CN-122005640-A - Application of coreopsis tinctoria water extract in preparation of medicine for improving autism core symptoms

Abstract

Application of coreopsis tinctoria water extract in preparation of medicine for improving autism core symptoms belongs to the technical field of biological medicine. The invention provides application of coreopsis tinctoria water extract in preparing the coreopsis tinctoria core symptom improving medicine, solves the problems that the prior art lacks medicines with small side effects and natural sources, and has the advantages of high safety and small side effects, and the coreopsis tinctoria core symptom improving medicine is prepared from the multi-dimensional synergistic effects of adjusting synaptic plasticity, inhibiting neuroinflammation, improving behavioral phenotypes and the like, accords with the concept of treating complex nervous system diseases by traditional Chinese medicine, and fundamentally improves the coreopsis tinctoria core symptom.

Inventors

• LI NAN
• HU FEI
• HAO LIXIN
• Cui Kunying

Assignees

• 佳木斯大学

Dates

Publication Date

20260512

Application Date

20260306

Claims (10)

1. 1. Application of coreopsis tinctoria water extract in preparing medicine for improving autism core symptoms is provided.
2. 2. The use according to claim 1, wherein the preparation of the aqueous extract of coreopsis tinctoria comprises taking dry coreopsis tinctoria flower bud 40 60 G, adding triple distilled water according to the liquid-to-material ratio of (25-35) mL to 1 g, and boiling with slow fire for 15 times Filtering for 30 min, collecting filtrate 1, adding distilled water according to the liquid-to-material ratio of (15-25) mL:1 g into the filtered residue, boiling for 15 Filtering and collecting filtrate 2 for 25 min, mixing filtrate 1 and filtrate 2, and concentrating by rotary evaporation to 45 55 ML, yield 0.8 1.2 G/mL of coreopsis tinctoria aqueous extract is filtered and sterilized by a microporous filter membrane with the thickness of 0.22 mu m, and is stored at the temperature of 4 ℃ for standby after split charging.
3. 3. The use according to claim 1, wherein the aqueous extract of coreopsis tinctoria is administered in a dose of 0.25-1 g/kg body weight.
4. 4. A medicament for ameliorating the core symptoms of autism, comprising an aqueous extract of coreopsis tinctoria and pharmaceutically acceptable excipients including, but not limited to, fillers, disintegrants, flavouring agents or preservatives.
5. 5. The medicament of claim 4, wherein the filler includes, but is not limited to, starch and lactose.
6. 6. The medicament according to claim 4, wherein the disintegrant comprises, but is not limited to, sodium carboxymethyl starch.
7. 7. The medicament of claim 4, wherein the flavoring agent includes, but is not limited to, steviol glycosides.
8. 8. The medicament of claim 4, wherein the preservative includes, but is not limited to, sodium benzoate.
9. 9. The medicament according to claim 4, wherein the dosage form of the medicament comprises any one of oral liquid, tablet or capsule.
10. 10. The medicine according to claim 9, wherein when the dosage form is an oral liquid, the preparation method comprises the steps of mixing 45-55 mL of coreopsis tinctoria aqueous extract, 0.08-0.12-g of stevioside and 0.04-0.06-g of sodium benzoate uniformly, adjusting pH to 6.0-7.5, adding water to a volume of 90-110 mL, filtering and sterilizing by a 0.22 μm microporous filter membrane, filling the mixture in a brown oral liquid bottle under aseptic condition, and sterilizing by a damp-heat sterilization method under 115 ℃ and 0.11 MPa conditions for 15 20 Minutes.

Description

Application of coreopsis tinctoria water extract in preparation of medicine for improving autism core symptoms Technical Field The invention belongs to the technical field of biological medicines, and particularly relates to application of coreopsis tinctoria water extract in preparation of a medicine for improving autism core symptoms. Background Autism spectrum disorder (autism) is a complex neuro-developmental disorder with core symptoms including social interaction disorder, repetitive notch behavior and cognitive dysfunction. At present, effective medicines capable of obviously improving the core symptoms of autism are lacking clinically, most of the existing therapeutic medicines are symptomatic treatment, such as antipsychotics for controlling emotion and behavior problems, but obvious side effects are often accompanied, and social and cognitive functions cannot be fundamentally improved. Traditional Chinese medicine has the advantages of multiple targets and overall regulation in the treatment of nervous system diseases, but the research on natural medicines aiming at autism is still less, and candidate medicines with clear pharmacological mechanisms and experimental evidence support are lacked. Therefore, those skilled in the art are eager to develop a drug which can improve the core symptoms of autism at the same time, has little side effect and natural sources, and has important clinical significance and application value for improving the core symptoms of autism. Disclosure of Invention The invention provides application of coreopsis tinctoria water extract in preparation of a medicament for improving coreopsis tinctoria core symptoms, which aims to solve the problems that the prior art lacks medicaments with small side effect and natural sources and is used for improving the coreopsis tinctoria core symptoms. One of the purposes of the invention is to provide an application of coreopsis tinctoria water extract in preparation of a medicine for improving autism core symptoms. In a preferred embodiment of the present invention, the aqueous extract of coreopsis tinctoria is prepared by taking dry coreopsis tinctoria flower bud 4060 G, adding triple distilled water according to the liquid-to-material ratio of (25-35) mL to 1 g, and boiling with slow fire for 15 timesFiltering for 30 min, collecting filtrate 1, adding distilled water according to the liquid-to-material ratio of (15-25) mL:1 g into the filtered residue, boiling for 15Filtering and collecting filtrate 2 for 25 min, mixing filtrate 1 and filtrate 2, and concentrating by rotary evaporation to 4555 ML, yield 0.81.2 G/mL of coreopsis tinctoria aqueous extract is filtered and sterilized by a microporous filter membrane with the thickness of 0.22 mu m, and is stored at the temperature of 4 ℃ for standby after split charging. In a preferred embodiment of the invention, the aqueous extract of coreopsis tinctoria in said application is administered in a dose of 0.25-1 g/kg body weight. It is a second object of the present invention to provide a medicament for ameliorating the core symptoms of autism, the medicament comprising an aqueous extract of coreopsis tinctoria and pharmaceutically acceptable excipients including, but not limited to, fillers, disintegrants, flavoring agents or preservatives. In a preferred embodiment of the invention, the medicament further comprises pharmaceutically acceptable excipients including, but not limited to, fillers, disintegrants, flavouring agents or preservatives. In a preferred embodiment of the present invention, the filler includes, but is not limited to, starch and lactose. In a preferred embodiment of the present invention, the disintegrant includes, but is not limited to sodium carboxymethyl starch. In a preferred embodiment of the present invention, the flavoring agent includes, but is not limited to, steviol glycosides. In a preferred embodiment of the present invention, the preservative includes, but is not limited to, sodium benzoate. In a preferred embodiment of the present invention, the dosage form of the drug includes, but is not limited to, any of oral liquid, tablet or capsule. In a preferred embodiment of the invention, when the dosage form is an oral liquid, the preparation method comprises the steps of mixing 45-55 mL of coreopsis tinctoria aqueous extract, 0.08-0.12-g of stevioside and 0.04-0.06-g of sodium benzoate uniformly, regulating pH to 6.0-7.5, adding water to a volume of 90-110 mL, filtering with a 0.22 μm microporous filter membrane, sterilizing, filling in a brown oral liquid bottle under aseptic condition, sterilizing by a damp-heat sterilization method under 115 ℃ and 0.11 MPa condition for 1520 Minutes. Compared with the prior art, the invention has the beneficial effects that the application of the coreopsis tinctoria water extract in preparing the medicine for improving the core symptoms of autism is provided, the active ingredients of the coreopsis tinctoria water extract