CN-122005533-A - Application of coltsfoot ketone in preparing anti-radiation injury medicine

Abstract

The invention discloses application of coltsfoot ketone in preparing a radiation damage resistant medicament, and belongs to the technical field of biology. The invention aims to solve the technical problem of radiation damage resistance. The application provided by the invention is particularly the application of coltsfoot ketone in preparing a product for treating or/and relieving body injury caused by radiation. Experiments prove that coltsfoot can effectively relieve hyperemia hemorrhage and inflammatory cell infiltration of alveoli of a mouse after radiation, relieve hepatic cable structural damage and hepatic blood sinus hyperemia in liver tissues, relieve disturbance and cavitation of bone marrow structures, promote recovery of hematopoietic cells in bone marrow, relieve edema and shedding of intestinal villi, partially repair the integrity of intestinal structures, and improve hair follicle structural damage and fiber bundle hyperplasia in skin tissues.

Inventors

• ZHU HENG
• ZHAO SHIRONG
• WU ZUZE
• TANG JIE
• LI PEILIN
• LI ZHILING

Assignees

• 中国人民解放军军事科学院军事医学研究院

Dates

Publication Date

20260512

Application Date

20260324

Claims (9)

1. 1. The application of coltsfoot ketone is characterized in that the application of coltsfoot ketone is the application of coltsfoot ketone in preparing a medicament or a product for treating or/and relieving radiation damage.
2. 2. The use according to claim 1, wherein the radiation is ionizing radiation.
3. 3. The use according to claim 2, wherein the ionizing radiation is gamma radiation.
4. 4. The anti-radiation injury drug is characterized in that the active ingredient of the anti-radiation injury drug is coltsfoot ketone.
5. 5. The medicament according to claim 4, wherein the radiation is ionizing radiation.
6. 6. The medicament according to claim 5, wherein the ionizing radiation is gamma radiation.
7. 7. The medicament of claim 6, wherein the subject animal of the medicament is a mammal.
8. 8. The medicament of claim 7, wherein the mammal comprises a mouse.
9. 9. The medicament of claim 4, wherein the medicament is administered by a method comprising intragastric administration or injection.

Description

Application of coltsfoot ketone in preparing anti-radiation injury medicine Technical Field The invention belongs to the technical field of biology, and particularly relates to application of coltsfoot ketone in preparation of a radiation damage resistant medicament. Background Ionizing radiation damage is common in nuclear attack, nuclear power station accidents, nuclear terrorist activities, irradiation device accidents, radioactive source accidents and the like, has the characteristics of serious injury, rapid development, difficult treatment, high death rate and the like, is also used for tumor radiotherapy and the like, and has a very wide application range in civil scenes. Ionizing radiation generally causes simultaneous injury to tissues and organs such as hematopoiesis, stomach and intestine, skin and the like, and besides the concern about injury to specific sensitive tissues and organs, research and establishment of treatment techniques and medicines applied to the ionizing radiation injury to tissues and organs are urgently needed. In addition, the difficulty in curing the injury of different tissues and organs of the body caused by the ionizing radiation is different. The existing medicines approved for curing the ionizing radiation injury in China are mainly estrogens, and have obvious female side effects. The FDA approved ionizing radiation injury treatment drugs are mainly of cytokines and are only used for the protection or treatment of bone marrow type acute radiation diseases, and in addition, the radioprotectors which are approved to be marketed or are currently subjected to clinical substitution test researches are only used for post-radiation relief treatment, injection administration, narrow protection time window, high production cost, difficult transportation and storage, large toxic and side effects and the like, and need to be improved. No drug is approved for preventing and treating the injury of multiple tissues and organs of the organism caused by ionizing radiation. In recent years, plant compounds have been shown to have a good effect in the prevention and treatment of a variety of diseases. Researchers find that some natural small molecules have a protective effect on radiation damage such as hematopoiesis, intestines and the like of rodents in research of ionizing radiation damage prevention and treatment medicines. Chinese herbal medicines and Chinese medicine theory are unique precious resources in China, and Chinese medicines have the advantages of wide medicine sources, low toxicity and the like, so that prevention and treatment of body injury caused by ionizing radiation by adopting Chinese herbal medicines have come into common attention. Disclosure of Invention The technical problem to be solved by the invention is how to resist radiation damage. The technical problems to be solved are not limited to the described technical subject matter, and other technical subject matter not mentioned herein will be clearly understood by those skilled in the art from the following description. In order to solve the technical problems, the invention provides the following technical scheme: The researches show that the Chinese herbal medicines with the characteristics of clearing heat and detoxicating, promoting blood circulation by removing blood stasis, replenishing blood and replenishing qi and nourishing yin and increasing white blood have the anti-radiation effect with different degrees. The inventor combines the theory of fire toxin theory and radiation toxin theory in traditional Chinese medicine, and original screening discovers natural medicinal micromolecular coltsfoot ketone which has the functions of resisting oxidation, scavenging free radicals, resisting inflammation and the like and has potential anti-radiation function. The invention provides application of coltsfoot ketone in preparation of a medicament or a product for treating or/and relieving radiation damage. The coltsfoot ketone is a compound with CAS number 104012-37-5. The coltsfoot ketone has the following structural formula: 。 In the above application, the radiation is ionizing radiation. In the above application, the ionizing radiation is gamma radiation. The invention also provides a radiation damage resistant medicament, and the active ingredient of the radiation damage resistant medicament is coltsfoot ketone. In the above medicament, the radiation is ionizing radiation. In the above medicine, the ionizing radiation is gamma radiation. In the above medicament, the radiation is ionizing radiation. In the above medicine, the ionizing radiation is gamma radiation. In the above medicament, the subject animal of the medicament is a mammal. In the above medicament, the mammal comprises a mouse. Among the above drugs, the modes of use of the drugs include gavage or injection. The term "treatment" generally refers to a method that is performed in order to obtain beneficial or desired clinical results. Beneficial