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CN-122005390-A - PH response type plaque visualization and triple anti-sensitization synergistic oral care composition and preparation method and application thereof

CN122005390ACN 122005390 ACN122005390 ACN 122005390ACN-122005390-A

Abstract

The invention discloses a pH response type plaque visualization and triple anti-sensitization synergistic oral care composition, and a preparation method and application thereof. The composition comprises a pH response microcapsule color developing agent, a triple anti-sensitization system compounded by potassium salt, bioactive glass and nano hydroxyapatite, a tooth Zhou Xiuhu system and a mild substrate. The microcapsule core material is food-grade dye which develops color at pH less than or equal to 5.5 and fades at pH more than or equal to 6.8, and the wall material is biocompatible polymer. The composition does not contain SLS, fluoride and nipagin ester preservative. The invention also provides a gradient cooling preparation process, a bacterial plaque detection method and application. The product realizes the synergistic interaction of plaque specificity visualization and triple anti-sensitization, has stable storage, is safe and non-irritating, is suitable for the whole population, and can be industrially produced.

Inventors

  • LI MINGYANG

Assignees

  • 北京名扬口腔门诊部有限公司

Dates

Publication Date
20260512
Application Date
20260226

Claims (8)

  1. 1. A pH-responsive plaque visualization and triple anti-sensitization synergistic oral care composition comprising: (a) The pH response type microcapsule color-developing agent is characterized in that the microcapsule consists of a wall material and a core material, wherein the core material is food-grade pH color-changing dye which fades in the pH6.8 environment, the wall material is a biocompatible polymer film-forming material, and the particle size of the microcapsule is 8-20 mu m; (b) The triple anti-allergic system is formed by compounding potassium salt, bioactive glass and nano hydroxyapatite, wherein the weight ratio of the potassium salt to the bioactive glass to the nano hydroxyapatite is 1:0.5-1.5:1.5-2.5; (c) The tooth Zhou Xiuhu system is composed of centella asiatica extract, dipotassium glycyrrhizinate, sodium hyaluronate and zinc citrate; (d) A mild substrate comprising a soft hydrated silica abrasive, sodium lauroyl sarcosinate as a surfactant, 1, 2-hexanediol as a preservative, and p-hydroxyacetophenone, and being free of sodium lauryl sulfate, free of fluoride, and free of parabens preservatives.
  2. 2. The oral care composition according to claim 1, wherein the core material is at least one selected from gardenia blue pigment, an anthocyanin derivative or curcumin, the wall material is selected from a gelatin-gum arabic system or a sodium alginate-chitosan system, and the microcapsule surface is provided with a micropore structure, and the micropore size is 0.1-0.5 μm.
  3. 3. The oral care composition of claim 2, wherein the oral care composition is in the form of a toothpaste, and the adult formulation comprises, by weight, 55.03% deionized water, 28.00% sorbitol, polyethylene glycol-8.50%, soft hydrated silica 5.00%, nano-hydroxyapatite 2.00%, bioactive glass 1.00%, sodium lauroyl sarcosine 1.40%, microcapsule color former 0.16%, potassium nitrate 1.00%, dipotassium glycyrrhizinate 0.10%, centella asiatica extract 0.12%, sodium hyaluronate 0.10%, zinc citrate 0.08%, xanthan gum 0.55%, guar gum 0.25%, edible flavors 0.80%, WS-23 cooling agents 0.01%, stevioside 0.04%, vitamin E0.05%, 1, 2-hexanediol 0.45%, and p-hydroxyacetophenone 0.36%.
  4. 4. The oral care composition of claim 2, wherein the oral care composition is a toothpaste formulation for children, and is free of potassium nitrate and bioactive glass, and the formulation for children comprises, by weight, 56.41% deionized water, 28.50% sorbitol, polyethylene glycol-8.20% ultra soft hydrated silica 4.80%, nano-hydroxyapatite 1.80%, sodium lauroyl sarcosine 1.10%, microcapsule developer 0.15%, dipotassium glycyrrhizinate 0.06%, centella asiatica extract 0.08%, vitamin B5.06%, xanthan gum 0.50%, guar gum 0.25%, edible essence 0.80%, stevioside 0.04%, 1, 2-hexanediol 0.40%, and p-hydroxyacetophenone 0.32%.
  5. 5. A method of preparing the oral care composition of any one of claims 1-4, comprising a gradient cooling process: (1) Preparing the rubber at high temperature, namely mixing and swelling the water-based component and the thickener at 70-80 ℃ and the vacuum degree of-0.06 to-0.08 MPa to form a rubber base; (2) Mixing at medium temperature, cooling to 40-50deg.C, adding abrasive and mineral powder, and vacuum stirring for 20-30min to uniformity; (3) Keeping the temperature at low temperature, namely continuously cooling to be less than or equal to 38 ℃, adding microcapsule color developing agent, and controlling the stirring speed to be 300-500rpm; (4) Post-treatment, namely, uniformly mixing, vacuum degassing for 30min, standing and curing for 20-24h, and aseptically filling and forming.
  6. 6. The method according to claim 5, wherein the microcapsule color-developer in step (3) is prepared in advance by a complex coacervation method, and has an average particle diameter of 10 to 15 μm.
  7. 7. A method of detecting plaque using the oral care composition of any one of claims 1 to 4 comprising the step of applying the oral care composition to a tooth surface and brushing for 1 to 2 minutes to rupture the microcapsules under shear forces and automatically disappear in the acidic environment of plaque, ph 6.8.
  8. 8. Use of the oral care composition of any one of claims 1-4 in the preparation of an oral care product for anti-dentinal sensitivity, inhibition of plaque, periodontal restoration or mildly whitening teeth.

Description

PH response type plaque visualization and triple anti-sensitization synergistic oral care composition and preparation method and application thereof Technical Field The invention belongs to the technical field of oral care, and particularly relates to an oral care composition with plaque visual detection, dentin sensitivity resistance, tooth Zhou Xiuhu and mildness and whitening functions, and a preparation method and application thereof. Background With the promotion of national oral health consciousness, the functional compounding performance and effect visualization requirements of consumers on toothpaste products are continuously improved. However, the prior art has the following technical drawbacks: The technical defect of plaque display is that most of the existing plaque display agents are directly added with dyes, and the existing plaque display agents have the problems of poor stability, easiness in releasing in advance, pollution to paste, staining of teeth and oral mucosa and the like, and are difficult to stably coexist with toothpaste matrixes. When in use, the accurate visual effect of 'only staining plaque and not staining teeth' cannot be realized. The traditional anti-allergic toothpaste mostly adopts single action mechanism components, such as realizing nerve relief by potassium nitrate, or realizing tubule blocking by bioactive glass, or realizing remineralization by hydroxyapatite, and has difficult to achieve quick-acting relief and long-acting restoration, and has limited anti-allergic effect. The multi-component compounding has the defect that when various functional components such as a color developing agent, an anti-allergic agent, a whitening friction agent and the like are compounded, the problems of early leakage of the color developing agent, inactivation of the anti-allergic component, water separation, layering, pigment migration and the like of paste are easy to occur. The safety defect is that the conventional toothpaste contains a plurality of pungent components such as sodium lauryl sulfate, fluoride, nipagin ester preservative and the like, has potential stimulation to teeth Zhou Mingan, people after oral surgery, children and pregnant people, and is not suitable for long-term use. The detection method has the defects that the prior art lacks a simple and visual plaque visual detection method, and consumers are difficult to quantitatively judge the tooth brushing effect, so that the improvement of oral hygiene habit is influenced. In the prior art, there is still a need to develop an integrated oral care product that can simultaneously address color development stability, multi-component compatibility, anti-sensitization synergy, low irritation safety, and provide a visual detection method. Disclosure of Invention Object of the Invention The invention aims to overcome the defects of the prior art and provide an oral care composition which has high component compatibility, excellent long-term stability and plaque visualization and multiple repairing functions, and a preparation method and application thereof. General inventive concept All technical schemes of the invention are around the general inventive concept of a multifunctional oral care system with pH response type microcapsule color development, products, preparation methods, detection methods and applications are integrated into a unified technical scheme, and the multifunctional oral care system meets the requirement of patent law singleness and can be applied in a legal manner. Technical proposal 1. PH responsive microcapsule color developing agent The present invention comprises a microcapsule-embedded pH-responsive color developer. The microcapsule is composed of a wall material and a core material: Core material is selected from food-grade pH color-changing dye such as gardenia blue pigment, anthocyanin derivative or curcumin, and automatically fades in neutral water environment with pH of 6.8. Preferably gardenia blue pigment, which has clear color development, complete color fading and high stability. The design realizes the accurate visual effect of 'only staining plaque and not staining teeth'. The wall material is prepared by adopting gelatin-Arabic gum or sodium alginate-chitosan through a complex coacervation method, and has good film forming property, moderate strength and high biocompatibility. Preferably a gelatin-gum arabic system, which has a controlled mechanical strength and is easy to achieve shear force responsive release. Particle size and response properties the average particle size of the microcapsules is 8-20. Mu.m, preferably 10-15. Mu.m, the wall thickness is 0.5-2. Mu.m, preferably 0.8-1.2. Mu.m. Within this parameter, the microcapsules remain intact under low shear forces and controllably rupture to release the core material under brushing shear forces. Microporous structure, wherein the surface of the microcapsule is provided with a microporous structure, and the pore diameter of th