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CN-122005392-A - Prinsepia utilis royle allergy-relieving composition and application thereof in sensitive skin care

CN122005392ACN 122005392 ACN122005392 ACN 122005392ACN-122005392-A

Abstract

The application discloses a Prinsepia utilis royle allergy relieving composition and application thereof in sensitive skin care. The Prinsepia utilis royle sensitivity-relieving composition is prepared by scientifically compounding three special plants of Prinsepia utilis royle, armillariella prinoides Luo Mu and Magnolia officinalis and adopting a plurality of advanced extraction technical means such as ultrasonic assistance, low-temperature control, inert gas protection, secondary molecular distillation and the like, and a novel cosmetic composition based on a multi-target mechanism and having the effects of immediate relief and long-term repair is prepared.

Inventors

  • WANG BIAO
  • HU WEI
  • BU YALAN
  • XU JIAOJIAO
  • ZHAO JIAXIN

Assignees

  • 沭阳源于自然生物科技有限公司

Dates

Publication Date
20260512
Application Date
20260306

Claims (10)

  1. 1. The prinsepia utilis royle allergy-relieving composition is characterized by being prepared by the following preparation method: (1) Screening, drying and crushing Prinsepia utilis royle, miao Luo Mu and Magnolia officinalis respectively, and mixing to obtain mixed powder; (2) Adding an antioxidant and an enzyme inhibitor into the mixed powder, adding an ethanol-ethyl acetate composite solvent for leaching, filtering, centrifuging and collecting supernatant; (3) Collecting heavy components by secondary molecular distillation; (4) Adding Prinsepia utilis royle oil, stirring and dissolving to form uniform oily system, and obtaining the Prinsepia utilis royle allergy relieving composition.
  2. 2. The prinsepia utilis royle and chloranthus spicatus allergy free composition according to claim 1, wherein in the step (1), prinsepia utilis royle and chloranthus spicatus are crushed to 40-60 meshes, and the honey Luo Mufen is crushed to 60-80 meshes, and the magnolia officinalis is crushed to 40-60 meshes, and then uniformly mixed according to the weight ratio of 5-10:1-5:1-3.
  3. 3. The prinsepia utilis royle and chlorpyrifos allergy free composition according to claim 1, wherein the antioxidant in the step (2) is added in an amount of 0.01-0.05% by weight of the total weight of the mixed powder, the antioxidant is a mixture of vitamin E and ascorbyl palmitate in a weight ratio of 1-5:1-5, and the enzyme inhibitor is disodium EDTA in an amount of 0.01-0.1% by weight of the total weight of the mixed powder.
  4. 4. The prinsepia utilis royle and chlorpyrifos allergy free composition according to claim 1, wherein in the step (2), the volume ratio of ethanol to ethyl acetate of the ethanol-ethyl acetate composite solvent is 1-3:1, the feed liquid ratio of the mixed powder to the composite solvent is 1:10-15 g/mL, and nitrogen is introduced for protection during the whole leaching process.
  5. 5. The prinsepia utilis royle soothing composition according to claim 1, wherein the leaching conditions in step (2) are a constant temperature of 45 ℃, a stirring speed of 80 r/min, a 200W ultrasound assisted leaching, intermittent ultrasound of 3 s/3 s, a leaching time of 2.5h.
  6. 6. The Prinsepia utilis royle allergy free composition according to claim 1, wherein the filtering and centrifuging in step (2) comprises filtering with gauze to remove coarse residue, centrifuging the filtrate at 4500 r/min for 20: 20 min, collecting supernatant, adding 1/3 of complex solvent into the residue, repeatedly leaching for 30: 30 min, and mixing the supernatants.
  7. 7. The prinsepia utilis royle soothing composition according to claim 1, wherein the combined supernatant is filtered through a 0.22 μm organic filter before the second fraction is distilled in step (3).
  8. 8. The prinsepia utilis royle composition according to claim 1 or 7, wherein the specific parameters of the secondary molecular distillation in step (3) are: Primary distillation, namely evaporating temperature is 75-80 ℃, condensing temperature is 20 ℃, vacuum degree is 0.001 MPa, feeding speed is 2 mL/min, and film scraping rotating speed is 200 r/min; and the second-stage distillation is carried out at the evaporating temperature of 110-115 ℃, the condensing temperature of 30 ℃ and the vacuum degree of 0.0005 MPa, the feeding speed of 1.5 mL/min and the film scraping rotating speed of 250 r/min.
  9. 9. Use of the prinsepia utilis royle soothing composition as claimed in any one of claims 1 to 8 for the preparation of a cosmetic having soothing, repairing and moisturizing effects.
  10. 10. Shu Minyou bead essence is characterized by comprising the following components in percentage by mass: Glycerol 3-10% 3-10% Of 1, 3-propanediol Carbomer 0.2-0.4% 0.2 To 0.6 percent of p-hydroxyacetophenone 1, 2-Hexanediol 0.4-0.8% Sodium hydroxide 0.03-0.08% Olive (Olea EUROPAEA) fruit oil 1-5% Coco-caprylate/caprate 3-8% 0.1-1% Of castor oil/IPDI copolymer Caprylic/capric triglyceride 0.3-5% 1-5% Of flat core wood (PRINSEPIA UTILIS) oil Prinsepia utilis royle and chloranthus spicatus allergy free composition 1-5% as claimed in any one of claims 1-8 The balance of water; The preparation process comprises the steps of adding water, glycerol, 1, 3-propylene glycol, carbomer, p-hydroxyacetophenone and 1, 2-hexanediol into an emulsifying pot, heating to 85 ℃ under slow stirring, starting to uniformly disperse and dissolve, adding sodium hydroxide, stirring uniformly to obtain a dilute gel system, adding coco-caprylate/caprate, castor oil/IPDI copolymer and caprylic/capric triglyceride into an oil phase pot, heating and dissolving under stirring, adding olive (Olea EUROPAEA) fruit oil, platykurtic (PRINSEPIA UTILIS) oil and prinsepia utilis royle (Prinsepia) fruit allergy composition, stirring uniformly to obtain an oil phase, starting the emulsifying pot to stir at medium speed, cooling to 60 ℃, slowly adding the oil phase into the emulsifying pot, and stirring uniformly to obtain allergy essence of the gel system with uniformly dispersed fine oil beads.

Description

Prinsepia utilis royle allergy-relieving composition and application thereof in sensitive skin care Technical Field The invention relates to the field of cosmetics, in particular to a Prinsepia utilis royle allergy relieving composition and application thereof in sensitive skin care. Background Consumer demand for cosmetics with "soothing", "repairing", "anti-irritation" effects has increased significantly, and soothing-type skin care products have become an important subdivision of functional cosmetics. The soothing effect generally means that the product can alleviate or prevent skin discomfort caused by external stimuli (such as ultraviolet rays, chemicals, temperature changes or mechanical friction), including subjective symptoms such as stinging, burning, redness, itching, etc., and inhibit release of inflammatory factors to some extent, and regulate the state of nerve hypersensitivity. From the action mechanism, skin sensitivity is related to multiple factors, mainly comprising the susceptibility of external stimulus to penetration caused by the damaged skin barrier structure, abnormal activation of epidermal sensory nerve endings, transient Receptor Potential (TRP) channel (such as TRPV 1) overresponse, local immune cells (such as Langerhans cells and mast cells) release histamine, interleukin-6 (IL-6), tumor necrosis factor-alpha (TNF-alpha) and other pro-inflammatory mediators, and skin microecological imbalance further amplifies inflammatory signals. Therefore, the ideal soothing effect covers multidimensional synergism of barrier repair, nerve sedation, anti-inflammatory regulation, microecological balance and the like. However, there are still significant technical limitations to the existing soothing cosmetics. Firstly, most products rely on single classical components (such as bisabolol, dipotassium glycyrrhizinate, allantoin and the like), have certain anti-inflammatory or sedative effects, but are difficult to completely intervene in a sensitive complex passage, and secondly, partial soothing formulas ignore barrier function reconstruction, only pursue instant 'cool feeling' or 'fading' appearance, and cannot realize long-term protection. Prinsepia utilis royle (PRINSEPIA UTILIS ROYLE), which is mainly distributed in the high-altitude areas of Yunnan, sichuan and the like, has very high application value in the fields of skin relief and barrier repair in recent years. Chinese patent document CN108553527A discloses a preparation method of Prinsepia utilis royle total flavone extract. The method takes the Prinsepia utilis royle as a single raw material, and the total flavone extract is obtained through enrichment by degreasing treatment, alcohol or aqueous solution reflux extraction, macroporous resin column separation and purification and other steps. The technology realizes the enrichment of specific active ingredients (total flavonoids) in the prinsepia utilis royle, but aims at a single plant raw material, the extraction target is limited to flavonoid compounds, and the synergistic skin care effect of various active ingredients (such as unsaturated fatty acids, polyphenols and the like) in the prinsepia utilis royle is not fully utilized. In addition, the process involves heating reflux extraction and macroporous resin separation, the steps are relatively complicated, and the heating process may cause loss of heat-sensitive active ingredients. Therefore, there is a need in the market to develop a novel cosmetic composition based on a multi-target mechanism that combines immediate relief and long-term repair capabilities. Disclosure of Invention The technical problem to be solved by the invention is to provide a novel cosmetic composition which is based on a multi-target mechanism and has the effects of immediate relief and long-term repair. The technical scheme of the invention is as follows: a Prinsepia utilis royle allergy-relieving composition is prepared by a process comprising the steps of: (1) The prinsepia utilis royle, the honey Luo Mu and the magnolia officinalis are respectively subjected to screening, drying and crushing treatment to obtain mixed powder. The step aims at preprocessing the three raw materials according to the unified preprocessing standard so as to improve the efficiency and uniformity of the subsequent extraction process. In some embodiments, the Prinsepia utilis royle is crushed into 40-60 meshes, the density Luo Mufen is crushed into 60-80 meshes, the magnolia officinalis is crushed into 40-60 meshes, and then the materials are uniformly mixed according to the weight ratio of 5-10:1-5:1-3. (2) Adding antioxidant and enzyme inhibitor into the mixed powder, adding ethanol-ethyl acetate composite solvent, leaching, filtering, centrifuging, and collecting supernatant. The purpose of adding antioxidants and enzyme inhibitors in this step is to inhibit oxidation of the active ingredient and degradation of magnolol. In some embodiments, the antioxidant is added in an