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CN-122005681-A - Traditional Chinese medicine composition for preventing and treating avian influenza disease as well as preparation method and application thereof

CN122005681ACN 122005681 ACN122005681 ACN 122005681ACN-122005681-A

Abstract

The invention discloses a traditional Chinese medicine composition for preventing and treating avian influenza diseases, and a preparation method and application thereof. The traditional Chinese medicine composition contains active ingredients, wherein the active ingredients are prepared from trollflower, radix isatidis, selfheal, cordate houttuynia, cyrtomium rhizome, cowpea, astragalus mongholicus and liquorice. The medicines are combined together to realize synergistic effect, and have the effects of clearing heat and detoxicating, dispersing lung qi and purging heat, and relieving cough and asthma. The formula of the invention can be effectively used for preventing and treating avian influenza diseases, and has the advantages of wide raw material sources, safety, environmental protection, simple preparation process, low production cost and the like.

Inventors

  • GE DAIXING
  • LU GUIMEI
  • LI JIANGONG
  • WANG LIYING
  • YUAN LEI

Assignees

  • 北京大北农动物保健科技有限责任公司
  • 韶山大北农动物药业有限公司

Dates

Publication Date
20260512
Application Date
20260310

Claims (10)

  1. 1. A Chinese medicinal composition for preventing and treating avian influenza disease is characterized by comprising active ingredients, wherein the active ingredients are prepared from trollflower, radix isatidis, selfheal, cordate houttuynia, cyrtomium rhizome, cowpea, astragalus mongholicus and liquorice.
  2. 2. The Chinese medicinal composition for preventing and treating avian influenza disease according to claim 1, wherein the active ingredient is prepared from 60-100 parts of trollius chinensis, 20-80 parts of radix isatidis, 20-60 parts of selfheal, 30-80 parts of houttuynia cordata, 20-50 parts of cyrtomium fortunei, 60-120 parts of cowpea, 30-50 parts of astragalus mongholicus and 10-30 parts of liquorice.
  3. 3. The Chinese medicinal composition for preventing and treating avian influenza disease according to claim 2, wherein the active ingredient is prepared from 70-90 parts of trollius chinensis, 40-60 parts of radix isatidis, 30-50 parts of selfheal, 40-70 parts of houttuynia cordata, 30-45 parts of cyrtomium fortunei, 80-100 parts of cowpea, 35-45 parts of astragalus membranaceus and 15-25 parts of liquorice.
  4. 4. The Chinese medicinal composition for preventing and treating avian influenza disease according to claim 3, wherein the active ingredients are 80 parts of trollius chinensis, 50 parts of isatis root, 40 parts of selfheal, 60 parts of houttuynia cordata, 36 parts of cyrtomium rhizome, 90 parts of cowpea, 40 parts of astragalus and 20 parts of liquorice.
  5. 5. A method for preparing a traditional Chinese medicine composition for preventing and treating avian influenza disease according to any one of claims 1 to 4, which is characterized by comprising the following steps: (1) Weighing the raw materials of the medicines according to the weight ratio; (2) Pulverizing the above materials, sieving, or extracting with water or ethanol, concentrating, and directly making into capsule or adding pharmaceutically acceptable adjuvants or auxiliary components.
  6. 6. The method for preparing a Chinese medicinal composition for preventing and treating avian influenza disease according to claim 5, wherein the prepared dosage form comprises powder, premix, powder, granule or oral liquid.
  7. 7. The method for preparing a Chinese medicinal composition for preventing and treating avian influenza disease according to claim 6, wherein the particle size of the powder is below 50 microns, each 1g of the granule and the powder is equivalent to 2g of the primary drug, and each 1ml of the oral liquid is equivalent to 2g of the primary drug.
  8. 8. The use of the Chinese medicinal composition for preventing and treating avian influenza disease according to any one of claims 1 to 4 in the preparation of medicaments for preventing and treating avian influenza disease.
  9. 9. The use of a Chinese medicinal composition for preventing and treating avian influenza disease according to any one of claims 1 to 4 in preparing feed for preventing and treating avian influenza disease.
  10. 10. A feed comprising the Chinese medicinal composition for preventing and treating avian influenza disease according to any one of claims 1 to 4.

Description

Traditional Chinese medicine composition for preventing and treating avian influenza disease as well as preparation method and application thereof Technical Field The invention relates to a traditional Chinese medicine composition, in particular to a traditional Chinese medicine composition for preventing and treating avian influenza diseases, and a preparation method and application thereof. Background Avian influenza is a viral influenza of birds, and is an infectious disease of birds with various symptoms such as severe sepsis from the respiratory system to the whole body caused by influenza a virus. Typically occurs mainly in spring and winter. Avian influenza viruses are able to attack healthy cells and propagate in the avian digestive tract. The infectious agent is mainly poultry, wild fowl or pig with avian influenza or avian influenza virus. Chickens and turkeys are most susceptible, chickens and turkeys of various ages can be infected and die, the morbidity and the mortality are high, waterfowl such as ducks, geese and the like are easy to infect, the waterfowl can be infected with poison or recessive, and the mortality of the waterfowl such as duckling and gosling is high. The probability of infection of poultry with avian influenza is different in different varieties, and the occurrence of highly pathogenic avian influenza is not found to be related to the sex of the poultry at present. The transmission of highly pathogenic avian influenza between flocks is largely dependent on horizontal transmission, such as air, feed, manure, drinking water, etc., while there is little evidence of vertical transmission. The avian influenza virus can be infected and developed along with the respiratory tract, feces and ocular and nasal secretions of the sick birds through the digestive tract and respiratory tract ways. The world health organization considers that the feces of the sick birds are a main channel for transmission, and experts consider that the migration of the waiting birds is one of transmission paths. Avian influenza virus is easier to survive and spread in low-temperature and humid environments, and the viability and spreading ability of the virus are relatively weak under warm, dry and sunny conditions, so that epidemic situations are more likely to occur in low-temperature and humid areas and seasons (such as autumn, winter and spring). The highly pathogenic avian influenza virus is mainly transmitted through air, and is combined with corresponding receptors on the surface of airway mucosal epithelial cells by means of hemagglutinin (H) on the surface of the virus, so as to be adsorbed on the host airway epithelial cells. The neuraminidase (N) on the surface of the virus acts on the nucleoprotein receptor to combine the virus with the nucleoprotein of the epithelial cells, form RNA-type soluble antigen in the nucleus, exude to the periphery of cytoplasm, replicate the progeny virus, and discharge the epithelial cells in a budding mode by the action of neuraminidase. The period of one replication process is 4-6 hours, and the expelled virus spreads to nearby cells to generate inflammatory reaction, and systemic toxemia-like reaction such as muscle pain, fever, leucopenia and the like clinically occurs. Influenza viruses mainly invade epithelial cells of respiratory mucosa, causing catarrhal lesions such as epithelial cell proliferation, local congestion, necrosis, edema and superficial ulcers of the mucosa. After 4-5 d, basal cell layer lesions can be expanded to bronchi, bronchioles, alveoli and surrounding tissues of bronchi, so as to cause mucosal edema, congestion and lymphocyte infiltration, and can be accompanied by microvascular embolism, necrosis, arteriolopathy, hemorrhage and the like, so as to cause systemic toxemia-like reaction. In addition to bronchiolitis, a few severe progressive pneumonia may have alveolar wall congestion edema, fibrin exudation, mononuclear cell infiltration and hyaline membrane formation, and lung hemorrhage, etc., causing a number of complications. At present, the vaccine for treating the avian influenza at home and abroad has poor multiple effects and no specific medicine for treating the avian influenza. Therefore, the control of good transmission paths is critical, but the enhancement of the immunity of the susceptible animal poultry flock and the improvement of the infection threshold of the susceptible animal are important measures for preventing and controlling the avian influenza diseases. Disclosure of Invention In order to solve the technical problems, the invention provides a traditional Chinese medicine composition for preventing and treating avian influenza diseases. The traditional Chinese medicine composition contains active ingredients, wherein the active ingredients are prepared from trollflower, radix isatidis, selfheal, cordate houttuynia, cyrtomium rhizome, cowpea, astragalus mongholicus and liquorice. Further, the active ingredients are p