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CN-122005698-A - Temperature control type dragon's blood cataplasm and preparation method and application thereof

CN122005698ACN 122005698 ACN122005698 ACN 122005698ACN-122005698-A

Abstract

The invention discloses a temperature-control type dragon's blood cataplasm and a preparation method and application thereof, belonging to the technical field of medical equipment and external traditional Chinese medicine preparations. The cataplasm is of a layered composite structure, and comprises a backing layer, a temperature control heating layer, a heat insulation temperature control layer, a cataplasm matrix layer containing sanguis Draxonis extract and an anti-sticking layer. The application temperature can be precisely controlled at 40-50 ℃ and lasts for 2-4 hours by matching the heating layer material and the ventilation temperature control material, and the pharmacological actions of the controllable low-temperature thermal therapy and the dragon's blood are organically combined, so that the synergy of thermal therapy and medical therapy is realized. The product of the invention can obviously promote hematoma absorption, relieve swelling and pain, is safe and convenient to use, is especially suitable for treating subacute stages such as subcutaneous hematoma after trauma, subcutaneous hematoma after arterial puncture operation, soft tissue injury and the like, and has wide clinical application prospect.

Inventors

  • XU RUI
  • LIU JUN
  • LIU ZHIQIANG

Assignees

  • 江油市九〇三医院

Dates

Publication Date
20260512
Application Date
20260325

Claims (10)

  1. 1. The temperature control type dragon's blood cataplasm is characterized by being of a layered composite structure, and sequentially comprising the following components from one side far away from skin to one side applying the skin: A backing layer (1); The temperature control heating layer (2) comprises a heating material and a ventilation temperature control material, wherein the ventilation temperature control material is used for controlling the oxygen entering rate, so that the temperature of a skin contact surface is stably maintained between 40 ℃ and 50 ℃ during application, and the heating can be continuously carried out for 2 to 4 hours; The heat insulation temperature control layer (3) is positioned between the temperature control heating layer (2) and the medicated cataplasm matrix layer (4) and is made of microporous materials or materials with low heat conductivity coefficients and used for homogenizing heat flow; the medicated cataplasm matrix layer (4) is cataplasm paste loaded with sanguis Draxonis extract; An anti-sticking layer (5).
  2. 2. The temperature-controlled dragon's blood cataplasm according to claim 1, wherein the mass percentage of the dragon's blood extract in the medicated cataplasm matrix layer (4) is 1-20%.
  3. 3. The temperature-controlled dragon's blood cataplasm according to claim 1 or 2, wherein the medicated cataplasm matrix layer (4) comprises, by weight, 2-8 parts of sodium polyacrylate, 0.2-1.0 part of aluminum glycinate, 30-50 parts of glycerol, 0.5-2.0 parts of sodium carboxymethylcellulose, 3-15 parts of dragon's blood extract, 0.1-0.5 part of tartaric acid and 40-60 parts of purified water.
  4. 4. The temperature-controlled dragon's blood cataplasm according to claim 3, wherein the medicated cataplasm matrix layer (4) comprises, by weight, 4-6 parts of sodium polyacrylate, 0.4-0.6 part of aluminum glycinate, 35-45 parts of glycerin, 0.8-1.2 parts of sodium carboxymethylcellulose, 5-10 parts of dragon's blood extract, 0.2-0.4 part of tartaric acid and 45-55 parts of purified water.
  5. 5. The temperature-control type dragon's blood cataplasm according to claim 1, wherein the heating material is a mixture of iron powder, activated carbon, vermiculite, salt and water, the mass ratio of the heating material is the iron powder, the activated carbon, the vermiculite, the salt=80-120:15-35:5-15:3-8, and the addition amount of the water is 10% -25% of the total mass of the four dry powders of the iron powder, the activated carbon, the vermiculite and the salt.
  6. 6. The temperature-controlled dragon's blood cataplasm according to claim 1, wherein the air-permeable temperature-controlling material is an air-permeable film or a nonwoven fabric, the oxygen transmission amount thereof is 500-5000 cm 3/(m2.24h.atm), or the average pore diameter thereof is 0.1-50 μm.
  7. 7. A method for preparing the temperature-controlled dragon's blood cataplasm according to any one of claims 1 to 6, which comprises the following steps: Preparing a medicine-containing paste, namely dispersing the dragon's blood extract in glycerin, adding sodium polyacrylate, mixing uniformly to obtain a phase A, mixing aluminum glycollate and sodium carboxymethylcellulose to obtain a phase B, dissolving tartaric acid in purified water to prepare a phase C, adding the phase B into the phase A, mixing uniformly, slowly adding the phase C, stirring uniformly at a high speed, and defoaming in vacuum to obtain a medicine-containing paste; Prefabricating a temperature control heating layer, namely mixing iron powder, active carbon, vermiculite and salt in proportion, adding water accounting for 10-25% of the total mass of dry powder, filling the mixture into a bag made of a breathable temperature control material to form a heating inner core, and then compounding a heat preservation material on at least one surface of the heating inner core to form the temperature control heating layer; The whole assembly comprises the steps of coating the ointment body obtained in the step 1 on an anti-sticking layer (5) to form a medicated cataplasm matrix layer (4), then sequentially covering and fixing a heat insulation temperature control layer (3), a prefabricated temperature control heating layer (2) and a backing layer (1) on the medicated cataplasm matrix layer (4) by adopting a mode of edge hot pressing sealing or spot gluing, and cutting and packaging.
  8. 8. Use of a temperature-controlled dragon's blood cataplasm according to any one of claims 1-6 for the preparation of a topical product for promoting hematoma absorption and alleviating swelling pain.
  9. 9. The method of claim 8, wherein the treatment is for the subacute phase of soft tissue injury.
  10. 10. The method of claim 9, wherein the subacute phase is 48 hours to 2 weeks after injury.

Description

Temperature control type dragon's blood cataplasm and preparation method and application thereof Technical Field The invention belongs to the technical field of medical equipment and external traditional Chinese medicine preparations, and particularly relates to temperature-control type dragon's blood cataplasm and a preparation method and application thereof. Background Subcutaneous hematoma and soft tissue contusion after trauma are clinically common conditions. After the acute phase (typically 48-72 hours after injury), a subacute phase characterized by blood stasis coagulation, swelling pain, tissue repair is entered. The core of the treatment at this stage is to promote hematoma absorption, eliminate inflammation, relieve pain and accelerate tissue repair. There are a number of limitations to the treatment methods currently in clinical use. Physical therapy such as infrared irradiation, hot compress and the like can dilate local blood vessels and promote blood circulation, but lacks direct drug intervention, has single curative effect, strong equipment dependence and poor convenience for patients. The traditional Chinese medicine external application, for example, the traditional Chinese medicine external application is prepared by mixing the traditional Chinese medicines such as dragon's blood and the like with vinegar or wine to obtain powder, and has the advantages of easy drying and falling of the medicine, uneven release of active ingredients, limited permeability, uncontrollable temperature, easy pollution to clothes, inconvenient self operation of patients and the like. Modern external plaster such as common cataplasm or rubber plaster is convenient to use, but generally has no heating function, can not enhance transdermal absorption and local blood flow of the medicine through heat effect, and common spontaneous heating plaster (such as a warm baby) on the market can only provide heat treatment, does not contain therapeutic medicine, and has single function. The dragon's blood has definite pharmacological actions of resisting inflammation, easing pain, improving microcirculation, promoting tissue repair and the like, and the curative effects of treating pressure injury, diabetic foot, phlebitis and the like by external application of the dragon's blood are proved by a great deal of researches, and the core effects correspond to pathological demands of removing blood stasis, diminishing inflammation and promoting repair in the subacute stage of hematoma. The cataplasm is used as a modern transdermal drug delivery carrier and has the advantages of large drug loading capacity, good air permeability, repeated sticking and the like. In theory, the controllable thermal therapy is combined with the traditional Chinese medicine cataplasm, and the local blood circulation and the medicine permeation are promoted by the thermal effect, so that the aim of synergistic treatment is hopefully realized. However, no mature product report of combining the dragon's blood cataplasm with a safe, stable and controllable low-temperature spontaneous heating technology and specially used for treating hematoma in subacute stage is currently seen. Therefore, the research and development of the compound product which can organically combine the pharmacological action of the dragon's blood with the continuous and safe physical heat curative effect, is convenient to use and has definite curative effect, and has important clinical significance and market value. Disclosure of Invention The invention aims to provide a temperature-control type dragon's blood cataplasm as well as a preparation method and application thereof, which can completely solve the defects of the prior art. The aim of the invention is achieved by the following technical scheme: the temperature control type dragon's blood cataplasm is a layered composite structure, and sequentially comprises the following components from one side far away from skin to one side applied to skin: A backing layer; The temperature control heating layer comprises a heating material and a ventilation temperature control material, wherein the ventilation temperature control material is used for controlling the oxygen entering rate, so that the temperature of a skin contact surface is stably maintained between 40 ℃ and 50 ℃ during application, and the heating can be continuously carried out for 2 to 4 hours; The heat insulation temperature control layer is positioned between the temperature control heating layer and the medicated cataplasm matrix layer and is composed of microporous materials or materials with low heat conductivity coefficients and used for homogenizing heat flow; The medicated cataplasm matrix layer is cataplasm paste loaded with sanguis Draxonis extract; An anti-sticking layer. The heat conductivity of the heat insulation temperature control layer is 0.03-0.3W/(m.K), preferably 0.05-0.15W/(m.K), and the heat resistance value is 0.01-0.1 m2.K/W. When microporous m