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CN-122005665-A - Traditional Chinese medicine composition for improving sleep quality and preparation method and application thereof

CN122005665ACN 122005665 ACN122005665 ACN 122005665ACN-122005665-A

Abstract

The invention provides a traditional Chinese medicine composition for improving sleep quality, and a preparation method and application thereof, and belongs to the technical field of liquid medicine of heating non-combustion devices. The modified porous silica hollow sphere is prepared from the following raw materials, by weight, 6-12 parts of coptis chinensis, 1-3 parts of cinnamon, 10-20 parts of fried spina date seeds, 5-10 parts of beta-cyclodextrin, 5-7 parts of modified porous silica hollow spheres, 3-5 parts of n-behenate, 0.5-1 part of borneol, 0.5-1 part of menthol, 3-5 parts of lecithin, 1-3 parts of essence, 75-85 parts of an atomizing agent and 2-3 parts of a sweetener, wherein the modified porous silica hollow spheres are porous silica hollow spheres with amino groups on the surfaces. The invention solves the defects of large quantity, bitter taste and instability through the modern preparation technology, and the prepared ancient classical Chinese herbal compound preparation has better storability, can realize controlled release, has good drug effect, has fall asleep quick and refreshing body feeling, and improves the compliance of patients.

Inventors

  • FAN XINRONG
  • YANG XUAN
  • LI XIANGYU
  • Ran Qingzhi

Assignees

  • 中国中医科学院医学实验中心

Dates

Publication Date
20260512
Application Date
20260306

Claims (10)

  1. 1. A traditional Chinese medicine composition for improving sleep quality is characterized by comprising, by weight, 6-12 parts of coptis chinensis, 1-3 parts of cinnamon, 10-20 parts of fried spina date seeds, 5-10 parts of beta-cyclodextrin, 5-7 parts of modified porous silica hollow spheres, 3-5 parts of n-behenane, 0.5-1 part of borneol, 0.5-1 part of menthol, 3-5 parts of lecithin, 1-3 parts of essence, 75-85 parts of an atomizing agent and 2-3 parts of a sweetener, wherein the modified porous silica hollow spheres are porous silica hollow spheres with amino groups on the surfaces.
  2. 2. A method for preparing the traditional Chinese medicine composition for improving sleep quality according to claim 1, comprising the following steps: S1, extracting cinnamon by supercritical fluid to obtain volatile oil, and collecting residues; s2, mixing the residues, coptis chinensis and fried spina date seeds, adding the mixture into deuterium-depleted water, heating and reflux-extracting, adding ethanol for precipitation to remove polysaccharide, filtering, removing protein from filtrate, and drying to obtain a water-soluble extract; S3, adding beta-cyclodextrin into water, adding the volatile oil into ethanol, mixing the two solutions, heating and stirring, filtering, washing and drying to obtain a volatile oil clathrate; S4, dissolving an emulsifying agent and a pore-forming agent in water to obtain a water phase, mixing and dissolving alkyl orthosilicate and an aminosilane coupling agent in an organic solvent to obtain an oil phase, mixing the water phase and the oil phase, emulsifying, adjusting the pH value, stirring for reaction, centrifuging and drying to obtain modified porous silica hollow spheres; S5, mixing the modified porous silica hollow sphere, the volatile oil inclusion compound and the water-soluble extract, adding into water, stirring, filtering, washing, drying, adding n-docosane, heating, stirring, mixing, cooling and grinding to obtain the medicine-carrying porous silica sphere; S6, dissolving borneol and menthol in ethanol, volatilizing, and filtering to obtain eutectic; S7, uniformly mixing the medicine-carrying porous silica spheres, eutectic crystals, lecithin, essence, an atomizing agent and a sweetener to obtain the traditional Chinese medicine composition for improving sleep quality.
  3. 3. The process according to claim 2, wherein the supercritical fluid extraction in step S1 is performed under conditions of 20-22MPa, 30-40deg.C, and 15-25L/h CO 2 flow rate.
  4. 4. The preparation method according to claim 2, wherein the solid-to-liquid ratio of the slag and the deuterium depleted water in step S2 is 1:5-10g/mL, the heating reflux extraction time is 3-5h, and the concentration of the deuterium depleted water is 50-100mg/kg.
  5. 5. The method according to claim 2, wherein the temperature of the heating and stirring treatment in step S3 is 35 to 45 ℃ for 1 to 3 hours.
  6. 6. The preparation method according to claim 2, wherein the emulsifier in the step S4 is at least one selected from tween 20, tween 40, tween 60, tween 80 and tween 85, the porogen is at least one selected from ethylene oxide-propylene oxide triblock copolymer PEO20-PPO70-PEO20 and ethylene oxide-propylene oxide triblock copolymer PEO106-PPO70-PEO106, the alkyl orthosilicate is methyl orthosilicate or ethyl orthosilicate, and the aminosilane coupling agent is KH550.
  7. 7. The preparation method according to claim 2, wherein in the step S4, the mass ratio of the emulsifier, the pore-forming agent, the alkyl orthosilicate and the aminosilane coupling agent is 1-2:0.1-0.3:5-8:1-2, the emulsifying speed is 5000-8000r/min, the time is 10-20min, the pH is adjusted to 10-11, and the stirring reaction time is 8-12h.
  8. 8. The method according to claim 2, wherein the temperature of the heating and stirring mixture in step S5 is 50 to 60 ℃, and the cooling is performed to a temperature of 4 to 6 ℃.
  9. 9. The method according to claim 2, wherein the atomizing agent in step S7 is a mixture of water and propylene glycol in a volume ratio of 1:8-10, and the sweetener is sucralose or erythritol.
  10. 10. Use of the Chinese medicinal composition for improving sleep quality according to claim 1 for preparing a heated non-combustible liquid medicine for treating insomnia and improving sleep quality.

Description

Traditional Chinese medicine composition for improving sleep quality and preparation method and application thereof Technical Field The invention relates to the technical field of traditional Chinese medicines, in particular to a traditional Chinese medicine composition for improving sleep quality, and a preparation method and application thereof. Background Is the life phenomenon of wakefulness and sleep. The insomnia is one of the common clinical diseases, including insomnia, somnolence, sleepiness, etc. Can be either symptoms but also diseases. The "Huangdi's interior channel" includes the expressions of "not sleeping", "not eye not sleeping", "lying restlessness", "sleeping well", "lying more", "but less" and so on. Modern medicine is known as "sleep disorder". The understanding of the physiological mechanism of the insomnia from the yellow emperor's inner channel has formed a systematic theory and explains the etiology and pathogenesis of the insomnia from multiple aspects, and the theory has important guiding effects on the treatment of insomnia, somnolence and other diseases and daily health care. With the rapid and rapid pace of modern life, competition is more and more intense, and insomnia is a common disorder. Mainly manifested by difficulty in falling asleep, reduced sleep quality, reduced memory function, reduced attention, reduced work capacity, etc. Severely affecting the quality of life of people. At present, most of the medicaments for treating insomnia are tranquilization hypnotic. Especially, some old people are very easy to generate insomnia, but most of the existing medical means adopt western medicines, and although the insomnia can be relieved, some western medicines have a plurality of toxic and side effects, after stopping taking medicines, the insomnia is easy to relapse, and the old people have weak immunity, so that the memory and the immunity can be further reduced when the western medicines are taken. Although the traditional Chinese medicine decoction plays an important role in the traditional Chinese medicine treatment, the traditional Chinese medicine decoction does have a defect in practical application. For example, the dosage is large, the administration is inconvenient, the effective components of certain medicines are not easy to decoct or volatile and volatile, the storage and the carrying are difficult, the effective components are lower, the preparation is not easy, the further popularization and the application are inconvenient, and the like. These deficiencies may affect patient compliance and therapeutic effects, so in modern medical practice, how to improve the preparation and administration modes of traditional Chinese medicine decoction, and how to better retain and exert the traditional advantages of the traditional Chinese medicine decoction, and how to prepare a class of innovative traditional Chinese medicine is an important subject faced by traditional Chinese medicine development. The traditional sedative hypnotic is a drug for inhibiting the central nervous system, has practical value in relieving the stress, anxiety and insomnia symptoms, anticonvulsant, antiepileptic and the like of patients, but the drugs such as zolpidem tartrate, eszolam, triazolam, zopiclone and the like have almost different degrees of harm after long-term administration. Disclosure of Invention The invention aims to provide a traditional Chinese medicine composition for improving sleep quality, a preparation method and application thereof, and the defects of large quantity, bitter taste and instability are overcome by a modern preparation technology, so that the traditional Chinese medicine compound preparation with an ancient classical prescription is prepared, has good storability, can realize controlled release, has good drug effect, has a quick fall asleep and refreshing body feeling, improves patient compliance, and is safe and free of side effects. The technical scheme of the invention is realized as follows: The invention provides a traditional Chinese medicine composition for improving sleep quality, which comprises, by weight, 6-12 parts of coptis chinensis, 1-3 parts of cinnamon, 10-20 parts of fried spina date seed, 5-10 parts of beta-cyclodextrin, 5-7 parts of modified porous silica hollow spheres, 3-5 parts of n-behenane, 0.5-1 part of borneol, 0.5-1 part of menthol, 3-5 parts of lecithin, 1-3 parts of essence, 75-85 parts of an atomizing agent and 2-3 parts of a sweetener, wherein the modified porous silica hollow spheres are porous silica hollow spheres with amino groups on the surfaces. The invention further provides a preparation method of the traditional Chinese medicine composition for improving sleep quality, which comprises the following steps: S1, extracting cinnamon by supercritical fluid to obtain volatile oil, and collecting residues; s2, mixing the residues, coptis chinensis and fried spina date seeds, adding the mixture into deuterium-depleted water, he