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CN-122005419-A - Vagina nourishing nursing gel and preparation method thereof

CN122005419ACN 122005419 ACN122005419 ACN 122005419ACN-122005419-A

Abstract

The invention relates to the technical field of gel, in particular to a vagina nourishing nursing gel and a preparation method thereof, wherein the vagina nourishing nursing gel comprises a composite extract, a mixed extract, lactobacillus fermentation products, collagen, hexapeptide, oligopeptide-1, trehalose, dextran, sodium hyaluronate, sclerotium gum, carbomer, glycerol, 1, 3-propanediol, PEG-400, 1, 2-hexanediol, p-hydroxyacetophenone, lactic acid and water, the composite extract is prepared by mixing four raw materials, contains polysaccharide powder and polyphenol purified matters, the mixed extract is prepared by mixing four raw materials, contains flavone powder and alkaloid powder, and has the synergistic effect of all the components, is mild and safe, and can maintain the health state of vagina. The extraction process is efficient and environment-friendly, improves the utilization rate of raw materials, reduces the cost, is suitable for industrial production, has mild and non-irritating product formulation, has synergistic effect of all components, can repair vaginal mucosa, adjust microecological balance, meets the requirement of female long-term private maintenance, and has remarkable advantages.

Inventors

  • SUN HAI

Assignees

  • 成都宇泽中医药生物科技有限公司

Dates

Publication Date
20260512
Application Date
20260318

Claims (10)

  1. 1. A vaginal nourishing nursing gel is characterized by comprising, by mass, 1-5% of a grifola frondosa, aster, rhizoma polygonati, ganoderma lucidum composite extract, 0.5-2% of a mixed extract of pepper, kuh-seng, phellodendron bark and baical skullcap root, 0.2-2% of a lactobacillus fermentation product, 0.2-2% of collagen, 0.05-0.2% of hexapeptide, 0.05-0.2% of oligopeptide, 0.5-2% of trehalose, 0.2-1% of glucan, 0.01-1% of sodium hyaluronate, 0.1-0.5% of sclerotium gum, 0.1-0.5% of carbomer, 1-5% of glycerol, 1, 3-propanediol, 1-400-5% of PEG, 0.5-2% of hexanediol, 0.5-1% of p-hydroxyacetophenone, 0.02-5% of lactic acid and the balance of water; The mixed extract of the Chinese prickly ash, the radix asteris, the rhizoma polygonati and the lucid ganoderma is prepared by mixing the Chinese grifola, the radix asteris, the rhizoma polygonati and the lucid ganoderma according to the mass ratio of 1.5:1:1:0.5, and comprises polysaccharide powder and polyphenol purified matters according to the mass ratio of 2:1, and the mixed extract of the Chinese prickly ash, the radix sophorae flavescentis, the cortex phellodendri and the radix scutellariae is prepared by mixing the Chinese prickly ash, the radix sophorae flavescentis, the cortex phellodendri and the radix scutellariae according to the mass ratio of 1.5:1:1:0.5, and comprises flavone powder and alkaloid powder according to the mass ratio of 5:1.
  2. 2. The vaginal nourishing and caring gel according to claim 1, wherein the content of the compound extract of grifola frondosa, aster, rhizoma polygonati and ganoderma lucidum is 2-4% by mass, and the content of the mixed extract of pricklyash peel, kuh-seng root, phellodendron bark and baical skullcap root is 1-1.5%.
  3. 3. The vaginal nourishing and caring gel according to claim 1, wherein the lactobacillus fermentation product is 0.5-1.5% by mass, the collagen is 0.5-1.5% by mass, and the total content of hexapeptide and oligopeptide-1 is 0.15-0.3% by mass.
  4. 4. The vaginal nourishing care gel according to claim 1, wherein the sodium hyaluronate is a compound of macromolecular sodium hyaluronate and micromolecular sodium hyaluronate, and the compound mass ratio is 1:1-3:1.
  5. 5. The vaginal nourishing care gel according to claim 1, wherein the total content of the sclerotium gum and carbomer is 0.3-0.8% and the total content of the glycerol, 1, 3-propanediol and PEG-400 is 4-12% by mass.
  6. 6. The vaginal nourishing care gel according to claim 1, wherein the lactic acid is used for adjusting the pH value of the gel system to 3.8-4.5, and the lactic acid bacteria fermentation product is used for cooperatively maintaining the acidic micro-ecological environment of the vagina.
  7. 7. A method of preparing a vaginal nourishing care gel as claimed in any one of claims 1 to 6, comprising the steps of: s1, preparing a composite extract of grifola frondosa, aster, rhizoma polygonati and ganoderma lucidum: S11, sample pretreatment, namely respectively taking grifola frondosa, aster, rhizoma polygonati and lucid ganoderma, drying at 60 ℃, crushing, sieving with a 60-mesh sieve, and uniformly mixing according to the mass ratio of 1.5:1:1:0.5 to obtain mixed powder; S12, polysaccharide extraction, namely adding deionized water into mixed powder according to a feed liquid ratio of 1:30g/mL, adjusting pH to 4.0, adding compound enzyme accounting for 1% of the mass of the mixed powder, wherein the compound enzyme is prepared by compounding cellulase and pectase according to a mass ratio of 1:1, heating to 90 ℃ for enzyme deactivation for 10min after enzymolysis for 1h at 50 ℃, carrying out ultrasonic extraction for 30min under the conditions of 150W power and 55 ℃, and carrying out centrifugation, filtration, concentration and spray drying to obtain polysaccharide powder; S13, polyphenol extraction, namely taking residues obtained after polysaccharide extraction in S12, adding 55% ethanol solution according to the feed liquid ratio of 0.5:20g/mL, carrying out ultrasonic extraction for 50min at 55 ℃ and 200W power, cooling to room temperature, centrifuging for 10min at 3000r/min, filtering supernatant, rotary steaming, and drying to obtain a polyphenol crude product; S14, preparing a composite extract, namely mixing the polysaccharide powder prepared in the step S12 and the polyphenol purified product prepared in the step S13 according to the mass ratio of 2:1, crushing and sieving with a 60-mesh sieve to prepare the composite extract of the grifola frondosa, the aster, the rhizoma polygonati and the ganoderma lucidum; s2, preparing mixed extracts of pepper, kuh-seng root, phellodendron bark and baical skullcap root: S21, sample pretreatment, namely respectively taking pepper, kuh-seng root, phellodendron bark and baical skullcap root, drying at 60 ℃, crushing, sieving with a 60-mesh sieve, and uniformly mixing according to the mass ratio of 1.5:1:1:0.5 to obtain mixed powder; S22, extracting flavone, namely adding buffer solution with pH value of 4.5 into the mixed powder, adding cellulase, pectase and papain according to the proportion of 4:6:3mg/mL, carrying out enzymolysis for 1h at 50 ℃, adding 80% ethanol solution with pH value of 13 according to the feed liquid ratio of 1:20g/mL, carrying out ultrasonic extraction for 30min at 50 ℃ and 175W, leaching for 2h at 90 ℃, centrifuging, filtering, concentrating and spray drying to obtain flavone powder; S23, extracting alkaloid, namely taking residues after flavone extraction in S22, adding 70% ethanol solution with pH=2 according to a feed liquid ratio of 1:30g/mL, adding 30mg/mL of sodium lauroyl sarcosinate, performing ultrasonic extraction for 20min at 70 ℃ and 200W power, and performing centrifugation, filtration, concentration and spray drying to obtain alkaloid powder; S24, preparing a mixed extract, namely mixing the flavone powder prepared in the S22 and the alkaloid powder prepared in the S23 according to a mass ratio of 5:1, crushing and sieving with a 60-mesh sieve to prepare a mixed extract of pepper, kuh-seng, phellodendron and baical skullcap root; s3, gel matrix preparation: weighing glycerol, 1, 3-propylene glycol, PEG-400, sodium hyaluronate, sclerotium gum and carbomer according to a formula, adding into purified water, stirring until the mixture is completely swelled and dispersed uniformly to obtain a gel matrix; s4, mixing active ingredients, namely weighing the composite extract prepared in the step 1 according to a formula, the mixed extract prepared in the step 2, lactobacillus fermentation products, collagen, hexapeptide, oligopeptide-1, trehalose, dextran, 1, 2-hexanediol and p-hydroxyacetophenone, adding the mixture into the gel matrix prepared in the step 3, and stirring until the mixture is completely and uniformly dispersed; S5, preparing a finished product, namely adding lactic acid with the formula amount into the mixed system obtained in the step S4 to adjust the pH value, adding the rest water to the whole amount, uniformly stirring, and then degassing and sterilizing to obtain the vagina nourishing and nursing gel.
  8. 8. The method for preparing the vaginal nourishing and caring gel according to claim 7, wherein the pretreatment step of the D-101 macroporous resin in S13 is that the D-101 macroporous resin is soaked in 95% ethanol for 24 hours, distilled water is washed until no alcohol smell exists, then 1mol/L NaOH solution is used for soaking for 8 hours, distilled water is washed to be neutral, finally 1mol/L HCl solution is used for soaking for 8 hours, distilled water is used for washing to be neutral, then the gel is kept stand for later use, and during chromatographic purification, a polyphenol crude extract is loaded at a speed of 3mL/min and is eluted by 80% ethanol solution after adsorption.
  9. 9. The method according to claim 7, wherein the cellulase, pectase and papain are added in the ratio of S22, and wherein 4mg of cellulase, 6mg of pectase and 3mg of papain are added per 1g of the mixed powder based on the mass of the mixed powder.
  10. 10. The method for preparing a vaginal nourishing and caring gel according to claim 7, wherein the pH value in S5 is adjusted to 3.8-4.5, and the sterilization mode is 121 ℃ high pressure steam sterilization for 15min or irradiation sterilization.

Description

Vagina nourishing nursing gel and preparation method thereof Technical Field The invention relates to the technical field of gel, in particular to a vagina nourishing nursing gel and a preparation method thereof. Background The invention relates to the technical field of plant extract application, in particular to female vagina nourishing and nursing gel and a preparation technology thereof. With the overall rise in female health awareness and the shift in lifestyle, the market demand for female privacy health care continues to grow. Factors such as age increase, hormone level fluctuation, fertility, bad living habit and the like easily cause the problems of atrophy, dryness, epithelial mucosa thinning, local resistance reduction and the like of female vagina, further cause repeated infection of bacteria and fungi, and symptoms such as inflammation discomfort, relaxation, dryness and the like appear, and seriously influence the living quality and physical and mental health of females, so that a vagina daily care product with mild safety and long-acting repairing effect becomes a research and development focus and core direction in the field. The vaginal care products on the market at present are mainly divided into western medicines and traditional Chinese medicines. The western medicine products mainly take antibacterial and anti-inflammatory chemical components as cores, can only pointedly relieve the symptoms of gynecological inflammation in the acute stage, can not repair damaged vaginal mucosa barriers from root sources, can easily destroy normal microecological balance in vagina, causes repeated attack of inflammation, and can not realize fundamental maintenance and conditioning. Most traditional Chinese medicine products are single plant extracts or simple component compounding, active ingredients are single, the efficacy is limited, the basic bacteriostasis or moisturizing effect can be realized, and a multi-target and multi-dimensional integral repairing scheme cannot be formed. Meanwhile, in the prior art, aiming at the defects of low raw material utilization rate, high production cost and complicated process flow of the extraction of plant active ingredients, the continuous extraction of flavone and alkaloid in pepper, radix sophorae flavescentis, phellodendron bark and radix scutellariae and the fractional extraction process of polysaccharide and polyphenol in grifola frondosa, aster, rhizoma polygonati and ganoderma lucidum are mainly single ingredient extraction processes, no mature technical report exists at present, and high-efficiency collaborative preparation of various active ingredients cannot be realized. In addition, the existing nursing products have the defects of a formula system, most of the nursing products only pay attention to maintenance in a single dimension, the maintenance of physical structures of mucous membranes and the balance adjustment of micro-ecology cannot be considered, and most of the nursing products are added with irritant components such as preservative and the like, so that secondary damage is easily caused to delicate vaginal mucous membranes, and the long-term mild maintenance requirement of females is difficult to meet. Therefore, developing a natural, safe and multi-effect synergistic vaginal nourishing nursing gel and a matched efficient extraction and preparation process become the technical problems to be solved in the field. Disclosure of Invention (One) solving the technical problems Aiming at the defects of the prior art, the invention provides a vagina nourishing nursing gel and a preparation method thereof. (II) technical scheme The vaginal nourishing nursing gel comprises, by mass, 1-5% of a compound extract of grifola frondosa, aster, rhizoma polygonati and ganoderma lucidum, 0.5-2% of a mixed extract of pepper, radix sophorae flavescentis, phellodendron bark and radix scutellariae, 0.2-2% of a lactobacillus fermentation product, 0.2-2% of collagen, 0.05-0.2% of hexapeptide, 0.05-0.2% of oligopeptide-1, 0.5-2% of trehalose, 0.2-1% of glucan, 0.01-1% of sodium hyaluronate, 0.1-0.5% of sclerotium (SCLEROTIUM ROLFSSII) gum, 0.1-0.5% of carbomer, 1-5% of glycerol, 1, 3-propanediol, 1-400-5% of PEG, 0.5-2% of hexanediol, 0.5-1% of p-hydroxyacetophenone, 0.02-5% of lactic acid and the balance of water; The mixed extract of the Chinese prickly ash, the radix asteris, the rhizoma polygonati and the lucid ganoderma is prepared by mixing the Chinese grifola, the radix asteris, the rhizoma polygonati and the lucid ganoderma according to the mass ratio of 1.5:1:1:0.5, and comprises polysaccharide powder and polyphenol purified matters according to the mass ratio of 2:1, and the mixed extract of the Chinese prickly ash, the radix sophorae flavescentis, the cortex phellodendri and the radix scutellariae is prepared by mixing the Chinese prickly ash, the radix sophorae flavescentis, the cortex phellodendri and the radix scutellariae according to the mass ratio