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CN-122005626-A - Application of lactobacillus rhamnosus MP108 in preparation of products for maintaining nerve health

CN122005626ACN 122005626 ACN122005626 ACN 122005626ACN-122005626-A

Abstract

The invention provides an application of lactobacillus rhamnosus MP108 in preparing a product for maintaining nerve health. The invention discovers that lactobacillus rhamnosus MP108 can improve the filial generation nerve dysplasia, abnormal behavior, cognitive dysfunction, nerve injury and nerve inflammation induced by the maternal high-fat diet through maternal and infant transmission when being applied to a mother, and can protect a filial generation nervous system and even the whole health. The new application of the invention expands the application range of lactobacillus rhamnosus as probiotics, has important significance for developing probiotics with higher health care value by deeply digging the functions of the probiotics, and opens up a new way and solution for protecting the health of the nervous system by using a diet strategy.

Inventors

  • ZHONG WEIZHI
  • LI WEI
  • CHEN CAILING
  • ZHAO YUEMING
  • YANG BO
  • LIU SHIFENG
  • GUAN XIN
  • LIU MIN
  • YE HUILAN
  • WANG JIAQI

Assignees

  • 澳优乳业（中国）有限公司
  • 锦乔生物科技有限公司

Dates

Publication Date
20260512
Application Date
20260409

Claims (10)

  1. 1. The application of lactobacillus rhamnosus Lactobacillus rhamnosus MP to the preparation of cultures, microbial preparations or fermentation agents for maintaining nerve health is characterized in that the lactobacillus rhamnosus Lactobacillus rhamnosus MP108 has a preservation number of CGMCC No.21225, a preservation date of 2020, 11 months and 23 days and a preservation unit of China general microbiological culture Collection center.
  2. 2. The use of claim 1, wherein maintaining neurological health comprises at least one of improving or promoting neurological development, alleviating or inhibiting behavioral abnormalities, alleviating or inhibiting cognitive impairment, alleviating or inhibiting nerve injury, and alleviating or inhibiting neuroinflammation.
  3. 3. The use according to claim 1 or 2, wherein the maintenance of neurological health is manifested as: Improving the expression of the gene encoding oligodendrocyte transcription factor 2 in the hippocampus, and/or, Improving the expression of myelin basic protein-encoding genes in the hippocampus, and/or, Improving the expression of cyclooxygenase-2 encoding gene in the hippocampus, and/or, Improving the expression of nuclear factor κB encoding gene in hippocampus.
  4. 4. The use according to claim 1 or 2, wherein the culture, microbial preparation or starter culture for maintaining neurological health comprises a culture, microbial preparation or starter culture for improving neurological health of offspring via maternal-to-infant transmission after application to the mother.
  5. 5. The use according to claim 1 or 2, wherein the microbial preparation is a liquid preparation or a solid preparation.
  6. 6. The use according to claim 5, wherein when the microbial preparation is a liquid preparation, the viable count of lactobacillus rhamnosus Lactobacillus rhamnosus MP108,108 is 1 x 10 6 CFU/mL-1×10 10 CFU/mL; when the microbial preparation is a solid preparation, the viable count of the lactobacillus rhamnosus Lactobacillus rhamnosus MP108,108 is 1 multiplied by 10 6 CFU/g-1×10 10 CFU/g.
  7. 7. The use according to claim 1 or 2, wherein in the microbial preparation, the lactobacillus rhamnosus Lactobacillus rhamnosus MP108,108 is in the form of at least one of live bacteria, inactivated bacteria and lyophilized powder.
  8. 8. The use according to claim 1 or 2, wherein the microbial preparation further comprises a carrier and/or physiologically acceptable excipients.
  9. 9. The use of claim 8, wherein the carrier comprises at least one of microcapsules, microspheres, nanoparticles, liposomes.
  10. 10. The use according to claim 8, wherein the adjuvant comprises at least one of a filler, a flavouring agent, a diluent, a wetting agent, a binder, a disintegrant, a lubricant, a color-fragrance modulator, a solvent, a solubilizer, a co-solvent, an emulsifier, an antioxidant, a metal complexing agent, an inert gas, a preservative, a local analgesic, a pH modulator, an isotonic or isotonic modulator.

Description

Application of lactobacillus rhamnosus MP108 in preparation of products for maintaining nerve health Technical Field The invention relates to a microbiological technology, in particular to an application of lactobacillus rhamnosus MP108 in preparing a product for maintaining nerve health. Background Neural health is a core foundation for maintaining normal physiological functions, cognitive abilities, behavioral activities, and emotional regulation of the body, and encompasses multiple dimensions of neural development, cognitive functions, behavioral states, neural tissue integrity, and inflammatory homeostasis. Along with the aging of the global population, the change of life style and the influence of environmental factors, the incidence rate of the nerve related diseases is continuously increased, including cognitive dysfunction, neurodegenerative diseases, neuroinflammation, abnormal developmental nerve behaviors and the like, and the system brings heavy burden to the life quality of patients, families and social medical systems. Meanwhile, more and more researches prove that the neural development state in the early life stage has a decisive influence on the life-long neural health of an individual, and a close relation exists between the maternal health and the offspring neural development, so that the role of the maternal and infant transmission pathway in the neural health regulation gradually becomes a research hot spot. Currently, strategies for neurological health maintenance and related disease intervention remain somewhat limited. Traditional micromolecular medicaments, immunotherapy, gene therapy and the like focus on local targets of the central nervous system, and can relieve symptoms to a certain extent, but the problems of poor blood brain barrier penetrability, obvious side effect, narrow application range, incapability of radically regulating and controlling the neuropathological process and the like generally exist. Especially for abnormal developmental neural behaviors and age-related cognitive decline, the existing intervention means are difficult to achieve dual targets of early prevention and long-term maintenance, and development of a novel intervention scheme which is safe, efficient and wide in application scene is urgently needed. Therefore, the development of the probiotic strain which has definite neuroprotective activity and specific action targets and can play a role through maternal and infant transmission has important theoretical significance and practical application value for filling the blank of the existing intervention scheme and expanding the strategy and path of nerve health maintenance. Disclosure of Invention The invention aims to provide a novel application of lactobacillus rhamnosus Lactobacillus rhamnosus MP108,108. The invention discovers that lactobacillus rhamnosus Lactobacillus rhamnosus MP can improve the filial generation nerve dysplasia, abnormal behavior, cognitive disorder, nerve injury and nerve inflammation induced by the maternal high-fat diet through the transmission of mother and infant when being applied to the mother, and can protect the filial generation nerve system and even the whole health. The new application of the invention expands the application range of lactobacillus rhamnosus as probiotics, has important significance for developing probiotics with higher health care value by deeply digging the functions of the probiotics, and opens up a new way and solution for protecting the health of the nervous system by using a diet strategy. The invention provides an application of lactobacillus rhamnosus Lactobacillus rhamnosus MP in preparing a culture, a microbial preparation or a starter for maintaining nerve health, wherein the preservation number of lactobacillus rhamnosus Lactobacillus rhamnosus MP is CGMCC No.21225, the preservation date is 11 months 23 in 2020, and the preservation unit is China general microbiological culture Collection center. The use as described above, wherein maintaining neurological health comprises at least one of improving or promoting neurological development, alleviating or inhibiting behavioral abnormalities, alleviating or inhibiting cognitive impairment, alleviating or inhibiting nerve injury, alleviating or inhibiting neuroinflammation. The use as described above, wherein maintaining neurological health is manifested as: Improving the expression of the gene encoding oligodendrocyte transcription factor 2 in the hippocampus, and/or, Improving the expression of myelin basic protein-encoding genes in the hippocampus, and/or, Improving the expression of cyclooxygenase-2 encoding gene in the hippocampus, and/or, Improving the expression of nuclear factor κB encoding gene in hippocampus. The use as described above wherein the culture, microbial preparation or starter for maintaining neurological health comprises a culture, microbial preparation or starter which, after application to the mother, improves neurolog