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CN-122005505-A - Double-layer temperature-sensitive microcapsule essential oil for improving swelling and preparation method thereof

CN122005505ACN 122005505 ACN122005505 ACN 122005505ACN-122005505-A

Abstract

The invention discloses a double-layer temperature-sensitive microcapsule essential oil for improving swelling and a preparation method thereof, and belongs to the technical field of medicines. The microcapsule essential oil is prepared from a mixed core material, an inner wall material, an outer wall material and an oil phase system, wherein the mixed core material comprises raw materials including frankincense, paeonol, dragon's blood, myrrh, agilawood, bezoar, tea oil and lauric acid-myristic acid binary mixture, the inner wall material comprises gelatin and Arabic gum, and the outer wall material comprises hydroxypropyl methyl cellulose and modified montmorillonite. The preparation method effectively reduces the loss of volatile active ingredients in the processing process, and improves the embedding rate and the storage stability. When the microcapsule essential oil structure is used, the temperature of hot compress skin enables the phase change material in the core material to change phase, pressure is generated from the inside, meanwhile, the outer wall material is actively ruptured to cooperatively release active ingredients, and the microcapsule essential oil structure can promote the transdermal effect of the active ingredients, further promote transdermal absorption and further improve the swelling effect.

Inventors

  • ZHONG WEIJIE
  • ZHANG XIAN
  • YIN CHENGHUI
  • LIU WANYING
  • HUANG ZHUOMING
  • HUANG DONGMING

Assignees

  • 广州莱可福生物科技有限公司

Dates

Publication Date
20260512
Application Date
20260409

Claims (10)

  1. 1. The temperature-sensitive microcapsule essential oil for improving swelling is characterized by being prepared from a mixed core material, an inner wall material, an outer wall material and an oil phase system, wherein the mixed core material comprises raw materials including frankincense, paeonol, dragon's blood, myrrh, agilawood, bezoar, tea oil and lauric acid-myristic acid binary mixture, the inner wall material comprises gelatin and acacia, the outer wall material comprises hydroxypropyl methyl cellulose and modified montmorillonite, and the oil phase system comprises lecithin, tea oil, eucalyptus oil, menthol, camphor, natural borneol and hydrophobic fumed silica.
  2. 2. The swelling-improving temperature-sensitive microcapsule essential oil according to claim 1, wherein the raw materials of the mixed core material comprise, by mass, 1-5 parts of tea oil, 0.1-1 part of frankincense, 0.1-1 part of paeonol, 0.1-1 part of dragon's blood, 0.1-1 part of myrrh, 0.1-1 part of agilawood, 0.1-1 part of bezoar and 5-10 parts of lauric acid-myristic acid binary mixture, and the lauric acid-myristic acid binary mixture comprises lauric acid and myristic acid in a mass ratio of 12:7.4.
  3. 3. The temperature-sensitive microcapsule essential oil for improving swelling according to claim 1 is characterized in that gelatin and acacia are prepared into aqueous solutions, HPMC and modified montmorillonite are prepared into aqueous solutions, the concentration of the gelatin, the acacia and the HPMC are all 1-3%, the concentration of the modified montmorillonite into the aqueous solutions is 1-5%, and the oil phase system comprises, by mass, 100 parts of tea oil, 9 parts of eucalyptus oil, 4 parts of menthol, 5 parts of camphor, 4 parts of natural borneol, and 0.5-3% of lecithin and 0.8-1.5% of hydrophobic fumed silica of the total weight of the tea oil, the eucalyptus oil, menthol, camphor and natural borneol.
  4. 4. A method for preparing a swelling-improving thermo-sensitive microcapsule essential oil according to any of claims 1-3, characterized in that it comprises the steps of: preparation of (one) Mixed core Material S1, heating lauric acid and myristic acid to be melted into liquid, mixing, and cooling to room temperature to obtain a binary mixture; s2, adding tea oil, frankincense, paeonol, dragon' S blood, myrrh, agilawood and bezoar into the binary mixture in batches, and continuously stirring; s3, shearing and homogenizing at a high speed to obtain a core material mixed solution; Method for preparing inner layer wall material by complex coacervation S4, respectively taking a gelatin aqueous solution and a acacia aqueous solution, adding a core material mixed solution into the acacia aqueous solution, forming a uniform emulsion through high-speed shearing, and adding the gelatin solution under continuous stirring; s5, dropwise adding acid to adjust the pH to 4.0, and stirring to obtain microcapsule suspension; S6, cooling the obtained microcapsule suspension to 10 ℃ for gelation treatment; S7, dropwise adding alkaline solution into the microcapsule suspension to adjust the pH to 6.0, adding a transglutaminase curing agent to cure the microcapsule, filtering after curing, and adding water into the obtained solid to obtain suspension to obtain a wet complex coacervation microcapsule; (III) spray drying method for preparing outer wall material S8, dissolving sodium-based montmorillonite in deionized water, stirring until montmorillonite is uniformly dispersed, standing, and taking an aqueous dispersion liquid of the upper sodium-based montmorillonite; Dissolving cetyl trimethyl ammonium bromide in concentrated hydrochloric acid, stirring at 70-80 ℃ to dissolve the cetyl trimethyl ammonium bromide, then dropwise adding the mixture into aqueous dispersion of sodium montmorillonite, carrying out suction filtration and separation at room temperature when the system has no obvious turbidity change, no precipitate on the upper layer and no obvious layering, repeatedly washing a filter cake with deionized water until no bromide ions exist in the filtrate, and drying, cooling, grinding and sieving the filter cake to obtain organic montmorillonite; S9, uniformly mixing the organic montmorillonite and the binary acid mixture, heating to enable the mixture to be in a molten state, preserving heat for a period of time, cooling and grinding to obtain modified montmorillonite; s10, preparing modified montmorillonite into an aqueous solution, adding the aqueous solution into the HPMC aqueous solution, heating and stirring uniformly, and cooling to room temperature to compound montmorillonite and HPMC to obtain HPMC-modified montmorillonite suspension; S11, mixing the obtained wet complex coacervation microcapsule and HPMC-modified montmorillonite suspension according to a volume ratio of 1:2, and homogenizing to form uniform emulsion; S12, performing spray drying on the emulsion to obtain double-layer microcapsule powder; (IV) dispersing double-layer microcapsules in an oil phase S13, dispersing the tea oil, the eucalyptus oil, menthol, camphor, natural borneol, lecithin and hydrophobic fumed silica at a high speed until the system is uniform and no obvious particles are generated to obtain an oil phase; S14, adding the double-layer microcapsule powder into the oil phase in batches, dispersing at a high speed, and then, carrying out vacuum defoaming to obtain the double-layer temperature-sensitive microcapsule essential oil.
  5. 5. The preparation method according to claim 4, wherein in the step S4, the mass concentration of the aqueous gelatin solution and the aqueous acacia solution is 1-3%, the ratio of the aqueous acacia solution to the core material mixed solution is 4-6:1, and the dosage ratio of the aqueous gelatin solution to the aqueous acacia solution is 1:1.
  6. 6. The method according to claim 4, wherein in the step S4, the high-speed shearing rate is 1000r/min, in the step S11, the homogenizing rate is 4000-5000 r/min, the time is 3-10 min, and in the step S13, the high-speed dispersing rate is 2500-2500 r/min, and the dispersing time is 3-10 min.
  7. 7. The preparation method of the aqueous dispersion of claim 4, wherein in the step S7, the added amount of transglutaminase is 15U/g gelatin, in the step S8, sodium montmorillonite and deionized water are added in a ratio of 10-30 g:500-1000 ml, cetyltrimethylammonium bromide and concentrated hydrochloric acid are added in a ratio of 3-5 g:5-15 ml, and the temperature of the filter cake is 110-130 ℃ and the time of drying is 3-5 h.
  8. 8. The preparation method of the organic montmorillonite, according to claim 4, is characterized in that in the step S9, the mass ratio of the organic montmorillonite to the diacid mixture is 8-12:5-9, the organic montmorillonite and the diacid mixture are heated to 70 ℃ for reaction, and the heat preservation time is 60-80 min.
  9. 9. The preparation method according to claim 4, wherein in the step S10, the concentration of the aqueous solution prepared from the modified montmorillonite is 1-3%, the concentration of the aqueous solution of HPMC is 1-3%, the volume ratio of the aqueous solution of the modified montmorillonite to the aqueous solution of HPMC is 1:1.5-3, the temperature of heating and stirring is 55-65 ℃, the air inlet temperature of spray drying is 140-160 ℃ and the outlet temperature is 60-80 ℃.
  10. 10. The method according to claim 4, wherein in step S13, the mass ratio of tea oil, eucalyptus oil, menthol, camphor, natural borneol, lecithin to hydrophobic fumed silica is 100:9:4:5:4:1.85:1.22; In the step S14, the double-layer microcapsule powder is added according to 5-15% of the mass of the oil phase, the high-speed dispersion speed is 2000r/min, the dispersion time is 5-10 min, the vacuum defoaming condition is 0.08MPa, the temperature is 30 ℃, and the time is 3-5 min.

Description

Double-layer temperature-sensitive microcapsule essential oil for improving swelling and preparation method thereof Technical Field The invention belongs to the technical field of medicines, and particularly relates to a double-layer temperature-sensitive microcapsule essential oil for improving swelling and a preparation method thereof. Background The external preparation of the traditional Chinese medicine can directly act on the body surface focus or the meridian striae and striae, and has rapid effect. However, most of the active ingredients are volatile substances, so that the active ingredients are easy to be heated and deactivated in the preparation processing process, and the active ingredients have the problem of natural dissipation in long-term storage. For example, the Chinese patent publication No. CN113144220A adopts the beta-cyclodextrin inclusion technology to treat the volatile oil of peppermint and Ligusticum wallichii, while the stability and the solubility are improved to a certain extent, the limitation of lower embedding rate still exists. In the external treatment of traditional Chinese medicine, the application source of hot compress for assisting seepage is long-standing and can be traced to the ironing method carried by Huangdi's internal channel. Modern researches have also proved that the hot compress can enhance the lipid fluidity of the skin horny layer, so that the transdermal rate of the medicine is improved by 3-5 times. Based on this, the design of a combined hot compress and drug delivery system is of great value. The microcapsule technology can effectively protect the core material, wherein the temperature response type microcapsule can realize the controllable release of the core material through the structural change of the wall material when the ambient temperature reaches the phase change point. The patent publication No. CN104771381A successfully prepares the microcapsule with good temperature response by taking volatile Chinese medicinal essential oil as a core material and a temperature-sensitive polymer as a wall material, however, the preparation process still needs heating, and the volatile loss of part of essential oil can be caused in the processing stage. Therefore, how to further reduce the escape of active ingredients during processing and storage in microcapsule preparation remains a critical issue to be optimized. Disclosure of Invention In order to solve the problem of instability of the microcapsule in the processing and storage processes due to the fact that the medicine is easy to volatilize, the invention provides the double-layer temperature-sensitive microcapsule essential oil for improving the swelling and a preparation method thereof. In order to achieve the above purpose, the invention adopts the following technical scheme: The double-layer temperature-sensitive microcapsule essential oil for improving swelling is prepared from a mixed core material, an inner wall material, an outer wall material and an oil phase system, wherein the mixed core material comprises raw materials including frankincense, paeonol, dragon's blood, myrrh, agilawood, bezoar, tea oil and lauric acid-myristic acid binary mixture, the inner wall material comprises gelatin and acacia, and the outer wall material comprises hydroxypropyl methylcellulose (HPMC) and modified montmorillonite. The oil phase system comprises lecithin, tea oil, eucalyptus oil, menthol, camphor, natural borneol and hydrophobic fumed silica. Further, the mixed core material comprises, by mass, 1-5 parts of tea oil, 0.1-1 part of frankincense, 0.1-1 part of paeonol, 0.1-1 part of dragon's blood, 0.1-1 part of myrrh, 0.1-1 part of agilawood, 0.1-1 part of bezoar and 5-10 parts of lauric acid-myristic acid binary mixture, wherein the lauric acid-myristic acid binary mixture is lauric acid and myristic acid with a mass ratio of 12:7.4. Further preferably, 2 parts of tea oil, 1 part of frankincense, 0.6 part of paeonol, 0.5 part of dragon's blood, 1 part of myrrh, 0.4 part of agilawood, 0.2 part of bezoar and 6 parts of lauric acid-myristic acid binary mixture. Wherein, lauric acid-myristic acid binary mixture is phase change material. The inner wall material is gelatin and acacia. Further, gelatin and acacia are prepared as aqueous solutions, wherein the concentration of the gelatin and acacia are prepared as aqueous solutions of 1-3% (w/w), preferably 2% (w/w). The raw materials used for the outer wall material are hydroxypropyl methylcellulose (HPMC) and modified montmorillonite. Further, HPMC and modified montmorillonite are prepared into aqueous solution, the concentration of the aqueous solution prepared by HPMC is 1-3% (w/w), and the concentration of the aqueous solution prepared by modified montmorillonite is 1-5% (w/w), preferably 2% (w/w). Further preferably, the HPMC has a viscosity of 50mPa.s, a methoxy group of 28-30%, a hydroxypropyl group of 7.0-12%, and modified montmorillonite sodium montmo