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CN-122005669-A - Composition for improving myocardial cell function and application thereof

CN122005669ACN 122005669 ACN122005669 ACN 122005669ACN-122005669-A

Abstract

The invention discloses a composition for improving myocardial cell function and application thereof. The composition comprises procyanidine, inulin, radix astragali extract, and seville orange flower extract. The invention belongs to the technical field of medical health care, and the components in the composition have a synergistic interaction effect, can comprehensively play an antioxidant role, improve intestinal functions, strengthen the treatment effect on constipation, obviously reduce myocardial infarction area, comprehensively improve myocardial cell functions from multiple aspects of 'qi-blood double-tonifying', oxygen free radical inhibition, constipation improvement and the like, and can be applied to preparing medicaments for preventing or treating cardiovascular diseases such as myocardial infarction and the like.

Inventors

  • SUN XIAOOU
  • ZHANG HAO
  • Ke Qingjin

Assignees

  • 广东工业大学

Dates

Publication Date
20260512
Application Date
20250515

Claims (9)

  1. 1. A composition for improving myocardial cell function is characterized by comprising, by weight, 6-20 parts of procyanidine, 5-15 parts of inulin, 3-10 parts of astragalus extract and 3-10 parts of seville orange flower extract.
  2. 2. The composition for improving myocardial cell function according to claim 1, wherein the composition comprises, by weight, 12 parts of procyanidine, 10 parts of inulin, 6 parts of astragalus extract, and 8 parts of seville orange flower extract.
  3. 3. A composition for improving myocardial cell function as claimed in claim 1 or 2, wherein the preparation method of the astragalus extract comprises the following steps: S1, crushing astragalus mongholicus; s2, adding 10-15 times of water into the crushed astragalus raw material in the step S1 to decoct for 1-2 times, and filtering to obtain filtrate and filter residues; S3, adding water with the mass 2-4 times of that of the filter residue into the filter residue obtained in the step S2, sterilizing, and adding activated lactobacillus plantarum liquid with the mass 0.1-0.3% of that of the filter residue for fermentation; And S4, combining the filtrate in the step S2 and the fermentation broth in the step S3, centrifuging, taking supernatant, concentrating under reduced pressure to obtain thick paste with the relative density of 1.1-1.3, drying the thick paste under reduced pressure, crushing and sieving to obtain the astragalus extract.
  4. 4. A composition for improving myocardial cell function according to claim 1 or 2, wherein the preparation method of the seville orange flower extract comprises the steps of: S1, crushing the substituted flowers; s2, adding 10-15 times of water into the crushed substituted flower raw material in the step S1, decocting for 1-2 times, and filtering to obtain filtrate and filter residue; S3, adding water with the mass 2-4 times of that of the filter residue into the filter residue obtained in the step S2, sterilizing, and adding activated lactobacillus plantarum liquid with the mass 0.1-0.3% of that of the filter residue for fermentation; And S4, combining the filtrate in the step S2 and the fermentation broth in the step S3, centrifuging, taking supernatant, concentrating under reduced pressure to obtain thick paste with the relative density of 1.1-1.3, drying the thick paste under reduced pressure, crushing and sieving to obtain the seville orange flower extract.
  5. 5. A composition for improving myocardial cell function according to claim 1 or 2, wherein the procyanidins are one or both of apple procyanidins and grape seed procyanidins.
  6. 6. A composition for improving myocardial cell function according to claim 3 or 4, wherein the lactobacillus plantarum liquid has a fermentation time of 48-72 hours and a fermentation temperature of 30-37 ℃.
  7. 7. An oral formulation comprising the composition of any one of claims 1-6, wherein the oral formulation comprises any one of a powder, a tablet, a granule, a capsule, a solution, an emulsion, and a suspension.
  8. 8. Use of a composition according to any one of claims 1-6 or a formulation according to claim 7 in the manufacture of a medicament for the prevention or treatment of myocardial damage.
  9. 9. The use according to claim 8, wherein the myocardial injury is myocardial infarction.

Description

Composition for improving myocardial cell function and application thereof Technical Field The invention relates to the technical field of medical health care, in particular to a composition for improving myocardial cell function and application thereof. Background Myocardial preservation is one of the important technologies for cardiovascular therapy. Myocardial ischemia is a pathological condition in which the heart is not able to support its normal functioning due to reduced blood perfusion, resulting in reduced oxygenation of the heart, abnormal energy metabolism of the heart. The clinical manifestations of ischemic heart disease are myocardial ischemic symptoms such as angina pectoris and myocardial infarction. Oxygen radicals generated during myocardial ischemia reperfusion are one of the important causes of myocardial cell injury and apoptosis. Oxygen radicals have extremely strong oxidizing properties and can damage myocardial cells through a variety of mechanisms including lipid peroxidation, protein oxidation, DNA damage, mitochondrial dysfunction, and the like. These mechanisms interact, together resulting in the occurrence and progression of myocardial ischemia and reperfusion injury. For patients suffering from myocardial ischemia, traditional Chinese medicine treatment is often focused on activating blood circulation to dissipate blood stasis, supplementing qi and nourishing blood. Meanwhile, myocardial cell membranes, proteins and DNA can be protected through antioxidation, and normal functions of cells can be maintained. In addition, clinical statistics show that the incidence rate of constipation of patients with acute myocardial infarction is up to 40% -60%, the incidence rate of acute heart failure of the patients is increased by forceful defecation, sudden death is even caused by serious patients, and the patients have great influence on life quality and great pain on body and mind. Therefore, how to effectively prevent and treat constipation of patients with myocardial infarction is also one of the key contents for protecting the cardiac muscle. Disclosure of Invention Aiming at the defects of the prior art, the invention provides a composition for improving the myocardial cell function and application thereof, so as to comprehensively improve the myocardial cell function from multiple aspects of 'qi-blood double-supplement', oxygen free radical inhibition, constipation improvement and the like. In order to achieve the purpose of the invention, the invention is realized by the following technical scheme: A composition for improving myocardial cell function comprises, by weight, 6-20 parts of procyanidine, 5-15 parts of inulin, 3-10 parts of astragalus extract and 3-10 parts of seville orange flower extract. Further, the composition for improving the myocardial cell function comprises 12 parts of procyanidine, 10 parts of inulin, 6 parts of astragalus extract and 8 parts of seville orange flower extract in parts by weight. Further, the preparation method of the astragalus extract comprises the following steps: S1, crushing astragalus mongholicus; s2, adding 10-15 times of water into the crushed astragalus raw material in the step S1 to decoct for 1-2 times, and filtering to obtain filtrate and filter residues; S3, adding water with the mass 2-4 times of that of the filter residue into the filter residue obtained in the step S2, sterilizing, and adding activated lactobacillus plantarum liquid with the mass 0.1-0.3% of that of the filter residue for fermentation; And S4, combining the filtrate in the step S2 and the fermentation broth in the step S3, centrifuging, taking supernatant, concentrating under reduced pressure to obtain thick paste with the relative density of 1.1-1.3, drying the thick paste under reduced pressure, crushing and sieving to obtain the astragalus extract. The preparation method of the substituted flower extract comprises the following steps: S1, crushing the substituted flowers; s2, adding 10-15 times of water into the crushed substituted flower raw material in the step S1, decocting for 1-2 times, and filtering to obtain filtrate and filter residue; S3, adding water with the mass 2-4 times of that of the filter residue into the filter residue obtained in the step S2, sterilizing, and adding activated lactobacillus plantarum liquid with the mass 0.1-0.3% of that of the filter residue for fermentation; And S4, combining the filtrate in the step S2 and the fermentation broth in the step S3, centrifuging, taking supernatant, concentrating under reduced pressure to obtain thick paste with the relative density of 1.1-1.3, drying the thick paste under reduced pressure, crushing and sieving to obtain the seville orange flower extract. Further, the procyanidine is preferably one or two of apple procyanidine and grape seed procyanidine. Further, the fermentation time of the lactobacillus plantarum liquid is 48-72h, and the fermentation temperature is 30-37 ℃. Further, the in