Search

CN-122005472-A - High-stability watered pill and preparation method and application thereof

CN122005472ACN 122005472 ACN122005472 ACN 122005472ACN-122005472-A

Abstract

The invention provides a high-stability watered pill and a preparation method and application thereof, wherein the watered pill is prepared by the steps of S1, mixing starch and water, carrying out ultrasonic stirring to obtain paste, S2, spraying medicine powder into the paste, wherein the spraying distance is 1-7cm, the pressure is 1-7bar, the air flow speed is 1-7m/S, stirring to form a dough, S3, carrying out microwave preheating treatment on the dough to obtain a pretreated dough, S4, rubbing the pretreated dough on a pill rubbing base plate to form strips, rolling in a tank circuit to obtain the watered pill, S5, carrying out high-pressure auxiliary curing on the watered pill at 35-75MPa for 15-45min, and then carrying out normal-pressure drying at 25-55 ℃ for 10-30h to obtain the target high-stability watered pill. The watered pill prepared by the invention has moderate softness and hardness, good viscosity, stable quality of finished products, good uniformity, solubility and high stability, long shelf life, easy mass production and practical significance.

Inventors

  • LIU MEIZHEN

Assignees

  • 海南灵汲科技有限公司

Dates

Publication Date
20260512
Application Date
20260313

Claims (10)

  1. 1. The preparation method of the water-paste pill with high stability is characterized by comprising the following specific steps: s1, mixing starch and water, and stirring ultrasonically to obtain paste; s2, spraying the medicine powder into the paste, wherein the spraying distance is 1-7cm, the pressure is 1-7bar, the air flow speed is 1-7m/S, and stirring to form a dough; S3, carrying out microwave preheating treatment on the dough to obtain a pretreated dough; s4, rubbing the pretreated dough on a ball rubbing bottom plate into strips, and rolling in a tank way to obtain water balls; S5, carrying out high-pressure auxiliary curing on the water pill for 15-45min under 35-75MPa, and then carrying out normal-pressure drying for 10-30h under 25-55 ℃ to obtain the target water pill with high stability.
  2. 2. The method for preparing the high-stability watered pill according to claim 1, wherein in the step S1, the starch is any one of potato starch, sweet potato starch and wheat flour, and the mass ratio of the starch to the water is 5-6:20.
  3. 3. The method for preparing a highly stable watered pill as claimed in claim 1, wherein in step S1, the temperature of the ultrasonic agitation is 15-25 ℃, the power is 10-20KHz, and the time is 40-60min.
  4. 4. The method of claim 1, wherein in step S2, the mass ratio of the paste to the powder is 1.25-1.3:1.
  5. 5. The method of claim 1, wherein in step S2, the powder is sieved through a 100-120 mesh sieve.
  6. 6. The method for preparing high-stability watered pellets according to claim 1, wherein in the step S2, the spraying distance is 2-6cm, the pressure is 1-5bar, the air flow speed is 2-5m/S, and the shape of the dough is that the extruded dough is not cracked and not diverged.
  7. 7. The method of claim 1, wherein in step S3, the microwave preheating is performed at 40-50 ℃ for 30-40min under 200-300W.
  8. 8. The method for preparing high-stability watered pills according to claim 1, wherein in the step S5, the high-pressure auxiliary curing pressure is 40-60MPa, the time is 20-40min, the temperature is 20-30 ℃, the normal-pressure drying temperature is 30-50 ℃ and the time is 12-24h.
  9. 9. A highly stable watered pill prepared by the method of any one of claims 1-8.
  10. 10. Use of a highly stable watered pill as claimed in claim 9 in the preparation of a drug delivery vehicle.

Description

High-stability watered pill and preparation method and application thereof Technical Field The invention relates to the technical field of medical materials, in particular to a high-stability watered pill and a preparation method and application thereof. Background The watered pill is also called water-blown pill, which is a small spherical pill prepared by taking cold boiled water, medicinal juice or other liquid as adhesive (wetting) agent. The watered pill is developed based on decoction, and is prepared by decocting one part of medicines and the other part of medicine fine powder in a prescription by a dripping pill method, then gradually evolves, and all or part of medicine fine powder in the prescription is prepared into pellets by a general method by taking various water-soluble liquids as adhesives. The preparation process flow of the general preparation method comprises the steps of raw material preparation, drawing, molding, capping, drying, pill selection, quality inspection and packaging. The preparation process is easy to have the following problems that 1, stable quality of a finished product of the water-bindered pill is difficult to control, uneven problems are easy to occur, 2, the surface of the water-bindered pill is uneven or cracked to influence the stability of the water-bindered pill, 3, if the water-bindered pill is poorly controlled, uneven drying of the water-bindered pill is caused to influence the strength and the quality of the water-bindered pill, 4, the pill selecting efficiency is low, and the difficulty is high and the time is consumed. These problems affect the quality, stability and production efficiency of the final pellets and require strict control. Therefore, the watered pill obtained by the preparation process needs to be researched, has moderate softness, good viscosity, high stability, stable quality, good uniformity and solubility, short dissolution time limit, easy mass production and practical significance. Disclosure of Invention In view of the above, the invention provides a high-stability watered pill, and a preparation method and application thereof. The technical scheme of the invention is realized as follows: a preparation method of a high-stability watered pill comprises the following specific steps: s1, mixing starch and water, and stirring ultrasonically to obtain paste; s2, spraying the medicine powder into the paste, wherein the spraying distance is 1-7cm, the pressure is 1-7bar, the air flow speed is 1-7m/S, and stirring to form a dough; S3, carrying out microwave preheating treatment on the dough to obtain a pretreated dough; s4, rubbing the pretreated dough on a ball rubbing bottom plate into strips, and rolling in a tank way to obtain water balls; S5, carrying out high-pressure auxiliary curing on the water pill for 15-45min under 35-75MPa, and then carrying out normal-pressure drying for 10-30h under 25-55 ℃ to obtain the target water pill with high stability. In the step S1, the starch is any one of potato starch, sweet potato starch and wheat flour, and the mass ratio of the starch to the water is 5-6:20. Further, in the step S1, the temperature of the ultrasonic stirring is 15-25 ℃, the power is 10-20KHz, and the time is 40-60min. Further, in step S2, the mass ratio of the paste to the drug powder is 1.25-1.3:1. Further, in step S2, the medicine powder is sieved by a 100-120 mesh sieve. In the step S2, the spraying distance is 2-6cm, the pressure is 1-5bar, the air flow speed is 2-5m/S, and the shape of the dough is that the extruded dough is not cracked and not diverged. Further, in the step S3, the microwave preheating treatment is performed under the conditions of 40-50 ℃ and 200-300W for 30-40min. Further, in the step S5, the pressure of the high-pressure auxiliary curing is 40-60MPa, the time is 20-40min, the temperature is 20-30 ℃, the temperature of the normal-pressure drying is 30-50 ℃ and the time is 12-24h. A high-stability watered pill is prepared by the preparation method. Use of high stability watered pill in preparation of drug delivery vehicle is provided. Compared with the prior art, the invention has the beneficial effects that: 1. the watered pill prepared by the invention has moderate softness and hardness, good viscosity, stable quality of finished products, good uniformity, solubility and high stability, short dissolution time limit, long quality guarantee period of finished products, easy mass production and good market prospect, and has practical significance. 2. The paste with specific starch types and specific proportion of starch and water subjected to ultrasonic stirring can be well adhered to a dough formed by the medicine powder, the medicine powder is fine and smooth in sieving (100-120 meshes), the absorption effect is good, the medicine powder is easy to agglomerate, and the production efficiency is improved. The ultrasonic stirring can improve the uniformity and the fineness of paste, prevent agglomeration and i