CN-122005414-A - High-activity traditional Chinese medicine extract whitening skin care formula and preparation process thereof

CN122005414ACN 122005414 ACN122005414 ACN 122005414ACN-122005414-A

Abstract

The invention discloses a whitening skin care formula of a high-activity traditional Chinese medicine extract and a preparation process thereof, belonging to the technical field of cosmetics. The formula comprises a core whitening compound extract, a rutin-based nano liposome carrier, a moisturizing matrix, a skin conditioner and deionized water in a weight ratio, wherein the core whitening compound extract is prepared by compounding a ganoderma lucidum spore wall-breaking enzymolysis extract, an phyllanthus emblica polyphenol extract and a mother-of-pearl soluble collagen chelated zinc extract according to a mass ratio of 3:4:2. The preparation process adopts a dual-phase gradient enzymolysis combined low-temperature supercritical CO2 flash extraction and in-situ embedding process, can realize multi-target collaborative whitening, greatly improves the extraction rate, storage stability and transdermal absorptivity of active ingredients, does not add chemical synthesis whitening agents, is safe and mild, and is suitable for large-scale production of cosmetics.

Inventors

Deng Maoxin
DONG FAWU
LI WEIJIAO
WANG HAIMING
MA KAIYUE
ZHANG YING

Assignees

云南中医药大学

Dates

Publication Date: 20260512
Application Date: 20260316

Claims (10)

1. The whitening and skin care formula of the high-activity traditional Chinese medicine extract is characterized in that: The high-activity traditional Chinese medicine extract whitening skin care formula comprises, by weight, 12-18 parts of a core whitening composite extract, 8-12 parts of a rutin-based nano liposome carrier, 25-35 parts of a moisturizing matrix, 3-6 parts of a skin conditioner and the balance of deionized water, wherein the core whitening composite extract is prepared by compounding a ganoderma lucidum spore wall breaking enzymolysis extract, an phyllanthus emblica polyphenol extract and a mother-of-pearl soluble collagen chelated zinc extract according to a mass ratio of 3:4:2, the rutin-based nano liposome carrier is prepared from rutin derived from pagodatree flower bud, hydrogenated lecithin and glycerol according to a mass ratio of 2:5:3, the core whitening composite extract targets five core whitening paths in a full life cycle of melanin, and the rutin-based nano liposome carrier is used for in-situ embedding, oxidation resistance and stability and transdermal permeation promotion of the core whitening composite extract.
2. The high activity traditional Chinese medicine extract whitening skin care formulation according to claim 1, wherein: the moisturizing matrix is prepared by compounding glycerol, propylene glycol and sodium hyaluronate according to a mass ratio of 5:3:2.
3. The high activity traditional Chinese medicine extract whitening skin care formulation according to claim 1, wherein: The skin conditioner is prepared by compounding panthenol, ceramide 3 and dipotassium glycyrrhizinate according to a mass ratio of 2:2:1.
4. The high activity traditional Chinese medicine extract whitening skin care formulation according to claim 1, wherein: after the rutin-based nano liposome carrier is used for embedding the core whitening composite extract, the particle size of the embedded composite is 80-120 nm.
5. The high activity traditional Chinese medicine extract whitening skin care formulation according to claim 1, wherein: the high-activity traditional Chinese medicine extract whitening skin care formula does not add a chemical synthesis whitening agent, and all core efficacy raw materials of the high-activity traditional Chinese medicine extract whitening skin care formula are from medicine and food homologous traditional Chinese medicines.
6. The process for preparing the high-activity traditional Chinese medicine extract whitening skin care formula as claimed in any one of claims 1 to 5, which is characterized in that: The preparation process sequentially comprises a core extract combined preparation step, an in-situ embedding and stabilizing treatment step and a preparation forming step, wherein the core extract combined preparation step adopts a biphase gradient enzymolysis combined low-temperature supercritical CO 2 flash technology, the in-situ embedding and stabilizing treatment step adopts a high-pressure homogenizing embedding technology under the condition of nitrogen protection, and the preparation forming step adopts a gradient cooling, stirring, mixing and vacuum defoaming technology, and the contact temperature of the heat-sensitive active ingredients is controlled to be not more than 45 ℃ in the whole process.
7. The process for preparing the high-activity traditional Chinese medicine extract whitening skin care formula according to claim 6, which is characterized in that: In the combined preparation step of the core extract, the biphase gradient enzymolysis technology adopts a cellulase and pectinase complex enzyme system, carries out enzymolysis for 2.5 hours at the pH of 4.5 and 40 ℃ and then adopts neutral protease for gradient enzymolysis for 1.5 hours.
8. The process for preparing the high-activity traditional Chinese medicine extract whitening skin care formula according to claim 6, which is characterized in that: In the combined preparation step of the core extract, the treatment temperature of the low-temperature supercritical CO 2 flash process is-4 ℃, and the whole process is in an oxygen-free closed environment.
9. The process for preparing the high-activity traditional Chinese medicine extract whitening skin care formula according to claim 6, which is characterized in that: In the in-situ embedding stable-activity treatment step, the temperature of high-pressure homogenization treatment is 35 ℃, the number of high-pressure homogenization cycles is 3, and the particle size of the prepared embedding compound is 80-120 nm.
10. The process for preparing the high-activity traditional Chinese medicine extract whitening skin care formula according to claim 6, which is characterized in that: In the preparation molding step, firstly, the moisturizing substrate, the skin conditioning agent and deionized water are mixed and heated to 45 ℃ and stirred uniformly, the temperature is reduced to 38 ℃, then the embedding compound is added, and the finished product is prepared after vacuum defoaming.

Description

High-activity traditional Chinese medicine extract whitening skin care formula and preparation process thereof Technical Field The invention relates to the field of traditional Chinese medicine extract whitening skin care formulas, in particular to a high-activity traditional Chinese medicine extract whitening skin care formula and a preparation process thereof. Background The invention belongs to the technical field of cosmetics, and particularly relates to a whitening skin care formula of a traditional Chinese medicine extract and a preparation process related technology. With the continuous improvement of the natural, safety and efficacy requirements of consumers on skin care products, the whitening active ingredients with medicinal and edible sources of traditional Chinese medicines become research and development hot spots in the cosmetic industry due to the characteristics of multi-target effect and mild and low irritation, and gradually replace part of chemical synthetic whitening agents with safety disputes. The existing traditional Chinese medicine whitening skin care formula has the defect that the action target point of a core whitening active ingredient is single, the antagonism effect is easy to generate by the compounded traditional Chinese medicine extract component, the multi-path intervention of the full life cycle of melanin cannot be realized, the whitening effect and the skin barrier repair are difficult to be simultaneously considered, and part of products are added with chemical synthesis whitening agents for improving the whitening effect, so that obvious skin irritation and sensitization risks exist. The traditional Chinese medicine whitening active ingredients are prepared by adopting a conventional water extraction or alcohol extraction process, so that oxidative degradation of the thermosensitive whitening active ingredients is easy to cause, the extraction rate of the active ingredients is low, and meanwhile, the existing technology lacks a special stable and active permeation promoting system which is suitable for the traditional Chinese medicine whitening active ingredients, so that the active ingredients are easy to deactivate after being stored at normal temperature and the skin transdermal absorption rate is low, and the efficacy exertion and the large-scale industrialized application of the traditional Chinese medicine whitening skin care products are severely limited. Disclosure of Invention The invention aims to overcome the defects of the technology and provide a whitening skin care formula and a preparation process of a high-activity traditional Chinese medicine extract. In order to solve the technical problems, the technical scheme provided by the invention is that the high-activity traditional Chinese medicine extract whitening skin care formula and the preparation process thereof are as follows: The high-activity traditional Chinese medicine extract whitening skin care formula comprises, by weight, 12-18 parts of a core whitening composite extract, 8-12 parts of a rutin-based nano liposome carrier, 25-35 parts of a moisturizing matrix, 3-6 parts of a skin conditioner and the balance of deionized water, wherein the core whitening composite extract is prepared by compounding a ganoderma lucidum spore wall breaking enzymolysis extract, an phyllanthus emblica polyphenol extract and a mother-of-pearl soluble collagen chelated zinc extract according to a mass ratio of 3:4:2, the rutin-based nano liposome carrier is prepared from rutin derived from pagodatree flower bud, hydrogenated lecithin and glycerol according to a mass ratio of 2:5:3, the core whitening composite extract targets five core whitening paths in a full life cycle of melanin, and the rutin-based nano liposome carrier is used for in-situ embedding, oxidation resistance and stability and transdermal permeation promotion of the core whitening composite extract. As an improvement, the moisturizing matrix is prepared by compounding glycerol, propylene glycol and sodium hyaluronate according to a mass ratio of 5:3:2. As an improvement, the skin conditioner is prepared by compounding panthenol, ceramide 3 and dipotassium glycyrrhizinate according to a mass ratio of 2:2:1. As an improvement, after the rutin-based nano-liposome carrier is embedded in the core whitening composite extract, the particle size of the formed embedding compound is 80-120 nm. As an improvement, the high-activity traditional Chinese medicine extract whitening skin care formula does not add a chemical synthesis whitening agent, and all core efficacy raw materials of the high-activity traditional Chinese medicine extract whitening skin care formula are from medicine and food homologous traditional Chinese medicines. The preparation process sequentially comprises a core extract combined preparation step, an in-situ embedding stable activity treatment step and a preparation forming step, wherein the core extract combined preparation step adopts