CN-122005570-A - Application of MEC1 in preparation of medicines for preventing and treating white hair, alopecia and related diseases

Abstract

The invention belongs to the technical field of medicines. In particular to the application of MEC1 in preparing the medicine for preventing and treating white hair, alopecia and related diseases. According to the research of the invention, MEC1 intervention can remarkably improve the problems of white hair and alopecia, in particular can improve the functions of melanin stem cells and hair follicle stem cells, activate hair follicle stem cells, promote hair follicle regeneration, promote hair pigment generation and deposition, and has very positive effects on preventing and treating the problems of hair whitening, alopecia and related hair. The MEC1 is effective in an internal administration mode and still has very excellent effects of preventing and treating white hair and alopecia under an external administration mode, so that the MEC1 has very good application value in the aspects of developing medicaments and related products for preventing and treating white hair, alopecia and related diseases.

Inventors

• SUN YAN

Assignees

• 广东省人民医院

Dates

Publication Date

20260512

Application Date

20251229

Priority Date

20241231

Claims (10)

1. Use of mec1 in the manufacture of a medicament for the prevention and treatment of grey hair and/or hair loss.
2. Use of mec1 in the manufacture of a medicament for the prevention and treatment of hair related disorders.
3. Use of mec1 for the preparation of a medicament for improving the function of hair follicle stem cells and/or melanocytes.
4. Use of mec1 in the manufacture of a medicament for activating hair follicle stem cells.
5. Use of mec1 in the manufacture of a medicament for promoting hair follicle regeneration.
6. Use of mec1 in the manufacture of a medicament for promoting hair pigmentation and deposition.
7. 7. The use according to claim 2, wherein the hair-related disorder comprises white hair, folliculitis, androgenetic alopecia, alopecia areata, diffuse alopecia, telogen effluvium, anagen effluvium, cicatricial alopecia, syphilis induced alopecia, iron deficiency alopecia, thyroid dysfunction induced alopecia, systemic lupus erythematosus, discoid lupus erythematosus or traction alopecia.
8. 8. The use according to any one of claims 1-2, 7, wherein MEC1 achieves the effect of preventing and treating white hair, hair loss and/or hair related disorders by at least one of the following a-e: a. improving the function of the hair follicle stem cells, B. the stem cells of the hair follicle are activated, C. promote the regeneration of hair follicles, D. Improving the function of the melanin stem cells, E. Promote hair pigmentation and deposition.
9. 9. A medicine for preventing and treating white hair and/or alopecia and related diseases, which is characterized by comprising MEC1 and auxiliary materials.
10. 10. The medicament according to claim 9, which further comprises other components than MEC1 having the effect of preventing and treating white hair and/or alopecia and related diseases.

Description

Application of MEC1 in preparation of medicines for preventing and treating white hair, alopecia and related diseases Technical Field The invention belongs to the technical field of medicines. More specifically, relates to the application of MEC1 in preparing medicines for preventing and treating poliosis, alopecia and related diseases. Background White hair and hair loss are major hair problems that plague modern people, and there is an increasing trend towards younger age. The white hair English title HAIR GRAYING, also known as achromotrichia or canties, refers to the whitening of some or all of the hair. Is a natural phenomenon associated with aging and is affected by a variety of factors including genetics, environment, and lifestyle. Irradiation, in particular ionizing radiation, is one of the external environmental factors that cause the hair to whiten. Hair follicle stem cells (hair follicle STEM CELLS, HFSCs) belong to adult stem cells, are in a quiescent state in vivo, and exhibit a surprising proliferation capacity under in vitro culture. It has been found that hair follicle stem cells have a multipotential differentiation potential which can differentiate into hair follicles, whereas melanocytes (Melanocyte stem cell, mcSC) distributed adjacent to hair follicle stem cells can differentiate to produce mature melanocytes to impart hair pigment. The hair follicle stem cells and the melanin stem cells have fundamental close relation with the hair problems such as white hair, alopecia and the like, and are novel directions for treating the white hair, the alopecia and related hair diseases. At present, a plurality of medicines for treating alopecia are reported on the market, but the effects are poor. However, the white hair treatment medicines are few, and the effect is unsatisfactory. The medicine market for simultaneously preventing and treating white hair and alopecia is more blank. Disclosure of Invention The invention aims to develop a medicament capable of preventing and treating white hair, alopecia and related hair diseases. The invention aims to provide an application of MEC1 in preparing medicines for preventing and treating poliosis, alopecia and related diseases. The above object of the present invention is achieved by the following technical scheme: The radiation-induced hair whitening has many similarities with aging in molecular and cellular mechanisms, and radiation induces cellular aging (inducing cells to enter an aging state, affecting the functions and regeneration capacity of melanocytes and hair follicle stem cells), affecting melanin generation pathway (irradiation affects the functions of melanocytes, interferes with the synthesis and distribution of melanin), and causing DNA damage of melanocytes and hair follicle stem cells, so that the invention uses C57BL/6 mice with natural black hair as experimental animals, and constructs an animal model for related research of white hair and hair loss treatment by radiation induction. Research shows that MEC1 intervention can significantly improve the problems of white hair and alopecia of mice. The MEC1 intervention can improve the functions of the melanin stem cells and the hair follicle stem cells, promote the regeneration of hair follicles, promote the generation and deposition of hair pigment, and has very positive effects on preventing and treating white hair, alopecia and related hair problems. Thus, the present invention provides: the application of MEC1 in preparing medicine for preventing and treating poliosis or related diseases. Use of MEC1 in the manufacture of a medicament for the prevention and treatment of hair loss or related diseases. The application of MEC1 in preparing medicine for preventing and treating poliosis and alopecia and related diseases. Use of MEC1 in the manufacture of a medicament for improving the function of hair follicle stem cells. Use of MEC1 in the manufacture of a medicament for improving the function of melanocytes. Use of MEC1 in the manufacture of a medicament for improving the function of melanocytes and hair follicle stem cells. Use of MEC1 in the manufacture of a medicament for activating hair follicle stem cells. Use of MEC1 in the manufacture of a medicament for promoting hair follicle regeneration. Use of MEC1 in the manufacture of a medicament for promoting hair pigmentation and deposition. According to our research, MEC1 can achieve the effect of preventing and treating white hair, alopecia and/or hair related diseases through at least one of the following a-e: a. improving the function of the hair follicle stem cells, B. the stem cells of the hair follicle are activated, C. promote the regeneration of hair follicles, D. Improving the function of the melanin stem cells, E. Promote hair pigmentation and deposition. Therefore, MEC1 has an advantage in preventing and treating white hair, alopecia and hair-related diseases, since it acts from rooted hair follicle stem cells and melanin s