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CN-122005508-A - Antiallergic heavy metal-free black plaster and preparation method thereof

CN122005508ACN 122005508 ACN122005508 ACN 122005508ACN-122005508-A

Abstract

The application relates to the field of medicine preparation, and in particular discloses an antiallergic heavy metal-free black plaster and a preparation method thereof. The method comprises pulverizing the medicinal materials, sieving to obtain medicinal powder, mixing the medicinal powder with vegetable oil, parching at 150-200deg.C until the medicinal powder is carbonized to black, grinding the obtained mixture with colloid mill until the solid particle size is below 10 μm to obtain uniform slurry, heating the slurry, adding natural rubber and/or natural resin, stirring to form uniform gelatinous paste, cooling, and coating to form. The application completely eliminates yellow lead and artificial pigment in the traditional process, eliminates heavy metal sensitization source from the source, adopts low-temperature stir-frying combined colloid mill refinement, ensures that the ointment is fine and uniform and has natural color while retaining the medicinal components, and further ensures the biocompatibility of the product by taking natural polymer materials as forming matrixes. The prepared black plaster has good antiallergic property, and simultaneously maintains the appearance and curative effect of the traditional black plaster.

Inventors

  • ZHANG HONGRUI
  • RUI XUDONG
  • ZHANG ZICHEN
  • ZHANG QINHE

Assignees

  • 贵州苗老吉药业有限公司

Dates

Publication Date
20260512
Application Date
20260313

Claims (10)

  1. 1. A method for preparing an antiallergic and heavy metal-free black plaster, which is characterized by comprising the following steps: Pulverizing the medicinal materials, and sieving to obtain medicinal powder; Mixing the medicinal powder with vegetable oil, parching at 150-200deg.C until the medicinal powder is carbonized to brown to obtain a mixture of medicinal oil and medicinal powder carbon; grinding and refining the mixture by adopting a colloid mill process to obtain uniform and fine slurry; Heating the slurry, adding natural rubber and/or natural resin, and stirring to form uniform gelatinous paste; And cooling the gelatinous paste, and then performing coating forming to obtain the antiallergic heavy metal-free black plaster.
  2. 2. The method for preparing antiallergic heavy metal-free black plaster according to claim 1, wherein the mass ratio of the medicinal powder to the vegetable oil is 1:2-2.5.
  3. 3. The method for preparing an antiallergic heavy metal-free black plaster according to claim 1, wherein the natural rubber is a natural rubber latex or a cyclized natural rubber, and/or the natural resin is at least one selected from rosin, hydrogenated rosin glyceride, and dammar resin.
  4. 4. The method for preparing an antiallergic heavy metal-free black plaster according to claim 3, wherein the addition amount of the natural rubber and/or the natural resin is 5% -30% of the mass of the mixture of the medicinal oil and the medicinal powder charcoal.
  5. 5. The method for preparing an antiallergic heavy metal-free black plaster according to claim 1, wherein the colloid mill process grinds the mixture to a solid particle size of 10 μm or less, and the grinding is refined to be circularly grinding for 2-4 times.
  6. 6. The method for preparing an antiallergic heavy metal-free black plaster according to claim 1, wherein the vegetable oil is at least one selected from sesame oil, soybean oil, rapeseed oil, and vegetable blend oil.
  7. 7. The method for preparing an antiallergic heavy metal-free black plaster according to claim 1, wherein the medicinal powder is obtained by pulverizing the medicinal materials and sieving with 100-400 mesh sieve.
  8. 8. The method for preparing an antiallergic heavy metal-free black plaster according to claim 1, wherein the low-temperature stir-frying time is 1.5-2h.
  9. 9. The method for preparing antiallergic heavy metal-free black plaster according to claim 1, wherein the carbonization end point of the medicinal powder is determined with the aid of monitoring the viscosity of the medicinal oil or the content change of specific components in the low-temperature parching process.
  10. 10. An antiallergic, heavy metal-free black plaster prepared by the method of any one of claims 1 to 9, wherein the black plaster is free of yellow lead and synthetic pigments.

Description

Antiallergic heavy metal-free black plaster and preparation method thereof Technical Field The application relates to the field of medicine preparation, in particular to an antiallergic heavy metal-free black plaster and a preparation method thereof. Background The black plaster is used as a traditional Chinese medicine external application formulation, has the advantages of durable efficacy, convenient use and the like, and is widely used for the application treatment of joint pain, muscle and bone injury and other diseases. The traditional black plaster is prepared by pulverizing the raw materials, sieving, frying in sesame oil at high temperature to brown, removing residues, heating the medicinal oil to drop bead state, adding Plumbum Preparatium and melanin, stirring to obtain paste, cooling, and spreading on backing material. However, the traditional process has the defects that firstly, yellow lead (the main component is lead tetraoxide) and artificial melanin contain heavy metal components such as lead, arsenic, mercury and the like, the heavy metal components are easy to permeate through skin in the application process, and contact anaphylactic reaction is caused, the red swelling, itching and even ulceration of the application part are shown, and the use safety and the compliance of patients are seriously influenced. Secondly, the traditional process relies on the experience judgment of high-temperature frying and dripping beading, and has poor process controllability, and is easy to cause the destruction of medicinal components or unstable paste quality. In addition, pigments have to be added to achieve the unique appearance of black plaster, further increasing the risk of sensitization and chemical residues. In order to solve the problem of allergy, the prior art attempts to add antihistamine components into plaster or use hypoallergenic adhesive materials, but fails to fundamentally avoid heavy metal introduction, and also attempts to try alternative coloring methods, but often affect plaster adhesiveness or drug effect release. Therefore, a preparation method which not only maintains the appearance and curative effect of the traditional black plaster, but also thoroughly eliminates the heavy metal sensitization risk is needed to be provided. The invention aims to overcome the defects of the prior art and provides a preparation method of a black plaster which is free of yellow lead, free of artificial pigment, controllable in process and has antiallergic property. Disclosure of Invention In order to solve the problems, the application provides an antiallergic heavy metal-free black plaster and a preparation method thereof. The application adopts the following technical scheme: in a first aspect, the present application provides a method for preparing an antiallergic heavy metal-free black plaster, comprising: Pulverizing the medicinal materials, and sieving to obtain medicinal powder; Mixing the medicinal powder with vegetable oil, parching at 150-200deg.C until the medicinal powder is carbonized to brown to obtain a mixture of medicinal oil and medicinal powder carbon; grinding and refining the mixture by adopting a colloid mill process to obtain uniform and fine slurry; Heating the slurry, adding natural rubber and/or natural resin, and stirring to form uniform gelatinous paste; And cooling the gelatinous paste, and then performing coating forming to obtain the antiallergic heavy metal-free black plaster. Further, the mass ratio of the medicinal powder to the vegetable oil is 1:2-2.5. Further, the natural rubber is a natural latex or a cyclized natural rubber, and/or the natural resin is at least one selected from rosin, hydrogenated rosin glyceride and dammar resin. Further, the addition amount of the natural rubber and/or the natural resin is 5-30% of the mass of the mixture of the medicinal oil and the medicinal powder carbon. Further, the colloid mill process grinds the mixture to a solid particle size below 10 microns, and the grinding is refined into cyclic grinding for 2-4 times. Further, the vegetable oil is at least one selected from sesame oil, soybean oil, rapeseed oil and vegetable blend oil. Further, the above medicinal powder is obtained by pulverizing the medicinal materials and sieving with 100-400 mesh sieve. Further, the low-temperature stir-frying time is 1.5-2 hours. Further, in the low-temperature stir-frying process, the carbonization end point of the medicinal powder is judged in an auxiliary way by monitoring the viscosity of the medicinal oil or the content change of specific components. In a second aspect, the application also provides an antiallergic and heavy metal-free black plaster prepared by the preparation method, and the black plaster does not contain yellow lead and artificial synthetic pigment. In summary, the application has the following beneficial effects: 1. The invention eliminates the introduction of heavy metal sensitization components such as lead, a