CN-122005413-A - Preparation method of facial mask containing embryo extract

CN122005413ACN 122005413 ACN122005413 ACN 122005413ACN-122005413-A

Abstract

The invention relates to the technical field of mask preparation, in particular to a preparation method of a mask containing embryo extract, which comprises the steps of mixing water phase raw materials, oil phase raw materials, an emulsifier and a thickener, adding embryo extract, a conditioning agent and a preservative into a cooled matrix mixture, carrying out homogenizing rotation on the primary mixture under the condition of cold and hot medium circulation to obtain a homogenized mixture, determining whether solidification and freezing are carried out or not according to particle size distribution width and cooling power under the condition of solidification and freezing are carried out, obtaining the viscosity of the homogenized mixture if solidification and freezing are not carried out, determining the maximum temperature rising rate of cold and hot medium circulation, degassing the homogenized mixture to obtain the primary embryo extract mask, detecting pH value variation of the homogenized mixture before and after degassing, and filling the primary embryo extract mask to obtain a finished embryo extract mask. The invention realizes the improvement of the preparation stability of the mask.

Inventors

LI MEIHUA
LI YUANHAO
DENG YIN
XIE PEIZENG

Assignees

广州新征程生物科技有限公司
广东新征程生命科学研究院

Dates

Publication Date: 20260512
Application Date: 20260313

Claims (10)

1. A method for preparing a mask containing embryoid bodies, comprising: Step S1, mixing an aqueous phase raw material, an oil phase raw material, an emulsifying agent and a thickening agent to form a matrix mixture; Step S2, adding embryosin, a conditioner and a preservative into the matrix mixture after cooling, and stirring to obtain a primary mixture; Step S3, carrying out homogenizing rotation on the primary mixture under the condition of cold and hot medium circulation to obtain a homogenized mixture, and detecting the particle size of particles in the primary mixture; step S4, acquiring a particle size distribution width according to the particle size of the particles, and determining whether solidification and freezing are carried out or not and the cooling power under the condition of solidification and freezing are carried out according to the particle size distribution width; step S5, if the solidification and freezing are not carried out, obtaining the viscosity of the homogeneous mixture; Step S6, determining the maximum temperature rising rate of the cold and hot media circulation according to the viscosity of the homogeneous mixture; Step S7, degassing the homogenized mixture to obtain a primary embryon mask, and detecting the pH value change amount of the homogenized mixture before and after degassing; Step S8, filling the primary embryon mask to obtain a finished embryon mask, Wherein the filling temperature is determined according to the pH value variation.
2. The method for producing a mask containing embryon according to claim 1, wherein the step of obtaining a width of a particle size distribution according to the particle size of the particles comprises: Sampling the particle size of the primary mixture at equal time intervals when the primary mixture performs homogeneous rotation under the condition of cold and hot medium circulation; calculating an average particle diameter corresponding to 50% of cumulative distribution based on the particle diameters, a large particle diameter corresponding to 90% of cumulative distribution and a small particle diameter corresponding to 10% of cumulative distribution; Calculating the particle size distribution width from the average particle size, the small particle size and the large particle size, Wherein the width of the particle size distribution is the ratio of the difference value of the large particle size and the small particle size to the average particle size.
3. The method for producing a mask containing embryon according to claim 2, wherein determining whether to perform solidification freezing and a cooling power under the condition of performing solidification freezing according to the width of the particle size distribution comprises: Acquiring the particle size distribution width; comparing the particle size distribution width with a preset first distribution width and a preset second distribution width respectively; If the particle size distribution width is larger than or equal to a preset second distribution width, solidifying and freezing are carried out, and the cooling power is increased; And if the particle size distribution width is smaller than or equal to the preset first distribution width, not performing solidification and freezing.
4. The method of claim 3, wherein the increase in cooling power is determined based on a difference between the width of the particle size distribution and the predetermined second distribution width.
5. The method of preparing an embryon-containing mask according to claim 4, wherein the step S6 includes: obtaining a viscosity of the homogenized mixture; Comparing the viscosity with a preset viscosity; and if the viscosity is greater than or equal to the preset viscosity, increasing the maximum temperature rising rate of the cold and hot medium circulation.
6. The method of claim 5, wherein the filling temperature is determined according to the pH variation, comprising: Acquiring the pH value variation; comparing the pH value variation with a preset variation; And if the pH value variation is greater than or equal to the preset variation, increasing the filling temperature.
7. The method of claim 6, wherein the pH change is the absolute value of the difference between the pH of the homogenized mixture and the pH of the primary embryoid's mask.
8. The method for preparing the embryoid body-containing mask according to claim 7, wherein the total weight percentage of the mask is 75% -85% of water phase raw materials, 2% -8% of oil phase raw materials, 1% -3% of emulsifying agents, 0.1% -1% of thickening agents, 0.1% -2% of embryoid bodies, 0.5% -5% of conditioning agents and 0.2% -1% of preservatives.
9. The method of claim 8, wherein the aqueous phase material comprises deionized water, a humectant and a chelating agent; The oil phase raw materials comprise an emollient and a stabilizer; the conditioner comprises one or more of vitamin, vitamin E, nicotinamide, peptide compound, dipotassium glycyrrhizinate.
10. The method for preparing a mask containing embryonin according to claim 9, wherein the rotational speed of the homogenizing rotation is 2000-8000 rpm, and the rotational time is 3-15 min.

Description

Preparation method of facial mask containing embryo extract Technical Field The invention relates to the technical field of mask preparation, in particular to a preparation method of a mask containing embryo extract. Background In the prior art, the embryosin mask preparation process mainly comprises the steps of mixing, directly stirring and mixing embryosin raw materials with a humectant, a preservative, a thickener and the like, and then filling, wherein the process stability is poor, active ingredients are easy to inactivate, oil phase and water phase ingredients and embryosin active ingredients are uniformly dispersed through high-pressure homogenization, microemulsification and other technologies to form a stable emulsion system, the embryosin raw materials are influenced by factors such as planting environment, harvesting time and the like, the content fluctuation of the active ingredients is large, although the recombinant embryosin active peptide technology can accurately prepare, the biological activity of part of recombinant protein is difficult to be completely matched with that of a natural extract, and the production cost is high. CN115300415A discloses a preparation method of a carboxymethyl cellulose fiber mask, comprising the following steps of 1, preparing a mask base fabric, namely (1) dispersing fibers, namely mixing carboxymethyl cellulose fibers and chitosan fibers in deionized water, dropwise adding an acetic acid solution, then placing the mixture in a constant-temperature water bath for heating reaction, cooling to room temperature, purifying and drying, and placing the obtained mixed fibers in N, N-dimethylformamide to form uniform solution to obtain fiber dispersion; preparing triacetyl gallic acid, namely mixing p-toluenesulfonic acid and acetic anhydride, stirring uniformly, adding the dried gallic acid, heating and stirring in a constant-temperature water bath for reaction, naturally cooling to room temperature, adding deionized water, stirring uniformly, dripping hydrochloric acid until the pH is 1.0-1.5, generating a large amount of precipitate, extracting and drying to obtain triacetyl gallic acid, and (3) adding alpha-cyclodextrin, geraniol and triacetyl gallic acid into a fiber dispersion liquid in sequence, stirring uniformly, adding a catalyst, heating and stirring for reaction, naturally cooling to room temperature, then adding the mixture into glacial diethyl ether for precipitation, quickly filtering out the precipitate, recrystallizing, drying under reduced pressure to obtain modified carboxymethyl cellulose fiber, wherein the modified carboxymethyl cellulose fiber is dissolved in N, N-dimethylformamide to form a uniform solution, and the uniform solution is formed into a spinning solution, and the spinning solution is subjected to electrostatic spinning to obtain the facial mask base cloth, and the preparation solution is prepared through the steps of preparing the facial mask base cloth, namely preparing the plant extract, and 3, preparing the mask, namely, completely soaking the mask base cloth in the mask liquid, starting ultrasonic waves, taking out the mask base cloth after the ultrasonic waves are completed, and folding and packaging the mask base cloth soaked with the mask liquid to obtain the mask. Therefore, the preparation method of the carboxymethyl cellulose fiber mask has the problems of unstable microstructure and backset of dispersion effect due to reagglomeration of fine particle sizes mixed by raw materials through brownian motion collision in the mixing process of the raw materials. Disclosure of Invention Therefore, the invention provides a preparation method of a mask containing embryoid bodies, which is used for solving the problems of unstable microstructure and backspacing of dispersing effect caused by reagglomeration of fine particle sizes mixed by raw materials through Brownian motion collision in the mixing process of the raw materials in the prior art. In order to achieve the above object, the present invention provides a method for preparing a facial mask containing embryoin, comprising: Step S1, mixing an aqueous phase raw material, an oil phase raw material, an emulsifying agent and a thickening agent to form a matrix mixture; Step S2, adding embryosin, a conditioner and a preservative into the matrix mixture after cooling, and stirring to obtain a primary mixture; Step S3, carrying out homogenizing rotation on the primary mixture under the condition of cold and hot medium circulation to obtain a homogenized mixture, and detecting the particle size of particles in the primary mixture; step S4, acquiring a particle size distribution width according to the particle size of the particles, and determining whether solidification and freezing are carried out or not and the cooling power under the condition of solidification and freezing are carried out according to the particle size distribution width; step S5, if the solidification and free