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CN-122005680-A - A composition for improving gingivitis, its preparation method, and oral liquid

CN122005680ACN 122005680 ACN122005680 ACN 122005680ACN-122005680-A

Abstract

The invention relates to a composition for improving gingivitis, a preparation method thereof and mouth rinse, and relates to the technical field of gingivitis, wherein the composition for improving gingivitis comprises, by weight, 20-40 parts of shinyleaf yellowhorn leaves, 5-15 parts of peach gum and 10-25 parts of hops. The invention uses the shinyleaf yellowhorn leaf, peach gum and hop which are used as both medicine and food as the efficacy raw materials, and combines the modern supercritical carbon dioxide extraction technology under proper parameters to extract the effective components, thereby not only remarkably improving the treatment effect of the obtained composition on gingivitis diseases, but also greatly improving the use safety of patients. Based on the characteristics, the invention also provides the deep-fried mouth rinse capable of improving oral diseases such as gingivitis, and the like, and the deep-fried mouth rinse has the characteristics of safety, effectiveness and the like, and has wide application prospect.

Inventors

  • ZHENG YING
  • ZENG YUNING
  • WU ZHIXIN
  • TANG SIMING

Assignees

  • 南昌大学附属口腔医院(江西省口腔医院)

Dates

Publication Date
20260512
Application Date
20260310

Claims (10)

  1. 1. A gingivitis-improving composition, which is characterized by comprising the following components in parts by weight: 20-40 parts of shinyleaf yellowhorn leaves, 5-15 parts of peach gum and 10-25 parts of hops.
  2. 2. The gingivitis-improving composition according to claim 1, wherein the ratio of parts by weight M1 of the shinyleaf yellowhorn leaf to the total parts by weight M2 of both the peach gum and the hops is M1/M2 of 1.
  3. 3. The gingivitis-ameliorating composition according to claim 1, wherein the gingivitis-ameliorating composition comprises the following components in parts by weight: 30 parts of shinyleaf yellowhorn leaf, 10 parts of peach gum and 20 parts of hop.
  4. 4. A method for preparing the gingivitis-improving composition according to any one of claims 1 to 3, comprising the steps of: Crushing and mixing shinyleaf yellowhorn leaves, peach gum and hops to obtain a mixture; And (3) extracting the mixture by supercritical carbon dioxide to obtain the gingivitis-improving composition.
  5. 5. The method for preparing gingivitis-improving composition according to claim 4, wherein the working condition parameters of supercritical carbon dioxide extraction comprise a temperature of 40-50 ℃, a pressure of 20-30 MPa, a medium of carbon dioxide fluid, and an entrainer consisting of heptane and ethanol in a volume ratio of (1-3): 4-7.
  6. 6. The method for producing gingivitis-improving composition according to claim 4, wherein the supercritical carbon dioxide extraction temperature is 46 ℃.
  7. 7. The method for producing gingivitis-improving composition according to claim 4, wherein the supercritical carbon dioxide extraction pressure is 23MPa.
  8. 8. The method of claim 4, wherein the entrainer is comprised of heptane and ethanol in a volume ratio of 3:7.
  9. 9. A mouthwash comprising the gingivitis-ameliorating composition according to any one of claims 1 to 3 or a gingivitis-ameliorating composition produced by the production process according to any one of claims 4 to 8.
  10. 10. The mouthwash of claim 9, wherein the mouthwash comprises the following components in mass percent: the traditional Chinese medicine composition for improving gingivitis is 5% -25%; sorbitol 5-10% Tween-60:0.1% -0.5%; 0.3% -0.7% of PEG-40 hydrogenated castor oil; 0.1% -0.5% of sodium benzoate; sodium citrate 0.2-0.5%; 0.1% -0.3% of stevioside; The balance being water.

Description

A composition for improving gingivitis, its preparation method, and oral liquid Technical Field The invention relates to the technical field of gingivitis, in particular to a composition for improving gingivitis, a preparation method thereof and water for a mouth. Background Gingivitis is a common oral disease with a high incidence among the population. Epidemiological investigations have shown that there are different degrees of gingivitis problem for people of different ages, especially in adolescents and adults. The main clinical manifestations of gingivitis include gum redness, bleeding, pain and the like, which not only bring physical discomfort to patients and influence basic life functions such as daily eating, speaking and the like, reduce life quality, but also possibly cause negative effects on psychological health of the patients, such as speeches, anxiety and the like caused by problems such as oral cavity peculiar smell, gum appearance change and the like. If gingivitis is not treated effectively in time, the disease condition may further develop, causing more serious oral diseases such as periodontitis. Periodontitis can cause alveolar bone absorption, loosening or even falling of teeth, so that not only can the chewing function of the oral cavity be destroyed, but also the facial beauty can be influenced, and the economic burden and the treatment difficulty of a patient are increased. In addition, a great deal of researches show that the oral health is closely related to the whole body health, and oral diseases such as gingivitis and the like can be related to the occurrence and development of systemic diseases such as cardiovascular diseases, diabetes, respiratory diseases and the like, so that the whole health level of a patient is seriously threatened. Currently, chemical drugs for treating gingivitis, which are commonly used clinically, mainly comprise antibiotics, anti-inflammatory drugs and the like. Although antibiotic medicines such as metronidazole, amoxicillin and the like can effectively inhibit or kill pathogenic bacteria in the oral cavity and relieve inflammation symptoms, the problem of bacterial drug resistance is easy to cause after long-term use, so that the curative effect of the medicine is reduced, and even the normal flora balance in the oral cavity is possibly destroyed, and adverse reactions such as double infection and the like are caused. Anti-inflammatory drugs such as ibuprofen, aspirin and the like reduce inflammatory reaction mainly by inhibiting synthesis and release of inflammatory mediators, but the drugs may have certain side effects on gastrointestinal tract, liver and kidney functions and the like, and particularly have higher using risks for some patients suffering from basic diseases. In order to solve the side effects of the existing chemical drugs on gingivitis patients, natural plant extracts are gradually paid attention to the treatment of gingivitis in recent years. Some plant extracts, such as honeysuckle extract, peppermint extract, etc., having anti-inflammatory, antibacterial, hemostatic, etc. effects are used in oral care products. However, most of the natural plant extract products on the market at present have the problems of single component and limited efficacy, so that the treatment effect is poor, and the ideal treatment effect is difficult to achieve. Moreover, the extraction processes of the active ingredients of different plant extracts are different, and if the extraction processes are improper, the loss of the active ingredients or the introduction of impurities can be caused, so that the quality and the safety of the product are affected. Disclosure of Invention In order to solve the problems, the invention provides a composition for improving gingivitis, a preparation method thereof and water for oral cavity. In a first aspect, the present invention provides a gingivitis-ameliorating composition comprising the following components in parts by weight: 20-40 parts of shinyleaf yellowhorn leaves, 5-15 parts of peach gum and 10-25 parts of hops. Further, the ratio M1/M2 of the weight part M1 of the shinyleaf yellowhorn leaf to the total weight part M2 of the peach gum and the hop is 1. Further, the gingivitis-improving composition comprises the following components in parts by weight: 30 parts of shinyleaf yellowhorn leaf, 10 parts of peach gum and 20 parts of hop. In a second aspect, the present invention provides a method for preparing the gingivitis-ameliorating composition according to the first aspect, comprising the steps of: Crushing and mixing shinyleaf yellowhorn leaves, peach gum and hops to obtain a mixture; And (3) extracting the mixture by supercritical carbon dioxide to obtain the gingivitis-improving composition. Further, the working condition parameters of the supercritical carbon dioxide extraction comprise that the temperature is 40-50 ℃, the pressure is 20-30 MPa, the medium is carbon dioxide fluid, and the entrainer