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CN-122005624-A - Composition with weight and blood fat reducing effects and application thereof

CN122005624ACN 122005624 ACN122005624 ACN 122005624ACN-122005624-A

Abstract

The invention discloses a composition with weight and blood lipid reducing effects and application thereof, and belongs to the technical field of biology. The composition comprises 30-80% of a probiotic compound and 20-70% of a raw material containing glyceroglycolipid, wherein the probiotic compound takes lactobacillus reuteri as an essential component and also comprises any one or more of bifidobacterium, lactobacillus fermentum, lactobacillus acidophilus, lactobacillus casei, lactobacillus rhamnosus, lactobacillus brevis and bacillus coagulans. According to the invention, the specific probiotic compound is screened and compounded with the raw material rich in the glyceroglycolipid, and the synergistic effect of the probiotic compound and the raw material is utilized to improve the weight and blood lipid reducing effects. The composition developed by the invention breaks through the problem of resource waste caused by the fact that the raw materials such as the nannochloropsis oil which are rich in glyceroglycolipid cannot be effectively absorbed in the prior art, improves the nutrition efficacy of the nannochloropsis oil, and has wide application prospect in the fields of foods, health products and medicines.

Inventors

  • LIU YANJUN
  • GAO KUNPENG
  • XIE ZHEN
  • XUE CHANGHU
  • XU JIE
  • LIU LINLIN
  • FENG TINGYU
  • GAO RUI
  • YU WEI
  • SONG YU
  • ZHANG WEI

Assignees

  • 中国海洋大学
  • 青岛海洋食品营养与健康创新研究院
  • 广西小藻农业科技有限公司

Dates

Publication Date
20260512
Application Date
20260211

Claims (10)

  1. 1. The composition with the weight and blood fat reducing effects is characterized by comprising, by mass, 30% -80% of a probiotic compound and 20% -70% of a raw material containing glyceroglycolipid; The probiotic compound takes lactobacillus reuteri as an essential component and also comprises any one or more of bifidobacterium, lactobacillus fermentum, lactobacillus acidophilus, lactobacillus casei, lactobacillus rhamnosus, lactobacillus brevis and bacillus coagulans.
  2. 2. The composition of claim 1, wherein the glyceroglycolipid-containing material comprises algae oil, algae meal, or a glyceroglycolipid-rich plant-derived lipid extract.
  3. 3. The composition according to claim 1, wherein the mass percentage of glyceroglycolipids in the composition is 6% -30%.
  4. 4. The composition according to claim 1, wherein in the composition the total viable count is 2 x 10 8 -1×10 12 CFU/g and the viable count of lactobacillus reuteri is 1 x 10 8 -9×10 11 CFU/g.
  5. 5. Use of a composition according to any one of claims 1-4 for the manufacture of a medicament for weight loss.
  6. 6. Use of a composition according to any one of claims 1-4 for the preparation of a hypolipidemic medicament.
  7. 7. Use of a composition according to any one of claims 1-4 for the manufacture of a medicament for the treatment of fatty liver.
  8. 8. Use of a composition according to any one of claims 1 to 4 for the preparation of a product that helps to maintain a healthy level of blood lipids, wherein the product comprises a functional food or a health care product.
  9. 9. Use of a composition according to any one of claims 1 to 4 for the preparation of a product useful for controlling fat in the body, wherein the product comprises a functional food or a nutraceutical.
  10. 10. A hypolipidemic agent, comprising the composition of any one of claims 1-4.

Description

Composition with weight and blood fat reducing effects and application thereof Technical Field The invention relates to the technical field of biology, in particular to a composition with the effects of reducing weight and blood fat and application thereof. Background With the improvement of the living standard and the change of the dietary structure of people, the incidence rate of metabolic diseases such as obesity, hyperlipidemia, hyperglycemia, metabolic fatty liver and the like is increased year by year, and the disease has become a global public health problem. The metabolic diseases not only can reduce the life quality of patients, but also can induce various complications such as cardiovascular diseases, diabetic nephropathy and the like, and seriously threaten human health. The current clinically commonly used weight and blood lipid reducing means depend on drug intervention or diet exercise regulation, but drug treatment often accompanies side effects such as gastrointestinal discomfort, liver and kidney function burden and the like, diet and exercise regulation is limited by individual compliance, and stable and lasting improvement effect is difficult to achieve, so that the development of safe, efficient and high-compliance nutritional health-care weight and blood lipid reducing products becomes a research hotspot and urgent need in the current field. Currently, products aimed at weight and blood lipid reduction are mainly classified into chemical drugs and natural products. Although the chemical drugs have certain lipid-lowering and weight-reducing effects, the chemical drugs often have the problems of large side effects, easy drug resistance, poor long-term administration safety and the like, and are difficult to meet the requirements of clinic and daily health care. Natural products are hot research spots due to the advantages of high safety, small side effects and the like, wherein probiotics and plant active ingredients are two important research directions. Glyceroglycolipids, a class of naturally active lipids widely found in algae and plants, have a variety of physiological functions, and have been demonstrated to have potential benefits of anti-inflammatory, lipid metabolism regulation, cardiovascular protection, and the like. For example, the pseudomicroalgae is used as marine microalgae, the oil content of the pseudomicroalgae is up to 20% -50%, the n-3 polyunsaturated fatty acid content is rich (> 50%), the pseudomicroalgae not only contains triglyceride, but also contains polar lipid components such as glyceroglycolipid, and the content of the glyceroglycolipid is above 20%. In addition, wheat polar lipids are also rich in glycolipids such as digalactosyl diglycerides (> 30%). Unlike conventional lipids, the digestion and absorption process of glyceroglycolipids is unique in that it is difficult to be fully decomposed and absorbed in the stomach and the anterior segment of the small intestine, most of which can enter the colon part, and the subsequent metabolic transformation is completed under the action of intestinal microflora. However, when glyceroglycolipid is taken alone, the metabolic conversion efficiency is low, the lipid regulation potential of the glyceroglycolipid is difficult to fully develop, and the digestion and absorption characteristics and the function of the glyceroglycolipid from different sources are different, so that the large-scale application of the glyceroglycolipid in the field of weight reduction and blood fat reduction is limited. Intestinal microbiota plays a key role in the regulation of metabolic homeostasis of a human body, and in particular probiotics can influence host metabolic health by regulating the structure of intestinal microbiota, participating in substrate metabolic conversion and the like. The beneficial metabolites of the organism can be further effectively and accurately produced by the synergistic compounding of probiotics and food components, so that the metabolism of the organism is improved. However, application researches on probiotics and glyceroglycolipids in weight and blood fat reduction are not seen at present, and the mechanism of synergistic action of the probiotics and the glyceroglycolipids is not clear. Disclosure of Invention The invention aims to provide a composition with the effects of reducing weight and blood fat and application thereof, so as to solve the problems in the prior art. The invention provides a composition with the effects of reducing weight and reducing blood fat, which is prepared by screening specific probiotic compounds and raw materials rich in glyceroglycolipid, and can improve the effects of reducing weight and reducing blood fat by utilizing the synergistic effect of the probiotic compounds and the raw materials. The composition developed by the invention breaks through the problem of resource waste caused by the fact that the raw materials such as the nannochloropsis oil which are rich in glyc