Search

CN-122005685-A - Traditional Chinese medicine composition for treating pediatric adenoid hypertrophy, preparation method and application thereof, and pharmaceutical preparation

CN122005685ACN 122005685 ACN122005685 ACN 122005685ACN-122005685-A

Abstract

The invention relates to a traditional Chinese medicine composition for treating pediatric adenoid hypertrophy, a preparation method and application thereof, and a pharmaceutical preparation, and belongs to the technical field of traditional Chinese medicines. The technical problem to be solved is that the existing traditional Chinese medicine composition for treating the pediatric adenoid hypertrophy has poor effect, complex components and high cost. The technical scheme is that the traditional Chinese medicine composition for treating the pediatric adenoid hypertrophy comprises the following components of platycodon grandiflorum, houttuynia cordata, perilla stem, spina gleditsiae, radix scrophulariae, liquorice, dried orange peel and astragalus membranaceus.

Inventors

  • XUAN ZHENYU
  • TAN ZHIMIN
  • SUN HUAYUN
  • SHI DIANYI

Assignees

  • 玉森(佛山)新药研发有限公司

Dates

Publication Date
20260512
Application Date
20260205

Claims (10)

  1. 1. A Chinese medicinal composition for treating infantile adenoid hypertrophy is characterized by comprising the following components of platycodon grandiflorum, houttuynia cordata, perilla stem, spina gleditsiae, radix scrophulariae, liquorice, dried orange peel and astragalus membranaceus.
  2. 2. The traditional Chinese medicine composition according to claim 1, which is characterized by comprising, by weight, 2-10 parts of platycodon grandiflorum, 4-12 parts of houttuynia cordata, 2-10 parts of perilla stem, 2-10 parts of spina gleditsiae, 4-12 parts of radix scrophulariae, 2-10 parts of liquorice, 4-12 parts of dried orange peel and 4-12 parts of astragalus membranaceus.
  3. 3. The traditional Chinese medicine composition according to claim 2, which is characterized by comprising, by weight, 4-10 parts of platycodon grandiflorum, 6-12 parts of houttuynia cordata, 4-10 parts of perilla stem, 4-10 parts of spina gleditsiae, 6-12 parts of radix scrophulariae, 4-10 parts of liquorice, 6-12 parts of dried orange peel and 6-12 parts of astragalus membranaceus.
  4. 4. The method for preparing a Chinese medicinal composition according to any one of claims 1 to 3, comprising the steps of mixing the above materials, decocting with water, mixing the filtrates, and concentrating.
  5. 5. The method according to claim 4, wherein the water is 6-12 times of the total mass of the medicinal materials, the number of times of the decoction is 2-4 times, and the time of the decoction is 1-3 h.
  6. 6. The process of claim 4, wherein the concentration provides an extract having a relative density of 1.15 to 1.25 g/mL at 60 ℃.
  7. 7. A pharmaceutical formulation comprising the traditional Chinese medicine composition of any one of claims 1-3 and pharmaceutically acceptable excipients.
  8. 8. The pharmaceutical preparation according to claim 7, wherein the auxiliary materials comprise one or more of a preservative, a wetting agent, a suspending agent, a flavoring agent, a diluent, a flavoring agent and a cosolvent, wherein the preparation is in the form of a tablet, a capsule, a granule, a liquid preparation or a paste, and the pH of the preparation is 5.0-6.1.
  9. 9. The pharmaceutical formulation of claim 8, wherein the flavoring agent comprises one or more of grapefruit essence, passion fruit essence, blueberry essence, mango essence, milk essence, juicy peach essence, orange essence, sweet orange essence, pineapple essence, grape essence, apple essence, banana essence, strawberry essence, and chocolate essence.
  10. 10. Use of a traditional Chinese medicine composition according to any one of claims 1-3 or a pharmaceutical formulation according to any one of claims 7-9 for the manufacture of a medicament for the treatment of adenoid hypertrophy diseases.

Description

Traditional Chinese medicine composition for treating pediatric adenoid hypertrophy, preparation method and application thereof, and pharmaceutical preparation Technical Field The invention belongs to the technical field of traditional Chinese medicines, and in particular relates to a traditional Chinese medicine composition for treating pediatric adenoid hypertrophy, a preparation method and application thereof, and a pharmaceutical preparation. Background The adenoid body is also called pharyngeal tonsils or proliferation bodies, is an important peripheral immune organ of a human body in childhood, and is the largest lymphoid tissue of the nasopharynx. Under the stimulation of pathological factors such as repeated infection, allergy and the like, the pediatric adenoid appears, inflammation and pathological hyperplasia are Adenoid Hypertrophy (AH), nasal obstruction, open mouth respiration, snoring and sleep suffocation are clinically taken as main symptoms, the adenoid appearance appears for a long time, secretory otitis media, nasosinusitis and the like are easy to occur, even serious illness such as children obstructive sleep apnea-hypopnea syndrome (OSAHS) and the like occur, the physical and psychological health of the infant is influenced, and the incidence rate can reach 34 percent according to statistics. In terms of treatment, western medicine is largely divided into surgical treatment and medical drug conservation treatment. Surgical treatment involves the risk of reducing the immune function of the infant or eradicating the disease causing recurrence, such as bleeding, infection, sound changes, etc. Furthermore, surgical treatment weakens the immune system of the human body, makes patients more susceptible to attack by bacteria, viruses, etc., and may lead to recurrence of adenoid hypertrophy. There is no specific medicine for medical conservation treatment. Compared with western medicine treatment methods, the traditional Chinese medicine has the advantages of fundamentally improving immunity and reducing recurrence, and has remarkable effect, less adverse reaction and high safety, but no Chinese patent medicine is marketed at present. The related patent documents: The Chinese patent publication No. CN116870122A discloses a traditional Chinese medicine composition for treating infantile adenoid hypertrophy and application thereof, wherein the traditional Chinese medicine composition comprises, by weight, 4.5-13.5 parts of trollius chinensis, 7.5-22.5 parts of cercis chinensis, 7.5-22.5 parts of magnolia flower, 6-18 parts of glabrous greenbrier rhizome, 4.5-13.5 parts of spina gleditsiae, 5-15 parts of oyster, 4.5-13.5 parts of asteriscus Pseudosciaenae, 4.5-13.5 parts of rhizoma curcumae, 6-18 parts of selfheal and 1.5-4.5 parts of stevia rebaudiana. The traditional Chinese medicine composition is used for tangent treatment of pathogenesis of the pediatric adenoid hypertrophy, and the whole formula has the effects of clearing heat and detoxicating, promoting nasal orifices, removing blood stasis and resolving masses. Experiments prove that the traditional Chinese medicine composition not only inhibits the occurrence and the development of the pediatric adenoid hypertrophy by anti-inflammation, but also can obviously improve the traditional Chinese medicine symptoms of the pediatric adenoid hypertrophy, and the curative effect is obviously better than the conventional treatment. The relevant non-patent literature: Journal name is "journal of the department of otorhinolaryngology combined with Chinese traditional and western medicine", literature name is "discussing mechanism and treatment of adenoid hypertrophy from wind evil and children's pure yang theory", volume number 33 (06), publication date 2025, 12 months and 18 days, the literature discloses that pure yang of children does not mean that there is no yin or yang, but on the basis of yin-yang balance, children have a slightly more yang and slightly less yin relative unbalanced tendency, and pure yang heat transformation and phlegm coagulation appear under the influence of wind evil. Dispelling pathogenic wind, clearing heat, resolving hard mass, regulating spleen and nourishing stomach, and relieving adenoid hypertrophy. Pure Yang Huare is the root cause of the pathology of adenoid hypertrophy, and spleen dysfunction and transportation caused by pathogenic wind attack is the sign of the pathology of adenoid hypertrophy. However, the traditional Chinese medicine composition disclosed in the patent of the invention still has poor effect of treating the pediatric adenoid hypertrophy, and has complex components and high cost. Disclosure of Invention The invention aims to provide that: a traditional Chinese medicine composition for treating pediatric adenoid hypertrophy and a preparation method and application thereof are provided, which are used for solving the technical problems of poor effect, complex components and high cost or the combin