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CN-122005461-A - Plant carbon point mouth drop powder and preparation method and application thereof

CN122005461ACN 122005461 ACN122005461 ACN 122005461ACN-122005461-A

Abstract

The application discloses plant carbon point mouth drop powder and a preparation method and application thereof, belonging to the technical field of oral instant preparations. The preparation method of the plant carbon dot mouth-drop powder provided by the application comprises the steps of Plant Carbon Dot (PCDs) preparation, integration of carbon dots and the original process and the like. The stability, dissolution speed and mucous membrane absorption efficiency of the active ingredients of the oral instant powder are improved through plant-derived carbon dots (PCDs), and seamless integration of carbon dot preparation and the original process is realized. By accurately controlling the preparation process parameters, the addition proportion and the dispersion process of the carbon dots, the high stability and the high effect of the product are ensured. The application has obvious technical advantages and market application prospect, and can be widely applied to the field of oral instant preparations.

Inventors

  • CUI XU
  • ZHU GUANGHUA

Assignees

  • 北京旭华时代科技有限公司
  • 北京乔安投资有限公司

Dates

Publication Date
20260512
Application Date
20260316

Claims (10)

  1. 1. The preparation method of the plant carbon spot mouth-dropping powder is characterized by comprising the following steps: (1) Dividing plant powder into two parts for preparing carbon dots and performing subsequent treatment respectively; (2) Mixing plant powder for carbon dot preparation with water to obtain suspension; (3) Placing the suspension in a polytetrafluoroethylene reaction kettle for carbonization reaction; (4) Sequentially performing ultrasonic crushing and centrifugation on the carbonization reaction product, and taking supernatant for dialysis to obtain plant carbon points; (5) Carrying out nano-crushing on the plant powder used for subsequent treatment in the step (1), and mixing the nano-crushed body with water to obtain a plant dispersion liquid; (6) Mixing the plant carbon dots with the plant dispersion liquid, and sequentially stirring, ultrasonically dispersing, homogenizing and drying to obtain the plant carbon dot mouth-dropping powder.
  2. 2. The method for preparing the plant carbon spot mouth-drop powder according to claim 1, wherein in the step (1), the plant powder is at least one of ganoderma lucidum spores, astragalus, salvia miltiorrhiza, rhizoma polygonati, lycium ruthenicum, honeysuckle, liquorice, angelica and ginseng; The grain diameter of the plant powder is 8-12 mu m; The dosage of the plant powder for preparing the carbon dots is 5-10% of the total mass of the plant powder.
  3. 3. The method for preparing the plant carbon dot falling mouth eliminating powder according to claim 1, wherein in the step (2), the mass concentration of the plant powder for preparing the carbon dots in the suspension is 5-10%.
  4. 4. The preparation method of the plant carbon spot mouth-dropping powder agent according to claim 1, wherein in the step (3), the filling degree of the suspension in a polytetrafluoroethylene reaction kettle is 70-80%; The temperature of the carbonization reaction is 180-220 ℃; The carbonization reaction time is 6-12 hours.
  5. 5. The preparation method of the plant carbon spot mouth-dropping powder agent according to claim 1, wherein in the step (4), the power of ultrasonic crushing is 450-550W, and the time of ultrasonic crushing is 55-65 min; the rotating speed of the centrifugation is 11000-13000 rpm, and the time of the centrifugation is 15-25 min; the molecular weight cut-off of a dialysis membrane used for dialysis is 1000Da, the temperature of the dialysis is 23-27 ℃, and the time of the dialysis is 45-50 hours; The vegetable carbon point is the carbon point with the molecular weight of less than 1000Da in the dialyzate.
  6. 6. The method for preparing the plant carbon spot mouth-drop powder according to claim 1, wherein in the step (5), the particle size of the nano-powder is 8-12 nm; The mass concentration of the nano-powder in the plant dispersion liquid is 2-5%.
  7. 7. The method for preparing a plant carbon dot drop mouth powder according to claim 1, wherein in the step (6), the addition amount of the plant carbon dot is 0.01-0.05% of the total mass of the plant carbon dot and the plant dispersion liquid.
  8. 8. The preparation method of the plant carbon spot mouth-dropping powder agent according to claim 1, wherein in the step (6), the stirring speed is 250-350 rpm, and the stirring time is 8-12 min; The power of ultrasonic dispersion is 400-500W, and the time of ultrasonic dispersion is 25-35 min; the homogenizing pressure is 100-120 MPa, the homogenizing times are 2-4 times, and the homogenizing time is 40-80 min each time; The drying is carried out until the water content is less than or equal to 1%; The drying is vacuum drying; The vacuum degree of the vacuum drying is less than or equal to 50Pa, and the temperature of the vacuum drying is 40-50 ℃.
  9. 9. The plant carbon spot mouth-dropping powder is characterized by being prepared by the preparation method of any one of claims 1-9.
  10. 10. The use of a botanical carbon spot mouth-drop powder as claimed in claim 9 in the manufacture of a medicament for the treatment of oral mucosal disease.

Description

Plant carbon point mouth drop powder and preparation method and application thereof Technical Field The application belongs to the technical field of oral instant preparations, and particularly relates to a plant carbon point mouth drop powder and a preparation method and application thereof. Background The oral instant preparation is taken as an important component of a modern drug delivery system and is widely applied to the field of oral mucosa administration. However, the traditional oral instant powder has a plurality of technical bottlenecks that active ingredients are easily degraded by the oral environment (such as flavonoid and alkaloid ingredients are rapidly deactivated under the action of salivary enzymes), the mucous membrane absorptivity is low (usually less than 50%), the stability after dissolution is poor (agglomeration or precipitation is easy to occur), and the like. In the prior art, nano materials (such as metal nanoparticles and silicon dioxide nanoparticles) are often added for improving the solubility and the absorption efficiency, but the nano materials may introduce biosafety risks (such as metal ion toxicity and accumulation effect of the nano particles in the body), have poor compatibility with plant components, and are difficult to be compatible with the traditional plant medicine preparation process. Conventional carbon dot preparation processes (such as high temperature calcination method and microwave method) are usually carried out under high temperature (> 500 ℃), which causes structural damage of plant active ingredients and is difficult to retain original biological activity and functional groups (such as hydroxyl and carboxyl). In addition, these processes are not compatible with the phytodrug formulation process, requiring additional separation and purification steps, increasing production costs and complexity. Therefore, development of a carbon dot preparation method which can not only retain plant active ingredients, but also can be seamlessly integrated with a preparation process is needed to solve the problems of stability, mucous membrane absorption efficiency and stability after dissolution of active ingredients in an oral instant preparation. Disclosure of Invention In order to overcome the defects in the prior art, the application provides plant carbon dot drop mouth eliminating powder, a preparation method and application thereof, wherein the stability and absorption efficiency of active ingredients are improved through Plant Carbon Dots (PCDs), the seamless integration of carbon dot preparation and an original process is realized, the side effects of agglomeration, solubility reduction and the like are avoided, and a ten-thousandth precise adding and homogenizing dispersion control system is established. In order to achieve the above object, the present application provides the following technical solutions: in one aspect, the application provides a preparation method of plant carbon point mouth drop powder, which comprises the following steps: (1) Dividing plant powder into two parts for preparing carbon dots and performing subsequent treatment respectively; (2) Mixing plant powder for carbon dot preparation with water to obtain suspension; (3) Placing the suspension in a polytetrafluoroethylene reaction kettle for carbonization reaction; (4) Sequentially performing ultrasonic crushing and centrifugation on the carbonization reaction product, and taking supernatant for dialysis to obtain plant carbon points; (5) Carrying out nano-crushing on the plant powder used for subsequent treatment in the step (1), and mixing the nano-crushed body with water to obtain a plant dispersion liquid; (6) Mixing the plant carbon dots with the plant dispersion liquid, and sequentially stirring, ultrasonically dispersing, homogenizing and drying to obtain the plant carbon dot mouth-dropping powder. Optionally, in the step (1), the plant powder source comprises at least one of ganoderma lucidum spores, astragalus, red sage root, rhizoma polygonati, lycium ruthenicum, honeysuckle, liquorice, angelica and ginseng; The grain diameter of the plant powder is 8-12 mu m; The dosage of the plant powder for preparing the carbon dots is 5-10% of the total mass of the plant powder. According to the application, the plant powder is split into 5-10% of the total powder to the carbon point preparation system by arranging the splitter valve or the splitter pipeline, and the splitting process is realized by the automatic control system, so that the splitting proportion is ensured to be accurate and controllable. Optionally, in the step (2), the mass concentration of the plant powder used for preparing the carbon dots in the suspension is 5-10%. Optionally, in the step (3), the filling degree of the suspension in a polytetrafluoroethylene reaction kettle is 70-80%; The temperature of the carbonization reaction is 180-220 ℃; The carbonization reaction time is 6-12 hours. According to the applicati