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CN-122005696-A - Ointment for strengthening body resistance and consolidating constitution and warming yang and dredging collaterals

CN122005696ACN 122005696 ACN122005696 ACN 122005696ACN-122005696-A

Abstract

The invention relates to the technical field of traditional Chinese medicine preparations, and in particular discloses a paste for strengthening body resistance and warming yang and dredging collaterals, which has the technical key points that: the ointment is prepared from ephedra, cornus, safflower, red paeony root, stevia rebaudiana, thin aconite, chinese yam, kudzuvine root, prepared rhizome of rehmannia, platycodon root, cattail pollen, szechuan lovage rhizome, chinese angelica, twotooth achyranthes root, membranous milkvetch root, manchurian wildginger, chinese thorowax root, liquoric root, peach seed, rosewood heart wood and bitter orange according to a specific weight part ratio. The ointment of the invention combines Yan Dexin teaching 'balance method' theory with Guo Ziguang medical university 'Qi Ge Fang' experience, establishes a treatment system for warming yang, tonifying qi, activating blood, removing stasis, strengthening body resistance, dredging collaterals and restoring, and accurately aims at the heart pathogenesis of yang deficiency and blood stasis type coronary heart disease angina and chronic heart failure. Clinical experiments prove that the ointment formula is obviously superior to the conventional treatment (P is less than 0.05) in improving the symptoms of traditional Chinese medicine and improving the heart function, has good safety, is an oral ointment formula, is moist and sweet in quality, is convenient to take for a long time, and has obvious clinical application value and popularization prospect.

Inventors

  • ZHOU WENBIN
  • CHEN ZIKANG
  • CHEN HONGXIN
  • PENG HAIKE

Assignees

  • 广州医科大学附属中医医院(广州市中医中药研究所、广州市中医医院、广州中医药大学附属广州中医医院、广州市针灸医院)

Dates

Publication Date
20260512
Application Date
20260410

Claims (8)

  1. 1. The ointment for strengthening body resistance and consolidating constitution and warming yang and dredging collaterals is characterized by being prepared from the following medicinal materials in parts by weight: 6 parts of ephedra, 16 parts of cornus officinalis, 4 parts of safflower, 10 parts of red paeony root, 2 parts of stevia rebaudiana, 12 parts of thin aconite, 20 parts of Chinese yam, 16 parts of kudzuvine root, 16 parts of prepared rhizome of rehmannia, 4 parts of platycodon root, 10 parts of cattail pollen, 10 parts of szechuan lovage rhizome, 10 parts of Chinese angelica, 10 parts of twotooth achyranthes root, 24 parts of membranous milkvetch root, 2 parts of manchurian wildginger, 4 parts of Chinese thorowax root, 6 parts of liquoric root, 8 parts of peach seed, 4 parts of rosewood and 4 parts of bitter orange.
  2. 2. The paste for strengthening body resistance and warming yang and invigorating pulse according to claim 1, wherein the paste for strengthening body resistance and warming yang is an oral paste prescription.
  3. 3. The preparation method of the paste for strengthening body resistance and warming yang and dredging collaterals according to claim 1 or 2, which is characterized by comprising the following steps: S1, preparing materials and soaking, namely selecting traditional Chinese medicine decoction pieces according to a proportion, requiring no mildew or worm damage, cleaning, filling into a non-woven fabric bag, sealing and wrapping, and soaking in water for 12-20 hours; S2, decocting and concentrating for multiple times by adopting a steaming and decocting machine, wherein the temperature of the decoction is controlled to be 100-105 ℃, the first decoction time is 3.5 hours, the second decoction time is 2.5 hours, and the third decoction time is 1.5 hours; S3, collecting and mixing the paste, namely standing and precipitating the concentrated solution, collecting supernatant fluid, collecting the paste, and adding auxiliary materials according to the requirement for mixing; S4, sub-packaging and cooling, namely filling the paste into a clean packaging container according to a dosage standard, cooling to room temperature or below 20 ℃ and sealing; S5, quality control and packaging, namely performing external packaging, coding and storage after three layers of quality inspection pass each batch of paste.
  4. 4. The method of claim 3, wherein the decocting in step S2 is performed using a KSP-400 type steamer.
  5. 5. A method according to claim 3, wherein the concentration in step S2 is performed using a high pressure concentrator.
  6. 6. The method of claim 3, wherein the clean packaging container in step S4 is an aluminum foil bag or a glass bottle.
  7. 7. The method according to claim 3, wherein the three-layer quality inspection in step S5 is a 80 day, 100 day, 120 day stability spot inspection, and the storage humidity condition is 50% -70%.
  8. 8. The use of the paste for strengthening body resistance and warming yang and dredging collaterals according to claim 1 or 2 in preparing a medicament for treating coronary heart disease angina or chronic heart failure due to yang deficiency and blood stasis.

Description

Ointment for strengthening body resistance and consolidating constitution and warming yang and dredging collaterals Technical Field The invention relates to the technical field of traditional Chinese medicine preparations, in particular to a paste for strengthening body resistance, consolidating constitution, warming yang and dredging collaterals. Background Coronary heart disease, angina pectoris and chronic heart failure are clinically common cardiovascular diseases, and have the characteristics of high morbidity, high recurrence rate and high disability rate, and seriously threaten the life quality of patients. The traditional Chinese medicine considers that the pathogenesis of the diseases is complex and is mostly related to heart-yang deficiency, qi-blood deficiency, cold coagulation and blood stasis and phlegm stasis. Especially for patients with longer disease course and weak constitution, the 'yang deficiency and blood stasis' is the key syndrome feature, namely, yang deficiency is the root and blood stasis is the principal, and the two are causal to form malignant circulation. Therefore, the recipe can achieve the effect of treating both principal and secondary aspect of the disease in the treatment by activating blood and removing obstruction in collaterals to treat the principal and secondary aspect of the disease and warming yang and strengthening body resistance to strengthen the root. At present, various traditional Chinese medicine preparations are used for auxiliary treatment of coronary heart disease, angina and chronic heart failure on the market, such as red sage root dripping pills, compound red sage root tablets, ginseng-ophiopogon injection, astragalus and lepidium seed heart strengthening capsules and the like. However, the existing products on the market have the following defects and shortcomings, and the clinical requirements of long-term nursing and individual intervention of patients with yang deficiency and blood stasis are difficult to meet: 1. The theory of treatment is single, failing to grasp the nature of yang deficiency Most of the traditional Chinese patent medicine preparations have the effects of promoting blood circulation by removing blood stasis, clearing heat and dredging collaterals, and neglect the key effects of yang deficiency in the onset of coronary heart disease, angina pectoris and chronic heart failure. For example, although the preparation containing the components of the red sage root, the pseudo-ginseng and the like has a certain efficacy of activating blood and relieving pain, the preparation has no obvious curative effect on heart-yang deficiency, qi deficiency and hypodynamia, aversion to cold and cold limbs, soreness and weakness of waist and knees and the like caused by yang deficiency, and even has long-term yang injury caused by cold property, which is not beneficial to long-term conditioning of patients with deficiency syndromes. 2. The prescription combination lacks classical support and has incomplete compatibility structure Part of the products have simple medicinal flavor, focus on single treatment dimension (such as blood circulation activating or qi tonifying), lack the integrity and layering sense of traditional Chinese medicine classical prescriptions, and fail to embody the compatibility principle of 'monarch, minister, assistant and guide'. The formula thought of the individual combat is difficult to realize the treatment aim of treating both principal and secondary aspects of the disease, so that the curative effect is short, the conditioning power is insufficient, and the treatment idea of bidirectional regulation and control of strengthening body resistance to eliminate evil in traditional Chinese medicine can not be met. 3. Poor dosage form design and poor compliance of chronic diseases after long-term administration Most of the existing related medicines are tablets, capsules, dripping pills or injection, and although the existing related medicines are convenient for quantitative and mass production, the existing related medicines have poor adaptability to long-term administration requirements of the old people. The tablet and capsule are disintegrated and absorbed slowly in the body, the dripping pill has the advantages of quick effect but short acting time, and the injection has the problems of inconvenient use and low patient acceptance. Part of the preparation is bitter and cold, difficult to swallow, and affects patient compliance. These dosage forms do not meet the spirit of "treating diseases by the root and moistening the ointment" in the internal channels. 4. Lack of famous experience integration and no individual nursing idea At present, the system is not integrated with academic experience of a famous Chinese medicine (such as 'constant law' theory taught by Yan Dexin and 'Qihong Ge Fang' experience of Guo Ziguang medical university) and falls to be an industrialized special prescription paste product. Most of similar pr