CN-122005629-A - Preparation method and equipment of Cordyceps sinensis freeze-dried powder tablet

CN122005629ACN 122005629 ACN122005629 ACN 122005629ACN-122005629-A

Abstract

The invention relates to the technical field of preparation of Cordyceps sinensis freeze-dried powder, and discloses a Cordyceps sinensis freeze-dried powder tablet and a preparation method thereof, comprising the following steps of S1, preparing a moisture-absorbing tablet, wherein the moisture-absorbing tablet is insoluble in water but has moisture absorption; S2, coating a mucous membrane layer on one side of the moisture absorption sheet, solidifying and fixing the freeze-dried powder at a low temperature, dissolving the freeze-dried powder in hot water, S3, loading the Cordyceps sinensis freeze-dried powder on the surface of the mucous membrane layer, solidifying at a low temperature to form a composite tablet, and S4, vacuum-packaging the composite tablet. According to the preparation method of the Cordyceps sinensis freeze-dried powder, the mucosa layer is coated on the moisture absorption tablet and the Cordyceps sinensis freeze-dried powder is loaded, so that the scheme of the composite tablet is formed, and the problems that the existing freeze-dried powder is easy to absorb moisture and deteriorate, severe in preservation condition, poor in rehydration and the like are solved by utilizing the characteristics of the moisture absorption tablet that the moisture absorption tablet is insoluble in water but has hygroscopicity and the characteristics that the mucosa layer can be solidified and fixed in the freeze-dried powder and can be dissolved in hot water at low temperature.

Inventors

WU LI
Lin Shuanghu
SUN SHUJUN
HOU JINBO
SHEN SHUYU
HUANG DONGYUN
ZHANG MIAOMIAO
WANG QIANYU
ZHANG MENGRU
ZHOU XINYU
GUO YUHAN
GAO XIANG

Assignees

阜阳师范大学

Dates

Publication Date: 20260512
Application Date: 20260122

Claims (10)

1. The preparation method of the Cordyceps sinensis freeze-dried powder tablet is characterized by comprising the following steps: s1, mixing resistant starch and hydrocolloid according to the mass ratio of (8-10) (0.5-1.5), adding water with the mass fraction of 25-35%, mixing, casting into a film with the thickness of 0.5-0.8mm, drying at 60-80 ℃ until the water content is 5-8%, and cutting into rectangular pieces, wherein the moisture absorption pieces are insoluble in water and have moisture absorption; S2, dissolving lactose and maltose compound with the mass ratio of (6-8) (2-4) in water at the temperature of 40-50 ℃, preparing mixed solution with the mass fraction of 40-50%, coating the mixed solution on one side of the moisture absorption sheet with the coating weight of 0.1-0.2g/cm < 2 >, and then placing the coated moisture absorption sheet in an environment at the temperature of 45-50 ℃ for activation for 3-10 minutes to form a viscous mucous membrane layer, wherein the mucous membrane layer can be solidified and fixed into freeze-dried powder at the temperature of 0-4 ℃ and can be dissolved in hot water; s3, uniformly spreading Cordyceps sinensis freeze-dried powder with the particle size of 80-150 meshes on the surface of the mucous membrane layer according to the powder carrying amount of 0.15-0.3g/cm < 2 >, cooling and solidifying for 5-30min at the temperature of 0-4 ℃ to enable the mucous membrane layer to be vitrified so as to fix the freeze-dried powder, and forming a composite tablet; S4, vacuum packaging the composite tablet.
2. The method of claim 1, wherein the resistant starch is high amylose corn starch and the hydrocolloid is konjac glucomannan.
3. The method of claim 1, wherein in the step S2, the dissolution temperature of the mixed solution is controlled to be 42-48 ℃.
4. The method of claim 1, wherein the activation time in step S2 is 5-8 minutes.
5. The method according to claim 1, wherein in the step S3, the particle size of the Cordyceps sinensis lyophilized powder is 100-120 meshes, and the powder loading amount is 0.20-0.25g/cm2.
6. The method of claim 1, wherein in the step S3, the cooling solidification temperature is 0-4 ℃ and the solidification time is 5-30min.
7. The method for preparing Cordyceps sinensis freeze-dried powder tablet as claimed in claim 1, wherein the packaging method in step S4 is that a vacuum aluminum foil bag is used for nitrogen filling and sealing of the composite tablet, and a drying agent is arranged in the vacuum aluminum foil bag, wherein the drying agent is one of silica gel, seaweed and zeolite.
8. A device for preparing a Cordyceps sinensis freeze-dried powder tablet, which is used for preparing the Cordyceps sinensis freeze-dried powder tablet as claimed in any one of claims 1 to 7, and is characterized by comprising: the preparation device of the moisture absorption sheet is used for completing the preparation of the moisture absorption sheet in the step S1, and has the functions of raw material mixing, slurry casting film forming, film drying, shaping and cutting; The mucous membrane layer coating device is used for finishing the coating of the mucous membrane layer in the step S2 and has the function of activating the moisture absorption sheet after the coating of the mixed solution; The freeze-dried powder loading device is used for loading and low-temperature solidification of the Cordyceps sinensis freeze-dried powder in the step S3, and has the functions of uniformly spreading the freeze-dried powder and cooling and solidifying the composite structure; the vacuum packaging device is used for completing the vacuum packaging of the composite tablets in the step S4 and has the functions of supplying a vacuum aluminum foil bag, filling nitrogen into the bag, sealing the mouth of the bag and placing a drying agent.
9. The apparatus for preparing a lyophilized powder tablet of Cordyceps sinensis according to claim 8, wherein the moisture absorption tablet preparing device comprises a mixing unit for uniformly mixing and preparing a slurry of resistant starch and hydrocolloid, a casting film forming unit for casting the slurry into a film sheet of a set thickness, a drying unit for drying the film sheet by controlling the temperature, and a cutting unit for cutting the dried film sheet into rectangular sheets of a set size.
10. The apparatus for preparing Cordyceps sinensis freeze-dried powder tablet according to claim 8, wherein the mucous membrane layer coating device comprises a coating unit for uniformly coating the mixed solution on one side of the moisture absorption tablet and controlling the coating amount, and an activating unit for providing an activating environment with a set temperature and time, wherein the freeze-dried powder loading device comprises a powdering unit for controlling the spreading amount of the freeze-dried powder and uniformly spreading, and a cooling and solidifying unit for providing a cooling and solidifying environment with a set temperature and time, and the vacuum packaging device comprises a vacuum aluminum foil bag supply unit for automatically supplying the vacuum aluminum foil bag and opening the bag mouth, a nitrogen filling unit for filling nitrogen gas into the bag, a sealing unit for thermally pressing and sealing the bag mouth, and a drying agent placing unit for placing the drying agent into the bag.

Description

Preparation method and equipment of Cordyceps sinensis freeze-dried powder tablet Technical Field The invention relates to the technical field of preparation of Cordyceps sinensis freeze-dried powder, in particular to a preparation method and equipment of Cordyceps sinensis freeze-dried powder tablets. Background Cordyceps sinensis is taken as a precious traditional Chinese medicine material, and has high medicinal value and health care effect. Along with the importance of health, the demand of Cordyceps sinensis products is increasing, wherein, the Cordyceps sinensis freeze-dried powder is favored because of the convenience of storage and use. At present, the common preparation method of the Cordyceps sinensis freeze-dried powder mainly adopts a vacuum freeze-drying technology, so that the Cordyceps sinensis is pre-frozen, sublimated and dried in a low-temperature environment, but part of active ingredients still can be influenced to a certain extent, so that the storage rate of the active ingredients of the freeze-dried powder is not high enough, and secondly, the existing Cordyceps sinensis freeze-dried powder usually needs to strictly control environmental conditions such as temperature, humidity and the like in the storage process, otherwise, the problems of moisture absorption, oxidization and the like are easy to occur, the quality and stability of the product are influenced, and the shelf life is shortened, and furthermore, the problems of slow dissolution speed, incomplete rehydration and the like of part of Cordyceps sinensis freeze-dried powder influence the experience and the rapid exertion of the drug effect of the Cordyceps sinensis freeze-dried powder in the taking process. In view of the above problems in the prior art, a new solution needs to be proposed. Disclosure of Invention The invention overcomes the defects of the prior art and provides a preparation method and equipment of a cordyceps sinensis freeze-dried powder tablet. S1, mixing resistant starch and hydrocolloid according to the mass ratio of (8-10) (0.5-1.5), adding 25-35% of water, mixing pulp, casting into a film with the thickness of 0.5-0.8mm, drying at 60-80 ℃ until the water content is 5-8%, and cutting into rectangular sheets, wherein the moisture absorption sheet is insoluble in water and has moisture absorption; S2, dissolving lactose and maltose compound with the mass ratio of (6-8) in water with the temperature of 40-50 ℃, preparing mixed solution with the mass fraction of 40-50%, coating the mixed solution on one side of a moisture absorption sheet with the coating weight of 0.1-0.2g/cm < 2 >, then placing the coated moisture absorption sheet in an environment with the temperature of 45-50 ℃ for activation for 3-10 minutes to form an adhesive mucous membrane layer, solidifying and fixing the mucous membrane layer at the temperature of 0-4 ℃ and dissolving the mucous membrane layer in hot water, S3, uniformly spreading Cordyceps sinensis freeze-dried powder with the particle size of 80-150 meshes on the surface of the mucous membrane layer with the powder carrying amount of 0.15-0.3g/cm < 2 >, cooling and solidifying for 5-30min at the temperature of 0-4 ℃ to enable the mucous membrane layer to be vitrified so as to fix the mucous membrane layer, and forming the compound tablet, and S4, vacuum packaging the compound tablet. In a preferred embodiment of the present invention, the resistant starch is high amylose corn starch and the hydrocolloid is konjac gum. In a preferred embodiment of the present invention, in the step S2, the dissolution temperature of the mixed solution is controlled to be 42 ℃ to 48 ℃. In a preferred embodiment of the present invention, in the step S2, the activation time is 5-8 minutes. In a preferred embodiment of the present invention, in the step S3, the particle size of the Cordyceps sinensis lyophilized powder is 100-120 mesh, and the powder loading amount is 0.20-0.25g/cm2. In a preferred embodiment of the present invention, in the step S3, the cooling and solidifying temperature is 0 ℃ to 4 ℃ and the solidifying time is 5 to 30 minutes. In a preferred embodiment of the present invention, the packaging method in step S4 is that a vacuum aluminum foil bag is used to seal the composite tablet by filling nitrogen, and a desiccant is arranged in the vacuum aluminum foil bag, wherein the desiccant is one of silica gel, seaweed and zeolite. In another aspect, the present invention provides a preparation apparatus for preparing the Cordyceps sinensis freeze-dried powder tablet, which comprises: the preparation device of the moisture absorption sheet is used for completing the preparation of the moisture absorption sheet in the step S1, and has the functions of raw material mixing, slurry casting film forming, film drying, shaping and cutting; The mucous membrane layer coating device is used for finishing the coating of the mucous membrane layer in the step S2 and has the function of activating th