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CN-122005410-A - A plant composition for relieving alopecia, promoting hair growth and blackening hair

CN122005410ACN 122005410 ACN122005410 ACN 122005410ACN-122005410-A

Abstract

The invention discloses a plant composition for relieving alopecia, promoting hair growth and blackening hair, and belongs to the technical field of cosmetics. The composition consists of kudzu root extract, bean leaf/stem extract, phyllanthus emblica fruit extract and tulip flower extract according to a specific proportion of (0.25-0.5) (0.002-0.006) (0.005-0.025) (0.0064-0.0096). Experiments prove that the composition can obviously promote proliferation of human hair papilla cells, up-regulate Vascular Endothelial Growth Factor (VEGF) expression to improve hair follicle microcirculation, down-regulate DKK-1 gene expression to delay hair follicle from entering a resting stage, and promote melanin synthesis and tyrosinase activity under a DKK-1 inhibition model. The results of human trials show that the composition has significantly reduced hair loss and significantly increased local hair density and hair diameter. The composition is derived from natural plants, is safe and free of side effects, and realizes the integrated effects of preventing hair loss, promoting hair growth and blackening hair by regulating and controlling the hair follicle microenvironment through multi-target-point cooperation.

Inventors

  • GU RONG
  • PAN JIAHUI
  • SHI ZEYU
  • ZHAO JIN
  • LIN QINYI

Assignees

  • 上海尊雅实业有限公司

Dates

Publication Date
20260512
Application Date
20260331

Claims (9)

  1. 1. A plant composition for alleviating hair loss, promoting hair growth and blackening hair is characterized by comprising the following components of kudzu root extract, watercress leaf/stem extract, phyllanthus emblica fruit extract and tulip flower extract as active ingredients.
  2. 2. The plant composition for alleviating hair loss, promoting hair growth and blackening hair of claim 1, wherein the weight ratio of the kudzu root extract, the watercress leaf/stem extract, the phyllanthus emblica fruit extract and the tulip flower extract is (0.25-0.5): 0.002-0.006): 0.005-0.025): 0.0064-0.0096.
  3. 3. A plant composition for alleviating hair loss, promoting hair growth and blackening hair according to claim 1 or 2, wherein the total concentration of the extract of kudzu root, the extract of watercress leaf/stem, the extract of phyllanthus emblica fruit and the extract of tulip flower is 0.005-5% of the total weight of the composition.
  4. 4. A plant composition for alleviating hair loss, promoting hair growth and blackening hair according to any of claims 1 to 3, further comprising a pharmaceutically acceptable carrier selected from one or more of butylene glycol, glycerol, 1, 3-propanediol, maltodextrin, disodium EDTA, ammonium glycyrrhizate, water.
  5. 5. A method of preparing a plant composition for alleviating hair loss, promoting hair growth and blackening hair according to any one of claims 1 to 4, comprising the step of mixing the extract of kudzu root, the extract of watercress leaf/stem, the extract of phyllanthus emblica fruit and the extract of tulip flower in a proportion.
  6. 6. The method of preparing a plant composition for alleviating hair loss, promoting hair growth and blackening hair according to claim 5, wherein the step of mixing comprises: step a, preparing phase A, namely uniformly mixing water, kudzu root extract, EDTA disodium, watercress leaf/stem extract, ammonium glycyrrhizate and butanediol; step B, preparing a phase B, namely uniformly mixing the phyllanthus emblica fruit extract, glycerol and 1, 3-propanediol; step C, preparing phase C, namely uniformly mixing the tulip flower extract, maltodextrin and water; And d, adding the phase B into the phase A, mixing uniformly, adding the phase C into the mixture of the phase A and the phase B, and mixing uniformly to obtain the plant composition.
  7. 7. Use of a plant composition for alleviating hair loss, promoting hair growth and blackening hair as claimed in any of claims 1 to 4 for the preparation of a cosmetic for alleviating hair loss, promoting hair growth and/or blackening hair.
  8. 8. A cosmetic for scalp care, characterized by comprising the plant composition of any one of claims 1 to 4 and a cosmetically acceptable adjuvant.
  9. 9. A cosmetic for scalp care according to claim 8, characterized in that the cosmetic is a shampoo, a conditioner, a scalp essence, a spray or a hair film.

Description

A plant composition for relieving alopecia, promoting hair growth and blackening hair Technical Field The invention relates to the technical field of cosmetics, in particular to a plant composition for relieving alopecia, promoting hair growth and blackening hair, and specifically relates to a plant composition for scalp care and hair care. More particularly, the present invention relates to a plant composition comprising a kudzu root extract, a watercress leaf/stem extract, an phyllanthus emblica fruit extract and a tulip flower extract, a method for preparing the composition and its use in preparing cosmetics for relieving hair loss, promoting hair growth and/or blackening hair. Background The problems of alopecia and poliosis become a common phenomenon which afflicts a plurality of people in the modern society, and have obvious negative effects on mental health and quality of life of people. With the increasing pace of life, increasing work pressure and changing dietary structure, the problem of hair loss has seen a trend towards younger and more generalized hair loss. Common types of hair loss include physiological hair loss, stress hair loss, and androgenic hair loss. Although physiological alopecia is a normal periodic replacement of hair, changes in environmental stress and dietary structure often make it misjudged as a pathological state, thus increasing psychological burden and even inducing or aggravating stress alopecia. Investigation has shown that a significant portion of the hair loss population is afflicted with the problem of white hair. Research shows that the stress alopecia and the androgenetic alopecia not only lead to the reduction of hair density, but also can induce the formation of white hair through mechanisms such as oxidative stress, hair follicle microcirculation disturbance and the like, form malignant circulation of alopecia-white hair-psychological stress, and bring heavy physical and psychological burden to patients. Hair follicles are core micro-organs for hair regeneration, and their physiological functions mainly depend on the coordinated regulation of three types of cells, namely hair follicle stem cells, hair papilla cells and hair matrix cells. The level of activation of hair follicle stem cells directly affects the division and differentiation viability of hair matrix cells, thereby determining the diameter, color and structural integrity of the hair shaft. Hair papilla cells regulate the alternation of the hair follicle cycle by secreting various growth factors, which play a key role in the dynamic balance of the hair follicle in anagen, catagen and telogen phases. In order to cope with the problems of hair loss and grey hair, various solutions have been proposed in the prior art, but these solutions have limitations to varying degrees. Chemical agents such as minoxidil and finasteride are common choices in promoting hair growth. Minoxidil, a potassium channel opener, promotes hair growth by opening ATP-sensitive potassium channels, up-regulating VEGF expression to improve hair follicle blood supply. However, the formulations thereof mostly contain high amounts of 1, 2-propanediol penetration enhancers, and contact dermatitis occurs at a high rate (about 7%), and the user may develop symptoms such as scalp erythema, desquamation, itching, etc. Adverse reactions such as facial and limb hirsutism can also occur to some users. More importantly, the alopecia degree can be restored to the baseline before treatment within 612 months after stopping the drug, and the phenomenon of 'rebound and restitution' is presented, so that the treatment effect is difficult to last. Finasteride promotes hair growth by selectively inhibiting type II 5α reductase, reducing dihydrotestosterone concentration in the scalp and serum. However, the medicament has limited curative effect on female alopecia and may cause adverse reactions related to sexual functions, so that the medicament is limited in wide application, especially application in female population. In the aspect of hair blacking, the existing methods are mainly divided into oxidation color-imparting and biological color-imparting. Oxidative coloring methods, such as using melanin precursors such as 5,6 Dihydroxyindole (DHI), impart black hair by in vitro oxidative polymerization. The method has chemical irritation and poor biological safety, and can cause adverse reactions such as scalp allergy, itching and the like after long-term use. Biological color-imparting method, such as Polygoni Multiflori radix, can promote melanin synthesis by enhancing gene expression of tyrosinase and MITF in hair follicle, but has great individual difference in effect. More importantly, the polygonum multiflorum contains anthraquinone compounds (such as emodin and rhein) and has the risk of hepatotoxicity after long-term use. The national drug administration has listed it in the cosmetics banned component catalog in 2020 for safety reasons. In additio