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CN-122005363-A - High-stability tooth care paste containing bioactive glass

CN122005363ACN 122005363 ACN122005363 ACN 122005363ACN-122005363-A

Abstract

The invention relates to the technical field of medical dental preparation and tooth care composition with clinical treatment efficacy, and discloses tooth care paste containing bioactive glass with high stability, which comprises a carrier composed of polyethylene glycol-400 and polyethylene glycol-3000 in a mass ratio of 8:1 to 12:1, xylitol, anhydrous sodium citrate and bioactive glass, wherein the xylitol is in a supersaturated precipitation state in the carrier, the anhydrous sodium citrate induces in-situ precipitation of the xylitol and builds a three-dimensional crystallization grid formed by interlacing dendrite microcrystals with the diameter of 200nm to 500nm, the bioactive glass is physically locked through a steric effect, the temperature sensitivity of rheological properties is reduced by utilizing the rigid support of the crystallization grid, component sedimentation is inhibited, the grid has water-induced dissolution property, the bioactive glass reactive surface is instantaneously dissolved and completely exposed when contacting saliva, ion instant exchange is ensured, and the problems of poor storage stability and passivation of the active surface of the system are solved.

Inventors

  • XIANG WEIHONG
  • ZHANG JUN
  • XIANG ZHENG

Assignees

  • 湖南海元生物科技有限公司

Dates

Publication Date
20260512
Application Date
20260413

Claims (10)

  1. 1. The high-stability bioactive glass-containing tooth care paste is characterized by comprising the following components in parts by weight: 40 to 80 parts of polyethylene glycol carrier, which is formed by mixing polyethylene glycol-400 and polyethylene glycol-3000 in a mass ratio of 8:1 to 12:1, 6 to 14 parts of xylitol as a crystallization monomer, 0.05 to 2 parts of anhydrous sodium citrate as a heterogeneous nucleation site, and 2 to 20 parts of bioactive glass as a nursing component; The refractive index of the tooth care paste is in a constant state at 72 ℃ to represent that xylitol reaches a molecular level homogeneous dissolution state in a polyethylene glycol carrier, and the temperature is reduced to 45 DEG C To 50 In the crystallization Wen Chuang, xylitol is in a supersaturated precipitation state in a polyethylene glycol carrier, and anhydrous sodium citrate is used as a heterogeneous nucleation center to induce xylitol to be precipitated in situ and construct a three-dimensional crystallization grid; The three-dimensional crystallization grid consists of a diameter of 200 To 500 th The xylitol dendrite microcrystal is interwoven, the bioactive glass is physically locked in the grid gaps through the steric hindrance effect generated by the three-dimensional crystallization grid, so as to inhibit sedimentation and agglomeration of the bioactive glass in the system, and the tooth care paste is enabled to be 50 percent The anti-sedimentation parameter in the environment is not less than 25 95% Of the anti-sedimentation parameter in the environment, and the three-dimensional crystallization grid is dissolved when contacting with moisture so as to remove the steric hindrance effect and completely expose the reactive surface of the bioactive glass.
  2. 2. The high stability bioactive glass-containing dental care cream of claim 1, wherein the polyethylene glycol carrier has a water content of less than 0.1 The bioactive glass is calcium sodium phosphosilicate powder Particle size of 3 To 10 The precipitation morphology of xylitol in polyethylene glycol carrier is from 1.5 /Min to 2.0 Controlling the cooling rate of/min to lock the average grain size of dendrite microcrystals at 200 To 500 th In the range, the surface of the bioactive glass is not provided with a continuous organic polymer coating film.
  3. 3. The high stability bioactive glass-containing dental care cream of claim 1, wherein the anhydrous sodium citrate is an ultrafine powder having a surface energy higher than the spontaneous nucleation energy barrier of xylitol in the polyethylene glycol carrier to induce asymmetric heterogeneous nucleation of xylitol on the surface of the anhydrous sodium citrate.
  4. 4. The high stability bioactive glass-containing dental care cream of claim 1, wherein the three-dimensional crystalline network down regulates the temperature sensitivity of the rheology of the dental care cream by rigid support of dendritic crystallites to give a dental care cream at 0 The consistency of the extrusion pressure is maintained in the environment.
  5. 5. The high stability bioactive glass-containing dental care paste of claim 1, wherein the three-dimensional crystalline network is present in the dental care paste at a distributed concentration The following formula is satisfied: , wherein, Is the distribution concentration of the three-dimensional crystallization grid, Is the input quality of xylitol and is used for preparing the xylitol, Is the crystallization proportion of xylitol in the cooling process of polyethylene glycol carrier, Is the total volume of the tooth care paste.
  6. 6. The high stability bioactive glass-containing dental care cream of claim 1, wherein the bioactive glass has a surface that is free of a polyethylene glycol carrier, such that the bioactive glass produces an immediate ion exchange response upon contact with moisture.
  7. 7. The high stability bioactive glass-containing dental care cream of claim 1, wherein xylitol is added through 70 Dissolving the lower molecular level and then passing through 48 Regenerated crystallites formed by heterogeneous nucleation.
  8. 8. The high stability bioactive glass-containing dental care paste of claim 1, further comprising not less than 2 parts of a silica abrasive nested within the secondary pores of the three-dimensional crystalline network.
  9. 9. The high stability bioactive glass-containing dental care paste of claim 1, wherein the three-dimensional crystalline lattice exhibits a discontinuous physical support lattice that establishes a dynamic equilibrium state with self-supporting characteristics within the dental care paste.
  10. 10. The high stability bioactive glass-containing dental care paste of claim 1, wherein the directional deposition morphology of xylitol on the surface of anhydrous sodium citrate is from 1200 To 1500 to Is induced to control the spatial distribution density of dendrite crystallites.

Description

High-stability tooth care paste containing bioactive glass Technical Field The invention belongs to the technical field of medical dental preparations and tooth care compositions with clinical treatment effects, and particularly relates to a high-stability tooth care paste containing bioactive glass. Background Currently, the dental tubules are closed by inducing apatite formation, in order to prevent the components from losing effectiveness due to ion exchange in an aqueous system, the prior art generally selects polyalcohol such as polyethylene glycol or glycerol as a carrier, and in order to maintain the suspension stability of functional powder in the carrier, physical damping is established by adding macromolecule thickening agents such as carbomer or cellulose derivatives, however, solvated films formed by the macromolecule components in the polyalcohol carrier can be coated on the surfaces of bioactive glass particles. In a tooth brushing scene, the shielding film prevents active particles from being contacted with moisture in saliva, so that the ion release rate is delayed, the instant nursing effect is weakened, the consumption of a thickening agent is increased, the interface passivation effect is aggravated, the consumption of the thickening agent is reduced, the composition is subjected to powder sedimentation and agglomeration under a high-temperature transportation environment, the stable mode driven by exogenous thickening is difficult to balance the conflict between storage stability and instant release activity, after the stability of a paste matrix and a thickening system hardware layer is optimized and the bottleneck is overcome, a strategy of modifying functional particles by researching and turning to surface modifying software is changed, for example, chinese patent publication No. CN119385842A discloses a surface modifying bioactive glass tooth desensitizer, a preparation method and application thereof, the adhesive force and the penetration depth of gelatin outer layer reinforcing particles in dentin tubules are built on the surface of mesoporous bioactive glass by using polydopamine, the interface passivation effect is aggravated by the continuous organic polymer coating of the active particles, the bioactive glass reactive surface is difficult to be completely exposed in the instant in contact with saliva, and the problem of component sedimentation of a carrier in a wide-temperature environment is not fundamentally solved. Therefore, how to construct a medical micro-grid system which provides steric support in a storage state and can release pathological repair activity in an application state without adding exogenous polymer thickener is a technical problem to be solved by the invention. Disclosure of Invention The invention provides a high-stability bioactive glass-containing tooth care paste, which comprises the following components in parts by weight: 40 to 80 parts of polyethylene glycol carrier, which is formed by mixing polyethylene glycol-400 and polyethylene glycol-3000 in a mass ratio of 8:1 to 12:1, 6 to 14 parts of xylitol as a crystallization monomer, 0.05 to 2 parts of anhydrous sodium citrate as a heterogeneous nucleation site, and 2 to 20 parts of bioactive glass as a nursing component; tooth care paste at 72 Under the condition that the refractive index is in a constant state, the xylitol reaches a molecular-level homogeneous dissolution state in the polyethylene glycol carrier, and the temperature is reduced to 45To 50In the crystallization Wen Chuang, xylitol is in a supersaturated precipitation state in a polyethylene glycol carrier, and anhydrous sodium citrate is used as a heterogeneous nucleation center to induce xylitol to be precipitated in situ and construct a three-dimensional crystallization grid; The three-dimensional crystallization grid consists of a diameter of 200 To 500 thThe xylitol dendrite microcrystal is interwoven, the bioactive glass is physically locked in the grid gaps through the steric hindrance effect generated by the three-dimensional crystallization grid, so as to inhibit sedimentation and agglomeration of the bioactive glass in the system, and the tooth care paste is enabled to be 50 percentThe anti-sedimentation parameter in the environment is not less than 2595% Of the anti-sedimentation parameter in the environment, and the three-dimensional crystallization grid is dissolved when contacting with moisture so as to remove the steric hindrance effect and completely expose the reactive surface of the bioactive glass. Preferably, the polyethylene glycol carrier has a water content of less than 0.1The bioactive glass is calcium sodium phosphosilicate powderParticle size of 3To 10The precipitation morphology of xylitol in polyethylene glycol carrier is from 1.5/Min to 2.0Controlling the cooling rate of/min to lock the average grain size of dendrite microcrystals at 200To 500 thIn the range, the surface of the bioactive glass is not provid