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CN-122005374-A - Preparation method of oral anti-wrinkle cosmetic product with carbon monoxide precursor and apple polyphenol fused

CN122005374ACN 122005374 ACN122005374 ACN 122005374ACN-122005374-A

Abstract

The invention discloses a preparation method of an oral anti-wrinkle cosmetic product fused by carbon monoxide precursor and apple polyphenol, which is used in the field of cosmetic products, and the product comprises 20% of apple polyphenol, 5% of carboxyhemoglobin (CO precursor), 10% of grape seed extract, 5% of vitamin C, 3% of natural vitamin E, 2% of sodium hyaluronate, 40% of maltodextrin, 1% of magnesium stearate, 10% of water-dispersible cellulose and 10% of auxiliary materials, wherein the purity of the apple polyphenol is more than or equal to 99%, the purity of the grape seed extract is more than or equal to 95%, and the auxiliary materials comprise one or more of sweetener, sour agent and essence, and the proportion of the sweetener is more than or equal to the essence and more than or equal to the sour agent. The apple polyphenol and carboxyheme synergistic effect of the invention not only enhances the antioxidant capacity of the product, but also promotes the skin microcirculation and cell activity, improves the anti-wrinkle and beautifying effects, and simultaneously improves the solubility and stability of the apple polyphenol by micronizing treatment and microcapsule coating technology of the apple polyphenol.

Inventors

  • ZHANG XUEJI
  • Liao Hongshi

Assignees

  • 中迪泰克(南京)生物科技有限公司

Dates

Publication Date
20260512
Application Date
20241111

Claims (7)

  1. 1. An oral anti-wrinkle cosmetic product fused by carbon monoxide precursor and apple polyphenol is characterized by comprising the following materials of 20% of apple polyphenol, 5% of carboxyhemoglobin (CO precursor), 10% of grape seed extract, 5% of vitamin C, 3% of natural vitamin E, 2% of sodium hyaluronate, 40% of maltodextrin, 1% of magnesium stearate, 10% of water-dispersible cellulose and 10% of auxiliary materials.
  2. 2. An oral anti-wrinkle cosmetic product according to claim 1, wherein the apple polyphenol has a purity of 99% or more and the grape seed extract has a purity of 95% or more.
  3. 3. The oral anti-wrinkle cosmetic product fused by carbon monoxide precursor and apple polyphenol according to claim 1, wherein the auxiliary materials comprise one or more of sweetener, acidulant and essence, and the ratio of the sweetener to the essence is equal to or more than that of the acidulant.
  4. 4. A method for the preparation of an oral anti-wrinkle cosmetic product, according to any one of claims 1-3, wherein the carbon monoxide precursor is fused with apple polyphenol, characterized in that it comprises in particular the following steps: s1, preparing proper materials for standby according to a proportion, and carrying out micronization treatment on apple polyphenol; s2, firstly adding maltodextrin and water dispersible cellulose into a mixer for preliminary mixing, and then adding apple polyphenol, carboxyheme, grape seed extract, vitamin C, natural vitamin E, sodium hyaluronate, magnesium stearate and auxiliary materials for high-speed stirring; S3, coating easily-oxidized or easily-volatilized components including vitamin C and carboxyhemoglobin by using a microcapsule coating technology; s4, feeding the uniformly mixed materials into a tablet press, pressing the materials into tablets through a die, and finally inspecting and packaging the products.
  5. 5. The method for preparing an oral anti-wrinkle cosmetic product by fusing a carbon monoxide precursor and apple polyphenol according to claim 4, wherein the micronizing treatment of apple polyphenol comprises the following specific steps: s11, taking fresh apples without plant diseases and insect pests and with moderate maturity as raw materials, and ensuring the quality and activity of apple polyphenol; s12, crushing apples, and adopting an ultrasonic-assisted ethanol extraction method, wherein cavitation effect and mechanical effect of ultrasonic waves accelerate cell wall rupture of apples to obtain apple extract; And S13, filtering and concentrating the extracting solution, removing the solvent by adopting a vacuum freeze-drying technology to obtain apple polyphenol dry powder, and carrying out micronization treatment by jet milling or a ball mill to ensure that the particle size reaches the nano-scale, thus obtaining the apple polyphenol micro powder.
  6. 6. The method for preparing an oral anti-wrinkle cosmetic product by fusing carbon monoxide precursor and apple polyphenol according to claim 1, wherein in S2, carboxyheme is subjected to screening and stabilizing treatment before being added, and the specific treatment steps are as follows: S21, selecting medical grade carboxyheme, and performing quality detection by a High Performance Liquid Chromatography (HPLC) method to remove impurities and unqualified products; S22, in order to prevent the carboxyheme from oxidation or degradation in the preparation process, adopting a cyclodextrin inclusion technology, mixing the carboxyheme and beta-cyclodextrin according to a certain proportion, and performing inclusion reaction to form a stable inclusion compound.
  7. 7. The method for preparing an oral anti-wrinkle cosmetic product by fusing a carbon monoxide precursor with apple polyphenol according to claim 6, wherein after the carboxyheme forms a stable clathrate, the carboxyheme is re-encapsulated by liposome, and the liposome is composed of lipid components such as phospholipid and cholesterol.

Description

Preparation method of oral anti-wrinkle cosmetic product with carbon monoxide precursor and apple polyphenol fused Technical Field The invention relates to the field of cosmetic products, in particular to a preparation method of an oral anti-wrinkle cosmetic product with a carbon monoxide precursor and apple polyphenol fused. Background With the rise of health and beauty concepts, consumers are increasingly demanding natural and efficient beauty products. Apple polyphenol is used as a natural antioxidant, and is a popular component of cosmetic products because of the effects of strong oxidation resistance, free radical removal, aging resistance, whitening and the like, and carbon monoxide precursors such as carboxyheme and the like are also found to have the effects of promoting skin microcirculation, enhancing cell viability and the like. However, in the prior art, the beauty product prepared by fusing the carbon monoxide precursor and the apple polyphenol is in a blank period, so the scheme provides a preparation method of an oral anti-wrinkle beauty product fused by the carbon monoxide precursor and the apple polyphenol, and aims to develop an oral product with obvious anti-wrinkle and beauty effects by fusing the carbon monoxide precursor and the apple polyphenol. Disclosure of Invention In order to overcome the problems, the invention aims to provide a preparation method of an oral anti-wrinkle cosmetic product with carbon monoxide precursor and apple polyphenol fused, which aims to solve the problems that model optimization and conflict detection mainly consider the spatial position of a component, but neglect parameters and attributes of the component, which can lead to incomplete detection and no potential problems are found. For this purpose, the invention adopts the following specific technical scheme: according to one aspect of the invention, there is provided an oral anti-wrinkle cosmetic product of carbon monoxide precursor fused with apple polyphenol, the product consisting of apple polyphenol 20%, carboxyhemoglobin (CO precursor) 5%, grape seed extract 10%, vitamin C5%, natural vitamin E3%, sodium hyaluronate 2%, maltodextrin 40%, magnesium stearate 1%, water dispersible cellulose 10%, and adjuvants 10%. Optionally, the purity of the apple polyphenol is more than or equal to 99%, and the purity of the grape seed extract is more than or equal to 95%. Optionally, the auxiliary materials comprise one or more of sweetener, acidulant and essence, wherein the proportion of the sweetener is equal to or more than that of the essence. According to another aspect of the present invention, there is also provided a method for preparing an oral anti-wrinkle cosmetic product in which a carbon monoxide precursor is fused with apple polyphenol, the method comprising the steps of: s1, preparing proper materials for standby according to a proportion, and carrying out micronization treatment on apple polyphenol; s2, firstly adding maltodextrin and water dispersible cellulose into a mixer for preliminary mixing, and then adding apple polyphenol, carboxyheme, grape seed extract, vitamin C, natural vitamin E, sodium hyaluronate, magnesium stearate and auxiliary materials for high-speed stirring; S3, coating easily-oxidized or easily-volatilized components including vitamin C and carboxyhemoglobin by using a microcapsule coating technology; s4, feeding the uniformly mixed materials into a tablet press, pressing the materials into tablets through a die, and finally inspecting and packaging the products. The specific process of micronizing apple polyphenol is as follows: s11, taking fresh apples without plant diseases and insect pests and with moderate maturity as raw materials, and ensuring the quality and activity of apple polyphenol; s12, crushing apples, and adopting an ultrasonic-assisted ethanol extraction method, wherein cavitation effect and mechanical effect of ultrasonic waves accelerate cell wall rupture of apples to obtain apple extract; And S13, filtering and concentrating the extracting solution, removing the solvent by adopting a vacuum freeze-drying technology to obtain apple polyphenol dry powder, and carrying out micronization treatment by jet milling or a ball mill to ensure that the particle size reaches the nano-scale, thus obtaining the apple polyphenol micro powder. In the step S2, carboxyheme is subjected to screening and stabilizing treatment before being added, and the specific treatment steps are as follows: S21, selecting medical grade carboxyheme, and performing quality detection by a High Performance Liquid Chromatography (HPLC) method to remove impurities and unqualified products; S22, in order to prevent the carboxyheme from oxidation or degradation in the preparation process, adopting a cyclodextrin inclusion technology, mixing the carboxyheme and beta-cyclodextrin according to a certain proportion, and performing inclusion reaction to form a stable inclusion compound. After the carbo