CN-122005671-A - Traditional Chinese medicine composition for preventing and treating pathogenic escherichia coli of birds as well as preparation method and application thereof

Abstract

The invention discloses a traditional Chinese medicine composition for preventing and treating pathogenic escherichia coli of birds, and a preparation method and application thereof, and relates to the technical field of veterinary medicines. The invention screens through subtractive genomics and reverse network pharmacology, and forms a traditional Chinese medicine composition for preventing and treating pathogenic escherichia coli of birds, namely the zhiqiao sausage Kang Fang, based on the compatibility theory of monarch, minister, assistant and guide and the dialectical theory of Chinese veterinarian pharmacy. The traditional Chinese medicine composition takes fructus forsythiae and radix angelicae as principal drugs, takes radix isatidis and clinopodium polycephalum as ministerial drugs, takes immature bitter orange, peppermint and plantain herb as adjuvant drugs, and takes liquorice as conductant drugs, so that the traditional Chinese medicine composition can inhibit the reproduction of pathogenic escherichia coli of birds and destroy the formation of biological membranes of pathogenic escherichia coli of birds, lighten the pathological damage of sick birds caused by APEC and has good treatment effect on the pathogenic escherichia coli of birds.

Inventors

• Zheng Pimiao
• WANG JUAN
• Qiu Zengwen
• LIU YONGXIA
• Chai Qinli
• Huo Wenxia
• DING LUYAO
• LIU YANG
• CAO SHUO
• WANG WENCHEN
• SHAN SHIJING
• ZHAO XIAONA
• LIU JIANZHU
• LUO HUIJIE
• BIAN YINGJIE

Assignees

• 山东农业大学

Dates

Publication Date

20260512

Application Date

20260304

Claims (9)

1. 1. The traditional Chinese medicine composition for preventing and treating the pathogenic escherichia coli of the poultry is characterized by comprising the following components in parts by mass: 7-9 parts of fructus forsythiae, 7-9 parts of radix angelicae, 0.8-1.2 parts of radix isatidis, 7-7.5 parts of clinopodium polycephalum, 0.8-1.2 parts of immature bitter orange, 3-3.5 parts of peppermint, 7-9 parts of plantain herb and 7-9 parts of liquorice.
2. 2. The traditional Chinese medicine composition for preventing and treating pathogenic escherichia coli of poultry according to claim 1, wherein the traditional Chinese medicine composition is prepared from the following components: 8 parts of fructus forsythiae, 8 parts of radix angelicae, 1 part of radix isatidis, 7.15 parts of clinopodium polycephalum, 1 part of immature bitter orange, 3.26 parts of peppermint, 8 parts of plantain herb and 8 parts of liquorice.
3. 3. The method for preparing the traditional Chinese medicine composition according to claim 1 or 2, which is characterized by comprising the following steps: mixing fructus forsythiae, radix Angelicae Dahuricae, radix Isatidis, herba Clinopodii, fructus Aurantii Immaturus, herba Menthae, herba plantaginis and Glycyrrhrizae radix to obtain a mixture, soaking in water, decocting with slow fire twice, filtering after each decoction, collecting water decoction, mixing the two water decoctions, concentrating to obtain medicinal liquid with concentration of 0.5-1.5g/mL, and making into Chinese medicinal composition for preventing and treating fowl pathogenic Escherichia coli.
4. 4. The method for preparing the Chinese medicinal composition according to claim 3, wherein the mass ratio of the mixture to water is 1g (8-12) mL, the soaking time is 20-30h, and the decocting time is 50-70min each time.
5. 5. Use of a traditional Chinese medicine composition according to claim 1 or 2 for the preparation of a product for the treatment of avian pathogenic escherichia coli.
6. 6. A product for the treatment of avian pathogenic escherichia coli, characterized in that it comprises the traditional Chinese medicine composition for the control of avian pathogenic escherichia coli according to claim 1 or 2.
7. 7. The product for treating avian pathogenic escherichia coli of claim 6, further comprising a pharmaceutically acceptable adjuvant.
8. 8. The product for treating avian pathogenic escherichia coli of claim 7, wherein the pharmaceutically acceptable excipients comprise a disintegrant, a lubricant, a sweetener, or a binder.
9. 9. The product for treating avian pathogenic escherichia coli according to claim 6, wherein the formulation of the product for treating avian pathogenic escherichia coli is decoction, soluble powder or injection.

Description

Traditional Chinese medicine composition for preventing and treating pathogenic escherichia coli of birds as well as preparation method and application thereof Technical Field The invention relates to the technical field of poultry medicines, in particular to a traditional Chinese medicine composition for preventing and treating pathogenic escherichia coli of poultry, and a preparation method and application thereof. Background Avian pathogenic escherichia coli (Avian pathogenic Escherichia coli, APEC), which is one of the parenteral pathogenic escherichia coli (ExPEC), can cause local or systemic infection of poultry such as broiler chickens, turkeys, quails, pigeons, waterfowl and the like, and is mainly manifested by acute sepsis, perihepatic inflammation, pericarditis, air sac inflammation and the like. This not only affects the health of the birds and the production of the birds, but also brings great economic losses to the farmers. Poultry farming plays an irreplaceable role in guaranteeing the supply of animal-derived foods such as meats, eggs and the like and promoting rural economic development as an important prop industry in the 21 st century agricultural development, however, diseases caused by pathogenic escherichia coli of poultry seriously jeopardize the development of the poultry farming industry, and even possibly spread dangers to human beings through a food chain. Since the feed end in 2020 completely prohibits the addition of antibiotics, the breeding industry faces diseases such as peritonitis, perihepatic inflammation, air sac inflammation and the like caused by APEC to prevent and control pressure surge. Searching for an alternative scheme which is safe, efficient, low in residue and not easy to induce drug resistance becomes a core problem for guaranteeing the health of poultry and the sustainable development of the breeding industry. The traditional Chinese medicine is taken as a unique medicine resource and cultural treasure in China, has the unique advantages of complex components, multiple action mechanisms, difficult generation of drug resistance, small toxic and side effects and the like, is regarded as one of the most potential 'alternate' resources, and is gradually paid attention to application in preventing and treating poultry diseases. Therefore, the traditional Chinese medicine composition is used for preventing and treating pathogenic escherichia coli of poultry, and has important theoretical value and practical significance for promoting green and healthy development of poultry farming industry. Disclosure of Invention Aiming at the prior art, the invention aims to provide a traditional Chinese medicine composition for preventing and treating pathogenic escherichia coli of poultry, and a preparation method and application thereof. After screening through subtractive genomics and reverse network pharmacology, the invention forms the traditional Chinese medicine composition for preventing and treating the pathogenic escherichia coli of the poultry based on the compatibility theory of monarch, minister, assistant and guide and the dialectical theory of Chinese veterinarian pharmacy. The traditional Chinese medicine composition takes fructus forsythiae and radix angelicae as principal drugs, takes radix isatidis and clinopodium polycephalum as ministerial drugs, takes immature bitter orange, peppermint and plantain herb as adjuvant drugs, and takes liquorice as conductant drugs, so that the traditional Chinese medicine composition can inhibit the reproduction of pathogenic escherichia coli of birds and destroy the formation of biological membranes of pathogenic escherichia coli of birds, lighten the pathological damage of sick birds caused by APEC and has good treatment effect on the pathogenic escherichia coli of birds. In order to achieve the above purpose, the invention adopts the following technical scheme: The invention provides a traditional Chinese medicine composition for preventing and treating pathogenic escherichia coli of birds, which comprises the following components in parts by mass: 7-9 parts of fructus forsythiae, 7-9 parts of radix angelicae, 0.8-1.2 parts of radix isatidis, 7-7.5 parts of clinopodium polycephalum, 0.8-1.2 parts of immature bitter orange, 3-3.5 parts of peppermint, 7-9 parts of plantain herb and 7-9 parts of liquorice. Preferably, the traditional Chinese medicine composition is prepared from the following components: 8 parts of fructus forsythiae, 8 parts of radix angelicae, 1 part of radix isatidis, 7.15 parts of clinopodium polycephalum, 1 part of immature bitter orange, 3.26 parts of peppermint, 8 parts of plantain herb and 8 parts of liquorice. In a second aspect, the invention provides a preparation method of the traditional Chinese medicine composition for preventing and treating pathogenic escherichia coli of poultry, which comprises the following steps: Mixing fructus forsythiae, radix Angelicae Dahuricae, radix Isatidis, herba Cl