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CN-122005693-A - Application of Jiaweidanzhi Xiaoyao powder or extract thereof in preparation of medicines for treating depression complicated with ulcerative colitis

CN122005693ACN 122005693 ACN122005693 ACN 122005693ACN-122005693-A

Abstract

The invention belongs to the technical field of medicine research, and in particular relates to an application of Jiawei Danzhi Xiaoyao powder or an extract thereof in preparing a medicine for treating depression complicated with ulcerative colitis. Experiments prove that the Jiaweidanzhi Xiaoyao powder can improve depression-like behaviors and relieve ulcerative colitis symptoms, and has remarkable treatment effect on treating depression complicated with ulcerative colitis.

Inventors

  • WANG YUANYUAN
  • XU ERPING
  • WANG BAOYING
  • LI XINGYI
  • LIU XIANGHUA
  • LU KEYI
  • SHAO YANNA

Assignees

  • 河南中医药大学

Dates

Publication Date
20260512
Application Date
20260320

Claims (10)

  1. 1. The application of the Jiawei Danzhi Xiaoyao powder or the extract thereof in preparing the medicine for treating depression complicated with ulcerative colitis is characterized by comprising, by weight, 10-14 parts of radix bupleuri, 8-11 parts of Chinese angelica, 10-14 parts of stir-fried white peony root, 8-12 parts of bighead atractylodes rhizome, 14-16 parts of poria cocos, 2-4 parts of liquorice, 10-14 parts of cortex moutan, 10-14 parts of raw gardenia, 10-14 parts of rhizoma acori graminei, 10-14 parts of polygala tenuifolia and 5-7 parts of peppermint.
  2. 2. The use according to claim 1, wherein the extract is prepared according to the following steps: Weighing the medicinal materials according to the parts by weight, mixing, soaking in water, decocting, collecting decoction, concentrating, and drying to obtain the traditional Chinese medicine.
  3. 3. The use according to claim 2, wherein the soaking in water is performed by adding water in an amount 8-10 times the total weight of the medicinal materials, and soaking for 1h is performed for 2-3 times, each time for 30min.
  4. 4. The use according to claim 2, wherein the concentration is carried out at 40-50 ℃.
  5. 5. The use according to claim 2, wherein the drying is freeze-drying and the extract is a lyophilized powder.
  6. 6. A medicament for treating depression complicated with ulcerative colitis, which is characterized in that the extract of claim 1 or the blood-entering component of the Jiawei Danzhiyaoyao powder is used as an active ingredient.
  7. 7. The medicament according to claim 6, wherein the blood-entering component is Salsalate、(+)-2-Phenyllactic acid、3-(3,4-dihydroxy-5-methoxyphenyl)prop-2-enoic acid、5-(Phenylsulfonyl)-2-thiophenecarboxylic acid、Dehydrologanin、FA 18:2+2o、1,3,7-Trimethyluric acid、6-Deoxy-.alpha.-L-mannopyranosyl-(1->3)-[.beta.-D-glucopyranosyl-(1->6)]-1-O-(3,27-dihydroxy-27,28-dioxolup-20(29)-en-28-yl)-.beta.-D-glucopyranose、D-Mannitol 1-phosphate、cis-Pinonic acid、Azelaic acid、2-Hydroxy-5-sulfonicotinic acid、[3-Me-His2] TRH、Aldosterone、Coumaric acid、9-Oxo-10(E),12(E)-octadecadienoic acid、6-{[4-(1,3-Dioxo-1,3-dihydro-2H-isoindol-2-yl)anilino]carbonyl}-3,4-dimethyl-3-cyclohexene-1-carboxylic acid、Homogentisic acid、Deoxyribose、Deoxycholic acid、Isomaltose、12(S)-HHT、Diethyl 3,4-dihydroxy-2,5-difuroate、N-Choloylglycine、(9E,11Z)-8-Hydroxyoctadeca-9,11-dienoic acid、N-Acetyl-L-tyrosine、Octyl gallate、Daidzein 4'-sulfate、Hippuric acid、Methyl 4-formyl-3-hydroxy-2-naphthoate、Preleptospermone、2-Isopropylmalic acid、4-Formyl-2-hydroxybenzoic acid、Acetylsyringic acid、Ethyl gallate、Baicalin、5,7-Dihydroxy-2-(4-hydroxyphenyl)-3-[3,5,7-trihydroxy-2-(4-hydroxyphenyl)chroman-8-yl]chroman-4-one、5'-Methylthioinosine、Paeoniflorin、Estrone-3-glucuronide、Amastatin、Benzenepropanoic acid, 4-hydroxy-、Liguiritigenin-7-O-beta-D-apiosyl-4'-O-beta-D-glucoside、Olivetol、{[3-Ethoxy-2-(ethoxycarbonyl)-3-oxo-1-propenyl]amino}acetic acid、3-Hydroxybenzoic acid、[(3R,4S,8S,8aS)-3-Hydroxy-6,8a-dimethyl-8-[(Z)-2-methylbut-2-enoyl]oxy-3-propan-2-yl-1,2,3a,4,5,8-hexahydroazulen-4-yl] 4-hydroxybenzoate、5-Fluoroindazole-3-carboxylic acid、Genipin 1-gentiobioside、3-Methoxygallic acid、Quinate、(2-Butoxyethoxy)acetic acid、Naringenin-4'-O-.beta.-D-glucuronide、Entecavir、3-Methoxytyrosine、Licoricesaponin h2、2-Oxocyclohexanepropanoic acid、5-Chloro-2,4-dihydroxy-6-methyl-3-[(2E,4E)-3-methyl-5-(1,2,6-trimethyl-5-oxocyclohex-3-en-1-yl)penta-2,4-dienyl]benzaldehyde、4-Methoxysalicylic acid、Hydrocinnamic acid, o-hydroxy-、4-Formylphenol、Vanillic acid、(3Z)-4-(Carboxymethyl)-2-(hexopyranosyloxy)-3-(2-(((2E)-3-(4-hydroxyphenyl)prop-2-enoyl)oxy)ethylidene)-3,4-dihydro-2H-pyran-5-carboxylic acid;Sulconazole、Stachydrine、3,4,5-Trimethoxy-N-(4-morpholinyl)benzamide、(r)-4-((5s,8r,9s,10s,13r,14s,17r)-10,13-dimethyl-3,7-dioxohexadecahydro-1h-cyclopenta[a]phenanthren-17-yl)pentanoic acid、2-(1-Piperazinyl)acetamide、Leucine, 4-methyl-、4-Guanidinobutyric acid、Bufalin、Lenticine、5-Methyl-2-tert-butyl-2H-pyrazol-3-ylamine、1b-Hydroxycholic acid、L-1,2,3,4-Tetrahydro-beta-carboline-3-carboxylic acid、Glycocholate、Geniposidic acid、[1,1'-Biphenyl]-2,3',4,5',6-pentol、5?-cholanic acid-3?-ol-7_12-dione、N-Cyclohexyl-N'-(6-methyl-2-pyridinyl)thiourea、Azepindole、2,2'-Dimethoxybenzoin、5-(2',4-dihydroxy-6-keto-1',1',4'a,6'-tetramethyl-spiro[3,8-dihydrofur[2,3-e]isoindole-2,5'-decalin]-7-yl)valeric acid、Shanziside methyl ester、4-Chlorophenylsulfinylacetic acid、Ticlopidine、Echinulin、Asiatic acid、Brefeldin C、4-Benzyl-N-propylpiperazine-1-carboxamide、7-Keto-3.alpha.,12-.alpha.-dihydroxycholanic acid、Isopropyl 4-hydroxybenzoate、CD 3254、Oxadixyl、.alpha.-CEHC、4-Keto-4-[3-methyl-5-(5,6,7-trihydroxy-1,2,4a,5-tetramethyldecalin-1-yl)pentoxy]butyric acid、Jasminoside A、.beta.-Homotyrosine、Dihydrocitrinone、Paeoniflorin、4-Methylumbelliferyl phosphate、5-Bromo-4-hexylpyrimidine、7-Dehydroestradiol、L-Arginine, methyl ester、Liquiritigenin、(+)-.gamma.-Tocopherol、3,23-Dihydroxy-1-oxo-12-oleanen-28-oic acid、Asp-Ile-Arg、Salicyl glucuronide、Indacaterol、Callosumin、Ncgc00180030-03!1-(2,4,5-trimethoxyphenyl)propane-1,2-diol、Viridiflorine、Austdiol、Enterolactone、Gibepyrone D、Naringenin-4'-O-.beta.-D-glucuronide、1,3-Benzodioxole, 4,5-dimethoxy-6-(1-propen-1-yl)-、Methyl 4-coumarate、ZINC100060148、Homogentisic acid、Galangin-5,7-dimethyl ether、N-[2-(4-Mesylpiperazino)ethyl]-N'-(p-tolyl)oxamide、Butacaine、4-Fluoro-N-[2-(4-morpholinyl)ethyl]benzamide.
  8. 8. The medicament of claim 6, further comprising a pharmaceutically acceptable adjuvant.
  9. 9. The medicament of claim 8, which is an oral formulation.
  10. 10. The medicament of claim 9, which is in the form of granules, syrups, tablets or capsules.

Description

Application of Jiaweidanzhi Xiaoyao powder or extract thereof in preparation of medicines for treating depression complicated with ulcerative colitis Technical Field The invention belongs to the technical field of medicine research, and in particular relates to an application of Jiawei Danzhi Xiaoyao powder or an extract thereof in preparing a medicine for treating depression complicated with ulcerative colitis. Background Depression is a common psychological disorder, with about 3.5 million people suffering from depression, on average, every 20 people who have had or are currently suffering from depression. The lifetime prevalence of depressive disorders in most countries is between 8% and 12%. Depression has recurrent characteristics and may occur as a recurrent condition even during remission. After recurrence, the patient has symptoms of low emotion, losing interest in life, fatigue feeling, slow thinking and the like, and the illness state repeatedly fluctuates. Epidemiological characteristics of depression are affected by a variety of factors including genetic, psychological, social and environmental factors, and the like. These factors may act alone or in combination to cause the occurrence and progression of depression. Ulcerative colitis (Ulcerative colitis, UC) belongs to one of the inflammatory bowel diseases (inflammatory bowel disease, IBD), chronic nonspecific inflammatory diseases of the colon and rectum, lesions being limited to the mucosa and submucosa of the large intestine. The etiology of ulcerative colitis is not completely understood, but is generally thought to be the result of interactions of foreign substances with host responses, genes, and immune effects. The incidence and prevalence of ulcerative colitis are increasing. It has been found that patients with ulcerative colitis have a high proportion of psychotic disorders such as depression and anxiety. Intestinal microbiota imbalance and metabolic disorders are thought to play an important role in ulcerative colitis or psychotic disorders. Possible mechanisms for ulcerative colitis concurrent with depression and anxiety include changes in brain signaling and morphology, increases in peripheral and intra-brain pro-inflammatory cytokines, damage to nitric oxide pathways, changes in vagal nerve signaling, gut flora imbalance, and genetic factors. Ulcerative colitis and depression and anxiety complications may have symptoms of common mental diseases such as anxiety and depression, because patients conduct bi-directional communication through intestinal-brain axes, and symptoms exist for a long time, quality of life is impaired, and social functions are reduced. However, the severity of this problem is still uncertain. The incidence of anxiety and depression symptoms is high in ulcerative colitis patients, with up to one third of patients having anxiety symptoms and one quarter of patients having depression symptoms. Prevalence of active disease patients has also increased, with half of these patients meeting anxiety symptomatology criteria and one third meeting depressive symptomatology criteria. Encouraging a gastroenterologist to screen and treat these diseases may improve prognosis for patients with ulcerative colitis. Clinical depression exacerbates the course of ulcerative colitis, however there is currently no drug for depression complicated with ulcerative colitis. The traditional Chinese medicine has the characteristics of multiple components and multiple targets and also has the characteristics of simplicity, convenience and cheapness, so that the defect that the traditional Chinese medicine can be used for solving the defect that the depression is combined with the ulcerative colitis and no medicine can be used for medicine when the traditional Chinese medicine is applied according to the characteristics of the depression and the ulcerative colitis. The added pill, cape jasmine and ease powder has the functions of soothing liver and relieving depression, eliminating phlegm, promoting resuscitation, supporting yang, nourishing brain, clearing heat, eliminating dampness, cooling blood, removing blood stasis and reducing turbidity; the mint strips are used for dispersing the liver and the turbid, are used for tonifying middle-jiao and strengthening spleen by taking poria cocos and bighead atractylodes rhizome as the basis of ascending and clearing, are used for tonifying liver and regulating ying by taking Chinese angelica and white paeony root, and are used for continuing the ascending and descending of turbid, and the ginger and the liquorice are used for harmonizing the medicines, so that the effects of soothing liver and relieving depression, strengthening spleen and regulating ying are achieved, and the symptoms of liver and spleen deficiency and wood and no soil are treated. The medicines are combined to strengthen brain, promote intelligence, clear liver and promote the circulation of qi and blood, and treat both liver a