CN-122005608-A - Anesthetic and preparation method thereof

Abstract

The invention belongs to the technical field of anesthetic drugs, and particularly relates to an anesthetic drug and a preparation method thereof. The anesthetic is prepared by mixing 1000 parts of bupivacaine liposome injection, 0.5-1 part of magnesium sulfate and 3-5 parts of dexmedetomidine hydrochloride according to the weight ratio, wherein the magnesium sulfate and the dexmedetomidine hydrochloride are auxiliary agents, so that the anesthetic onset time is shortened. The anesthetic prepared by the invention has smaller side effect, quick response and long maintenance time, can reduce the injection times of the anesthetic, reduce the infection risk and the nursing cost, has good anesthetic effect and has wide application prospect.

Inventors

• WU DONGHAI
• ZHANG YANZHUO
• ZHANG WEIHUA
• Ming Shaopeng
• LIN YING
• WEI YINGHUI
• Wu Zhouyan

Assignees

• 柳州市工人医院

Dates

Publication Date

20260512

Application Date

20260228

Claims (8)

1. 1. An anesthetic is characterized by being prepared by mixing 1000 parts of bupivacaine liposome injection, 0.5-1 part of magnesium sulfate and 3-5 parts of dexmedetomidine hydrochloride according to the weight ratio; Wherein the concentration of bupivacaine liposome in the bupivacaine liposome injection is 10 mg/mL-15 mg/mL.
2. 2. The anesthetic according to claim 1, wherein a concentration of bupivacaine liposome in the bupivacaine liposome injection is 13.3mg/mL.
3. 3. The anesthetic drug according to claim 2, wherein the weight part of the magnesium sulfate is 0.6 to 0.9.
4. 4. An anesthetic drug according to claim 3, wherein the weight part of the magnesium sulfate is 0.7 part.
5. 5. The anesthetic drug according to claim 4, wherein the dexmedetomidine hydrochloride is 4 parts by weight.
6. 6. An anesthetic according to claim 1, wherein the anesthetic is an anesthetic analgesic for use after an orthopedic operation.
7. 7. An anesthetic according to claim 6, wherein the orthopedic surgery is shoulder arthroscopic surgery.
8. 8. The method of preparing an anesthetic drug according to claim 1, comprising the steps of: preparing 1000 parts of bupivacaine liposome injection, 0.5-1 part of magnesium sulfate and 3-5 parts of dexmedetomidine hydrochloride according to the weight ratio; mixing the above materials uniformly to obtain the anesthetic.

Description

Anesthetic and preparation method thereof Technical Field The invention belongs to the technical field of anesthetic drugs, and particularly relates to an anesthetic drug and a preparation method thereof. Background The most intuitive effects of anesthetic drugs are anesthesia, including local anesthesia and general anesthesia, and there is a need for anesthetic drugs in terms of surgery, invasive examination procedures, pain management, etc. Reasonable anesthesia can not only relieve the pain of patients, but also reduce oxygen consumption, prevent man-machine antagonism, strive for precious time for the treatment of diseases, and enable patients to comfortably and safely receive examination and treatment under the condition of keeping consciousness or sedation. The existing anesthetic is mainly divided into two main categories according to the anesthetic time length. The first is a long-acting anesthetic, such as bupivacaine, ropivacaine, etc., which can last for several hours to tens of hours of anesthetic time, but the onset of such agents is relatively short. The second category is short acting narcotics such as etomidate, sodium thiopentetate, etc., which are fast acting but last only a few minutes, and most often hours. For many patients with surgical diseases, postoperative acute pain is a critical factor affecting the quality of recovery for the surgical patient. Because such patients are acutely painful and have long recovery time from surgical wounds, rapid onset and maintenance of long-lasting anesthesia is required to achieve rapid and long-lasting analgesic effects. However, the long-acting anesthetic in the prior art has long pain relief time, usually takes 4-6 hours to take effect, has slow effect, and the short-acting anesthetic has quick effect, but can only last for a plurality of hours at most, and has short pain relief time. In summary, the anesthetic of the prior art does not meet the anesthesia requirement of rapid onset and longer duration of anesthesia. Disclosure of Invention In order to solve the technical problems, the invention provides an anesthetic and a preparation method thereof, and the anesthetic has the advantages of quick response and long analgesic time. The invention aims to provide an anesthetic which is prepared by mixing 1000 parts of bupivacaine liposome injection, 0.5-1 part of magnesium sulfate and 3-5 parts of dexmedetomidine hydrochloride according to the weight ratio; Wherein the concentration of bupivacaine liposome in the bupivacaine liposome injection is 10 mg/mL-15 mg/mL. According to the invention, bupivacaine liposome is compounded with auxiliary medicines such as magnesium sulfate and dexmedetomidine hydrochloride, and the obtained injection preparation can meet the anesthesia and analgesia time of 72 hours or longer after operation after single injection, and patients can quickly feel anesthesia and analgesia effects after intravenous injection in operation or after operation within a few minutes. Is especially suitable for anesthesia and analgesia after bone surgery, such as postoperative anesthesia and analgesia of shoulder arthroscopy. Bubicaine liposome injection is commercially available in 10 ml/133 mg (Hunan Koren pharmaceutical Co., ltd.) or 20 ml/266 mg (Jiangsu Hengrui pharmaceutical Co., ltd.). Preferably, in the anesthetic, the concentration of bupivacaine liposome in the bupivacaine liposome injection is 13.3mg/mL. Preferably, the weight portion of the anesthetic drug is 0.6 to 0.9 portion. Preferably, the anesthetic comprises 0.7 part by weight of magnesium sulfate. Preferably, the anesthetic comprises 4 parts by weight of dexmedetomidine hydrochloride. Preferably, the anesthetic is an anesthetic analgesic used after an orthopedic operation. Preferably, the anesthetic is used for the bone surgery, and the bone surgery refers to shoulder arthroscopy surgery. Preferably, the preparation method of the anesthetic comprises the following steps: preparing 1000 parts of bupivacaine liposome injection, 0.5-1 part of magnesium sulfate and 3-5 parts of dexmedetomidine hydrochloride according to the weight ratio; mixing the above materials uniformly to obtain the anesthetic. Compared with the prior art, the invention has the following beneficial effects: The anesthetic disclosed by the invention is prepared by mixing 1000 parts of bupivacaine liposome injection, 0.5-1 part of magnesium sulfate and 3-5 parts of dexmedetomidine hydrochloride according to the weight ratio, and can be locally injected, for example, the anesthetic can be uniformly infiltrated and injected into tissues around an incision. In the anesthetic provided by the invention, the bupivacaine liposome is mainly coated by the liposome, and the liposome is orderly broken so as to slowly release the bupivacaine to achieve the effect of continuously easing pain, so that the bupivacaine still has the main anesthetic effect in the composition provided by the invention. The bupivacaine lip