that temporarily "plugs" the sweat gland ducts. The reduction of sweating directly brings multiple effects of firstly controlling the discomfort and embarrassment caused by hyperhidrosis or excessive sweat in daily life, keeping skin dry and refreshing, and secondly effectively preventing body odor caused by bacteria breeding in the wet environment of sweat, because most of antiperspirant has deodorizing function, the antibacterial components in the formula can decompose or mask peculiar smell. Therefore, the sweat-resistant clothes can not only improve personal comfort and self-confidence, but also avoid sweat damage to clothes. At present, the existing antiperspirant technology relies on the hydrolysis and cross-linking of active ingredients such as aluminum chlorohydrate, aluminum zirconium glycinate and the like in sweat to form physical gel to block sweat ducts, so as to achieve the antiperspirant effect, and the active ingredients are generally dispersed or dissolved in matrixes such as alcohol, water, silicone oil, esters and the like, and are prepared into emulsion or emulsion form through conventional processes such as emulsification, thickening and the like. The traditional antiperspirant technology is relatively 'passive' and 'direct', aluminum salt particles are randomly diffused to skin and sweat glands by means of concentration gradients, a large amount of aluminum ions are directly contacted with the skin surface, so that skin irritation is caused, meanwhile, active ingredients are easy to react with skin surface substances, loss is fast, precise space-time control is lacked, durability is short, nano micelles are formed by self-assembly of poloxamer and active ingredients, structural transformation is carried out under specific conditions (skin temperature and sweat pH), and therefore antiperspirant ingredients are activated and released, adhesiveness between nano composite gel formed by self-assembly and sweat ducts is strong while better antiperspirant effect is achieved by lower concentration, and effect is long-lasting and skin irritation is greatly reduced. Disclosure of Invention Aiming at the defects of the prior art, the invention provides a targeted antiperspirant, which solves the problems of poor effect, short acting time and strong skin irritation of the traditional antiperspirant. In order to achieve the above purpose, the invention is realized by the following technical scheme: a method for preparing a targeted antiperspirant, comprising the steps of: (1) Preparing a chelating protective agent, namely dissolving 0.1 part of EDTA disodium, 0.8 part of triethyl citrate and 5 parts of dipropylene glycol into 10 parts of water by mass, and stirring at 60 ℃ to form a transparent solution; (2) Preparing activated solution of aluminum hydroxide chloride, namely adding 8 parts of aluminum hydroxide chloride into the solution obtained in the step (1), and adding saturated solution of sodium bicarbonate under high-speed stirring to adjust the pH to 6.0; (3) Preparing blank micelle, namely dissolving 3 parts of poloxamer 407 into 57 parts of deionized water, refrigerating and stirring at 4 ℃ until a transparent blank micelle solution is formed; (4) Micelle loading, namely heating the blank micelle solution obtained in the step (3) to 15 ℃, adding the activation solution obtained in the step (2), heating to 37 ℃ at a speed of 1 ℃ per min under stirring at 300rpm, and carrying out heat preservation and stirring for 30 minutes to enable Al3+ to be coated in micelle hydrophobic cores; (5) Cooling and solidifying, namely cooling the system obtained in the step (4) to 25 ℃, adding 1.5 parts of trehalose and 10 parts of dipropylene glycol, and stirring and dissolving to obtain micelle dispersion liquid; (6) The preparation method comprises the steps of dissolving 2 parts of inulin in 88.595 parts of deionized water, uniformly mixing, mixing 0.2 part of bisabolol, 0.3 part of peppermint oil, 0.005 part of rose essence, 1.2 parts of phenoxyethanol, 0.7 part of hexyl glycerol and 2 parts of emulsifying agent WR-H07 in a hot melt manner, adding the mixture into an inulin aqueous solution, homogenizing at a high speed, cooling to normal temperature, adding 8 parts of micelle dispersion liquid obtained in the step (5),