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CN-122005697-A - External preparation for treating skin itch of jaundice patient and preparation method thereof

CN122005697ACN 122005697 ACN122005697 ACN 122005697ACN-122005697-A

Abstract

The invention relates to an external preparation for treating skin itch of a patient with jaundice and a preparation method thereof, and relates to the technical field of traditional Chinese medicines, wherein the external preparation for treating skin itch of a patient with jaundice comprises a traditional Chinese medicine extract; the traditional Chinese medicine extract comprises, by weight, 25-35 parts of hops, 10-20 parts of tassel leaves and 10-20 parts of bamboo roots. The Chinese medicinal composition has the advantages of effectively extracting and fully retaining the effective components by combining a gradient reduced pressure reflux extraction mode, obviously improving the effect of the obtained Chinese medicinal composition on the improvement of the skin itch symptoms of patients with jaundice, having better treatment effect than the existing conventional medicaments, providing a new means for treating the skin itch diseases of patients with jaundice, and having wide application prospect.

Inventors

  • LIU JIN
  • JI PING
  • HU YUEMEI
  • HU YABIN
  • LI QIAN

Assignees

  • 新疆医科大学第三附属医院

Dates

Publication Date
20260512
Application Date
20260223

Claims (10)

  1. 1. An external preparation for treating skin itch of patients with jaundice is characterized by comprising a traditional Chinese medicine extract; The traditional Chinese medicine extract comprises the following raw materials in parts by weight: 25-35 parts of hops, 10-20 parts of tassel leaves and 10-20 parts of bamboo roots.
  2. 2. The external preparation for treating skin itch of jaundice patients according to claim 1, wherein the weight ratio of the hops, the tassel leaves and the bamboo root seven is 2:1:1.
  3. 3. The external preparation for treating skin itch of jaundice patients according to claim 1, wherein the traditional Chinese medicine extract comprises the following raw materials in parts by weight: 30 parts of hops, 15 parts of tassel leaves and 15 parts of bamboo roots.
  4. 4. The external preparation for treating skin itch of jaundice patients according to claim 1, wherein the preparation method of the traditional Chinese medicine extract comprises the following steps: mixing and crushing hops, tassel leaves and radix bambusae to obtain a mixture; adding the mixture into water for first reduced pressure distillation and extraction, and stopping the first reduced pressure distillation and extraction when the volume of the distillate is half of the volume of the initial water addition amount to obtain a first distillate and a residual feed liquid containing dregs; Adding water with the same volume as the first distillate into the residual feed liquid containing the dregs, and then performing second reduced pressure distillation and extraction, and stopping the second reduced pressure distillation and extraction when the volume of the distillate is half of the volume of the initial water addition amount to obtain a second distillate; Combining, concentrating and drying the first distillate and the second distillate to obtain the traditional Chinese medicine extract; The working condition parameters of the first reduced pressure distillation and extraction comprise the temperature of 30-48 ℃ and the pressure of 3-9 kPa, the working condition parameters of the second reduced pressure distillation and extraction comprise the temperature of 78-85 ℃ and the pressure of 35-42 kPa, and the weight ratio of the mixture to the water is 1 (8-15).
  5. 5. The external preparation for treating skin itch of a patient with jaundice according to claim 4, wherein the working condition parameters extracted by the first reduced pressure distillation comprise a temperature of 37 ℃ and a pressure of 5kPa.
  6. 6. The external preparation for treating skin itch of a patient with jaundice according to claim 4, wherein the working condition parameters extracted by the second reduced pressure distillation comprise a temperature of 80 ℃ and a pressure of 38kPa.
  7. 7. The external preparation for treating skin itch of a patient with jaundice according to any one of claims 1 to 6, wherein the dosage form of the external preparation for treating skin itch of a patient with jaundice comprises at least one of a liquid lotion, a paste-like coating agent and a gel-like coating agent.
  8. 8. The external preparation for treating skin itch of a patient with jaundice according to any one of claims 1 to 6, wherein the external preparation for treating skin itch of a patient with jaundice comprises the following components in percentage by mass: 4% -9% of the traditional Chinese medicine extract; Carbomer 940:0.2% -0.5%; EDTA-2Na:0.02%~0.05%; 0.05 to 0.15 percent of methylparaben; 3% -5% of glycerol; ethanol is 2% -4%; A proper amount of pH regulator for regulating the pH of the system to 5.8-6.5; The balance being water.
  9. 9. The external preparation for treating skin itch in patients with jaundice according to claim 8, wherein the pH adjustor comprises a citrate-phosphate buffer.
  10. 10. A method for preparing the external preparation for treating skin itch of a patient with jaundice according to any one of claims 1 to 9, which is characterized by comprising the following steps: obtaining a traditional Chinese medicine extract; And stirring and mixing the traditional Chinese medicine extract and the rest components to obtain the external preparation for treating the skin itch of the patient with jaundice.

Description

External preparation for treating skin itch of jaundice patient and preparation method thereof Technical Field The invention relates to the technical field of traditional Chinese medicines, in particular to an external preparation for treating skin itch of a patient with jaundice and a preparation method thereof. Background Jaundice is a common clinical symptom and can be caused by various reasons, such as liver diseases (e.g. hepatitis, cirrhosis, etc.), biliary obstruction, hemolytic diseases, etc. In the process of jaundice, skin itching is a common and serious symptom which plagues patients, besides the typical manifestations of skin and scleral yellow stains. The skin itch is usually severe, can be systemic or local, seriously affects the life quality of patients, causes sleep disorder and emotional dysphoria of the patients, and even further aggravates the illness state due to complications such as skin damage, infection and the like caused by repeated scratching. At present, the treatment means for treating skin itch of patients with jaundice are limited. In clinical treatment, the methods commonly used mainly include treatment against primary diseases and symptomatic treatment. For the treatment of primary diseases, such as treating liver diseases, relieving biliary tract obstruction, etc., although the jaundice condition can be radically improved, a certain time is often required for relieving the symptoms of skin itch, and skin itch may still continuously exist in the primary disease treatment process, which brings great pain to patients. In the aspect of symptomatic treatment, western medicine adopts some antihistamines, bile acid binding resins and other medicines. Although the antihistamine can relieve itching to a certain extent, adverse reactions such as sleepiness and dry mouth exist, which affect the daily life and work of patients, and the bile acid binding resin medicine can cause gastrointestinal discomfort such as constipation and abdominal distention, and part of patients have poor tolerance. Moreover, these drugs may develop drug resistance after long-term use, resulting in gradual decrease of drug effect, and require increasing doses to maintain therapeutic effects, thereby increasing the risk of adverse reactions. In addition, some external medicines such as ointments containing glucocorticoids, although capable of rapidly relieving skin itch and inflammatory responses, are liable to cause serious adverse reactions such as skin atrophy, telangiectasia, hormone-dependent dermatitis and the like after long-term use, and are especially unsuitable for jaundice patients who need to control itch symptoms for a long time. Traditional Chinese medicines have a long history and unique advantages in treating skin diseases. The characteristics of multiple components and multiple targets of the traditional Chinese medicine enable the traditional Chinese medicine to regulate organism functions from multiple links, achieve the effect of treating both principal and secondary aspect of disease, and have relatively small adverse reaction. However, the traditional Chinese medicine external preparation specially aiming at the skin itch of patients with jaundice in the market at present is relatively few, has poor treatment effect, and cannot meet the requirements of clinical treatment. Disclosure of Invention In order to solve the problems, the invention provides an external preparation for treating skin itch of patients with jaundice and a preparation method thereof. In a first aspect, the invention provides an external preparation for treating skin itch of a patient with jaundice, which comprises a traditional Chinese medicine extract; The traditional Chinese medicine extract comprises the following raw materials in parts by weight: 25-35 parts of hops, 10-20 parts of tassel leaves and 10-20 parts of bamboo roots. Further, the weight ratio of the hops, the tassel leaves and the bamboo root seven is 2:1:1. Further, the traditional Chinese medicine extract comprises the following raw materials in parts by weight: 30 parts of hops, 15 parts of tassel leaves and 15 parts of bamboo roots. Further, the preparation method of the traditional Chinese medicine extract comprises the following steps: mixing and crushing hops, tassel leaves and radix bambusae to obtain a mixture; adding the mixture into water for first reduced pressure distillation and extraction, and stopping the first reduced pressure distillation and extraction when the volume of the distillate is half of the volume of the initial water addition amount to obtain a first distillate and a residual feed liquid containing dregs; Adding water with the same volume as the first distillate into the residual feed liquid containing the dregs, and then performing second reduced pressure distillation and extraction, and stopping the second reduced pressure distillation and extraction when the volume of the distillate is half of the volume of the initial w