CN-122005581-A - Composition comprising fatty acids and uses thereof

Abstract

The present invention relates to a composition comprising one or more fatty acid derivatives for promoting, supporting or optimizing one or more of the following aspects of offspring of a female subject, (i) from remyelination, (ii) brain structure, (iii) brain connectivity, (iv) intellectual potential, (v) cognitive potential, and (vi) learning potential, (vii) cognitive function, wherein the composition is for administration to the female subject.

Inventors

• SCHNEIDER NINA
• J. HAUSER
• I Xierwazuo Alvarez
• T. M. Samuel
• S dionyx
• T. Bart Fui

Assignees

• 雀巢产品有限公司

Dates

Publication Date

20260512

Application Date

20170330

Priority Date

20161213

Claims (9)

1. 1. A composition comprising docosahexaenoic acid (DHA) and arachidonic acid (ARA) in a weight ratio of 3:1 to 1:3, and sphingomyelin in an amount of 400 to 700 mg for preventing cognitive impairment, impaired cognitive ability and/or suboptimal cognitive development by promoting, supporting or optimizing the de novo myelination trajectories of offspring in female individuals, Wherein the composition is for administration to the female individual, and wherein the offspring is a fetus, neonate, infant or child, and wherein the composition is for administration to the female individual prior to pregnancy, during pregnancy, or during lactation, or a combination thereof.
2. 2. The composition for the use according to claim 1, wherein the composition promotes, supports or optimizes the amount and/or spatial distribution of myelinated material throughout the brain.
3. 3. The composition for use according to any preceding claim, wherein the female subject is a human.
4. 4. The composition for the use according to any preceding claim, wherein the composition further comprises one or more of vitamins, minerals, choline and phospholipids, or metabolites thereof, or metabolic precursors thereof, or mixtures thereof.
5. 5. The composition for the use according to claim 4, wherein the vitamin is selected from vitamin B12, folic acid, and combinations thereof.
6. 6. The composition for the use according to claim 4, wherein the mineral is selected from the group consisting of iron, zinc, calcium, phosphorus, copper, magnesium, and combinations thereof.
7. 7. The composition for use according to claim 4, wherein the phospholipid is selected from the group consisting of phosphatidylcholine, phosphatidylinositol, phosphatidylserine, phosphatidylethanolamine, and mixtures thereof, and metabolic precursors and metabolites of any of the foregoing, and mixtures thereof.
8. 8. The composition for the use according to any preceding claim, wherein the composition is in the form of a pre-pregnancy (pre-pregnancy) supplement and/or a maternal supplement (pregnant and/or lactation supplement).
9. 9. A composition comprising docosahexaenoic acid (DHA) and arachidonic acid (ARA) in a weight ratio of 3:1 to 1:3, and sphingomyelin in an amount of 400 to 700 mg, and further comprising choline and/or vitamin B12 and/or folic acid, and/or sphingomyelin and/or iron, wherein the composition is in the form of a pre-pregnancy (pre-pregnancy) supplement and/or a maternal supplement (pregnant and/or lactation supplement).

Description

Composition comprising fatty acids and uses thereof The application is a divisional application of PCT application PCT/EP2017/057576 filed in 2017, 03 and 30 and entitled "composition comprising fatty acid and use thereof", which enters the national stage of china on date of 2018, 09 and 10, application number 201780016207. X. Technical Field The present invention relates to compositions for promoting, supporting or optimizing one or more of the head myelination, and/or brain structure, and/or brain connectivity, and/or cognitive potential, learning potential and intellectual potential, and/or cognitive function of offspring of female individuals. Background Within the uterus and within the first weeks or months after birth, there are a number of external factors that may affect the growth and development of the infant. In particular, continued studies more clearly indicate that maternal diet may affect neurological development, particularly brain development, of infants, and that the effects may have irreversible short-term and long-term consequences. The neurological, especially brain, development is rapid and particularly high demands are placed on the infant to supply critical nutrients in utero and the first 2 or 3 years after birth. During this critical period, these nutritional requirements, if not met, can lead to suboptimal neurological development, particularly suboptimal brain development. One process, by which the naked axon is incorporated into myelin, plays a key role in neural development, particularly brain development, and may be particularly sensitive to nutritional factors, is de novo myelination. This process, and in particular the subsequent trajectories, play a critical role in determining the amount and/or spatial distribution of myelinated material in brain structures, in particular the entire brain. The correlation of brain structure, in particular the amount and/or spatial distribution of myelinated material throughout the brain, is well documented for cognitive function and intelligence. Essentially, myelin in the brain provides an insulating sheet along neurons, allowing nerve impulses to conduct faster. However, the brain structure, in particular the amount and/or spatial distribution of myelin throughout the brain, influences brain connectivity, e.g. by what way and how messages are rapidly and efficiently transferred in the form of nerve impulses within the brain, and in particular between different brain regions. Such inter-brain communication may play a role in cognitive function and learning, and may affect or even be used for physiological limitation, mental, cognitive and/or learning potential. Thus, there is a need to identify desirable nutrients to promote, support or optimize the formation of secondary myelination, particularly the trajectory of secondary myelination, whereby the amount and/or spatial distribution of myelinated material throughout the brain structure, particularly the entire brain. It is further desirable to provide compositions that can be taken before pregnancy, during pregnancy and during lactation to ensure that the mother is sufficiently supplied with any of said nutrients to meet the needs of their offspring and thereby promote, support or optimise the amount and/or spatial distribution of myelinated material from the head myelination, in particular from the head myelination locus, and thus the brain structure, more particularly the whole brain of said offspring. In addition, there is a need to find ways to optimize the mental potential and/or cognitive potential and/or learning potential and/or cognitive function of the offspring. Furthermore, it is important to ensure that the mother is sufficiently supplied with the nutritional substances to ensure his health and to avoid any consumption of the nutritional substances in his body, and any associated health effects, which may be caused by the demand for the nutritional substances by their offspring. Surprisingly, the present inventors have now found that fatty acid derivatives can promote, support or optimize the de novo myelination, in particular de novo myelination tracks, and/or the amount and/or spatial distribution of myelinated material in brain structures, in particular the whole brain, in infants. Disclosure of Invention The present invention is based on a maternal supplement comprising fatty acid derivatives, preferably docosahexaenoic acid and/or arachidonic acid or mixtures thereof, for administration to a female individual before, during and/or when offspring receive breast milk from the female individual. The maternal supplements of the present invention are considered to have a beneficial effect on the de novo myelination of offspring. Promoting, supporting and/or optimizing de novo myelination by maternal supplements enables a mother to provide health benefits to her offspring, including long-term benefits to the infant's later life when the infant is no longer breast fed. The fir