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CN-122005536-A - Application of Jiao Penge surgical ketone in preparation of ischemia reperfusion injury prevention and treatment medicine

CN122005536ACN 122005536 ACN122005536 ACN 122005536ACN-122005536-A

Abstract

The invention discloses an application of Jiao Penge surgical ketone in preparing a medicine for preventing and treating ischemia reperfusion injury. The invention provides and verifies that Jiao Penge surgical ketone can prevent and treat hepatic ischemia reperfusion injury for the first time, and the compound can effectively protect hepatic tissue and prevent liver function from being damaged by inhibiting the oxidative stress level of hepatic tissue after ischemia reperfusion, avoiding cell iron death and improving bone marrow-derived macrophages, thereby providing a novel medicament with great application potential for preventing and treating the ischemic reperfusion injury.

Inventors

  • ZHANG ERHAO
  • ZHANG YUFEI
  • YOU FEIYUE

Assignees

  • 南通大学

Dates

Publication Date
20260512
Application Date
20260323

Claims (10)

  1. 1. An application of Jiao Penge ketone in preparing medicine for preventing and treating ischemia reperfusion injury is provided.
  2. 2. The use according to claim 1, wherein Jiao Penge surgical ketones have CAS numbers 20013-75-6.
  3. 3. The use according to claim 1, wherein the ischemia reperfusion injury is a hepatic ischemia reperfusion injury.
  4. 4. The use according to claim 1, wherein the medicament is a medicament for inhibiting the level of oxidative stress in liver tissue following ischemia reperfusion.
  5. 5. The use according to claim 1, wherein the medicament is a medicament for inhibiting iron death in liver tissue cells following ischemia reperfusion.
  6. 6. The use according to claim 1, wherein the medicament is a medicament for modulating bone marrow derived macrophage activity.
  7. 7. The use according to any one of claims 1 to 6, wherein the medicament comprises Jiao Penge surgical ketone or a pharmaceutically acceptable salt, solvate, hydrate thereof as an active ingredient.
  8. 8. The use according to claim 7, wherein the medicament further comprises pharmaceutically acceptable excipients.
  9. 9. The use according to claim 8, wherein the pharmaceutically acceptable excipients comprise any one or more of excipients, diluents, lubricants, glidants, wetting agents, emulsifiers, pH buffering substances, solubilizers, co-solvents or solvents.
  10. 10. The use according to claim 1, wherein the pharmaceutical dosage form comprises a tablet, capsule, granule, powder, chewable tablet, effervescent tablet, sustained release tablet, pellet, injection, infusion solution, suspension, patch, suppository, transdermal patch, microemulsion liposome, nanoparticle.

Description

Application of Jiao Penge surgical ketone in preparation of ischemia reperfusion injury prevention and treatment medicine Technical Field The invention relates to the field of natural pharmaceutical chemistry, in particular to an application of Jiao Penge surgical ketone in preparation of a drug for preventing and treating ischemia reperfusion injury. Background Ischemia reperfusion injury (ischemia-reperfusion injury, IRI) refers to a pathological phenomenon in which an organ is further aggravated by its injury after blood flow is restored on the basis of ischemia. This process is particularly common in liver surgery such as liver resection and liver transplantation, and is one of the leading causes of impaired liver function, liver failure and even death of patients after surgery. The development and progression of hepatic ischemia reperfusion injury involves complex mechanisms, which are currently believed to be the result of a combination of factors, including mitochondrial injury, intracellular calcium overload, and release of various cytokines. Oxidative stress plays a central role in the pathogenesis of hepatic ischemia reperfusion injury. During the ischemic phase, hepatocytes are exposed to the hypoxic environment, burying a remark suggestive of later developments in a story, etc. for post-reperfusion injury. When blood flow is restored and oxygen is re-supplied, explosive generation of Reactive Oxygen Species (ROS) is triggered. Since hepatocytes are rich in mitochondria, damaged mitochondria become a major source of excess ROS, thereby attacking polyunsaturated fatty acids on cell membranes and organelle membranes, triggering Lipid Peroxidation (LP). Among them, lipid peroxidation of mitochondria itself is considered as a central molecular event of HIRI, which disrupts mitochondrial function, exacerbates hepatocyte injury, and further activates subsequent inflammatory cascades. Jiao Penge the xanthone (pyrocurzerenone) is a naturally occurring compound, which is mainly isolated from chloranthus (such as Heji) and zedoary, or obtained by hydrogenation of zedoary turmeric oil. At present, the research on Jiao Penge operation ketone mainly reveals the potential of inhibiting the migration and invasion of tumor cells such as oral cancer, but the application effect of the Jiao Penge operation ketone in the direction of ischemia reperfusion injury is not reported yet. Disclosure of Invention The invention aims to provide an application of Jiao Penge surgical ketone in preparing a medicament for preventing and treating ischemia reperfusion injury, in particular to a medicament for preventing and treating oxidative stress and cell iron death of liver tissues after ischemia reperfusion. The technical scheme is that Jiao Penge surgical ketone is applied to preparation of medicines for preventing and treating ischemia reperfusion injury. Preferably, the Jiao Penge surgical ketone has a CAS number of 20013-75-6. Preferably, the ischemia reperfusion injury is liver ischemia reperfusion injury. Preferably, the drug is a drug that inhibits the level of oxidative stress in liver tissue following ischemia reperfusion. Preferably, the medicament is an application of the medicament in inhibiting iron death of liver tissue cells after ischemia reperfusion. Preferably, the drug is a drug that modulates bone marrow-derived macrophage activity. Preferably, the medicament contains Jiao Penge operating ketones or pharmaceutically acceptable salts, solvates, hydrates thereof as active ingredient. Preferably, the medicament further comprises pharmaceutically acceptable auxiliary materials, and more preferably, the pharmaceutically acceptable auxiliary materials comprise any one or more of excipient, diluent, lubricant, glidant, wetting agent, emulsifier, pH buffer substance, solubilizer, cosolvent or solvent. Preferably, the dosage forms of the medicine comprise tablets, capsules, granules, powder, chewable tablets, effervescent tablets, sustained release tablets, micropills, injection, infusion solutions, suspensions, patches, suppositories, transdermal patches, microemulsion liposomes and nanoparticles. Compared with the prior art, the invention has the following remarkable advantages that Jiao Penge operation ketone can prevent and treat hepatic ischemia reperfusion injury, and the compound can effectively protect hepatic tissue and prevent liver function from being damaged by inhibiting the oxidative stress level of hepatic tissue after ischemia reperfusion, avoiding death of cell iron and improving bone marrow-derived macrophages, thereby providing a new medicament with great application potential for preventing and treating the ischemic reperfusion injury. Drawings FIG. 1 is a schematic diagram of an in vivo experimental procedure in mice; FIG. 2 is a representative image of liver tissue of a liver ischemia reperfusion mouse after various treatments; FIG. 3 is a statistical graph of liver tissue coefficients of liver