CN-122005534-A - Application of hexadecanole in preparation of medicine for treating eczema

Abstract

The invention belongs to the technical field of medicines. The invention provides application of hexadecanoic acid nitrile in preparation of a medicament for treating eczema, wherein the mass concentration of hexadecanoic acid nitrile is 0.20% -1.80%. The invention shows that hexadecanonitrile can be used for treating eczema and has no obvious side effect.

Inventors

• YANG LILI
• CHEN YAN
• Bai Lajuan
• LU ZHEN
• YAN WEIJUN
• CHENG YINA

Assignees

• 西安康华药业有限公司

Dates

Publication Date

20260512

Application Date

20260403

Claims (2)

1. 1. Use of hexadecanole in the manufacture of a medicament for the treatment of eczema.
2. 2. Use of hexadecanole according to claim 1 for the preparation of a medicament for the treatment of eczema, characterized in that the mass concentration of hexadecanole is 0.20% -1.80%.

Description

Application of hexadecanole in preparation of medicine for treating eczema Technical Field The invention belongs to the technical field of medicines, and particularly relates to application of hexadecanol in preparation of a medicine for treating eczema. Background Eczema is a common inflammatory skin disease of the epidermis and the superficial dermis caused by various internal and external factors. It features severe subjective itching, skin damage polymorphism, symmetrical distribution, exudative trend, chronic disease course and easy repeated attack. Acute eczema, periaural eczema, scrotum eczema, atopic dermatitis and infantile eczema of western medicine, such as 'immersion sore', 'ear sore', 'embroidery ball wind', 'four-bend wind', 'milk tinea', and the like, which are recorded in the traditional Chinese medicine literature. In recent years, the incidence of eczema has been on the rise. The onset of eczema is a result of the interaction of a number of factors. Some types of eczema are genetically closely related. Many studies confirm that environmental factors are one of the important causes of increased prevalence of eczema. The environment comprises a group environment and an individual environment, and the pathogenic factors of the group environment of human beings refer to outdoor large-scale air, water, soil, radioactive sources, large-area sensitized pollen vegetation, large-area air-borne sensitized bacteria sources and the like. The individual microenvironment refers to the living environment of an individual, and the living time of people is about 2/3 of the indoor time, so that the influence of the individual microenvironment on eczema is more intimate. Some eczema is associated with infection by microorganisms. These microorganisms include Staphylococcus aureus, malachite bacteria, and air-borne fungi such as Neurospora, mycospora, penicillium nodosum, aspergillus fumigatus, fusarium, penicillium chrysogenum, aspergillus niger, and Rhizopus niveus. In addition, human foods are very numerous and generally classified into plants, animals, minerals, and some chemically synthesized foods such as saccharin, acetic acid, citric acid, essence, synthetic dyes, etc. are often used in modern foods. These foods can cause allergies to the food, resulting in the creation of eczema. Drug factors are also the leading cause of some eczemas, especially eczematous drug eruptions. Eczema can also be caused by nervous and physical factors such as distress, fatigue, anxiety, tension, emotional agitation, insomnia, etc., and climatic and physical factors such as sunlight, ultraviolet rays, cold, humidity, dryness, friction, etc. In addition, chronic gastrointestinal diseases, chronic alcoholism, intestinal parasites, metabolic disorders, endocrine dyscrasia and other factors are all causes of eczema. The medicines for treating eczema, such as 999 dermatitis treating medicine, which is a compound preparation contains hormone components and antifungal components, has the functions of anti-inflammatory, antiallergic and antipruritic, and can be used for treating various types of eczema such as hand eczema, scrotum eczema, chronic eczema and the like. It can relieve inflammatory reaction, relieve itching symptom, and promote the regression of skin rash. However, the 999 dermatitis is a glucocorticoid medicine, and the frequent use of the dermatitis can cause certain skin atrophy, telangiectasia or secondary skin infection and other side effects of the skin at the part. Disclosure of Invention Aiming at the problems, the invention provides application of hexadecanoic acid in preparing a medicament for treating eczema, which shows that hexadecanoic acid can be used for treating eczema without obvious side effects. In order to achieve the above purpose, the technical scheme adopted by the invention is as follows: use of hexadecanole in the manufacture of a medicament for the treatment of eczema. Further, the mass concentration of the hexadecanoic acid nitrile is 0.20% -1.80%. Compared with the prior art, the invention has the following beneficial effects: The invention shows that the hexadecanoic acid component has no obvious side effect and higher safety, can effectively relieve the thickening of the ear skin of a mouse, acute and chronic scratching, can also improve the skin damage symptom and improve inflammatory hyperplasia to a certain extent. Drawings FIG. 1 is a graph showing the comparison trend of the weights of mice recorded daily for 6 days of continuous administration of (hexadecanoic acid) by painting; FIG. 2 is a graph showing comparative trend of ear skin thickness of mice recorded daily for 6 days of continuous application of (hexadecanoic acid) drug; FIG. 3 is a graph showing a comparative trend of ear scratch counts recorded in 30 min mice immediately after the end of the last challenge and administration (hexadecanoic acid); FIG. 4 is a graph showing a comparative trend of ear scratch counts recorde