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CN-122005668-A - Rose essential oil microencapsulation composition for improving sleep and preparation method and application thereof

CN122005668ACN 122005668 ACN122005668 ACN 122005668ACN-122005668-A

Abstract

The invention discloses a rose essential oil microencapsulation composition for improving sleep, and a preparation method and application thereof, and belongs to the technical field of medicinal preparations, wherein the composition comprises, by weight, 10-15 parts of rose essential oil, 2-6 parts of peony seed oil, 12-20 parts of octenyl succinic dextrin, 1-5 parts of freshly squeezed olive oil, 0.3-1 part of acer truncatum seed oil, 8-15 parts of beta-cyclodextrin, 1-5 parts of sodium ascorbate, 0.5-1 part of sleep-aiding raw material, 5-15 parts of acacia and 100-150 parts of water; compared with the prior art, the invention effectively solves the problems of easy volatilization and instability of the rose essential oil and low bioavailability of various active ingredients, realizes the targeted efficient release of the active ingredients in intestinal tracts, remarkably improves the effect of improving sleep, has high product safety and can be applied to preparing medicines for improving sleep.

Inventors

  • LIU YI
  • LIU QING

Assignees

  • 云心荟聚科技发展(成都)有限责任公司

Dates

Publication Date
20260512
Application Date
20260407

Claims (10)

  1. 1. The rose essential oil microencapsulation composition for improving sleep is characterized by comprising the following components in parts by weight: 10-15 parts of rose essential oil, 2-6 parts of peony seed oil, 12-20 parts of octenyl succinic dextrin, 1-5 parts of freshly squeezed olive oil, 0.3-1 part of acer truncatum seed oil, 8-15 parts of beta-cyclodextrin, 1-5 parts of sodium ascorbate, 0.5-1 part of sleep-aiding raw material, 5-15 parts of Arabic gum and 100-150 parts of water; the sleep-aiding raw material consists of valerian extract and hop extract according to the mass ratio of 2-4:1-3.
  2. 2. A method of preparing the sleep-improving rose essential oil microencapsulation composition of claim 1, comprising the steps of: step 1, adding rose essential oil and peony seed oil into a closed container, and stirring in a constant-temperature water bath environment to obtain an oil phase mixed solution; Step 2, adding octenyl succinic acid dextrin, freshly squeezed olive oil, acer truncatum seed oil, beta-cyclodextrin and sodium ascorbate into water, heating and stirring, and then adding sleep-aiding raw materials and continuously stirring for 5-15 minutes to obtain a water phase mixture; Step 3, shearing at a high speed, slowly pumping the water phase mixture into the oil phase mixture at a speed of 1-1.5mL/s, emulsifying, adding Arabic gum, reducing the rotating speed to 100-150r/min, and continuously stirring until the Arabic gum is completely dissolved to form rose essential oil composite emulsion; And 4, homogenizing the rose essential oil composite emulsion under high pressure, spray-drying the homogenized emulsion, and collecting the dried product to obtain the rose essential oil microencapsulated composition for improving sleep.
  3. 3. A method of preparing the sleep-improving rose essential oil microencapsulation composition of claim 1, comprising the steps of: Step 1, adding rose essential oil, peony seed oil and sleep-aiding raw materials into a closed container, and placing the closed container in a constant-temperature water bath environment for stirring to obtain an oil phase mixed solution; Step 2, adding octenyl succinic acid dextrin, freshly squeezed olive oil, acer truncatum seed oil, beta-cyclodextrin and sodium ascorbate into water, heating and stirring, and then continuing stirring for 5-15 minutes to obtain a water phase mixture; Step 3, shearing at a high speed, slowly pumping the water phase mixture into the oil phase mixture at a speed of 1-1.5mL/s, emulsifying, adding Arabic gum, reducing the rotating speed to 100-150r/min, and continuously stirring until the Arabic gum is completely dissolved to form rose essential oil composite emulsion; And 4, homogenizing the rose essential oil composite emulsion under high pressure, spray-drying the homogenized emulsion, and collecting the dried product to obtain the rose essential oil microencapsulated composition for improving sleep.
  4. 4. A method of preparing the sleep-improving rose essential oil microencapsulation composition of claim 1, comprising the steps of: Step 1, adding rose essential oil, peony seed oil, sleep-aiding raw materials and beta-cyclodextrin into a closed container, and stirring in a constant-temperature water bath environment to obtain an oil phase mixed solution; step 2, adding octenyl succinic acid dextrin, freshly squeezed olive oil, acer truncatum seed oil and sodium ascorbate into water, heating and stirring, and then continuing stirring for 5-15 minutes to obtain a water phase mixture; Step 3, shearing at a high speed, slowly pumping the water phase mixture into the oil phase mixture at a speed of 1-1.5mL/s, emulsifying, adding Arabic gum, reducing the rotating speed to 100-150r/min, and continuously stirring until the Arabic gum is completely dissolved to form rose essential oil composite emulsion; And 4, homogenizing the rose essential oil composite emulsion under high pressure, spray-drying the homogenized emulsion, and collecting the dried product to obtain the rose essential oil microencapsulated composition for improving sleep.
  5. 5. The method according to any one of claims 2 to 4, wherein the stirring in the constant temperature water bath environment in the step 1 is carried out in a constant temperature water bath environment of 40 to 60 ℃ and stirring and mixing are carried out for 10 to 20 minutes at a rotating speed of 80 to 150 r/min.
  6. 6. The method according to any one of claims 2 to 4, wherein the heating and stirring in the step 2 is performed at a speed of 100 to 400r/min for 20 to 60 minutes after the temperature is raised to 50 to 70 ℃.
  7. 7. The method according to any one of claims 2 to 4, wherein the high shear in step 3 has a rotation speed of 6000 to 8000r/min and an emulsification time of 2 to 8 minutes.
  8. 8. The method according to any one of claims 2 to 4, wherein the high-pressure homogenization in step 4 is performed at a pressure of 40 to 60MPa for 1 to 3 cycles of homogenization treatment.
  9. 9. The method according to any one of claims 2 to 4, wherein the spray drying in the step 4 is performed at an inlet air temperature of 160 to 175 ℃ and an outlet air temperature of 70 to 85 ℃, and the feeding flow rate is controlled to be 5 to 10mL/min.
  10. 10. Use of a rose essential oil microencapsulated composition for improving sleep as claimed in claim 1 in the preparation of a medicament for improving sleep.

Description

Rose essential oil microencapsulation composition for improving sleep and preparation method and application thereof Technical Field The invention relates to the technical field of medicinal preparations, in particular to a rose essential oil microencapsulation composition for improving sleep, and a preparation method and application thereof. Background As a natural active ingredient, the rose essential oil is rich in various functional substances such as alcohols, esters and the like, and has unique value in the field of emotion relief and sleep improvement, and related researches and applications are continuously expanded in recent years. However, the rose essential oil has the advantages of volatile components, poor thermal stability, obvious activity loss in the processing and storage processes, and low bioavailability when being directly taken, and the problems greatly limit the large-scale application of the rose essential oil in sleep-aiding products. The microencapsulation technology provides an effective way for solving the stability problem of essential oil components, and the core material is embedded by selecting a proper wall material, so that the loss of the active components can be obviously reduced, and the slow release and the controlled release of the active substances can be realized. At present, various microencapsulated compositions aiming at essential oils are developed, and relate to various fields of foods, health care products and the like, but most researches focus on embedding of single essential oil, and research on synergistic embedding and efficacy enhancement of essential oil and other sleep-aiding active ingredients is still lacking. The prior art has obvious limitations despite relevant research. The patent of publication No. CN113730299A proposes a preparation process of essential oil microcapsules, which can realize directional slow release of active ingredients, but does not optimize the formula aiming at the sleep-aiding effect, and the sleep-aiding effect of single essential oil is limited. The patent of publication No. CN115812939A discloses a zanthoxylum oil microcapsule, which is used for improving the high temperature resistance and storage stability of essential oil, but does not relate to the compounding of active ingredients related to sleep assistance. Although publication No. CN115428930A mentions the use of sleep-aiding plant extracts, the problem of ingredient stability and release efficiency is not solved by combining microencapsulation technology. In a comprehensive view, the prior art only focuses on the improvement of the stability of essential oil or only focuses on the application of a single sleep-aiding raw material, and the precise compounding and collaborative embedding of the rose essential oil and various sleep-aiding raw materials are not realized yet. Meanwhile, the existing microencapsulation process often has the problems of insufficient embedding efficiency, mismatching of active ingredient release with human sleep regulation law and the like, and the synergistic effect of the rose essential oil and the sleep-aiding raw material is difficult to fully develop. Therefore, the development of the microencapsulated composition capable of simultaneously solving the problems of poor stability of rose essential oil, weak cooperativity of sleep-aiding components, low accuracy of active release and the like becomes a technical direction to be broken through in the field of current sleep-aiding functional products. Disclosure of Invention Aiming at the defects of the prior art, the invention aims to provide a rose essential oil microencapsulation composition for improving sleep, and a preparation method and application thereof. In order to achieve the above object, the present invention adopts the following technical scheme: A rose essential oil microencapsulation composition for improving sleep comprises the following components in parts by weight: 10-15 parts of rose essential oil, 2-6 parts of peony seed oil, 12-20 parts of octenyl succinic dextrin, 1-5 parts of freshly squeezed olive oil, 0.3-1 part of acer truncatum seed oil, 8-15 parts of beta-cyclodextrin, 1-5 parts of sodium ascorbate, 0.5-1 part of sleep-aiding raw material, 5-15 parts of Arabic gum and 100-150 parts of water. The sleep-aiding raw material is at least one of a wild jujube seed extract, a longan pulp extract, a medlar polysaccharide, a rosemary extract, gamma-aminobutyric acid, a valerian extract, a pachyman extract, a blueberry extract and a hop extract. Preferably, the sleep-aiding raw material is composed of valerian extract and hop extract according to the mass ratio of 2-4:1-3. The preparation method of the rose essential oil microencapsulation composition for improving sleep comprises the following steps: step 1, adding rose essential oil and peony seed oil into a closed container, and stirring in a constant-temperature water bath environment to obtain an oil phase mixed s