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CN-122005394-A - Preparation method of water-soluble allergy-relieving anti-aging composition

CN122005394ACN 122005394 ACN122005394 ACN 122005394ACN-122005394-A

Abstract

The invention relates to the technical field of anti-aging compositions, and discloses a preparation method of a water-soluble allergy-relieving anti-aging composition, the invention adds peony water, peony branch, peony root bark extract, peony root extract, butanediol, 1 part by weight of glycerol, polysorbate-20, ergothioneine, inositol, mussel extract, 1, 2-hexanediol, modified sinapic acid, essence extract and intermediate 1 into a stirrer, and stirs the mixture to obtain the water-soluble allergy-relieving anti-aging composition after the completion of stirring. The amino acid contained in the intermediate 1 in the water-soluble allergy-relieving anti-aging composition has the effects of effectively improving skin, having excellent whitening effect and good moisturizing effect, wherein the peony water, the peony branches, the peony root bark extract, the peony root extract, the butanediol, the glycerol, the polysorbate-20, the ergothioneine, the inositol and the mussel extract have the effects of repairing, nourishing, relieving, resisting wrinkles and compacting.

Inventors

  • YAN ZICHEN
  • ZHANG DAN
  • ZHAO HUAJUN
  • SUN YANHONG

Assignees

  • 山东融元康医疗科技有限公司

Dates

Publication Date
20260512
Application Date
20260311

Claims (5)

  1. 1. The preparation method of the water-soluble allergy-relieving anti-aging composition is characterized by comprising the following steps of: (1) Mixing N-glycine, L-proline, L-threonine and L-serine, adding N, N-dimethylformamide, heating and stirring under reflux condition until dissolving, adding sodium carbonate and zinc acetate, adding dimethyl carbonate, introducing nitrogen to remove air, and continuously heating for 6-10 hr; (2) Adding chitosan and epsilon-caprolactone into a reactor, stirring uniformly, adding stannous octoate catalyst, introducing nitrogen for protection, reacting for 6-13h at 100-130 ℃, washing and drying after the reaction is finished to obtain chitosan modified epsilon-caprolactone; (3) Adding sinapic acid into methanol solution, stirring for dissolution, then continuously adding chitosan modified epsilon-caprolactone and p-toluenesulfonic acid catalyst into the solution for reaction for 6-10h at 90-110 ℃, and after the completion, carrying out reduced pressure distillation, washing and drying to obtain modified sinapic acid; (4) Respectively adding 20-30 parts by weight of gardenia, 15-25 parts by weight of elderberry and 10-30 parts by weight of radix isatidis into ethanol solution, heating and refluxing, and distilling under reduced pressure to remove ethanol after extraction is finished to obtain gardenia extract, elderberry extract and radix isatidis extract, namely essence extract; (5) 65 to 75 parts by weight of peony water, 0.5 to 1.5 parts by weight of peony branches, 1 to 10 parts by weight of peony root bark extract, 1 to 5 parts by weight of peony root extract, 10 to 15 parts by weight of butanediol, 1 to 5 parts by weight of glycerol, 1 to 5 parts by weight of polysorbate-20, 0.5 to 1.5 parts by weight of ergothioneine, 0.5 to 1.5 parts by weight of inositol, 0.05 to 0.3 parts by weight of mussel extract, 1 to 3 parts by weight of 1, 2-hexanediol, 0.2 to 0.5 parts by weight of modified sinapic acid, 1 to 2 parts by weight of essence extract and 0.6 to 0.8 parts by weight of intermediate 1 are added into a stirrer, and stirred for 10 to 15 minutes, thereby obtaining the water-soluble sensitivity-enhancing anti-aging composition.
  2. 2. The method for preparing the water-soluble allergy-free anti-aging composition according to claim 1, wherein the mass ratio of the N-glycine, the L-proline, the L-threonine, the L-serine, the sodium carbonate, the zinc acetate and the dimethyl carbonate in the composition (1) is 1:1.2-1.4:0.8-1:1.3-1.6.
  3. 3. The method for preparing the water-soluble allergy-free anti-aging composition according to claim 1, wherein the mass ratio of the chitosan, epsilon-caprolactone and stannous octoate catalyst in the step (2) is 1.1-1.4:1:0.01-0.03.
  4. 4. The method for preparing the water-soluble allergy-free anti-aging composition according to claim 1, wherein the mass ratio of sinapic acid, chitosan modified epsilon-caprolactone and p-toluenesulfonic acid catalyst in the step (3) is 0.8-1.2:1:1.4-1.6.
  5. 5. The method for preparing a water-soluble, allergy-free composition according to claim 1, wherein the reaction time in (4) is 15-25 hours.

Description

Preparation method of water-soluble allergy-relieving anti-aging composition Technical Field The invention relates to the technical field of anti-aging compositions, in particular to a preparation method of a water-soluble allergy-relieving anti-aging composition. Background Skin aging is a necessary stage of life activities of human body, and is affected by environmental factors and complicated morphology and structure of the whole body. In recent years, due to irregular diet, the skin of a plurality of people starts to have different levels of exogenous accelerated aging, wrinkles, looseness and other problems, for example, CN106726923A discloses a cosmetic additive and a preparation method thereof, wherein the cosmetic additive consists of mulberry bark extract, pomegranate flower extract, chamomile extract and sakura leaf essence, has good whitening efficacy, but the antibacterial and allergy-relieving effects are not improved. Disclosure of Invention (One) solving the technical problems Aiming at the defects of the prior art, the invention provides a preparation method of a water-soluble allergy-relieving anti-aging composition, which has the effects of repairing, nourishing, relieving, resisting wrinkle, compacting, resisting bacteria, preserving moisture, being applicable to sensitive muscles, and being mild and free from stimulation. (II) technical scheme In order to achieve the aim, the invention provides the following technical scheme that the preparation method of the water-soluble allergy-relieving anti-aging composition comprises the following steps of: (1) Mixing N-glycine, L-proline, L-threonine and L-serine, adding N, N-dimethylformamide, heating and stirring under reflux condition until dissolving, adding sodium carbonate and zinc acetate, adding dimethyl carbonate, introducing nitrogen to remove air, and continuously heating for 6-10 hr; (2) Adding chitosan and epsilon-caprolactone into a reactor, stirring uniformly, adding stannous octoate catalyst, introducing nitrogen for protection, reacting for 6-13h at 100-130 ℃, washing and drying after the reaction is finished to obtain chitosan modified epsilon-caprolactone; (3) Adding sinapic acid into methanol solution, stirring for dissolution, then continuously adding chitosan modified epsilon-caprolactone and p-toluenesulfonic acid catalyst into the solution for reaction for 6-10h at 90-110 ℃, and after the completion, carrying out reduced pressure distillation, washing and drying to obtain modified sinapic acid; (4) Respectively adding 20-30 parts by weight of gardenia, 15-25 parts by weight of elderberry and 10-30 parts by weight of radix isatidis into ethanol solution, heating and refluxing, and distilling under reduced pressure to remove ethanol after extraction is finished to obtain gardenia extract, elderberry extract and radix isatidis extract, namely essence extract; (5) 65 to 75 parts by weight of peony water, 0.5 to 1.5 parts by weight of peony branches, 1 to 10 parts by weight of peony root bark extract, 1 to 5 parts by weight of peony root extract, 10 to 15 parts by weight of butanediol, 1 to 5 parts by weight of glycerol, 1 to 5 parts by weight of polysorbate-20, 0.5 to 1.5 parts by weight of ergothioneine, 0.5 to 1.5 parts by weight of inositol, 0.05 to 0.3 parts by weight of mussel extract, 1 to 3 parts by weight of 1, 2-hexanediol, 0.2 to 0.5 parts by weight of modified sinapic acid, 1 to 2 parts by weight of essence extract and 0.6 to 0.8 parts by weight of intermediate 1 are added into a stirrer, and stirred for 10 to 15 minutes, thereby obtaining the water-soluble sensitivity-enhancing anti-aging composition. Preferably, the mass ratio of the N-glycine, the L-proline, the L-threonine, the L-serine, the sodium carbonate, the zinc acetate and the dimethyl carbonate in the step (1) is 1:1.2-1.4:0.8-1:1.3-1.6. Preferably, the mass ratio of the chitosan, epsilon-caprolactone and stannous octoate catalyst in the step (2) is 1.1-1.4:1:0.01-0.03. Preferably, the mass ratio of the sinapic acid to the chitosan modified epsilon-caprolactone to the p-toluenesulfonic acid catalyst in the step (3) is 0.8-1.2:1:1.4-1.6. Preferably, the reaction time in the step (4) is 15-25h. (III) beneficial technical effects The invention adds peony water, peony branch, peony root bark extract, peony root extract, butanediol, 1 part by weight of glycerol, polysorbate-20, ergothioneine, inositol, mussel extract, 1, 2-hexanediol, modified sinapic acid, essence extract and intermediate 1 into a stirrer, and stirs the mixture to obtain the water-soluble allergy-relieving anti-aging composition after the completion of stirring. The amino acid contained in the intermediate 1 in the water-soluble allergy-relieving anti-aging composition can effectively improve skin, has excellent whitening effect and good moisturizing effect, chitosan and sinapic acid groups in modified sinapic acid can play an antioxidant effect on the skin, and the essence extract plays role