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CN-122005642-A - Epimedium essence and preparation method and application thereof

CN122005642ACN 122005642 ACN122005642 ACN 122005642ACN-122005642-A

Abstract

The invention relates to an epimedium essence and a preparation method and application thereof. The preparation method of the epimedium essence lotion comprises the following steps of S1, taking fresh epimedium stems and leaves, cleaning and draining, S2, placing the clean epimedium stems and leaves into a closed microwave vacuum tank, heating the clean epimedium stems and leaves to 30-60 ℃ under vacuum decompression, decompressing and extracting for 1-4 hours to obtain steam, S3, guiding out and condensing the steam, and collecting condensate to obtain the epimedium essence lotion. According to the preparation method, the microwave vacuum decompression drying technology is adopted, the organic solvent is completely abandoned, the solvent residue risk is avoided, meanwhile, the decompression environment can accelerate the diffusion of intracellular components to the surface of the material, the extraction efficiency is improved, and the prepared epimedium essence has the effects of inhibiting melanin, resisting wrinkle, tightening skin, preserving moisture, controlling oil, relieving itching, removing acnes and the like, and can be effectively applied to medicaments or skin care products for preventing or treating skin problems.

Inventors

  • WANG ZHUOYI
  • WANG YONGPING

Assignees

  • 贵州贵基生物医药有限公司

Dates

Publication Date
20260512
Application Date
20260331

Claims (10)

  1. 1. The preparation method of the epimedium essence lotion is characterized by comprising the following steps of: s1, cleaning and draining fresh epimedium stems and leaves; S2, placing clean epimedium stems and leaves in a closed microwave vacuum tank, carrying out microwave heating to 30-60 ℃ under vacuum decompression, and decompressing and extracting for 1-4 hours to obtain steam; and S3, leading out and condensing steam, and collecting condensate to obtain the epimedium essence.
  2. 2. The preparation method of the epimedium essence lotion according to claim 1, which is characterized in that: In the step S2, the vacuum degree of the microwave vacuum tank body is-0.03 to-0.095 MPa, the microwave heating temperature is 45-55 ℃, and the vacuum extraction is carried out for 2-3 hours.
  3. 3. The method for preparing an Epimedium essence lotion according to claim 1 or 2, characterized in that the Epimedium stem and leaf is one or more selected from Epimedium Epimedium brevicomu Maxim, epimedium sagittatum Epimedium sagittatum (Sieb. Et Zucc.) Maxim, epimedium pubescens Epimedium pubescens Maxim, or Epimedium koreanum Epimedium koreanum Nakai.
  4. 4. An epimedium essence lotion which is characterized by being prepared by adopting the preparation method of any one of claims 1-3.
  5. 5. The icariin essence according to claim 4, which is characterized by comprising one or more of icariin, epimedin A, epimedin B, epimedin C, phenethyl alcohol, phyllitol and 2, 4-di-tert-butylphenol.
  6. 6. The application of the epimedium essence lotion according to claim 4 is characterized in that the epimedium essence lotion is used for preparing medicines and/or skin care products for preventing or treating skin problems, and the addition amount of the epimedium essence lotion is 0.01-100%.
  7. 7. The application of the epimedium essence lotion according to claim 6, which is characterized in that the application of the epimedium essence lotion in preparing a pharmaceutical preparation or a skin care product for inhibiting melanin synthesis.
  8. 8. The application of the epimedium essence lotion according to claim 6, which is characterized in that the application of the epimedium essence lotion in preparing anti-wrinkle and skin tightening pharmaceutical preparations and/or cosmetics.
  9. 9. The application of the epimedium essence lotion according to claim 6 is characterized in that the application of the epimedium essence lotion in preparing a skin moisturizing pharmaceutical preparation or a skin care product.
  10. 10. The application of the epimedium essence lotion according to claim 6, which is characterized in that the application of the epimedium essence lotion in preparing a pharmaceutical preparation or a skin care product for improving or treating oily skin, acne and seborrheic dermatitis.

Description

Epimedium essence and preparation method and application thereof Technical Field The invention relates to the technical field of epimedium extraction, in particular to an epimedium essence lotion and a preparation method and application thereof. Background The herba Epimedii extract is derived from stem and leaf of Epimedium (Epimedium) of Epimedium of berberidaceae Epimedium brevicomu Maxim., epimedium sagittatum Epimedium sagittatum (Sieb. Et Zucc.) Maxim, epimedium lansium Epimedium pubescens Maxim. Or Epimedium koreanum Epimedium koreanum Nakai, and is a plant extract rich in flavonoid active ingredient. The plants are widely distributed in China and mainly produced in Gansu, sichuan, shaanxi and other places, and the medicinal and health care values of the plants are recorded in the traditional classics. According to the records of Chinese pharmacopoeia of 2020 edition, the Chinese herbal medicine has the characteristics of pungent, sweet and warm nature, liver and kidney meridian return, has the effects of tonifying kidney yang, strengthening tendons and bones and dispelling wind-damp, is commonly used for impotence, spermatorrhea, flaccidity of tendons and bones, rheumatalgia and numbness and contracture caused by kidney yang deficiency, is a clinically common traditional Chinese medicine, but has no related application report of barrenwort in preventing or treating skin problems so far. At present, the industrialized preparation of the epimedium extract is still based on a solvent extraction method, and the method relies on the solubility difference of the solvent to the active ingredient to realize separation and extraction, has the advantages of low equipment requirement, mature process, simple and convenient operation and the like, and is a main technical means in the current industry. However, in practical application, the solvent extraction method has the inherent technical shortages due to the links of solvent selection, use, subsequent treatment and the like, and the physical and chemical properties of the solvent are easy to cause degradation of active ingredients, so that the efficacy value of the extract is reduced, which is contrary to the core requirements of various application fields. The flavonoid components (particularly icariin) in the epimedium are sensitive to temperature and solvent environment, the traditional solvent extraction method is often required to be accompanied by reflux heating (the temperature is 60-80 ℃) and the polarity effect of the solvent can accelerate the cleavage of glycosidic bonds of flavonoid glycoside components in a long-time high-temperature environment, so that target components are degraded and converted, the content of active components in the extract can be reduced, the effects of anti-inflammatory, analgesic, kidney tonifying and bone strengthening in the medicine field are weakened, the effects of resisting oxidation and repairing barriers cannot be effectively exerted in cosmetics, unknown degradation products can be generated, and the stability and safety of the product efficacy are influenced. Secondly, the problem of solvent residue directly threatens the safety and applicability of the extract, thereby limiting the landing of the extract in a core application scene. In industrial production, in order to improve the yield of flavonoid components, 30% -70% ethanol aqueous solution is usually selected as an extraction solvent, and organic solvents such as methanol, ethyl acetate and the like are also used in part of the scenes. Although the solvent can improve the dissolution efficiency of the active ingredients, the solvent is difficult to completely remove in the subsequent concentration and dealcoholization processes, and is easy to remain in the extract. For end products such as cosmetics, oral health products and the like, the organic solvent residues can cause skin irritation and anaphylactic reaction, and even have potential endocrine disruption risks. In addition, solvent use also brings about dual pressures of environmental protection and cost control. In industrial production, the solvent extraction method needs to consume a large amount of solvent, wherein the recovery of organic solvents such as ethanol, methanol and the like needs to rely on distillation, rectification and other equipment, the energy consumption is extremely high, a certain amount of solvent loss still occurs in the recovery process, and the raw material cost is increased. Meanwhile, if the residual solvents and impurities in the extracted waste liquid are improperly treated, water and soil pollution can be caused, and additional environmental protection equipment and funds are needed to be put into for wastewater treatment, so that the method meets the national environmental protection emission standard, and further aggravates the production burden of enterprises. If water is used as the solvent, the problems of organic solvent residue and environmental protection