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CN-122005384-A - A nutritional composition for promoting hair growth, and its preparation method

CN122005384ACN 122005384 ACN122005384 ACN 122005384ACN-122005384-A

Abstract

The application relates to the field of hair growth nutrients and discloses a nutrient composition for promoting hair growth and a preparation method thereof, wherein the composition comprises a basic hair growth nutrition group and an absorption promoting synergistic group; the basic hair-growing nutrition group comprises the following components in parts by weight: 0.3-0.8 part of ferrous lactate, 2-5 parts of zinc gluconate, 5-8 parts of magnesium stearate, 3-8 parts of coating material and 17-25 parts of milk mineral salt; the absorption-promoting synergistic group comprises the following components in parts by weight: the application discloses a method for preparing a composite intestinal epithelial membrane by using a biological permeation promoting effect, which comprises the steps of releasing 0.2-1.5 parts of black pepper extract, 2-10 parts of lecithin and 2-8 parts of casein phosphopeptide, and opening an intestinal epithelial channel by using the biological permeation promoting effect to establish a pre-permeation state; the CPP released later is complexed with divalent metal ions in intestinal juice to prevent precipitation, so that the CPP is synchronously and rapidly absorbed through a pre-opened channel, and the problems of high-dosage mineral competition antagonism and difficult absorption are effectively solved.

Inventors

  • WU WENYU
  • LIN JINRAN
  • WU XUEFENG

Assignees

  • 复旦大学附属华山医院
  • 贝拉医疗科技(苏州)有限公司

Dates

Publication Date
20260512
Application Date
20260210

Claims (10)

  1. 1. A nutrient composition for promoting hair growth comprising a basal hair growth nutrient population and an absorption promoting synergistic population; The basic hair-growing nutrition group comprises, by weight, 7-10 parts of vitamin C, 0.3-0.8 part of ferrous lactate, 4-8 parts of vitamin B complex powder, 2-5 parts of zinc gluconate, 2-5 parts of grape seed extract, 12-18 parts of gamma-aminobutyric acid, 5-8 parts of magnesium stearate, 3-8 parts of coating materials and 17-25 parts of milk mineral salt; The components of the absorption-promoting synergistic group comprise, by weight, 0.2-1.5 parts of black pepper extract, 2-10 parts of lecithin and 2-8 parts of casein phosphopeptide.
  2. 2. The hair growth promoting nutrient composition as claimed in claim 1, wherein the piperine content of said black pepper extract is not less than 95%, said lecithin is selected from soybean lecithin or egg yolk lecithin, wherein the acetone insoluble content is not less than 95%, and the total nitrogen content of said casein phosphopeptide is 10% -15%.
  3. 3. The hair growth promoting nutrient composition of claim 1, wherein the procyanidin content of said grape seed extract is greater than or equal to 95%.
  4. 4. The hair growth promoting nutrient composition of claim 1, wherein said gamma-aminobutyric acid has a purity of 95% or more and said milk mineral salt has a calcium content of 25% or more.
  5. 5. A method of preparing a hair growth promoting nutrient composition as claimed in any one of claims 1 to 4 comprising the steps of: S1, grouping raw materials, namely independently taking out black pepper extract and lecithin as synergistic components for standby, independently taking out coating materials and magnesium stearate for standby, and taking the rest other raw materials as basic powder for standby; S2, crushing, sieving, namely crushing, sieving and uniformly mixing the basic powder to obtain premixed powder; S3, preparing a penetration-promoting emulsion adhesive, namely dissolving and dispersing the black pepper extract and lecithin in an ethanol solution, and uniformly stirring to obtain the penetration-promoting emulsion adhesive; s4, granulating and drying, namely spraying the penetration-promoting emulsion adhesive into the premixed powder as a wetting agent to prepare a soft material, granulating, and then drying; S5, finishing, namely finishing the dried particles; step S6, total mixing, namely mixing the granules after finishing with the magnesium stearate taken out in the step S1; S7, tabletting, namely tabletting the total mixed materials to obtain a plain tablet; And S8, coating, namely preparing the coating material taken out in the step S1 into coating liquid, and coating the tablet after tabletting to obtain the nutrient composition.
  6. 6. The method according to claim 5, wherein in the step 2, the mesh size of the sieve is 80 to 100 mesh.
  7. 7. The method according to claim 5, wherein the concentration of the ethanol solution in the step S3 is 30% -40%, and the black pepper extract and lecithin form a uniform emulsion dispersion system in ethanol.
  8. 8. The method according to claim 5, wherein in the step S4, the environmental conditions of the drying treatment are controlled to be 50-60 ℃ and 2-4% humidity, and in the step S5, the number of the particles after the finishing is controlled to be 16-18 mesh.
  9. 9. The method according to claim 5, wherein in the step S7, the tabletting is performed at a temperature of 18 ℃ to 24 ℃ and a relative humidity of 45% -55%, and the weight difference of the tablets after tabletting is controlled within ±3%.
  10. 10. The method according to claim 5, wherein in the step S8, the coating process is performed at an inlet air temperature of 70-80 ℃, an outlet air temperature of 40-55 ℃ and a coating pan rotation speed of 3-5 rpm, and the coating weight gain is controlled to be + -3%.

Description

A nutritional composition for promoting hair growth, and its preparation method Technical Field The invention relates to the field of hair growth nutrients, in particular to a nutrient composition for promoting hair growth and a preparation method thereof. Background With the increase of life rhythm and working pressure in modern society, alopecia and damaged hair quality have become common health puzzles. Hair growth is a high metabolic process, extremely depends on sufficient and balanced nutrition supply, and is a mainstream means for improving scalp microenvironment and promoting hair follicle regeneration at present by supplementing protein, vitamins, iron, zinc, calcium and other key minerals through an oral route. The existing hair tonic nutritional compositions in the market mostly try to meet the hair growth requirement by stacking various nutrients, and are usually prepared by adopting a simple physical mixing process. However, the simple compound product in the prior art is difficult to achieve the expected hair growth effect in practical application, and the core technical bottlenecks are mainly concentrated on the following three aspects: First, the chemical stability of minerals contradicts solubility. After passing through the stomach into the intestinal tract, the multivalent metal ions such as iron, zinc, calcium and the like are subjected to a sharp change from acidic to weak alkaline in pH value. In the absence of specific protection mechanisms, these free metal ions are very susceptible to hydrolysis in intestinal fluids or chemical reaction with co-existing phosphates, phytates, yielding poorly soluble precipitates. This not only results in loss of the active ingredient by curing before it is absorbed, but may also cause gastrointestinal discomfort. Second, ion absorption competes for antagonism. In the traditional mixed release mode, multiple divalent metal ions reach the surface of intestinal epithelial cells simultaneously. Since the human body has non-specificity to the transport carrier of divalent metal ions (such as DMT 1), a certain ion (such as calcium) with high concentration can competitively occupy the transport channel, and the uptake of other trace elements (such as iron and zinc) is obviously inhibited. This antagonism does not allow a simple increase in the amount administered to be converted to an effective concentration in the blood. Third, physical barrier limitations of the intestinal epithelium. The surface of intestinal absorption epithelial cells is covered with a dense lipid bilayer, which forms a natural hydrophobic barrier. The existing formula lacks an effective biological permeation promoting strategy, so that a large amount of bioactive peptide and water-soluble vitamin with relatively high hydrophilicity cannot effectively penetrate through the lipid barrier, and most of nutrient substances only rely on passive diffusion due to the lack of a mechanism for actively opening a cell gap or activating an absorption channel, so that the bioavailability is extremely low, and the nutrient substances are difficult to concentrate on scalp hair follicle targets far away from an administration position along with blood circulation. Disclosure of Invention Aiming at the defects of the prior art, the invention provides a nutrient composition for promoting hair growth and a preparation method thereof, and solves the problems of low absorption rate of mineral substances in the existing hair growth formulation due to chemical precipitation and competitive antagonism and poor bioavailability caused by the fact that hydrophilic nutrient components are difficult to break through intestinal lipid barriers. To achieve the above object, a first aspect of the present invention provides a nutrient composition for promoting hair growth, comprising a basal hair growth nutrient group and an absorption-promoting synergistic group; The basic hair-growing nutrition group comprises, by weight, 7-10 parts of vitamin C, 0.3-0.8 part of ferrous lactate, 4-8 parts of vitamin B complex powder, 2-5 parts of zinc gluconate, 2-5 parts of grape seed extract, 12-18 parts of gamma-aminobutyric acid, 5-8 parts of magnesium stearate, 3-8 parts of coating materials and 17-25 parts of milk mineral salt; The components of the absorption-promoting synergistic group comprise, by weight, 0.2-1.5 parts of black pepper extract, 2-10 parts of lecithin and 2-8 parts of casein phosphopeptide. Preferably, the content of piperine in the black pepper extract is more than or equal to 95%, the lecithin is selected from soybean lecithin or egg yolk lecithin, the content of acetone insoluble matters is more than or equal to 95%, and the total nitrogen content of the casein phosphopeptide is 10% -15%. Preferably, the content of procyanidine in the grape seed extract is more than or equal to 95%. Preferably, the purity of the gamma-aminobutyric acid is more than or equal to 95 percent, and the calcium content of the milk