CN-122005396-A - Compound capable of repelling mosquitoes and preparation method and application thereof

CN122005396ACN 122005396 ACN122005396 ACN 122005396ACN-122005396-A

Abstract

The invention provides a compound capable of repelling mosquitoes and a preparation method and application thereof, and belongs to the technical field of external traditional Chinese medicine preparations. The mosquito-repellent compound comprises, by weight, 7-10 parts of wrinkled giant hyssop, 6.5-9.5 parts of virgate wormwood herb, 6-8.5 parts of peppermint, 6-9 parts of borneol and 6-9 parts of liquorice. The compound capable of repelling mosquitoes provided by the invention realizes adsorption, domain limiting and slow release of the traditional Chinese medicine composition (volatile oil) through the hierarchical pore structure of the carbon spheres, so that a long-acting, safe and stable mosquito repelling effect is obtained.

Inventors

ZHANG YANG
LIU YUANYUAN
JIAO FENG
JIN XINGLIN
DENG CHANGHONG
LI YANG
WEI HUANGZHAO
Li Gaotingyue
Nie Weiru

Assignees

大连医科大学附属第二医院

Dates

Publication Date: 20260512
Application Date: 20260313

Claims (10)

1. The mosquito-repellent compound is characterized by comprising, by weight, 7-10 parts of wrinkled giant hyssop, 6.5-9.5 parts of virgate wormwood herb, 6-8.5 parts of peppermint, 6-9 parts of borneol and 6-9 parts of liquorice.
2. The composite of claim 1, wherein the preparation method of the biomass asphalt-based porous activated carbon spheres comprises the steps of mixing asphalt powder with a viscosity reducer, melting at 120-200 ℃, dripping hot water containing a dispersing agent, cooling and shaping to obtain asphalt microspheres, removing the viscosity reducer to form porous sphere asphalt, performing pre-oxidation crosslinking treatment at 260-350 ℃ for 12-24 hours, and then performing carbonization and activation at 600-1000 ℃ to obtain the biomass asphalt-based porous activated carbon spheres.
3. The compound according to claim 2, wherein the softening point of the asphalt powder is 250-300 ℃, the viscosity reducer is an aromatic compound or a mixture of aromatic compounds, the aromatic compound comprises naphthalene, methylnaphthalene, phenylanthracene, toluene or biphenyl, the weight ratio of the asphalt powder to the viscosity reducer is 2-3:1, the dispersant comprises ethanol or glycerin, the diameter of the asphalt microsphere is 0.5-1 mm, and the condition for removing the viscosity reducer is that the asphalt microsphere is treated for 2-5 h under the conditions of vacuum degree of 0.02-0.06 MPa and temperature of 40-60 ℃.
4. The compound of claim 1, wherein the preparation method of the traditional Chinese medicine composition comprises the steps of mixing, crushing and sieving wrinkled giant hyssop, virgate wormwood herb, peppermint, borneol and liquorice to obtain powder, mixing the powder with 45% -55% ethanol solution by volume fraction, carrying out reflux extraction, and concentrating the extract until no alcohol smell exists, thereby obtaining the traditional Chinese medicine composition.
5. The compound according to claim 4, wherein the mesh number of the sieve is 60-100 mesh, the weight-volume ratio of the powder to the ethanol solution is 1 g:2-4 mL, the reflux extraction temperature is 55-65 ℃ and the time is 1.5-2.5 h, and the concentration method comprises reduced pressure concentration, wherein the vacuum degree of the reduced pressure concentration is 0.06-0.08 MPa, and the temperature is 55-65 ℃.
6. The compound of claim 1, wherein the weight ratio of the traditional Chinese medicine composition to the biomass asphalt-based porous activated carbon sphere is 1 (1-5).
7. The method for preparing the compound according to any one of claims 1 to 6, which is characterized by comprising the step of mixing and stirring the traditional Chinese medicine composition and the biomass asphalt-based porous activated carbon sphere.
8. The use of a composite according to any one of claims 1 to 6 for the preparation of an anti-mosquito product, wherein the anti-mosquito product comprises an anti-mosquito patch.
9. An anti-mosquito patch, which is characterized by comprising a backing layer, an adhesive layer, a traditional Chinese medicine matrix layer and a protective layer, wherein the traditional Chinese medicine matrix layer comprises the compound of any one of claims 1-6.
10. The method for preparing the mosquito-repellent patch according to claim 9, comprising the steps of coating the composite on one surface of a backing layer, coating an adhesive layer on the other surface of the backing layer and attaching a protective layer, cutting the patch, and packaging.

Description

Compound capable of repelling mosquitoes and preparation method and application thereof Technical Field The invention belongs to the technical field of external traditional Chinese medicine preparations, and particularly relates to a compound capable of repelling mosquitoes and a preparation method and application thereof. Background Although the mosquito is tiny in volume, the mosquito has too far influence on public safety and military operations in history and reality, and the damage degree is even no less than that of a conventional weapon. The mosquito bite not only can cause local discomfort such as skin itch and red swelling, but also can spread various infectious diseases such as malaria, dengue fever, chikungunya fever, zika virus disease and the like, and is an important factor causing disease burden and non-fight fighter reducing in the global scope. In war and severe environments, mosquitoes are more considered "stealth killers" whose effects are unpredictable and destructive. Historically there have been many cases where war situation was affected by the outbreak of a serious disease caused by mosquitoes. In modern times, mosquito threats remain unappealing from battlefield and post-disaster areas despite significant elevation in medical level. In this context, mosquito-repellent products are the most basic and critical personal protection means in outdoor activities and battlefield environments. However, the existing commercial mosquito-proof products mainly comprise two types of chemical synthesis and traditional Chinese medicines, and the two types of products are exposed to obvious defects in actual use, so that the comprehensive requirements of long-acting, safety and stability in high-risk environments are difficult to meet. Especially in high-strength environments such as field operation, military operations and the like, the existing products are required to be frequently coated in a supplementing mode due to short time effect or have poor stability of dosage forms, so that the operation efficiency is affected, and the requirements of long-time and high-frequency mosquito prevention are difficult to meet. In conclusion, the prior art cannot achieve the comprehensive performances of quick response, lasting effect, safety, mildness, convenient use and the like. Therefore, development of a novel mosquito-repellent traditional Chinese medicine patch which has long-acting slow release, is friendly to the skin and convenient to carry and use is needed to solve the technical problems of strong irritation, volatile active ingredients, short action time, insufficient practicability and the like of the existing product. Disclosure of Invention Aiming at the technical problems of quick volatilization, short acting time, strong irritation, sticky dosage form or easy falling of traditional Chinese medicine mosquito repellent components in the prior art, the invention aims to provide a compound prepared from a traditional Chinese medicine composition and biomass asphalt-based porous activated carbon spheres, and the adsorption, the domain limiting and the slow release of the traditional Chinese medicine composition (volatile oil) are realized through a carbon sphere hierarchical pore structure, so that a long-acting, safe and stable mosquito repellent effect is obtained. In order to achieve the above object, the present invention provides the following technical solutions: The invention provides a mosquito-repellent compound, which comprises biomass asphalt-based porous activated carbon spheres loaded with a traditional Chinese medicine composition, wherein the traditional Chinese medicine composition comprises, by weight, 7-10 parts of wrinkled giant hyssop, 6.5-9.5 parts of virgate wormwood herb, 6-8.5 parts of peppermint, 6-9 parts of borneol and 6-9 parts of liquorice. The preparation method of the biomass asphalt-based porous activated carbon spheres comprises the steps of mixing asphalt powder with a viscosity reducer, melting at 120-200 ℃, dripping hot water containing a dispersing agent, cooling and shaping to obtain asphalt microspheres, removing the viscosity reducer to form porous sphere asphalt, performing pre-oxidation crosslinking treatment at 260-350 ℃ for 12-24 hours, and then performing carbonization and activation at 600-1000 ℃ to obtain the biomass asphalt-based porous activated carbon spheres. Preferably, the softening point of the asphalt powder is 250-300 ℃, the viscosity reducer is an aromatic compound or a mixture of aromatic compounds, the aromatic compounds comprise naphthalene, methylnaphthalene, phenylanthracene, toluene or biphenyl, the weight ratio of the asphalt powder to the viscosity reducer is 2-3:1, the dispersing agent comprises ethanol or glycerol, the diameter of the asphalt microsphere is 0.5-1 mm, and the conditions for removing the viscosity reducer are that the asphalt microsphere is treated for 2-5 h under the conditions of vacuum degree of 0.02-0.06 MPa and