CN-122005622-A - Composition for improving, preventing or treating vaginitis or vulvitis comprising lactobacillus salivarius HHuMin-U

CN122005622ACN 122005622 ACN122005622 ACN 122005622ACN-122005622-A

Abstract

The present invention relates to a composition for improving, preventing or treating vaginitis or vulvitis comprising lactobacillus salivarius (Lactobacillus salivarius) HHuMin-U, which exhibits excellent antibacterial activity against pathogenic bacteria inducing vaginitis and vulvitis, and is very effective in improving and treating vaginitis and vulvitis.

Inventors

Pu Mingzhu
XU JIAN
Cheng Rongji
JIN SHANRONG
Bian Xiangjun
CUI ZHUYUAN
Zhao Zaiying
LI ZHIZHU

Assignees

比菲德股份有限公司

Dates

Publication Date: 20260512
Application Date: 20250730
Priority Date: 20241112

Claims (6)

1. A pharmaceutical composition for preventing or treating vaginitis or vulvitis, which comprises lactobacillus salivarius HHuMin-U having accession number KCCM13001P as an active ingredient.
2. The pharmaceutical composition for preventing or treating vaginitis or vulvitis as claimed in claim 1 wherein the strain is at least one selected from the group consisting of live bacterium of lactobacillus salivarius HHuMin-U strain with accession number KCCM13001P, disrupted product thereof, culture broth thereof, culture thereof, extract thereof and dead bacterium thereof.
3. The pharmaceutical composition for preventing or treating vaginitis or vulvitis as claimed in claim 1 wherein the vaginitis or vulvitis is any one selected from bacterial vaginitis, trichomonas vaginitis, candida albicans vaginitis, atrophic vaginitis, herpes virus infection and genital wart.
4. A health functional food for improving vaginitis or vulvitis, which is characterized by comprising lactobacillus salivarius HHuMin-U with deposit number of KCCM 13001P.
5. A skin external preparation for improving vaginitis or vulvitis, comprising lactobacillus salivarius HHuMin-U with deposit number KCCM 13001P.
6. A lotion composition for ameliorating vaginitis or vulvitis, comprising lactobacillus salivarius HHuMin-U deposited under accession number KCCM 13001P.

Description

Composition for improving, preventing or treating vaginitis or vulvitis comprising lactobacillus salivarius HHuMin-U Technical Field The present invention relates to a composition for improving, preventing or treating vaginitis or vulvitis comprising lactobacillus salivarius (Lactobacillus salivarius) HHuMin-U. Background Inflammation of the vagina and vulva is the most common cause of diagnosis and treatment from females to obstetrics, and the most typical and common diseases of the vagina and vulva are bacterial vaginitis, trichomonas vaginitis, candida albicans vaginitis, herpes virus infection causing ulcers of the vulva, genital warts and the like. Vaginitis refers to inflammation caused by bacterial infection of the vaginal mucosa. The pathogenic bacteria can be gonococcus, streptococcus, staphylococcus, escherichia coli, candida, trichomonas, etc., and also can be caused by partial symptoms of infectious diseases such as tuberculosis, syphilis, diphtheria, typhoid fever, measles, etc. The usual symptoms are increased leucorrhea (leukorrhagia), white or yellowish white turbidity, purulent or bloody, and often malodor. The private parts often have moist feeling, itching feeling and burning feeling, and the pain feeling is produced when urination is caused by erosion caused by leukorrhagia. Although there are cases where the vaginal patch is cured by insertion of an antibiotic substance, the focus of complete cure in the early stages of the onset is on accurate treatment after diagnosis by a doctor. The most important precaution is to keep the parts clean. Vulvitis is an inflammation that occurs in the female's external genitalia, which is the external genitalia of the female genitalia that can be seen from the outside. The part which is separated at ordinary times is called pudendum crack (pudendum crack). The labia majora, labia minora, clitoris, vaginal orifice and urethral orifice are gathered. The main causes of vulvitis can be divided into infectious and non-infectious. Infectious causes are most common with bacterial infections, which are generally caused by an imbalance of normal flora in the vagina. There are many cases associated with bacterial vaginitis. Mold infections are also common, and are more often caused by yeasts called candida albicans. Characterized by itching, redness and swelling, and abnormal secretions. Herpes virus or human papillomavirus infection also causes vulvitis, and chlamydia, gonorrhea, trichomonas and the like, which are known to be infectious pathogens, are also strains that can cause vulvitis. The cause of non-infectious vulvitis is allergic reactions, and inflammation can be induced by stimulating the pudendum with chemicals found in lotions, perfumes, sanitary napkins, condoms, and the like. Moreover, hormonal changes are also one of the important causes, especially during menopause, the decrease in estrogen number makes the skin of the vulva thinner and drier, and thus more sensitive to irritation. In addition, physical irritation also plays a role as a cause, and the vulva is stimulated by tight clothing or friction. The most common symptoms are itching, burning sensation, pain in the vulva, with redness and swelling of the vulva, and abnormal vaginal secretion. Under normal conditions, the vagina of a woman is in a weakly acidic environment due to many lactic acid bacteria inside the vagina, which acts to inhibit the proliferation of pathogenic microorganisms or mold. Such a weakly acidic environment in the vagina may be changed by various external factors such as excessive vaginal cleansing, long-term administration of antibiotics or contraceptives, pregnancy, production, menopause, and the like, which break the balance of hormones, causing the amount of lactic acid bacteria, which are probiotics normally present in the vagina, to be changed, thereby changing the weakly acidic environment. Sulfanilamide, antibiotics, chemically synthesized disinfectants, etc. are used in the treatment of vaginitis, but the drugs are fatal not only to harmful bacteria but also to lactic acid bacteria as probiotics, and especially the use of antibiotics induces resistance of antibiotics. In addition, in the case of a chemically synthesized disinfectant (povidone iodine), there is a problem that there is a risk of causing itching, burning, dermatitis, etc. due to allergy to iodine, etc. or mucosal injury, and hypothyroidism is induced due to an increase in iodine number. Accordingly, there is a need for a method of preventing the induction of secondary vaginitis and vulvitis due to imbalance of intestinal flora, while having excellent effects of improving and treating vaginitis and vulvitis without affecting the intestinal flora. Prior art literature Patent literature Patent document 1 korean patent No. 10-1860513 (day 16 of 05 of 2018) discloses a composition for preventing or treating candidal vaginitis, which comprises lactobacillus salivarius MG242 isolated from the vagina.