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CN-122005389-A - Skin repair mask and preparation method thereof

CN122005389ACN 122005389 ACN122005389 ACN 122005389ACN-122005389-A

Abstract

The invention discloses a skin repair mask and a preparation method thereof, and relates to the technical field of facial beauty care, the mask comprises mask base materials and mask liquid attached to the mask base materials, wherein the mask liquid comprises, by weight, 0.5-3.0 parts of liposome-coated NMN, 0.3-2.0 parts of retinol palmitate/ergothioneine compound nanocrystalline, 5.0-15.0 parts of moisturizing repair component, 0.1-2.0 parts of anti-inflammatory component, 0.1-0.8 parts of thickener, 0.1-0.5 parts of preservative, 0.01-0.1 parts of chelating agent, 0.01-0.2 parts of essence and 100 parts of deionized water. The facial mask has effects of resisting aging and deep repairing, and has good antiallergic effect and is suitable for sensitive muscle.

Inventors

  • ZHU FANGMING

Assignees

  • 慈如美制药(上海)有限公司

Dates

Publication Date
20260512
Application Date
20260226

Claims (10)

  1. 1. The skin repair mask is characterized by comprising a mask substrate and mask liquid attached to the mask substrate, wherein the mask liquid comprises, by weight, 0.5-3.0 parts of liposome-coated NMN, 0.3-2.0 parts of retinol palmitate/ergothioneine compound nanocrystalline, 5.0-15.0 parts of moisturizing repair component, 0.1-2.0 parts of anti-inflammatory component, 0.1-0.8 parts of thickener, 0.1-0.5 parts of preservative, 0.01-0.1 parts of chelating agent, 0.01-0.2 parts of essence and 100 parts of deionized water.
  2. 2. The skin repair mask according to claim 1, wherein the preparation method of the liposome-encapsulated NMN comprises the steps of adding lecithin and cholesterol into absolute ethyl alcohol, placing in a 60-70 ℃ constant-temperature water bath, and stirring to obtain a uniform transparent lipid organic solution; transferring the solution into a rotary evaporator, controlling the rotation speed to be 30-50r/min and the water bath temperature to be 45-55 ℃, removing absolute ethyl alcohol by slow rotary evaporation until a layer of uniform and compact blank liposome film is formed on the inner wall of a container, preparing phosphate buffer solution with the pH value of 6.0-7.0, dissolving NMN into the buffer solution to prepare NMN buffer solution with the concentration of 10-20mg/mL, slowly adding the NMN buffer solution into the spare blank liposome film, placing the spare blank liposome film into a water bath with the temperature of 30-35 ℃ for stirring and hydrating for 30-40min to obtain coarse liposome suspension, controlling the homogenizing temperature to be less than or equal to 30 ℃, homogenizing for 1-2 times under the pressure of 600-800bar to obtain liposome-coated NMN suspension with uniform particle size and good dispersibility, filtering with a microporous filter membrane with the pH value of 0.22 mu m to remove impurities and large agglomerates, adding mannitol into the filtered liposome-coated NMN suspension as a protective agent, stirring and completely transferring the coarse liposome suspension into a freeze-drying machine with the temperature of 30-35 ℃ to be completely and completely transferred to the temperature of 30-35 ℃ for 2 Pa, and the freeze drying for 2-30-16 ℃ until the freeze drying is performed in a freeze dryer with the temperature of 3 Pa to be 30-35 ℃ for 2h The powder liposome easy to be redissolved wraps NMN finished product.
  3. 3. The skin repair mask according to claim 2, wherein the mass ratio of lecithin, cholesterol, absolute ethyl alcohol, NMN and mannitol is (5-7) 1 (30-40) 0.5-2 (2.5-7).
  4. 4. The skin repair mask according to claim 1, wherein the preparation method of the retinol palmitate/ergothioneine compound nanocrystalline is characterized by comprising the steps of adding retinol palmitate and vitamin E into polyethylene glycol-400, stirring for 10-15min in a 35-40 ℃ water bath at a stirring speed of 500-800r/min until the retinol palmitate and vitamin E are completely dissolved to obtain an oil phase solution, simultaneously adding the ergothioneine, panthenol, tween 80 and lecithin into deionized water, stirring for 8-12min at a room temperature, stirring for 600r/min until the ergothioneine and the ergothioneine are completely dissolved to obtain an aqueous phase solution, slowly dropwise adding the oil phase solution into the aqueous phase solution, keeping the stirring at the room temperature in the dropwise adding process, lifting the stirring speed to 1200-1500r/min, continuing stirring for 20min after dropwise adding, transferring the pre-emulsified liquid into cosmetic grade zirconia beads, adjusting the grinding speed to 2200-2800r/min, grinding time to 40-50min, adopting a circulation temperature control water bath to strictly control the temperature in the grinding process, drying the system at the room temperature of 25-30 ℃ until the ergothioneine is completely dissolved, and finally obtaining the transparent composite crystalline nano-zirconia-crystalline-oxide-phase suspension, and finally removing the residual nanocrystalline-containing particles after the end of the freeze-drying of the composite crystalline-zirconia-oxide-containing nanocrystalline by adopting a vacuum grinding technology.
  5. 5. The skin repair mask of claim 4, wherein the mass ratio of retinol palmitate, vitamin E, polyethylene glycol-400, ergothioneine, panthenol, tween 80, lecithin, deionized water is (0.5-1.0): (0.2-0.5): (2.0-3.0): (0.1-0.3): (0.3-0.6): (1.0-1.5): (0.8-1.2): (85-90), Wherein the particle size of the cosmetic-grade zirconia beads is 0.2mm, and the volume ratio of the zirconia beads to the pre-emulsion is 2:1.
  6. 6. The skin repair mask according to claim 1, wherein the moisturizing repair component comprises, by weight, 3.0-8.0 parts of glycerin, 0.1-0.5 parts of sodium hyaluronate, 1.0-3.0 parts of panthenol, 0.5-2.0 parts of hydrolyzed collagen, and 0.1-0.5 parts of ceramide NP.
  7. 7. The skin repair mask of claim 1, wherein the soothing anti-inflammatory component comprises, by weight, 0.05-0.5 parts of centella asiatica extract, 0.03-0.3 parts of dipotassium glycyrrhizinate, and 0.02-0.2 parts of myrtle extract.
  8. 8. The skin repair mask of claim 1, wherein the preservative is at least one of sorbic acid and potassium sorbate, and the thickener is at least one of carbomer 940 and sodium carboxymethyl cellulose.
  9. 9. The skin repair mask according to claim 1, wherein the chelating agent is EDTA-disodium, the mask base material is a biological cellulose mask cloth, the biological cellulose mask cloth has a thickness of 0.1-0.3mm, and the porosity is 70% -85%.
  10. 10. A preparation method of the skin repair mask according to any one of claims 1-9 is characterized by comprising the steps of uniformly mixing the components of the mask liquid according to parts by weight, placing the mask liquid in a vacuum degassing tank, degassing for 10-15min under the condition of 0.05-0.07MPa of vacuum degree, detecting the pH value of the mask liquid after degassing, adjusting the pH value to 5.5-6.5 to obtain the mask liquid, selecting biological cellulose mask cloth, cutting the biological cellulose mask cloth into a shape conforming to the outline of the face, enabling the area of each mask to be 20-25cm & lt 2 & gt, uniformly coating the mask liquid on mask base materials, enabling the mask liquid carrying capacity of each mask to be 25-30g, placing the mask base materials carrying the mask liquid in an aseptic aluminum foil bag, sealing and packaging, controlling the environment temperature to be 20-25 ℃ and the relative humidity to be 40-60% in the packaging process, and placing the sealed mask in a low-temperature refrigerator for storage.

Description

Skin repair mask and preparation method thereof Technical Field The invention relates to the technical field of cosmetics, in particular to a skin repair mask and a preparation method thereof. Background Along with the influence of factors such as environmental deterioration, irregular life work and rest, improper skin care mode and the like, more and more people face the problems of damaged skin barrier, aging acceleration and the like, and the problems are particularly manifested by dry skin, roughness, sensitive redness, increased fine wrinkles, reduced elasticity and the like, so that the skin health and the appearance are seriously influenced. The skin repair mask is used as a convenient and efficient skin care product, can rapidly supplement moisture for skin, relieve stimulation and repair damaged barriers, and is one of core products for daily skin care of consumers. At present, most skin repairing masks in the market take moisturizing and soothing components as cores, such as sodium hyaluronate, panthenol, centella asiatica extract and the like, only achieve basic moisturizing and superficial layer soothing effects, and are difficult to solve the problems of skin aging and deep layer repairing from a cell level. With the improvement of anti-aging skin care requirements, NMN (nicotinamide mononucleotide), retinol palmitate, ergothioneine and other anti-aging active components are widely applied to the field of skin care, wherein NMN can supplement skin cellsThe level, activate the energy metabolism of the cell, promote DNA repair, retinol palmitate can promote collagen synthesis, ergothioneine can remove free radicals, and the three can obviously promote anti-aging effect in cooperation, but the application of the retinol palmitate has obvious technical bottleneck. In the prior art, NMN is usually added into cosmetics in a free form, the molecular structure of the free NMN is unstable and is easily degraded by amidase and the like on the surface of skin, the free NMN can not completely reach cells of dermis, the activity loss is serious, and meanwhile, the free NMN has strong water solubility and weak fat solubility, is difficult to penetrate through the barrier of skin horny layer and can not effectively enter the inside of cells to supplementThe retinol palmitate is easy to oxidize and decompose, the ergot sulfur molecule is strong in water solubility and weak in lipid solubility, and skin cell membranes mainly consist of lipid bilayer, so that the skin cell membrane barrier is difficult to break in a free state, most of the retinol palmitate can only stay on the skin surface layer and is easy to be metabolized and lost, and the biological activity of the retinol palmitate cannot be fully exerted. In the prior art, part of the products try to add one of the active components alone or simply mix, and the synergistic delivery of the two (similar) active components is not realized, so that the anti-aging and repairing effects of the products are poor, and meanwhile, part of the products try to improve the transdermal efficiency by adding the permeation enhancer, but the permeation enhancer tends to stimulate the skin, is especially not suitable for sensitive muscle groups, and has limited permeation enhancing effects. In addition, the existing skin repair mask has the problem of poor formula cooperativity, most products simply mix a plurality of active ingredients, and the interaction among the ingredients is not considered, so that the stability of part of the active ingredients is reduced, the effect superposition effect is not obvious, and even the phenomenon of ingredient antagonism occurs. Meanwhile, part of mask preparation process is crude, uniform dispersion and effective retention of active ingredients cannot be ensured, and the use effect and safety of the product are further affected. Therefore, developing a skin repair mask with anti-aging and deep repair effects becomes a technical problem to be solved urgently in the current cosmetic field. Disclosure of Invention The invention aims to overcome the defects of the prior art and provide a skin repair mask and a preparation method thereof, wherein the technical bottlenecks that anti-aging active components are difficult to break through skin cell membranes and have low bioavailability are solved through a nanocrystalline delivery technology and a liposome wrapping technology, and meanwhile, the formula and the preparation technology are optimized, so that the synergistic effect of anti-aging and deep skin repair is realized. The technical scheme includes that the skin repair mask comprises a mask substrate and mask liquid attached to the mask substrate, wherein the mask liquid comprises, by weight, 0.5-3.0 parts of liposome-coated NMN, 0.3-2.0 parts of retinol palmitate/ergothioneine compound nanocrystalline, 5.0-15.0 parts of moisturizing repair component, 0.1-2.0 parts of anti-inflammatory component, 0.1-0.8 parts of thickener, 0.1-0.5 p