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CN-122005689-A - Traditional Chinese medicine composition for treating sepsis as well as preparation method and application thereof

CN122005689ACN 122005689 ACN122005689 ACN 122005689ACN-122005689-A

Abstract

The invention discloses a traditional Chinese medicine composition for treating sepsis, and a preparation method and application thereof, wherein the traditional Chinese medicine composition comprises 1-15 parts of sulfur, 3-25 parts of human white, 1-20 parts of wine rheum officinale, 10-30 parts of fructus cannabis, 10-50 parts of radix bupleuri, 5-30 parts of radix scutellariae, 5-25 parts of dyers woad leaf, 5-25 parts of peach kernel, 5-30 parts of radix salviae miltiorrhizae, 5-30 parts of angelica sinensis, 5-30 parts of sophora flower charcoal, 5-25 parts of fructus gardeniae and 5-60 parts of wine fructus corni. According to the invention, through the combined mode of 'monarch drug targeting taking with ministerial drug and assistant and guide drug cooperative decoction', the whole-course intervention of 'upstream inhibition, midstream blocking and downstream regulation' of sepsis immune disorder can be realized, and meanwhile, yang warming, cold dispelling, blood cooling and detoxification are taken into consideration, so that the pro-inflammatory/anti-inflammatory balance is successfully restored to a physiological state, and the action mode is superior to the traditional single anti-inflammatory strategy and the application mode of the traditional Chinese medicine decocted from the whole formula. In a standard animal model, the traditional Chinese medicine composition has obvious effects of resisting inflammation, regulating immunity, protecting multiple organs and improving overall conditions in a dose-dependent manner, has a high-dose group curative effect equivalent to that of a classical powerful medicine, and has more advantages in the aspects of restoring immune homeostasis, warming yang and strengthening healthy energy.

Inventors

  • ZHENG XIAOHONG
  • TANG XINHAO
  • CHU BOWEN
  • CHEN QI

Assignees

  • 南京中医药大学

Dates

Publication Date
20260512
Application Date
20260122

Claims (10)

  1. 1. The traditional Chinese medicine composition for treating sepsis is characterized by comprising the following raw materials in parts by weight: 1-15 parts of sulfur, 3-25 parts of white in human, 1-20 parts of wine rheum officinale, 10-30 parts of fructus cannabis, 10-50 parts of radix bupleuri, 5-30 parts of radix scutellariae, 5-25 parts of dyers woad leaf, 5-25 parts of peach kernel, 5-30 parts of radix salviae miltiorrhizae, 5-30 parts of angelica sinensis, 5-30 parts of pagodatree flower charcoal, 5-25 parts of fructus gardeniae, and 5-60 parts of wine fructus corni.
  2. 2. The traditional Chinese medicine composition for treating sepsis according to claim 1, which is characterized by comprising the following raw materials in parts by weight: 1-10 parts of sulfur, 5-15 parts of white in human, 1-10 parts of wine rheum officinale, 10-20 parts of fructus cannabis, 10-30 parts of radix bupleuri, 5-15 parts of radix scutellariae, 10-20 parts of dyers woad leaf, 5-15 parts of peach kernel, 10-20 parts of radix salviae miltiorrhizae, 5-15 parts of angelica sinensis, 5-15 parts of pagodatree flower charcoal, 5-15 parts of fructus gardeniae, and 10-30 parts of wine fructus corni.
  3. 3. The traditional Chinese medicine composition for treating sepsis according to claim 2, which is characterized by comprising the following raw materials in parts by weight: 3-6 parts of sulfur, 10-15 parts of white in a person, 6-10 parts of wine rheum officinale, 15-20 parts of fructus cannabis, 15-30 parts of radix bupleuri, 10-15 parts of radix scutellariae, 15-20 parts of dyers woad leaf, 10-15 parts of peach kernel, 15-20 parts of radix salviae miltiorrhizae, 10-15 parts of Chinese angelica, 10-15 parts of pagodatree flower charcoal, 10-15 parts of fructus gardeniae, and 15-30 parts of wine fructus corni.
  4. 4. The traditional Chinese medicine composition for treating sepsis according to claim 3, which is characterized by comprising the following raw materials in parts by weight: 3 parts of sulfur, 10 parts of white in a person, 6 parts of rheum officinale, 15 parts of fructus cannabis, 15 parts of radix bupleuri, 10 parts of radix scutellariae, 15 parts of folium isatidis, 10 parts of peach kernel, 15 parts of radix salviae miltiorrhizae, 10 parts of Chinese angelica, 10 parts of pagodatree flower charcoal, 10 parts of fructus gardeniae preparata and 15 parts of fructus corni.
  5. 5. The method for preparing the traditional Chinese medicine composition for treating sepsis according to any one of claims 1 to 4, which is characterized by comprising the following steps: (1) Taking the wine rhubarb, fructus cannabis, radix bupleuri, radix scutellariae, folium isatidis, peach kernel, radix salviae miltiorrhizae, angelica sinensis, pagodatree flower charcoal, charred fructus gardeniae and wine fructus corni according to the weight parts, placing into a decocting device, adding appropriate amount of water, soaking for 40-60 min, heating and decocting for 1 hr, and filtering to obtain Chinese medicinal water decoction; (2) Taking sulfur and white people in parts by weight, pulverizing into powder, and mixing with the liquid medicine in the step (1) according to a certain proportion.
  6. 6. The method for preparing the traditional Chinese medicine composition for treating sepsis according to claim 5, which is characterized by comprising the following steps: (1) Taking, by weight, rheum officinale, fructus cannabis, radix bupleuri, radix scutellariae, folium isatidis, peach kernel, radix salviae miltiorrhizae, angelica sinensis, pagodatree flower charcoal, fructus gardeniae and pulp of wine dogwood fruit, placing the materials into a decoction vessel, adding 5-20 times of water into the materials for 10-60 minutes, heating and decocting for 1-3 times, each time for 0.5-3 hours, filtering, combining the decoction extracts, and storing the extracts in a refrigerator at 4 ℃ for standby; (2) Taking sulfur and white people in parts by weight, pulverizing into powder, and mixing with the liquid medicine in the step (1) according to a certain proportion.
  7. 7. The method for preparing the traditional Chinese medicine composition for treating sepsis according to claim 6, which is characterized by comprising the following steps: (1) Taking the wine rhubarb, fructus cannabis, radix bupleuri, radix scutellariae, folium isatidis, peach kernel, radix salviae miltiorrhizae, angelica sinensis, pagodatree flower charcoal, charred fructus gardeniae and wine fructus corni according to the weight parts, placing the materials in a decoction device, soaking the materials in 5-20 times of water for 40 minutes, heating and decocting the materials for 40 minutes, filtering the materials, and taking filtrate and storing the filtrate in a refrigerator at 4 ℃ for later use; (2) Taking sulfur and human leucorrhea according to parts by weight, pulverizing into powder, sieving with a 80-mesh sieve, uniformly mixing with the liquid medicine in the step (1), and adding a pharmaceutically acceptable carrier to prepare the traditional Chinese medicine preparation.
  8. 8. The use of the traditional Chinese medicine composition according to any one of claims 1-4 in preparing a medicament for treating sepsis.
  9. 9. The use of the traditional Chinese medicine composition according to any one of claims 1-4 in preparing a medicament for treating pre-sepsis shock.
  10. 10. The use according to claim 8 or 9, wherein the medicament is in the form of a tablet, pill, powder, granule or capsule.

Description

Traditional Chinese medicine composition for treating sepsis as well as preparation method and application thereof Technical Field The invention relates to the technical field of traditional Chinese medicines, in particular to a traditional Chinese medicine composition for treating sepsis, and a preparation method and application thereof. Background Sepsis is an imbalance in host response induced by infection, which in turn leads to life threatening organ dysfunction, and is one of the leading causes of death in critically ill patients worldwide. The pathological mechanism is complex, the core is the imbalance of organism immune inflammatory reaction, which is manifested by excessive release of pro-inflammatory mediators (such as TNF-alpha, IL-1 beta and IL-6) and insufficient anti-inflammatory mechanisms (such as IL-10), and causes 'cytokine storm', which finally leads to vascular endothelial injury, microcirculation disturbance and progressive injury and even failure of heart, liver, lung, kidney and other multi-organ functions. Currently, standardized treatment in modern medicine is centered on early anti-infective, full fluid resuscitation, vasoactive drug support and organ function replacement. However, this strategy is mainly focused on controlling the infectious source and maintaining macroscopic vital signs, lacking safe and effective specific intervention for systemic inflammatory reactions, immune disorders and early organ parenchymal lesions caused by them that have been initiated and out of control. Antibiotics cannot regulate host immune response, and powerful anti-inflammatory drugs (such as large doses of glucocorticoids) have risks of inducing secondary infection, aggravating metabolic disorder and the like, which highlight the limitation of the current treatment in the key link of regulating host response. Based on the theory of 'holistic view' and 'dialectical treatment', the traditional Chinese medicine shows unique potential in regulating complex inflammation and immune response by virtue of the multi-component, multi-target and multi-path synergistic action mode, and is regarded as a valuable supplementary strategy in comprehensive treatment of sepsis. Sepsis is mostly classified in the traditional Chinese medicine into the categories of warm disease, blood syndrome, syncope and the like, and the main clinical symptoms in the early stage of shock include chills and high fever secondary to suppurative infection, tachypnea with tachycardia, serious dyspnea and dying sensation, hypotension, constipation, reduced urine volume (oliguria), change of consciousness state, pale skin, damp coldness, change of pattern of spots or ecchymosis, multiple organ dysfunction and the like. At present, the treatment methods of clearing heat and detoxicating, activating blood and dissolving stasis, freeing viscera and purgating down, tonifying qi and relieving depletion are commonly used in clinic. However, the traditional Chinese medicine compound or research disclosed in the prior art focuses on the single pathogenesis of excessive heat toxin or incoordination between viscera, and the thinking of medication is often focused on the bitter and cold heat clearing or interior-dredging and purgation of big dosage. Although the scheme can relieve partial symptoms, a key pathogenesis is generally ignored, namely, the sepsis patient usually has a constitution foundation of 'yang qi deficiency and cold dampness easy to collapse' due to congenital deficiency or acquired imbalance. It is the internal cold-dampness and deficiency of healthy qi that causes the exterior-sensitive heat-toxin to sink deep and lodge with the interior-dampness, resulting in the problems of prolonged illness, difficult repair of tissue injury (easy ulceration) and rapid impairment of healthy qi (progress to shock). Clinically, the pre-shock patients show contradictory symptoms of shivering and high fever alternation, namely, damp-cold limbs, which is the external manifestation of cold-dampness stagnation transforming heat and vital qi deficiency evil loving complex pathogenesis. Therefore, aiming at the key window period of the early stage of sepsis shock, the prior Chinese and Western medicine strategies have obvious defects that modern medicine lacks a safe and effective host reaction regulator, while the prior Chinese medicine proposal focuses on the level of clearing heat, detoxicating and dredging downwards, and is difficult to realize early-stage cutting and torsion aiming at the compound pathogenesis of cold-dampness physique-heat toxin phenomena, blood stasis viscera excess-qi and yin to be removed. In view of this, there is a need in clinic to develop a three-dimensional treatment method based on innovative understanding of the pathogenesis of traditional Chinese medicine, which integrates 'Wen Huana cold-dampness to treat the root cause, clear heat toxin and eliminate inflammation to treat the symptoms, open the hollow viscera to